PMC:7546716 / 42095-42473 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T850","span":{"begin":43,"end":45},"obj":"Body_part"},{"id":"T851","span":{"begin":50,"end":52},"obj":"Body_part"},{"id":"T852","span":{"begin":61,"end":66},"obj":"Body_part"},{"id":"T853","span":{"begin":77,"end":80},"obj":"Body_part"},{"id":"T854","span":{"begin":93,"end":98},"obj":"Body_part"},{"id":"T855","span":{"begin":100,"end":110},"obj":"Body_part"},{"id":"T856","span":{"begin":105,"end":110},"obj":"Body_part"},{"id":"T857","span":{"begin":112,"end":123},"obj":"Body_part"},{"id":"T858","span":{"begin":258,"end":260},"obj":"Body_part"},{"id":"T859","span":{"begin":264,"end":268},"obj":"Body_part"},{"id":"T860","span":{"begin":264,"end":266},"obj":"Body_part"},{"id":"T861","span":{"begin":274,"end":276},"obj":"Body_part"},{"id":"T862","span":{"begin":312,"end":317},"obj":"Body_part"}],"attributes":[{"id":"A850","pred":"fma_id","subj":"T850","obj":"http://purl.org/sig/ont/fma/fma86578"},{"id":"A851","pred":"fma_id","subj":"T851","obj":"http://purl.org/sig/ont/fma/fma86578"},{"id":"A852","pred":"fma_id","subj":"T852","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A853","pred":"fma_id","subj":"T853","obj":"http://purl.org/sig/ont/fma/fma20935"},{"id":"A854","pred":"fma_id","subj":"T854","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A855","pred":"fma_id","subj":"T855","obj":"http://purl.org/sig/ont/fma/fma66784"},{"id":"A856","pred":"fma_id","subj":"T856","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A857","pred":"fma_id","subj":"T857","obj":"http://purl.org/sig/ont/fma/fma62860"},{"id":"A858","pred":"fma_id","subj":"T858","obj":"http://purl.org/sig/ont/fma/fma86578"},{"id":"A859","pred":"fma_id","subj":"T859","obj":"http://purl.org/sig/ont/fma/fma84051"},{"id":"A860","pred":"fma_id","subj":"T860","obj":"http://purl.org/sig/ont/fma/fma86578"},{"id":"A861","pred":"fma_id","subj":"T861","obj":"http://purl.org/sig/ont/fma/fma86578"},{"id":"A862","pred":"fma_id","subj":"T862","obj":"http://purl.org/sig/ont/fma/fma68646"}],"text":"Selective JAK2 inhibitors (eg, fedratinib) IL-23, IL-6 γδT17 cells, Th17, GM-CSF-producing T cells, mast cells, neutrophils Possibly inhibit inflammation in severe COVID-19 and do not interfere with JAK1-dependent interferon signalling Do not interfere with IL-9, IL-2, and IL-7-mediated expansion of effector T cells; might favour bacterial, viral, and opportunistic infections"}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T240","span":{"begin":141,"end":153},"obj":"Disease"},{"id":"T241","span":{"begin":164,"end":172},"obj":"Disease"},{"id":"T242","span":{"begin":368,"end":378},"obj":"Disease"}],"attributes":[{"id":"A240","pred":"mondo_id","subj":"T240","obj":"http://purl.obolibrary.org/obo/MONDO_0021166"},{"id":"A241","pred":"mondo_id","subj":"T241","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A242","pred":"mondo_id","subj":"T242","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"}],"text":"Selective JAK2 inhibitors (eg, fedratinib) IL-23, IL-6 γδT17 cells, Th17, GM-CSF-producing T cells, mast cells, neutrophils Possibly inhibit inflammation in severe COVID-19 and do not interfere with JAK1-dependent interferon signalling Do not interfere with IL-9, IL-2, and IL-7-mediated expansion of effector T cells; might favour bacterial, viral, and opportunistic infections"}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T580","span":{"begin":57,"end":60},"obj":"http://purl.obolibrary.org/obo/CLO_0050389"},{"id":"T581","span":{"begin":61,"end":66},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T582","span":{"begin":91,"end":98},"obj":"http://purl.obolibrary.org/obo/CL_0000084"},{"id":"T583","span":{"begin":105,"end":110},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T584","span":{"begin":225,"end":235},"obj":"http://purl.obolibrary.org/obo/SO_0000418"},{"id":"T585","span":{"begin":264,"end":268},"obj":"http://purl.obolibrary.org/obo/PR_000001379"},{"id":"T586","span":{"begin":301,"end":317},"obj":"http://purl.obolibrary.org/obo/CL_0000911"}],"text":"Selective JAK2 inhibitors (eg, fedratinib) IL-23, IL-6 γδT17 cells, Th17, GM-CSF-producing T cells, mast cells, neutrophils Possibly inhibit inflammation in severe COVID-19 and do not interfere with JAK1-dependent interferon signalling Do not interfere with IL-9, IL-2, and IL-7-mediated expansion of effector T cells; might favour bacterial, viral, and opportunistic infections"}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T661","span":{"begin":10,"end":25},"obj":"Chemical"},{"id":"T662","span":{"begin":15,"end":25},"obj":"Chemical"},{"id":"T663","span":{"begin":43,"end":45},"obj":"Chemical"},{"id":"T665","span":{"begin":50,"end":52},"obj":"Chemical"},{"id":"T667","span":{"begin":74,"end":76},"obj":"Chemical"},{"id":"T668","span":{"begin":214,"end":224},"obj":"Chemical"},{"id":"T669","span":{"begin":258,"end":260},"obj":"Chemical"},{"id":"T671","span":{"begin":264,"end":266},"obj":"Chemical"},{"id":"T673","span":{"begin":274,"end":276},"obj":"Chemical"},{"id":"T675","span":{"begin":301,"end":309},"obj":"Chemical"}],"attributes":[{"id":"A661","pred":"chebi_id","subj":"T661","obj":"http://purl.obolibrary.org/obo/CHEBI_76617"},{"id":"A662","pred":"chebi_id","subj":"T662","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"},{"id":"A663","pred":"chebi_id","subj":"T663","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A664","pred":"chebi_id","subj":"T663","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A665","pred":"chebi_id","subj":"T665","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A666","pred":"chebi_id","subj":"T665","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A667","pred":"chebi_id","subj":"T667","obj":"http://purl.obolibrary.org/obo/CHEBI_74120"},{"id":"A668","pred":"chebi_id","subj":"T668","obj":"http://purl.obolibrary.org/obo/CHEBI_52999"},{"id":"A669","pred":"chebi_id","subj":"T669","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A670","pred":"chebi_id","subj":"T669","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A671","pred":"chebi_id","subj":"T671","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A672","pred":"chebi_id","subj":"T671","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A673","pred":"chebi_id","subj":"T673","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A674","pred":"chebi_id","subj":"T673","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A675","pred":"chebi_id","subj":"T675","obj":"http://purl.obolibrary.org/obo/CHEBI_35224"}],"text":"Selective JAK2 inhibitors (eg, fedratinib) IL-23, IL-6 γδT17 cells, Th17, GM-CSF-producing T cells, mast cells, neutrophils Possibly inhibit inflammation in severe COVID-19 and do not interfere with JAK1-dependent interferon signalling Do not interfere with IL-9, IL-2, and IL-7-mediated expansion of effector T cells; might favour bacterial, viral, and opportunistic infections"}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T76","span":{"begin":354,"end":378},"obj":"Phenotype"}],"attributes":[{"id":"A76","pred":"hp_id","subj":"T76","obj":"http://purl.obolibrary.org/obo/HP_0031690"}],"text":"Selective JAK2 inhibitors (eg, fedratinib) IL-23, IL-6 γδT17 cells, Th17, GM-CSF-producing T cells, mast cells, neutrophils Possibly inhibit inflammation in severe COVID-19 and do not interfere with JAK1-dependent interferon signalling Do not interfere with IL-9, IL-2, and IL-7-mediated expansion of effector T cells; might favour bacterial, viral, and opportunistic infections"}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T116","span":{"begin":141,"end":153},"obj":"http://purl.obolibrary.org/obo/GO_0006954"},{"id":"T117","span":{"begin":225,"end":235},"obj":"http://purl.obolibrary.org/obo/GO_0023052"}],"text":"Selective JAK2 inhibitors (eg, fedratinib) IL-23, IL-6 γδT17 cells, Th17, GM-CSF-producing T cells, mast cells, neutrophils Possibly inhibit inflammation in severe COVID-19 and do not interfere with JAK1-dependent interferon signalling Do not interfere with IL-9, IL-2, and IL-7-mediated expansion of effector T cells; might favour bacterial, viral, and opportunistic infections"}

{"project":"LitCovid-sentences","denotations":[{"id":"T182","span":{"begin":0,"end":378},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Selective JAK2 inhibitors (eg, fedratinib) IL-23, IL-6 γδT17 cells, Th17, GM-CSF-producing T cells, mast cells, neutrophils Possibly inhibit inflammation in severe COVID-19 and do not interfere with JAK1-dependent interferon signalling Do not interfere with IL-9, IL-2, and IL-7-mediated expansion of effector T cells; might favour bacterial, viral, and opportunistic infections"}

{"project":"LitCovid-PubTator","denotations":[{"id":"1698","span":{"begin":10,"end":14},"obj":"Gene"},{"id":"1699","span":{"begin":43,"end":48},"obj":"Gene"},{"id":"1700","span":{"begin":50,"end":54},"obj":"Gene"},{"id":"1701","span":{"begin":74,"end":80},"obj":"Gene"},{"id":"1702","span":{"begin":258,"end":262},"obj":"Gene"},{"id":"1703","span":{"begin":264,"end":268},"obj":"Gene"},{"id":"1704","span":{"begin":274,"end":278},"obj":"Gene"},{"id":"1791","span":{"begin":141,"end":153},"obj":"Disease"},{"id":"1792","span":{"begin":164,"end":172},"obj":"Disease"},{"id":"1793","span":{"begin":354,"end":378},"obj":"Disease"}],"attributes":[{"id":"A1698","pred":"tao:has_database_id","subj":"1698","obj":"Gene:3717"},{"id":"A1699","pred":"tao:has_database_id","subj":"1699","obj":"Gene:51561"},{"id":"A1700","pred":"tao:has_database_id","subj":"1700","obj":"Gene:3569"},{"id":"A1701","pred":"tao:has_database_id","subj":"1701","obj":"Gene:1437"},{"id":"A1702","pred":"tao:has_database_id","subj":"1702","obj":"Gene:3578"},{"id":"A1703","pred":"tao:has_database_id","subj":"1703","obj":"Gene:3558"},{"id":"A1704","pred":"tao:has_database_id","subj":"1704","obj":"Gene:16196"},{"id":"A1791","pred":"tao:has_database_id","subj":"1791","obj":"MESH:D007249"},{"id":"A1792","pred":"tao:has_database_id","subj":"1792","obj":"MESH:C000657245"},{"id":"A1793","pred":"tao:has_database_id","subj":"1793","obj":"MESH:D009894"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Selective JAK2 inhibitors (eg, fedratinib) IL-23, IL-6 γδT17 cells, Th17, GM-CSF-producing T cells, mast cells, neutrophils Possibly inhibit inflammation in severe COVID-19 and do not interfere with JAK1-dependent interferon signalling Do not interfere with IL-9, IL-2, and IL-7-mediated expansion of effector T cells; might favour bacterial, viral, and opportunistic infections"}