PMC:7546716 / 4073-4901 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T56","span":{"begin":7,"end":12},"obj":"Body_part"},{"id":"T57","span":{"begin":14,"end":16},"obj":"Body_part"},{"id":"T58","span":{"begin":71,"end":85},"obj":"Body_part"},{"id":"T59","span":{"begin":80,"end":85},"obj":"Body_part"},{"id":"T60","span":{"begin":151,"end":153},"obj":"Body_part"},{"id":"T61","span":{"begin":264,"end":279},"obj":"Body_part"},{"id":"T62","span":{"begin":274,"end":279},"obj":"Body_part"},{"id":"T63","span":{"begin":291,"end":295},"obj":"Body_part"},{"id":"T64","span":{"begin":291,"end":293},"obj":"Body_part"},{"id":"T65","span":{"begin":315,"end":319},"obj":"Body_part"},{"id":"T66","span":{"begin":499,"end":519},"obj":"Body_part"},{"id":"T67","span":{"begin":640,"end":642},"obj":"Body_part"},{"id":"T68","span":{"begin":669,"end":673},"obj":"Body_part"},{"id":"T69","span":{"begin":711,"end":717},"obj":"Body_part"}],"attributes":[{"id":"A56","pred":"fma_id","subj":"T56","obj":"http://purl.org/sig/ont/fma/fma68877"},{"id":"A57","pred":"fma_id","subj":"T57","obj":"http://purl.org/sig/ont/fma/fma86578"},{"id":"A58","pred":"fma_id","subj":"T58","obj":"http://purl.org/sig/ont/fma/fma62499"},{"id":"A59","pred":"fma_id","subj":"T59","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A60","pred":"fma_id","subj":"T60","obj":"http://purl.org/sig/ont/fma/fma86578"},{"id":"A61","pred":"fma_id","subj":"T61","obj":"http://purl.org/sig/ont/fma/fma273565"},{"id":"A62","pred":"fma_id","subj":"T62","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A63","pred":"fma_id","subj":"T63","obj":"http://purl.org/sig/ont/fma/fma84051"},{"id":"A64","pred":"fma_id","subj":"T64","obj":"http://purl.org/sig/ont/fma/fma86578"},{"id":"A65","pred":"fma_id","subj":"T65","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A66","pred":"fma_id","subj":"T66","obj":"http://purl.org/sig/ont/fma/fma83023"},{"id":"A67","pred":"fma_id","subj":"T67","obj":"http://purl.org/sig/ont/fma/fma86578"},{"id":"A68","pred":"fma_id","subj":"T68","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A69","pred":"fma_id","subj":"T69","obj":"http://purl.org/sig/ont/fma/fma9637"}],"text":"In the lungs, IL-33 is promptly released, mainly by injured epithelial alveolar cells, following infection and cellular damage.12 Among its functions, IL-33 enhances TGFβ-mediated differentiation of Foxp3+ regulatory T (Treg) cells13 and stimulates CD11c+ myeloid dendritic cells to secrete IL-2, which drives Treg cell expansion, thus ultimately promoting resolution of inflammation.14 Individuals infected with SARS-CoV-2 who develop milder symptoms tend to have large numbers of Treg cells10 and alveolar macrophages showing a scavenger resolving (FABP4+) phenotype.15 In the presence of an adequate immune response and virus clearance, IL-33 might drive rapid Treg cell-dependent restoration of respiratory tissue homoeostasis, which probably accounts for the mild or asymptomatic forms of COVID-19 seen in most individuals."}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T6","span":{"begin":711,"end":717},"obj":"Body_part"}],"attributes":[{"id":"A6","pred":"uberon_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/UBERON_0000479"}],"text":"In the lungs, IL-33 is promptly released, mainly by injured epithelial alveolar cells, following infection and cellular damage.12 Among its functions, IL-33 enhances TGFβ-mediated differentiation of Foxp3+ regulatory T (Treg) cells13 and stimulates CD11c+ myeloid dendritic cells to secrete IL-2, which drives Treg cell expansion, thus ultimately promoting resolution of inflammation.14 Individuals infected with SARS-CoV-2 who develop milder symptoms tend to have large numbers of Treg cells10 and alveolar macrophages showing a scavenger resolving (FABP4+) phenotype.15 In the presence of an adequate immune response and virus clearance, IL-33 might drive rapid Treg cell-dependent restoration of respiratory tissue homoeostasis, which probably accounts for the mild or asymptomatic forms of COVID-19 seen in most individuals."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T44","span":{"begin":97,"end":106},"obj":"Disease"},{"id":"T45","span":{"begin":371,"end":383},"obj":"Disease"},{"id":"T46","span":{"begin":413,"end":421},"obj":"Disease"},{"id":"T47","span":{"begin":794,"end":802},"obj":"Disease"}],"attributes":[{"id":"A44","pred":"mondo_id","subj":"T44","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A45","pred":"mondo_id","subj":"T45","obj":"http://purl.obolibrary.org/obo/MONDO_0021166"},{"id":"A46","pred":"mondo_id","subj":"T46","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A47","pred":"mondo_id","subj":"T47","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"}],"text":"In the lungs, IL-33 is promptly released, mainly by injured epithelial alveolar cells, following infection and cellular damage.12 Among its functions, IL-33 enhances TGFβ-mediated differentiation of Foxp3+ regulatory T (Treg) cells13 and stimulates CD11c+ myeloid dendritic cells to secrete IL-2, which drives Treg cell expansion, thus ultimately promoting resolution of inflammation.14 Individuals infected with SARS-CoV-2 who develop milder symptoms tend to have large numbers of Treg cells10 and alveolar macrophages showing a scavenger resolving (FABP4+) phenotype.15 In the presence of an adequate immune response and virus clearance, IL-33 might drive rapid Treg cell-dependent restoration of respiratory tissue homoeostasis, which probably accounts for the mild or asymptomatic forms of COVID-19 seen in most individuals."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T39","span":{"begin":7,"end":12},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"},{"id":"T40","span":{"begin":60,"end":70},"obj":"http://purl.obolibrary.org/obo/CL_0000066"},{"id":"T41","span":{"begin":80,"end":85},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T42","span":{"begin":199,"end":204},"obj":"http://purl.obolibrary.org/obo/PR_000001350"},{"id":"T43","span":{"begin":220,"end":224},"obj":"http://purl.obolibrary.org/obo/CL_0000792"},{"id":"T44","span":{"begin":249,"end":254},"obj":"http://purl.obolibrary.org/obo/PR_000001013"},{"id":"T45","span":{"begin":256,"end":279},"obj":"http://purl.obolibrary.org/obo/CL_0000782"},{"id":"T46","span":{"begin":291,"end":295},"obj":"http://purl.obolibrary.org/obo/PR_000001379"},{"id":"T47","span":{"begin":310,"end":314},"obj":"http://purl.obolibrary.org/obo/CL_0000792"},{"id":"T48","span":{"begin":315,"end":319},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T49","span":{"begin":482,"end":486},"obj":"http://purl.obolibrary.org/obo/CL_0000792"},{"id":"T50","span":{"begin":528,"end":529},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T51","span":{"begin":623,"end":628},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T52","span":{"begin":664,"end":668},"obj":"http://purl.obolibrary.org/obo/CL_0000792"},{"id":"T53","span":{"begin":669,"end":673},"obj":"http://purl.obolibrary.org/obo/GO_0005623"}],"text":"In the lungs, IL-33 is promptly released, mainly by injured epithelial alveolar cells, following infection and cellular damage.12 Among its functions, IL-33 enhances TGFβ-mediated differentiation of Foxp3+ regulatory T (Treg) cells13 and stimulates CD11c+ myeloid dendritic cells to secrete IL-2, which drives Treg cell expansion, thus ultimately promoting resolution of inflammation.14 Individuals infected with SARS-CoV-2 who develop milder symptoms tend to have large numbers of Treg cells10 and alveolar macrophages showing a scavenger resolving (FABP4+) phenotype.15 In the presence of an adequate immune response and virus clearance, IL-33 might drive rapid Treg cell-dependent restoration of respiratory tissue homoeostasis, which probably accounts for the mild or asymptomatic forms of COVID-19 seen in most individuals."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T44","span":{"begin":14,"end":16},"obj":"Chemical"},{"id":"T46","span":{"begin":151,"end":153},"obj":"Chemical"},{"id":"T48","span":{"begin":291,"end":293},"obj":"Chemical"},{"id":"T50","span":{"begin":640,"end":642},"obj":"Chemical"}],"attributes":[{"id":"A44","pred":"chebi_id","subj":"T44","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A45","pred":"chebi_id","subj":"T44","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A46","pred":"chebi_id","subj":"T46","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A47","pred":"chebi_id","subj":"T46","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A48","pred":"chebi_id","subj":"T48","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A49","pred":"chebi_id","subj":"T48","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A50","pred":"chebi_id","subj":"T50","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A51","pred":"chebi_id","subj":"T50","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"}],"text":"In the lungs, IL-33 is promptly released, mainly by injured epithelial alveolar cells, following infection and cellular damage.12 Among its functions, IL-33 enhances TGFβ-mediated differentiation of Foxp3+ regulatory T (Treg) cells13 and stimulates CD11c+ myeloid dendritic cells to secrete IL-2, which drives Treg cell expansion, thus ultimately promoting resolution of inflammation.14 Individuals infected with SARS-CoV-2 who develop milder symptoms tend to have large numbers of Treg cells10 and alveolar macrophages showing a scavenger resolving (FABP4+) phenotype.15 In the presence of an adequate immune response and virus clearance, IL-33 might drive rapid Treg cell-dependent restoration of respiratory tissue homoeostasis, which probably accounts for the mild or asymptomatic forms of COVID-19 seen in most individuals."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T7","span":{"begin":315,"end":329},"obj":"http://purl.obolibrary.org/obo/GO_0016049"},{"id":"T8","span":{"begin":371,"end":383},"obj":"http://purl.obolibrary.org/obo/GO_0006954"},{"id":"T9","span":{"begin":603,"end":618},"obj":"http://purl.obolibrary.org/obo/GO_0006955"}],"text":"In the lungs, IL-33 is promptly released, mainly by injured epithelial alveolar cells, following infection and cellular damage.12 Among its functions, IL-33 enhances TGFβ-mediated differentiation of Foxp3+ regulatory T (Treg) cells13 and stimulates CD11c+ myeloid dendritic cells to secrete IL-2, which drives Treg cell expansion, thus ultimately promoting resolution of inflammation.14 Individuals infected with SARS-CoV-2 who develop milder symptoms tend to have large numbers of Treg cells10 and alveolar macrophages showing a scavenger resolving (FABP4+) phenotype.15 In the presence of an adequate immune response and virus clearance, IL-33 might drive rapid Treg cell-dependent restoration of respiratory tissue homoeostasis, which probably accounts for the mild or asymptomatic forms of COVID-19 seen in most individuals."}

{"project":"LitCovid-sentences","denotations":[{"id":"T18","span":{"begin":0,"end":828},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"In the lungs, IL-33 is promptly released, mainly by injured epithelial alveolar cells, following infection and cellular damage.12 Among its functions, IL-33 enhances TGFβ-mediated differentiation of Foxp3+ regulatory T (Treg) cells13 and stimulates CD11c+ myeloid dendritic cells to secrete IL-2, which drives Treg cell expansion, thus ultimately promoting resolution of inflammation.14 Individuals infected with SARS-CoV-2 who develop milder symptoms tend to have large numbers of Treg cells10 and alveolar macrophages showing a scavenger resolving (FABP4+) phenotype.15 In the presence of an adequate immune response and virus clearance, IL-33 might drive rapid Treg cell-dependent restoration of respiratory tissue homoeostasis, which probably accounts for the mild or asymptomatic forms of COVID-19 seen in most individuals."}

{"project":"LitCovid-PubTator","denotations":[{"id":"166","span":{"begin":14,"end":19},"obj":"Gene"},{"id":"167","span":{"begin":151,"end":156},"obj":"Gene"},{"id":"168","span":{"begin":166,"end":170},"obj":"Gene"},{"id":"169","span":{"begin":199,"end":204},"obj":"Gene"},{"id":"170","span":{"begin":249,"end":254},"obj":"Gene"},{"id":"171","span":{"begin":291,"end":295},"obj":"Gene"},{"id":"172","span":{"begin":551,"end":556},"obj":"Gene"},{"id":"173","span":{"begin":640,"end":645},"obj":"Gene"},{"id":"175","span":{"begin":413,"end":423},"obj":"Species"},{"id":"177","span":{"begin":97,"end":106},"obj":"Disease"},{"id":"178","span":{"begin":371,"end":383},"obj":"Disease"},{"id":"179","span":{"begin":399,"end":407},"obj":"Disease"},{"id":"180","span":{"begin":699,"end":730},"obj":"Disease"},{"id":"181","span":{"begin":794,"end":802},"obj":"Disease"}],"attributes":[{"id":"A166","pred":"tao:has_database_id","subj":"166","obj":"Gene:90865"},{"id":"A167","pred":"tao:has_database_id","subj":"167","obj":"Gene:90865"},{"id":"A168","pred":"tao:has_database_id","subj":"168","obj":"Gene:7039"},{"id":"A169","pred":"tao:has_database_id","subj":"169","obj":"Gene:50943"},{"id":"A170","pred":"tao:has_database_id","subj":"170","obj":"Gene:3687"},{"id":"A171","pred":"tao:has_database_id","subj":"171","obj":"Gene:3558"},{"id":"A172","pred":"tao:has_database_id","subj":"172","obj":"Gene:2167"},{"id":"A173","pred":"tao:has_database_id","subj":"173","obj":"Gene:90865"},{"id":"A175","pred":"tao:has_database_id","subj":"175","obj":"Tax:2697049"},{"id":"A177","pred":"tao:has_database_id","subj":"177","obj":"MESH:D007239"},{"id":"A178","pred":"tao:has_database_id","subj":"178","obj":"MESH:D007249"},{"id":"A179","pred":"tao:has_database_id","subj":"179","obj":"MESH:D007239"},{"id":"A180","pred":"tao:has_database_id","subj":"180","obj":"MESH:D012140"},{"id":"A181","pred":"tao:has_database_id","subj":"181","obj":"MESH:C000657245"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"In the lungs, IL-33 is promptly released, mainly by injured epithelial alveolar cells, following infection and cellular damage.12 Among its functions, IL-33 enhances TGFβ-mediated differentiation of Foxp3+ regulatory T (Treg) cells13 and stimulates CD11c+ myeloid dendritic cells to secrete IL-2, which drives Treg cell expansion, thus ultimately promoting resolution of inflammation.14 Individuals infected with SARS-CoV-2 who develop milder symptoms tend to have large numbers of Treg cells10 and alveolar macrophages showing a scavenger resolving (FABP4+) phenotype.15 In the presence of an adequate immune response and virus clearance, IL-33 might drive rapid Treg cell-dependent restoration of respiratory tissue homoeostasis, which probably accounts for the mild or asymptomatic forms of COVID-19 seen in most individuals."}

{"project":"2_test","denotations":[{"id":"33073244-31057533-66244514","span":{"begin":127,"end":129},"obj":"31057533"},{"id":"33073244-25043027-66244515","span":{"begin":231,"end":233},"obj":"25043027"},{"id":"33073244-25217167-66244516","span":{"begin":384,"end":386},"obj":"25217167"},{"id":"33073244-32460357-66244517","span":{"begin":492,"end":494},"obj":"32460357"},{"id":"33073244-32398875-66244518","span":{"begin":569,"end":571},"obj":"32398875"}],"text":"In the lungs, IL-33 is promptly released, mainly by injured epithelial alveolar cells, following infection and cellular damage.12 Among its functions, IL-33 enhances TGFβ-mediated differentiation of Foxp3+ regulatory T (Treg) cells13 and stimulates CD11c+ myeloid dendritic cells to secrete IL-2, which drives Treg cell expansion, thus ultimately promoting resolution of inflammation.14 Individuals infected with SARS-CoV-2 who develop milder symptoms tend to have large numbers of Treg cells10 and alveolar macrophages showing a scavenger resolving (FABP4+) phenotype.15 In the presence of an adequate immune response and virus clearance, IL-33 might drive rapid Treg cell-dependent restoration of respiratory tissue homoeostasis, which probably accounts for the mild or asymptomatic forms of COVID-19 seen in most individuals."}