PMC:7546716 / 18669-19429 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T350","span":{"begin":234,"end":241},"obj":"Body_part"},{"id":"T351","span":{"begin":430,"end":434},"obj":"Body_part"},{"id":"T352","span":{"begin":430,"end":432},"obj":"Body_part"},{"id":"T353","span":{"begin":467,"end":469},"obj":"Body_part"},{"id":"T354","span":{"begin":609,"end":618},"obj":"Body_part"}],"attributes":[{"id":"A350","pred":"fma_id","subj":"T350","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A351","pred":"fma_id","subj":"T351","obj":"http://purl.org/sig/ont/fma/fma86583"},{"id":"A352","pred":"fma_id","subj":"T352","obj":"http://purl.org/sig/ont/fma/fma86578"},{"id":"A353","pred":"fma_id","subj":"T353","obj":"http://purl.org/sig/ont/fma/fma86578"},{"id":"A354","pred":"fma_id","subj":"T354","obj":"http://purl.org/sig/ont/fma/fma67180"}],"text":"to activate NLRP3 during SARS-CoV infection, and a similar mechanism might be at play during SARS-CoV-2 infection.47\nAn imbalance in signalling from toll-like receptor (TLR) pathways, with the myeloid differentiation primary response protein (MyD88) pathway predominating over the TIR domain-containing adapter molecule 1 (TICAM-1, also known as TRIF) pathways, might further increase NLRP3 activation.48 Signalling downstream of IL-1 family receptors, including the IL-33 receptor ST2, and downstream of membrane TLRs, can activate MyD88 and elicit inflammation; whereas TRIF-mediated pathways downstream of endosomal TLRs would be expected to mount antiviral interferon responses and protect against coronaviruses.48, 49 Although coronaviruses are single-str"}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T107","span":{"begin":25,"end":43},"obj":"Disease"},{"id":"T108","span":{"begin":34,"end":43},"obj":"Disease"},{"id":"T109","span":{"begin":93,"end":101},"obj":"Disease"},{"id":"T110","span":{"begin":104,"end":113},"obj":"Disease"},{"id":"T111","span":{"begin":550,"end":562},"obj":"Disease"}],"attributes":[{"id":"A107","pred":"mondo_id","subj":"T107","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A108","pred":"mondo_id","subj":"T108","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A109","pred":"mondo_id","subj":"T109","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A110","pred":"mondo_id","subj":"T110","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A111","pred":"mondo_id","subj":"T111","obj":"http://purl.obolibrary.org/obo/MONDO_0021166"}],"text":"to activate NLRP3 during SARS-CoV infection, and a similar mechanism might be at play during SARS-CoV-2 infection.47\nAn imbalance in signalling from toll-like receptor (TLR) pathways, with the myeloid differentiation primary response protein (MyD88) pathway predominating over the TIR domain-containing adapter molecule 1 (TICAM-1, also known as TRIF) pathways, might further increase NLRP3 activation.48 Signalling downstream of IL-1 family receptors, including the IL-33 receptor ST2, and downstream of membrane TLRs, can activate MyD88 and elicit inflammation; whereas TRIF-mediated pathways downstream of endosomal TLRs would be expected to mount antiviral interferon responses and protect against coronaviruses.48, 49 Although coronaviruses are single-str"}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T268","span":{"begin":3,"end":11},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T269","span":{"begin":49,"end":50},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T270","span":{"begin":133,"end":143},"obj":"http://purl.obolibrary.org/obo/SO_0000418"},{"id":"T271","span":{"begin":391,"end":401},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T272","span":{"begin":402,"end":404},"obj":"http://purl.obolibrary.org/obo/CLO_0001382"},{"id":"T273","span":{"begin":405,"end":415},"obj":"http://purl.obolibrary.org/obo/SO_0000418"},{"id":"T274","span":{"begin":482,"end":485},"obj":"http://purl.obolibrary.org/obo/CLO_0051025"},{"id":"T275","span":{"begin":505,"end":513},"obj":"http://purl.obolibrary.org/obo/UBERON_0000158"},{"id":"T276","span":{"begin":524,"end":532},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T277","span":{"begin":716,"end":718},"obj":"http://purl.obolibrary.org/obo/CLO_0001382"}],"text":"to activate NLRP3 during SARS-CoV infection, and a similar mechanism might be at play during SARS-CoV-2 infection.47\nAn imbalance in signalling from toll-like receptor (TLR) pathways, with the myeloid differentiation primary response protein (MyD88) pathway predominating over the TIR domain-containing adapter molecule 1 (TICAM-1, also known as TRIF) pathways, might further increase NLRP3 activation.48 Signalling downstream of IL-1 family receptors, including the IL-33 receptor ST2, and downstream of membrane TLRs, can activate MyD88 and elicit inflammation; whereas TRIF-mediated pathways downstream of endosomal TLRs would be expected to mount antiviral interferon responses and protect against coronaviruses.48, 49 Although coronaviruses are single-str"}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T270","span":{"begin":234,"end":241},"obj":"Chemical"},{"id":"T271","span":{"begin":311,"end":319},"obj":"Chemical"},{"id":"T272","span":{"begin":430,"end":432},"obj":"Chemical"},{"id":"T274","span":{"begin":467,"end":469},"obj":"Chemical"},{"id":"T276","span":{"begin":651,"end":660},"obj":"Chemical"},{"id":"T277","span":{"begin":661,"end":671},"obj":"Chemical"}],"attributes":[{"id":"A270","pred":"chebi_id","subj":"T270","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A271","pred":"chebi_id","subj":"T271","obj":"http://purl.obolibrary.org/obo/CHEBI_25367"},{"id":"A272","pred":"chebi_id","subj":"T272","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A273","pred":"chebi_id","subj":"T272","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A274","pred":"chebi_id","subj":"T274","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A275","pred":"chebi_id","subj":"T274","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A276","pred":"chebi_id","subj":"T276","obj":"http://purl.obolibrary.org/obo/CHEBI_22587"},{"id":"A277","pred":"chebi_id","subj":"T277","obj":"http://purl.obolibrary.org/obo/CHEBI_52999"}],"text":"to activate NLRP3 during SARS-CoV infection, and a similar mechanism might be at play during SARS-CoV-2 infection.47\nAn imbalance in signalling from toll-like receptor (TLR) pathways, with the myeloid differentiation primary response protein (MyD88) pathway predominating over the TIR domain-containing adapter molecule 1 (TICAM-1, also known as TRIF) pathways, might further increase NLRP3 activation.48 Signalling downstream of IL-1 family receptors, including the IL-33 receptor ST2, and downstream of membrane TLRs, can activate MyD88 and elicit inflammation; whereas TRIF-mediated pathways downstream of endosomal TLRs would be expected to mount antiviral interferon responses and protect against coronaviruses.48, 49 Although coronaviruses are single-str"}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T49","span":{"begin":133,"end":143},"obj":"http://purl.obolibrary.org/obo/GO_0023052"},{"id":"T50","span":{"begin":405,"end":415},"obj":"http://purl.obolibrary.org/obo/GO_0023052"},{"id":"T51","span":{"begin":550,"end":562},"obj":"http://purl.obolibrary.org/obo/GO_0006954"}],"text":"to activate NLRP3 during SARS-CoV infection, and a similar mechanism might be at play during SARS-CoV-2 infection.47\nAn imbalance in signalling from toll-like receptor (TLR) pathways, with the myeloid differentiation primary response protein (MyD88) pathway predominating over the TIR domain-containing adapter molecule 1 (TICAM-1, also known as TRIF) pathways, might further increase NLRP3 activation.48 Signalling downstream of IL-1 family receptors, including the IL-33 receptor ST2, and downstream of membrane TLRs, can activate MyD88 and elicit inflammation; whereas TRIF-mediated pathways downstream of endosomal TLRs would be expected to mount antiviral interferon responses and protect against coronaviruses.48, 49 Although coronaviruses are single-str"}

{"project":"LitCovid-PubTator","denotations":[{"id":"766","span":{"begin":12,"end":17},"obj":"Gene"},{"id":"770","span":{"begin":25,"end":43},"obj":"Disease"},{"id":"771","span":{"begin":93,"end":113},"obj":"Disease"},{"id":"800","span":{"begin":243,"end":248},"obj":"Gene"},{"id":"801","span":{"begin":281,"end":321},"obj":"Gene"},{"id":"802","span":{"begin":323,"end":330},"obj":"Gene"},{"id":"803","span":{"begin":346,"end":350},"obj":"Gene"},{"id":"804","span":{"begin":385,"end":390},"obj":"Gene"},{"id":"805","span":{"begin":430,"end":434},"obj":"Gene"},{"id":"806","span":{"begin":533,"end":538},"obj":"Gene"},{"id":"807","span":{"begin":572,"end":576},"obj":"Gene"},{"id":"819","span":{"begin":702,"end":715},"obj":"Species"},{"id":"820","span":{"begin":732,"end":745},"obj":"Species"},{"id":"824","span":{"begin":550,"end":562},"obj":"Disease"},{"id":"825","span":{"begin":609,"end":623},"obj":"Disease"}],"attributes":[{"id":"A766","pred":"tao:has_database_id","subj":"766","obj":"Gene:114548"},{"id":"A770","pred":"tao:has_database_id","subj":"770","obj":"MESH:C000657245"},{"id":"A771","pred":"tao:has_database_id","subj":"771","obj":"MESH:C000657245"},{"id":"A800","pred":"tao:has_database_id","subj":"800","obj":"Gene:4615"},{"id":"A801","pred":"tao:has_database_id","subj":"801","obj":"Gene:148022"},{"id":"A802","pred":"tao:has_database_id","subj":"802","obj":"Gene:148022"},{"id":"A803","pred":"tao:has_database_id","subj":"803","obj":"Gene:148022"},{"id":"A804","pred":"tao:has_database_id","subj":"804","obj":"Gene:114548"},{"id":"A805","pred":"tao:has_database_id","subj":"805","obj":"Gene:3552"},{"id":"A806","pred":"tao:has_database_id","subj":"806","obj":"Gene:4615"},{"id":"A807","pred":"tao:has_database_id","subj":"807","obj":"Gene:148022"},{"id":"A819","pred":"tao:has_database_id","subj":"819","obj":"Tax:11118"},{"id":"A820","pred":"tao:has_database_id","subj":"820","obj":"Tax:11118"},{"id":"A824","pred":"tao:has_database_id","subj":"824","obj":"MESH:D007249"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"to activate NLRP3 during SARS-CoV infection, and a similar mechanism might be at play during SARS-CoV-2 infection.47\nAn imbalance in signalling from toll-like receptor (TLR) pathways, with the myeloid differentiation primary response protein (MyD88) pathway predominating over the TIR domain-containing adapter molecule 1 (TICAM-1, also known as TRIF) pathways, might further increase NLRP3 activation.48 Signalling downstream of IL-1 family receptors, including the IL-33 receptor ST2, and downstream of membrane TLRs, can activate MyD88 and elicit inflammation; whereas TRIF-mediated pathways downstream of endosomal TLRs would be expected to mount antiviral interferon responses and protect against coronaviruses.48, 49 Although coronaviruses are single-str"}

{"project":"2_test","denotations":[{"id":"33073244-26015500-66244583","span":{"begin":720,"end":722},"obj":"26015500"}],"text":"to activate NLRP3 during SARS-CoV infection, and a similar mechanism might be at play during SARS-CoV-2 infection.47\nAn imbalance in signalling from toll-like receptor (TLR) pathways, with the myeloid differentiation primary response protein (MyD88) pathway predominating over the TIR domain-containing adapter molecule 1 (TICAM-1, also known as TRIF) pathways, might further increase NLRP3 activation.48 Signalling downstream of IL-1 family receptors, including the IL-33 receptor ST2, and downstream of membrane TLRs, can activate MyD88 and elicit inflammation; whereas TRIF-mediated pathways downstream of endosomal TLRs would be expected to mount antiviral interferon responses and protect against coronaviruses.48, 49 Although coronaviruses are single-str"}