PMC:7546716 / 1614-2782
Annnotations
LitCovid-PD-FMA-UBERON
Id | Subject | Object | Predicate | Lexical cue | fma_id |
---|---|---|---|---|---|
T26 | 102-106 | Body_part | denotes | lung | http://purl.org/sig/ont/fma/fma7195 |
T27 | 395-405 | Body_part | denotes | macrophage | http://purl.org/sig/ont/fma/fma63261 |
T28 | 495-504 | Body_part | denotes | cytokines | http://purl.org/sig/ont/fma/fma84050 |
T29 | 536-549 | Body_part | denotes | interleukin-6 | http://purl.org/sig/ont/fma/fma264829 |
T30 | 552-554 | Body_part | denotes | IL | http://purl.org/sig/ont/fma/fma86578 |
T31 | 893-901 | Body_part | denotes | cytokine | http://purl.org/sig/ont/fma/fma84050 |
T32 | 1110-1114 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
LitCovid-PD-UBERON
Id | Subject | Object | Predicate | Lexical cue | uberon_id |
---|---|---|---|---|---|
T3 | 102-106 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
LitCovid-PD-MONDO
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T15 | 102-114 | Disease | denotes | lung disease | http://purl.obolibrary.org/obo/MONDO_0005275 |
T16 | 131-139 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T17 | 178-186 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T18 | 206-218 | Disease | denotes | inflammation | http://purl.obolibrary.org/obo/MONDO_0021166 |
T19 | 237-272 | Disease | denotes | acute respiratory distress syndrome | http://purl.obolibrary.org/obo/MONDO_0006502 |
T20 | 243-272 | Disease | denotes | respiratory distress syndrome | http://purl.obolibrary.org/obo/MONDO_0009971 |
T21 | 278-290 | Disease | denotes | coagulopathy | http://purl.obolibrary.org/obo/MONDO_0001531 |
T22 | 329-374 | Disease | denotes | secondary haemophagocytic lymphohistiocytosis | http://purl.obolibrary.org/obo/MONDO_0015542 |
T23 | 395-425 | Disease | denotes | macrophage activation syndrome | http://purl.obolibrary.org/obo/MONDO_0015545 |
T24 | 427-430 | Disease | denotes | MAS | http://purl.obolibrary.org/obo/MONDO_0015545 |
T25 | 523-526 | Disease | denotes | MAS | http://purl.obolibrary.org/obo/MONDO_0015545 |
T26 | 653-661 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T27 | 697-716 | Disease | denotes | respiratory disease | http://purl.obolibrary.org/obo/MONDO_0005087 |
T28 | 749-761 | Disease | denotes | inflammation | http://purl.obolibrary.org/obo/MONDO_0021166 |
T29 | 833-841 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T30 | 868-871 | Disease | denotes | MAS | http://purl.obolibrary.org/obo/MONDO_0015545 |
T31 | 902-916 | Disease | denotes | storm syndrome | http://purl.obolibrary.org/obo/MONDO_0008496 |
T32 | 925-933 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T33 | 974-977 | Disease | denotes | MAS | http://purl.obolibrary.org/obo/MONDO_0015545 |
T34 | 1131-1139 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T35 | 1162-1165 | Disease | denotes | MAS | http://purl.obolibrary.org/obo/MONDO_0015545 |
LitCovid-PD-CLO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T15 | 102-106 | http://purl.obolibrary.org/obo/UBERON_0002048 | denotes | lung |
T16 | 102-106 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lung |
T17 | 378-383 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
T18 | 406-416 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
T19 | 454-461 | http://purl.obolibrary.org/obo/CLO_0009985 | denotes | focused |
T20 | 536-549 | http://purl.obolibrary.org/obo/PR_000001393 | denotes | interleukin-6 |
T21 | 579-595 | http://purl.obolibrary.org/obo/PR_000000017 | denotes | interferon gamma |
T22 | 1004-1005 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T23 | 1040-1041 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T24 | 1108-1114 | http://purl.obolibrary.org/obo/CL_0000084 | denotes | T-cell |
T25 | 1148-1153 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
LitCovid-PD-CHEBI
Id | Subject | Object | Predicate | Lexical cue | chebi_id |
---|---|---|---|---|---|
T15 | 58-67 | Chemical | denotes | antiviral | http://purl.obolibrary.org/obo/CHEBI_22587 |
T16 | 552-554 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
T18 | 563-574 | Chemical | denotes | tocilizumab | http://purl.obolibrary.org/obo/CHEBI_64360 |
T19 | 579-589 | Chemical | denotes | interferon | http://purl.obolibrary.org/obo/CHEBI_52999 |
T20 | 590-595 | Chemical | denotes | gamma | http://purl.obolibrary.org/obo/CHEBI_30212 |
LitCovid-PD-HP
Id | Subject | Object | Predicate | Lexical cue | hp_id |
---|---|---|---|---|---|
T3 | 102-114 | Phenotype | denotes | lung disease | http://purl.obolibrary.org/obo/HP_0002088 |
T4 | 243-263 | Phenotype | denotes | respiratory distress | http://purl.obolibrary.org/obo/HP_0002098 |
T5 | 278-290 | Phenotype | denotes | coagulopathy | http://purl.obolibrary.org/obo/HP_0003256 |
T6 | 893-907 | Phenotype | denotes | cytokine storm | http://purl.obolibrary.org/obo/HP_0033041 |
LitCovid-PD-GO-BP
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T2 | 206-218 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammation |
T3 | 395-416 | http://purl.obolibrary.org/obo/GO_0042116 | denotes | macrophage activation |
T4 | 749-761 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammation |
LitCovid-sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T12 | 1-432 | Sentence | denotes | Given the public health emergency, scarcity of effective antiviral therapies, and rapid evolution of lung disease associated with COVID-19, patients who are critically ill with COVID-19 and have exuberant inflammation, life-threatening acute respiratory distress syndrome, and coagulopathy, are basically treated as if they had secondary haemophagocytic lymphohistiocytosis or virus-associated macrophage activation syndrome (MAS). |
T13 | 433-872 | Sentence | denotes | These treatments are focused on therapies that neutralise key cytokines driving classical MAS, such as interleukin-6 ([IL]-6; eg, tocilizumab) or interferon gamma (IFNγ; eg, emapalumab).1, 2 In fact, some fatal cases of COVID-19 are accompanied not only by severe respiratory disease, but also by increased systemic inflammation as shown by higher ferritin concentrations.2 However, in many aspects, COVID-19 does not resemble typical MAS. |
T14 | 873-1084 | Sentence | denotes | We propose that the cytokine storm syndrome seen in COVID-19 is dissimilar to that seen in canonical MAS and should be regarded as a distinct entity and approached in a novel way reflecting its unique qualities. |
T15 | 1086-1139 | Sentence | denotes | Cellular immunity and T-cell polarisation in COVID-19 |
LitCovid-PubTator
Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
---|---|---|---|---|---|
65 | 536-549 | Gene | denotes | interleukin-6 | Gene:3569 |
66 | 579-595 | Gene | denotes | interferon gamma | Gene:3458 |
67 | 597-601 | Gene | denotes | IFNγ | Gene:3458 |
68 | 603-605 | Gene | denotes | eg | Gene:50512 |
69 | 559-561 | Gene | denotes | eg | Gene:50512 |
72 | 141-149 | Species | denotes | patients | Tax:9606 |
74 | 102-114 | Disease | denotes | lung disease | MESH:D008171 |
75 | 131-139 | Disease | denotes | COVID-19 | MESH:C000657245 |
76 | 158-172 | Disease | denotes | critically ill | MESH:D016638 |
77 | 178-186 | Disease | denotes | COVID-19 | MESH:C000657245 |
78 | 206-218 | Disease | denotes | inflammation | MESH:D007249 |
79 | 237-272 | Disease | denotes | acute respiratory distress syndrome | MESH:D012128 |
80 | 278-290 | Disease | denotes | coagulopathy | MESH:D001778 |
81 | 329-374 | Disease | denotes | secondary haemophagocytic lymphohistiocytosis | MESH:D060085 |
82 | 395-425 | Disease | denotes | macrophage activation syndrome | MESH:D055501 |
83 | 653-661 | Disease | denotes | COVID-19 | MESH:C000657245 |
84 | 697-716 | Disease | denotes | respiratory disease | MESH:D012140 |
85 | 749-761 | Disease | denotes | inflammation | MESH:D007249 |
86 | 833-841 | Disease | denotes | COVID-19 | MESH:C000657245 |
87 | 925-933 | Disease | denotes | COVID-19 | MESH:C000657245 |
89 | 1131-1139 | Disease | denotes | COVID-19 | MESH:C000657245 |
2_test
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
33073244-30774631-66244503 | 619-620 | 30774631 | denotes | 1 |