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PMC:7546716 / 1439-2698 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T26 277-281 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T27 570-580 Body_part denotes macrophage http://purl.org/sig/ont/fma/fma63261
T28 670-679 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T29 711-724 Body_part denotes interleukin-6 http://purl.org/sig/ont/fma/fma264829
T30 727-729 Body_part denotes IL http://purl.org/sig/ont/fma/fma86578
T31 1068-1076 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T3 277-281 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T11 65-73 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T12 85-132 Disease denotes severe acute respiratory syndrome coronavirus 2 http://purl.obolibrary.org/obo/MONDO_0100096
T13 85-118 Disease denotes severe acute respiratory syndrome http://purl.obolibrary.org/obo/MONDO_0005091
T14 134-142 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T15 277-289 Disease denotes lung disease http://purl.obolibrary.org/obo/MONDO_0005275
T16 306-314 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T17 353-361 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T18 381-393 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T19 412-447 Disease denotes acute respiratory distress syndrome http://purl.obolibrary.org/obo/MONDO_0006502
T20 418-447 Disease denotes respiratory distress syndrome http://purl.obolibrary.org/obo/MONDO_0009971
T21 453-465 Disease denotes coagulopathy http://purl.obolibrary.org/obo/MONDO_0001531
T22 504-549 Disease denotes secondary haemophagocytic lymphohistiocytosis http://purl.obolibrary.org/obo/MONDO_0015542
T23 570-600 Disease denotes macrophage activation syndrome http://purl.obolibrary.org/obo/MONDO_0015545
T24 602-605 Disease denotes MAS http://purl.obolibrary.org/obo/MONDO_0015545
T25 698-701 Disease denotes MAS http://purl.obolibrary.org/obo/MONDO_0015545
T26 828-836 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T27 872-891 Disease denotes respiratory disease http://purl.obolibrary.org/obo/MONDO_0005087
T28 924-936 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T29 1008-1016 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T30 1043-1046 Disease denotes MAS http://purl.obolibrary.org/obo/MONDO_0015545
T31 1077-1091 Disease denotes storm syndrome http://purl.obolibrary.org/obo/MONDO_0008496
T32 1100-1108 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T33 1149-1152 Disease denotes MAS http://purl.obolibrary.org/obo/MONDO_0015545

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T15 277-281 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T16 277-281 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T17 553-558 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T18 581-591 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T19 629-636 http://purl.obolibrary.org/obo/CLO_0009985 denotes focused
T20 711-724 http://purl.obolibrary.org/obo/PR_000001393 denotes interleukin-6
T21 754-770 http://purl.obolibrary.org/obo/PR_000000017 denotes interferon gamma
T22 1179-1180 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T23 1215-1216 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T15 233-242 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T16 727-729 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T18 738-749 Chemical denotes tocilizumab http://purl.obolibrary.org/obo/CHEBI_64360
T19 754-764 Chemical denotes interferon http://purl.obolibrary.org/obo/CHEBI_52999
T20 765-770 Chemical denotes gamma http://purl.obolibrary.org/obo/CHEBI_30212

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T3 277-289 Phenotype denotes lung disease http://purl.obolibrary.org/obo/HP_0002088
T4 418-438 Phenotype denotes respiratory distress http://purl.obolibrary.org/obo/HP_0002098
T5 453-465 Phenotype denotes coagulopathy http://purl.obolibrary.org/obo/HP_0003256
T6 1068-1082 Phenotype denotes cytokine storm http://purl.obolibrary.org/obo/HP_0033041

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T2 381-393 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T3 570-591 http://purl.obolibrary.org/obo/GO_0042116 denotes macrophage activation
T4 924-936 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T11 0-175 Sentence denotes Intensive efforts are underway to unravel the immunopathology of COVID-19, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and to control the pandemic.
T12 176-607 Sentence denotes Given the public health emergency, scarcity of effective antiviral therapies, and rapid evolution of lung disease associated with COVID-19, patients who are critically ill with COVID-19 and have exuberant inflammation, life-threatening acute respiratory distress syndrome, and coagulopathy, are basically treated as if they had secondary haemophagocytic lymphohistiocytosis or virus-associated macrophage activation syndrome (MAS).
T13 608-1047 Sentence denotes These treatments are focused on therapies that neutralise key cytokines driving classical MAS, such as interleukin-6 ([IL]-6; eg, tocilizumab) or interferon gamma (IFNγ; eg, emapalumab).1, 2 In fact, some fatal cases of COVID-19 are accompanied not only by severe respiratory disease, but also by increased systemic inflammation as shown by higher ferritin concentrations.2 However, in many aspects, COVID-19 does not resemble typical MAS.
T14 1048-1259 Sentence denotes We propose that the cytokine storm syndrome seen in COVID-19 is dissimilar to that seen in canonical MAS and should be regarded as a distinct entity and approached in a novel way reflecting its unique qualities.

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
65 711-724 Gene denotes interleukin-6 Gene:3569
66 754-770 Gene denotes interferon gamma Gene:3458
67 772-776 Gene denotes IFNγ Gene:3458
68 778-780 Gene denotes eg Gene:50512
69 734-736 Gene denotes eg Gene:50512
70 85-132 Species denotes severe acute respiratory syndrome coronavirus 2 Tax:2697049
71 134-144 Species denotes SARS-CoV-2 Tax:2697049
72 316-324 Species denotes patients Tax:9606
73 65-73 Disease denotes COVID-19 MESH:C000657245
74 277-289 Disease denotes lung disease MESH:D008171
75 306-314 Disease denotes COVID-19 MESH:C000657245
76 333-347 Disease denotes critically ill MESH:D016638
77 353-361 Disease denotes COVID-19 MESH:C000657245
78 381-393 Disease denotes inflammation MESH:D007249
79 412-447 Disease denotes acute respiratory distress syndrome MESH:D012128
80 453-465 Disease denotes coagulopathy MESH:D001778
81 504-549 Disease denotes secondary haemophagocytic lymphohistiocytosis MESH:D060085
82 570-600 Disease denotes macrophage activation syndrome MESH:D055501
83 828-836 Disease denotes COVID-19 MESH:C000657245
84 872-891 Disease denotes respiratory disease MESH:D012140
85 924-936 Disease denotes inflammation MESH:D007249
86 1008-1016 Disease denotes COVID-19 MESH:C000657245
87 1100-1108 Disease denotes COVID-19 MESH:C000657245

2_test

Id Subject Object Predicate Lexical cue
33073244-30774631-66244503 794-795 30774631 denotes 1