PMC:7546716 / 13790-14191 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7546716","sourcedb":"PMC","sourceid":"7546716","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7546716","text":"ing both IFNγ and perforin (IFNγ−/−Prf1−/−) still develop a severe MAS-like disease that requires the IL-33–ST2 axis and is downstream mediated by GM-CSF-producing CD8+ T cells. The inflammatory burden in infected IFNγ−/−Prf1−/− mice is even higher than in Prf1−/− mice, being characterised by a 10–15 times increase in neutrophils and stronger upregulation of IL-1β and IL-6.32 The same interplay bet","tracks":[{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T236","span":{"begin":102,"end":104},"obj":"Body_part"},{"id":"T237","span":{"begin":112,"end":116},"obj":"Body_part"},{"id":"T238","span":{"begin":150,"end":153},"obj":"Body_part"},{"id":"T239","span":{"begin":171,"end":176},"obj":"Body_part"},{"id":"T240","span":{"begin":320,"end":331},"obj":"Body_part"},{"id":"T241","span":{"begin":361,"end":365},"obj":"Body_part"},{"id":"T242","span":{"begin":361,"end":363},"obj":"Body_part"},{"id":"T243","span":{"begin":371,"end":373},"obj":"Body_part"}],"attributes":[{"id":"A236","pred":"fma_id","subj":"T236","obj":"http://purl.org/sig/ont/fma/fma86578"},{"id":"A237","pred":"fma_id","subj":"T237","obj":"http://purl.org/sig/ont/fma/fma12520"},{"id":"A238","pred":"fma_id","subj":"T238","obj":"http://purl.org/sig/ont/fma/fma20935"},{"id":"A239","pred":"fma_id","subj":"T239","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A240","pred":"fma_id","subj":"T240","obj":"http://purl.org/sig/ont/fma/fma62860"},{"id":"A241","pred":"fma_id","subj":"T241","obj":"http://purl.org/sig/ont/fma/fma86583"},{"id":"A242","pred":"fma_id","subj":"T242","obj":"http://purl.org/sig/ont/fma/fma86578"},{"id":"A243","pred":"fma_id","subj":"T243","obj":"http://purl.org/sig/ont/fma/fma86578"},{"subj":"T236","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T237","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T238","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T239","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T240","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T241","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T242","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T243","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T85","span":{"begin":67,"end":70},"obj":"Disease"}],"attributes":[{"id":"A85","pred":"mondo_id","subj":"T85","obj":"http://purl.obolibrary.org/obo/MONDO_0015545"},{"subj":"T85","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T193","span":{"begin":58,"end":59},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T194","span":{"begin":108,"end":111},"obj":"http://purl.obolibrary.org/obo/CLO_0051025"},{"id":"T195","span":{"begin":164,"end":167},"obj":"http://purl.obolibrary.org/obo/CLO_0053438"},{"id":"T196","span":{"begin":169,"end":176},"obj":"http://purl.obolibrary.org/obo/CL_0000084"},{"id":"T197","span":{"begin":294,"end":298},"obj":"http://purl.obolibrary.org/obo/CLO_0001550"}],"attributes":[{"subj":"T193","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T194","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T195","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T196","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T197","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T169","span":{"begin":102,"end":104},"obj":"Chemical"},{"id":"T171","span":{"begin":147,"end":149},"obj":"Chemical"},{"id":"T172","span":{"begin":361,"end":363},"obj":"Chemical"},{"id":"T174","span":{"begin":371,"end":373},"obj":"Chemical"}],"attributes":[{"id":"A169","pred":"chebi_id","subj":"T169","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A170","pred":"chebi_id","subj":"T169","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A171","pred":"chebi_id","subj":"T171","obj":"http://purl.obolibrary.org/obo/CHEBI_74120"},{"id":"A172","pred":"chebi_id","subj":"T172","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A173","pred":"chebi_id","subj":"T172","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A174","pred":"chebi_id","subj":"T174","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A175","pred":"chebi_id","subj":"T174","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"subj":"T169","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T171","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T172","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T174","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"555","span":{"begin":9,"end":13},"obj":"Gene"},{"id":"556","span":{"begin":28,"end":32},"obj":"Gene"},{"id":"557","span":{"begin":35,"end":39},"obj":"Gene"},{"id":"558","span":{"begin":102,"end":107},"obj":"Gene"},{"id":"559","span":{"begin":147,"end":153},"obj":"Gene"},{"id":"560","span":{"begin":164,"end":167},"obj":"Gene"},{"id":"561","span":{"begin":214,"end":218},"obj":"Gene"},{"id":"562","span":{"begin":221,"end":225},"obj":"Gene"},{"id":"563","span":{"begin":257,"end":261},"obj":"Gene"},{"id":"564","span":{"begin":361,"end":366},"obj":"Gene"},{"id":"565","span":{"begin":371,"end":375},"obj":"Gene"},{"id":"568","span":{"begin":108,"end":111},"obj":"Gene"},{"id":"571","span":{"begin":229,"end":233},"obj":"Species"},{"id":"572","span":{"begin":265,"end":269},"obj":"Species"},{"id":"577","span":{"begin":205,"end":213},"obj":"Disease"}],"attributes":[{"id":"A555","pred":"tao:has_database_id","subj":"555","obj":"Gene:15978"},{"id":"A556","pred":"tao:has_database_id","subj":"556","obj":"Gene:15978"},{"id":"A557","pred":"tao:has_database_id","subj":"557","obj":"Gene:18646"},{"id":"A558","pred":"tao:has_database_id","subj":"558","obj":"Gene:77125"},{"id":"A559","pred":"tao:has_database_id","subj":"559","obj":"Gene:12981"},{"id":"A560","pred":"tao:has_database_id","subj":"560","obj":"Gene:925"},{"id":"A561","pred":"tao:has_database_id","subj":"561","obj":"Gene:15978"},{"id":"A562","pred":"tao:has_database_id","subj":"562","obj":"Gene:18646"},{"id":"A563","pred":"tao:has_database_id","subj":"563","obj":"Gene:18646"},{"id":"A564","pred":"tao:has_database_id","subj":"564","obj":"Gene:16175"},{"id":"A565","pred":"tao:has_database_id","subj":"565","obj":"Gene:16193"},{"id":"A568","pred":"tao:has_database_id","subj":"568","obj":"Gene:17082"},{"id":"A571","pred":"tao:has_database_id","subj":"571","obj":"Tax:10090"},{"id":"A572","pred":"tao:has_database_id","subj":"572","obj":"Tax:10090"},{"id":"A577","pred":"tao:has_database_id","subj":"577","obj":"MESH:D007239"},{"subj":"555","pred":"source","obj":"LitCovid-PubTator"},{"subj":"556","pred":"source","obj":"LitCovid-PubTator"},{"subj":"557","pred":"source","obj":"LitCovid-PubTator"},{"subj":"558","pred":"source","obj":"LitCovid-PubTator"},{"subj":"559","pred":"source","obj":"LitCovid-PubTator"},{"subj":"560","pred":"source","obj":"LitCovid-PubTator"},{"subj":"561","pred":"source","obj":"LitCovid-PubTator"},{"subj":"562","pred":"source","obj":"LitCovid-PubTator"},{"subj":"563","pred":"source","obj":"LitCovid-PubTator"},{"subj":"564","pred":"source","obj":"LitCovid-PubTator"},{"subj":"565","pred":"source","obj":"LitCovid-PubTator"},{"subj":"568","pred":"source","obj":"LitCovid-PubTator"},{"subj":"571","pred":"source","obj":"LitCovid-PubTator"},{"subj":"572","pred":"source","obj":"LitCovid-PubTator"},{"subj":"577","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"2_test","denotations":[{"id":"33073244-31400073-66244552","span":{"begin":376,"end":378},"obj":"31400073"}],"attributes":[{"subj":"33073244-31400073-66244552","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PD-FMA-UBERON","color":"#9396ec","default":true},{"id":"LitCovid-PD-MONDO","color":"#b0ec93"},{"id":"LitCovid-PD-CLO","color":"#ec93ca"},{"id":"LitCovid-PD-CHEBI","color":"#93e4ec"},{"id":"LitCovid-PubTator","color":"#ecda93"},{"id":"2_test","color":"#c093ec"}]}]}}