PMC:7546716 / 13536-14426 JSONTXT

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    LitCovid-PD-FMA-UBERON

    {"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T235","span":{"begin":195,"end":206},"obj":"Body_part"},{"id":"T236","span":{"begin":356,"end":358},"obj":"Body_part"},{"id":"T237","span":{"begin":366,"end":370},"obj":"Body_part"},{"id":"T238","span":{"begin":404,"end":407},"obj":"Body_part"},{"id":"T239","span":{"begin":425,"end":430},"obj":"Body_part"},{"id":"T240","span":{"begin":574,"end":585},"obj":"Body_part"},{"id":"T241","span":{"begin":615,"end":619},"obj":"Body_part"},{"id":"T242","span":{"begin":615,"end":617},"obj":"Body_part"},{"id":"T243","span":{"begin":625,"end":627},"obj":"Body_part"},{"id":"T244","span":{"begin":660,"end":662},"obj":"Body_part"},{"id":"T245","span":{"begin":673,"end":676},"obj":"Body_part"},{"id":"T246","span":{"begin":741,"end":749},"obj":"Body_part"}],"attributes":[{"id":"A235","pred":"fma_id","subj":"T235","obj":"http://purl.org/sig/ont/fma/fma62863"},{"id":"A236","pred":"fma_id","subj":"T236","obj":"http://purl.org/sig/ont/fma/fma86578"},{"id":"A237","pred":"fma_id","subj":"T237","obj":"http://purl.org/sig/ont/fma/fma12520"},{"id":"A238","pred":"fma_id","subj":"T238","obj":"http://purl.org/sig/ont/fma/fma20935"},{"id":"A239","pred":"fma_id","subj":"T239","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A240","pred":"fma_id","subj":"T240","obj":"http://purl.org/sig/ont/fma/fma62860"},{"id":"A241","pred":"fma_id","subj":"T241","obj":"http://purl.org/sig/ont/fma/fma86583"},{"id":"A242","pred":"fma_id","subj":"T242","obj":"http://purl.org/sig/ont/fma/fma86578"},{"id":"A243","pred":"fma_id","subj":"T243","obj":"http://purl.org/sig/ont/fma/fma86578"},{"id":"A244","pred":"fma_id","subj":"T244","obj":"http://purl.org/sig/ont/fma/fma86578"},{"id":"A245","pred":"fma_id","subj":"T245","obj":"http://purl.org/sig/ont/fma/fma20935"},{"id":"A246","pred":"fma_id","subj":"T246","obj":"http://purl.org/sig/ont/fma/fma84050"}],"text":"The effects of IFNγ deficiency have been investigated in an experimental model of haemophagocytic lymphohistiocytosis, which develops when perforin deficient (Prf1−/−) mice are infected with the lymphocytic choriomeningitis virus. Surprisingly, mice lacking both IFNγ and perforin (IFNγ−/−Prf1−/−) still develop a severe MAS-like disease that requires the IL-33–ST2 axis and is downstream mediated by GM-CSF-producing CD8+ T cells. The inflammatory burden in infected IFNγ−/−Prf1−/− mice is even higher than in Prf1−/− mice, being characterised by a 10–15 times increase in neutrophils and stronger upregulation of IL-1β and IL-6.32 The same interplay between IL-33 and GM-CSF might occur in patients with COVID-19, which would initiate the cytokine storm syndrome. Thus, severe forms of COVID-19 might represent atypical MAS or MAS-like reactions with incorporated interferon deficiencies."}

    LitCovid-PD-MONDO

    {"project":"LitCovid-PD-MONDO","denotations":[{"id":"T84","span":{"begin":195,"end":223},"obj":"Disease"},{"id":"T85","span":{"begin":321,"end":324},"obj":"Disease"},{"id":"T86","span":{"begin":706,"end":714},"obj":"Disease"},{"id":"T87","span":{"begin":750,"end":764},"obj":"Disease"},{"id":"T88","span":{"begin":788,"end":796},"obj":"Disease"},{"id":"T89","span":{"begin":822,"end":825},"obj":"Disease"},{"id":"T90","span":{"begin":829,"end":832},"obj":"Disease"}],"attributes":[{"id":"A84","pred":"mondo_id","subj":"T84","obj":"http://purl.obolibrary.org/obo/MONDO_0001449"},{"id":"A85","pred":"mondo_id","subj":"T85","obj":"http://purl.obolibrary.org/obo/MONDO_0015545"},{"id":"A86","pred":"mondo_id","subj":"T86","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A87","pred":"mondo_id","subj":"T87","obj":"http://purl.obolibrary.org/obo/MONDO_0008496"},{"id":"A88","pred":"mondo_id","subj":"T88","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A89","pred":"mondo_id","subj":"T89","obj":"http://purl.obolibrary.org/obo/MONDO_0015545"},{"id":"A90","pred":"mondo_id","subj":"T90","obj":"http://purl.obolibrary.org/obo/MONDO_0015545"}],"text":"The effects of IFNγ deficiency have been investigated in an experimental model of haemophagocytic lymphohistiocytosis, which develops when perforin deficient (Prf1−/−) mice are infected with the lymphocytic choriomeningitis virus. Surprisingly, mice lacking both IFNγ and perforin (IFNγ−/−Prf1−/−) still develop a severe MAS-like disease that requires the IL-33–ST2 axis and is downstream mediated by GM-CSF-producing CD8+ T cells. The inflammatory burden in infected IFNγ−/−Prf1−/− mice is even higher than in Prf1−/− mice, being characterised by a 10–15 times increase in neutrophils and stronger upregulation of IL-1β and IL-6.32 The same interplay between IL-33 and GM-CSF might occur in patients with COVID-19, which would initiate the cytokine storm syndrome. Thus, severe forms of COVID-19 might represent atypical MAS or MAS-like reactions with incorporated interferon deficiencies."}

    LitCovid-PD-CLO

    {"project":"LitCovid-PD-CLO","denotations":[{"id":"T192","span":{"begin":224,"end":229},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T193","span":{"begin":312,"end":313},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T194","span":{"begin":362,"end":365},"obj":"http://purl.obolibrary.org/obo/CLO_0051025"},{"id":"T195","span":{"begin":418,"end":421},"obj":"http://purl.obolibrary.org/obo/CLO_0053438"},{"id":"T196","span":{"begin":423,"end":430},"obj":"http://purl.obolibrary.org/obo/CL_0000084"},{"id":"T197","span":{"begin":548,"end":552},"obj":"http://purl.obolibrary.org/obo/CLO_0001550"}],"text":"The effects of IFNγ deficiency have been investigated in an experimental model of haemophagocytic lymphohistiocytosis, which develops when perforin deficient (Prf1−/−) mice are infected with the lymphocytic choriomeningitis virus. Surprisingly, mice lacking both IFNγ and perforin (IFNγ−/−Prf1−/−) still develop a severe MAS-like disease that requires the IL-33–ST2 axis and is downstream mediated by GM-CSF-producing CD8+ T cells. The inflammatory burden in infected IFNγ−/−Prf1−/− mice is even higher than in Prf1−/− mice, being characterised by a 10–15 times increase in neutrophils and stronger upregulation of IL-1β and IL-6.32 The same interplay between IL-33 and GM-CSF might occur in patients with COVID-19, which would initiate the cytokine storm syndrome. Thus, severe forms of COVID-19 might represent atypical MAS or MAS-like reactions with incorporated interferon deficiencies."}

    LitCovid-PD-CHEBI

    {"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T169","span":{"begin":356,"end":358},"obj":"Chemical"},{"id":"T171","span":{"begin":401,"end":403},"obj":"Chemical"},{"id":"T172","span":{"begin":615,"end":617},"obj":"Chemical"},{"id":"T174","span":{"begin":625,"end":627},"obj":"Chemical"},{"id":"T176","span":{"begin":660,"end":662},"obj":"Chemical"},{"id":"T178","span":{"begin":670,"end":672},"obj":"Chemical"},{"id":"T179","span":{"begin":866,"end":876},"obj":"Chemical"}],"attributes":[{"id":"A169","pred":"chebi_id","subj":"T169","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A170","pred":"chebi_id","subj":"T169","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A171","pred":"chebi_id","subj":"T171","obj":"http://purl.obolibrary.org/obo/CHEBI_74120"},{"id":"A172","pred":"chebi_id","subj":"T172","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A173","pred":"chebi_id","subj":"T172","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A174","pred":"chebi_id","subj":"T174","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A175","pred":"chebi_id","subj":"T174","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A176","pred":"chebi_id","subj":"T176","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A177","pred":"chebi_id","subj":"T176","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A178","pred":"chebi_id","subj":"T178","obj":"http://purl.obolibrary.org/obo/CHEBI_74120"},{"id":"A179","pred":"chebi_id","subj":"T179","obj":"http://purl.obolibrary.org/obo/CHEBI_52999"}],"text":"The effects of IFNγ deficiency have been investigated in an experimental model of haemophagocytic lymphohistiocytosis, which develops when perforin deficient (Prf1−/−) mice are infected with the lymphocytic choriomeningitis virus. Surprisingly, mice lacking both IFNγ and perforin (IFNγ−/−Prf1−/−) still develop a severe MAS-like disease that requires the IL-33–ST2 axis and is downstream mediated by GM-CSF-producing CD8+ T cells. The inflammatory burden in infected IFNγ−/−Prf1−/− mice is even higher than in Prf1−/− mice, being characterised by a 10–15 times increase in neutrophils and stronger upregulation of IL-1β and IL-6.32 The same interplay between IL-33 and GM-CSF might occur in patients with COVID-19, which would initiate the cytokine storm syndrome. Thus, severe forms of COVID-19 might represent atypical MAS or MAS-like reactions with incorporated interferon deficiencies."}

    LitCovid-PD-HP

    {"project":"LitCovid-PD-HP","denotations":[{"id":"T17","span":{"begin":741,"end":755},"obj":"Phenotype"}],"attributes":[{"id":"A17","pred":"hp_id","subj":"T17","obj":"http://purl.obolibrary.org/obo/HP_0033041"}],"text":"The effects of IFNγ deficiency have been investigated in an experimental model of haemophagocytic lymphohistiocytosis, which develops when perforin deficient (Prf1−/−) mice are infected with the lymphocytic choriomeningitis virus. Surprisingly, mice lacking both IFNγ and perforin (IFNγ−/−Prf1−/−) still develop a severe MAS-like disease that requires the IL-33–ST2 axis and is downstream mediated by GM-CSF-producing CD8+ T cells. The inflammatory burden in infected IFNγ−/−Prf1−/− mice is even higher than in Prf1−/− mice, being characterised by a 10–15 times increase in neutrophils and stronger upregulation of IL-1β and IL-6.32 The same interplay between IL-33 and GM-CSF might occur in patients with COVID-19, which would initiate the cytokine storm syndrome. Thus, severe forms of COVID-19 might represent atypical MAS or MAS-like reactions with incorporated interferon deficiencies."}

    LitCovid-sentences

    {"project":"LitCovid-sentences","denotations":[{"id":"T63","span":{"begin":0,"end":230},"obj":"Sentence"},{"id":"T64","span":{"begin":231,"end":431},"obj":"Sentence"},{"id":"T65","span":{"begin":432,"end":765},"obj":"Sentence"},{"id":"T66","span":{"begin":766,"end":890},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"The effects of IFNγ deficiency have been investigated in an experimental model of haemophagocytic lymphohistiocytosis, which develops when perforin deficient (Prf1−/−) mice are infected with the lymphocytic choriomeningitis virus. Surprisingly, mice lacking both IFNγ and perforin (IFNγ−/−Prf1−/−) still develop a severe MAS-like disease that requires the IL-33–ST2 axis and is downstream mediated by GM-CSF-producing CD8+ T cells. The inflammatory burden in infected IFNγ−/−Prf1−/− mice is even higher than in Prf1−/− mice, being characterised by a 10–15 times increase in neutrophils and stronger upregulation of IL-1β and IL-6.32 The same interplay between IL-33 and GM-CSF might occur in patients with COVID-19, which would initiate the cytokine storm syndrome. Thus, severe forms of COVID-19 might represent atypical MAS or MAS-like reactions with incorporated interferon deficiencies."}

    LitCovid-PubTator

    {"project":"LitCovid-PubTator","denotations":[{"id":"554","span":{"begin":159,"end":163},"obj":"Gene"},{"id":"555","span":{"begin":263,"end":267},"obj":"Gene"},{"id":"556","span":{"begin":282,"end":286},"obj":"Gene"},{"id":"557","span":{"begin":289,"end":293},"obj":"Gene"},{"id":"558","span":{"begin":356,"end":361},"obj":"Gene"},{"id":"559","span":{"begin":401,"end":407},"obj":"Gene"},{"id":"560","span":{"begin":418,"end":421},"obj":"Gene"},{"id":"561","span":{"begin":468,"end":472},"obj":"Gene"},{"id":"562","span":{"begin":475,"end":479},"obj":"Gene"},{"id":"563","span":{"begin":511,"end":515},"obj":"Gene"},{"id":"564","span":{"begin":615,"end":620},"obj":"Gene"},{"id":"565","span":{"begin":625,"end":629},"obj":"Gene"},{"id":"566","span":{"begin":660,"end":665},"obj":"Gene"},{"id":"567","span":{"begin":670,"end":676},"obj":"Gene"},{"id":"568","span":{"begin":362,"end":365},"obj":"Gene"},{"id":"569","span":{"begin":168,"end":172},"obj":"Species"},{"id":"570","span":{"begin":245,"end":249},"obj":"Species"},{"id":"571","span":{"begin":483,"end":487},"obj":"Species"},{"id":"572","span":{"begin":519,"end":523},"obj":"Species"},{"id":"573","span":{"begin":692,"end":700},"obj":"Species"},{"id":"574","span":{"begin":15,"end":30},"obj":"Disease"},{"id":"575","span":{"begin":82,"end":117},"obj":"Disease"},{"id":"576","span":{"begin":177,"end":185},"obj":"Disease"},{"id":"577","span":{"begin":459,"end":467},"obj":"Disease"},{"id":"578","span":{"begin":706,"end":714},"obj":"Disease"},{"id":"579","span":{"begin":788,"end":796},"obj":"Disease"}],"attributes":[{"id":"A554","pred":"tao:has_database_id","subj":"554","obj":"Gene:18646"},{"id":"A555","pred":"tao:has_database_id","subj":"555","obj":"Gene:15978"},{"id":"A556","pred":"tao:has_database_id","subj":"556","obj":"Gene:15978"},{"id":"A557","pred":"tao:has_database_id","subj":"557","obj":"Gene:18646"},{"id":"A558","pred":"tao:has_database_id","subj":"558","obj":"Gene:77125"},{"id":"A559","pred":"tao:has_database_id","subj":"559","obj":"Gene:12981"},{"id":"A560","pred":"tao:has_database_id","subj":"560","obj":"Gene:925"},{"id":"A561","pred":"tao:has_database_id","subj":"561","obj":"Gene:15978"},{"id":"A562","pred":"tao:has_database_id","subj":"562","obj":"Gene:18646"},{"id":"A563","pred":"tao:has_database_id","subj":"563","obj":"Gene:18646"},{"id":"A564","pred":"tao:has_database_id","subj":"564","obj":"Gene:16175"},{"id":"A565","pred":"tao:has_database_id","subj":"565","obj":"Gene:16193"},{"id":"A566","pred":"tao:has_database_id","subj":"566","obj":"Gene:90865"},{"id":"A567","pred":"tao:has_database_id","subj":"567","obj":"Gene:1437"},{"id":"A568","pred":"tao:has_database_id","subj":"568","obj":"Gene:17082"},{"id":"A569","pred":"tao:has_database_id","subj":"569","obj":"Tax:10090"},{"id":"A570","pred":"tao:has_database_id","subj":"570","obj":"Tax:10090"},{"id":"A571","pred":"tao:has_database_id","subj":"571","obj":"Tax:10090"},{"id":"A572","pred":"tao:has_database_id","subj":"572","obj":"Tax:10090"},{"id":"A573","pred":"tao:has_database_id","subj":"573","obj":"Tax:9606"},{"id":"A574","pred":"tao:has_database_id","subj":"574","obj":"MESH:D007153"},{"id":"A575","pred":"tao:has_database_id","subj":"575","obj":"MESH:D051359"},{"id":"A576","pred":"tao:has_database_id","subj":"576","obj":"MESH:D007239"},{"id":"A577","pred":"tao:has_database_id","subj":"577","obj":"MESH:D007239"},{"id":"A578","pred":"tao:has_database_id","subj":"578","obj":"MESH:C000657245"},{"id":"A579","pred":"tao:has_database_id","subj":"579","obj":"MESH:C000657245"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"The effects of IFNγ deficiency have been investigated in an experimental model of haemophagocytic lymphohistiocytosis, which develops when perforin deficient (Prf1−/−) mice are infected with the lymphocytic choriomeningitis virus. Surprisingly, mice lacking both IFNγ and perforin (IFNγ−/−Prf1−/−) still develop a severe MAS-like disease that requires the IL-33–ST2 axis and is downstream mediated by GM-CSF-producing CD8+ T cells. The inflammatory burden in infected IFNγ−/−Prf1−/− mice is even higher than in Prf1−/− mice, being characterised by a 10–15 times increase in neutrophils and stronger upregulation of IL-1β and IL-6.32 The same interplay between IL-33 and GM-CSF might occur in patients with COVID-19, which would initiate the cytokine storm syndrome. Thus, severe forms of COVID-19 might represent atypical MAS or MAS-like reactions with incorporated interferon deficiencies."}

    2_test

    {"project":"2_test","denotations":[{"id":"33073244-31400073-66244552","span":{"begin":630,"end":632},"obj":"31400073"}],"text":"The effects of IFNγ deficiency have been investigated in an experimental model of haemophagocytic lymphohistiocytosis, which develops when perforin deficient (Prf1−/−) mice are infected with the lymphocytic choriomeningitis virus. Surprisingly, mice lacking both IFNγ and perforin (IFNγ−/−Prf1−/−) still develop a severe MAS-like disease that requires the IL-33–ST2 axis and is downstream mediated by GM-CSF-producing CD8+ T cells. The inflammatory burden in infected IFNγ−/−Prf1−/− mice is even higher than in Prf1−/− mice, being characterised by a 10–15 times increase in neutrophils and stronger upregulation of IL-1β and IL-6.32 The same interplay between IL-33 and GM-CSF might occur in patients with COVID-19, which would initiate the cytokine storm syndrome. Thus, severe forms of COVID-19 might represent atypical MAS or MAS-like reactions with incorporated interferon deficiencies."}