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PMC:7546716 / 13536-14426 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T235 195-206 Body_part denotes lymphocytic http://purl.org/sig/ont/fma/fma62863
T236 356-358 Body_part denotes IL http://purl.org/sig/ont/fma/fma86578
T237 366-370 Body_part denotes axis http://purl.org/sig/ont/fma/fma12520
T238 404-407 Body_part denotes CSF http://purl.org/sig/ont/fma/fma20935
T239 425-430 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T240 574-585 Body_part denotes neutrophils http://purl.org/sig/ont/fma/fma62860
T241 615-619 Body_part denotes IL-1 http://purl.org/sig/ont/fma/fma86583
T242 615-617 Body_part denotes IL http://purl.org/sig/ont/fma/fma86578
T243 625-627 Body_part denotes IL http://purl.org/sig/ont/fma/fma86578
T244 660-662 Body_part denotes IL http://purl.org/sig/ont/fma/fma86578
T245 673-676 Body_part denotes CSF http://purl.org/sig/ont/fma/fma20935
T246 741-749 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T84 195-223 Disease denotes lymphocytic choriomeningitis http://purl.obolibrary.org/obo/MONDO_0001449
T85 321-324 Disease denotes MAS http://purl.obolibrary.org/obo/MONDO_0015545
T86 706-714 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T87 750-764 Disease denotes storm syndrome http://purl.obolibrary.org/obo/MONDO_0008496
T88 788-796 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T89 822-825 Disease denotes MAS http://purl.obolibrary.org/obo/MONDO_0015545
T90 829-832 Disease denotes MAS http://purl.obolibrary.org/obo/MONDO_0015545

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T192 224-229 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T193 312-313 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T194 362-365 http://purl.obolibrary.org/obo/CLO_0051025 denotes ST2
T195 418-421 http://purl.obolibrary.org/obo/CLO_0053438 denotes CD8
T196 423-430 http://purl.obolibrary.org/obo/CL_0000084 denotes T cells
T197 548-552 http://purl.obolibrary.org/obo/CLO_0001550 denotes a 10

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T169 356-358 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T171 401-403 Chemical denotes GM http://purl.obolibrary.org/obo/CHEBI_74120
T172 615-617 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T174 625-627 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T176 660-662 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T178 670-672 Chemical denotes GM http://purl.obolibrary.org/obo/CHEBI_74120
T179 866-876 Chemical denotes interferon http://purl.obolibrary.org/obo/CHEBI_52999

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T17 741-755 Phenotype denotes cytokine storm http://purl.obolibrary.org/obo/HP_0033041

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T63 0-230 Sentence denotes The effects of IFNγ deficiency have been investigated in an experimental model of haemophagocytic lymphohistiocytosis, which develops when perforin deficient (Prf1−/−) mice are infected with the lymphocytic choriomeningitis virus.
T64 231-431 Sentence denotes Surprisingly, mice lacking both IFNγ and perforin (IFNγ−/−Prf1−/−) still develop a severe MAS-like disease that requires the IL-33–ST2 axis and is downstream mediated by GM-CSF-producing CD8+ T cells.
T65 432-765 Sentence denotes The inflammatory burden in infected IFNγ−/−Prf1−/− mice is even higher than in Prf1−/− mice, being characterised by a 10–15 times increase in neutrophils and stronger upregulation of IL-1β and IL-6.32 The same interplay between IL-33 and GM-CSF might occur in patients with COVID-19, which would initiate the cytokine storm syndrome.
T66 766-890 Sentence denotes Thus, severe forms of COVID-19 might represent atypical MAS or MAS-like reactions with incorporated interferon deficiencies.

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
554 159-163 Gene denotes Prf1 Gene:18646
555 263-267 Gene denotes IFNγ Gene:15978
556 282-286 Gene denotes IFNγ Gene:15978
557 289-293 Gene denotes Prf1 Gene:18646
558 356-361 Gene denotes IL-33 Gene:77125
559 401-407 Gene denotes GM-CSF Gene:12981
560 418-421 Gene denotes CD8 Gene:925
561 468-472 Gene denotes IFNγ Gene:15978
562 475-479 Gene denotes Prf1 Gene:18646
563 511-515 Gene denotes Prf1 Gene:18646
564 615-620 Gene denotes IL-1β Gene:16175
565 625-629 Gene denotes IL-6 Gene:16193
566 660-665 Gene denotes IL-33 Gene:90865
567 670-676 Gene denotes GM-CSF Gene:1437
568 362-365 Gene denotes ST2 Gene:17082
569 168-172 Species denotes mice Tax:10090
570 245-249 Species denotes mice Tax:10090
571 483-487 Species denotes mice Tax:10090
572 519-523 Species denotes mice Tax:10090
573 692-700 Species denotes patients Tax:9606
574 15-30 Disease denotes IFNγ deficiency MESH:D007153
575 82-117 Disease denotes haemophagocytic lymphohistiocytosis MESH:D051359
576 177-185 Disease denotes infected MESH:D007239
577 459-467 Disease denotes infected MESH:D007239
578 706-714 Disease denotes COVID-19 MESH:C000657245
579 788-796 Disease denotes COVID-19 MESH:C000657245

2_test

Id Subject Object Predicate Lexical cue
33073244-31400073-66244552 630-632 31400073 denotes 32