PMC:7546716 / 0-708 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7546716","sourcedb":"PMC","sourceid":"7546716","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7546716","text":"Imperfect storm: is interleukin-33 the Achilles heel of COVID-19?\n\nAbstract\nThe unique cytokine signature of COVID-19 might provide clues to disease mechanisms and possible future therapies. Here, we propose a pathogenic model in which the alarmin cytokine, interleukin (IL)-33, is a key player in driving all stages of COVID-19 disease (ie, asymptomatic, mild–moderate, severe–critical, and chronic–fibrotic). In susceptible individuals, IL-33 release by damaged lower respiratory cells might induce dysregulated GATA-binding factor 3-expressing regulatory T cells, thereby breaking immune tolerance and eliciting severe acute respiratory syndrome coronavirus 2-induced autoinflammatory lung disease. Such d","divisions":[{"label":"article-title","span":{"begin":0,"end":65}}],"tracks":[{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T1","span":{"begin":20,"end":31},"obj":"Body_part"},{"id":"T2","span":{"begin":48,"end":52},"obj":"Body_part"},{"id":"T3","span":{"begin":87,"end":95},"obj":"Body_part"},{"id":"T4","span":{"begin":248,"end":256},"obj":"Body_part"},{"id":"T5","span":{"begin":258,"end":269},"obj":"Body_part"},{"id":"T6","span":{"begin":271,"end":273},"obj":"Body_part"},{"id":"T7","span":{"begin":439,"end":441},"obj":"Body_part"},{"id":"T8","span":{"begin":482,"end":487},"obj":"Body_part"},{"id":"T9","span":{"begin":547,"end":565},"obj":"Body_part"},{"id":"T10","span":{"begin":560,"end":565},"obj":"Body_part"},{"id":"T11","span":{"begin":688,"end":692},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"fma_id","subj":"T1","obj":"http://purl.org/sig/ont/fma/fma86578"},{"id":"A2","pred":"fma_id","subj":"T2","obj":"http://purl.org/sig/ont/fma/fma24994"},{"id":"A3","pred":"fma_id","subj":"T3","obj":"http://purl.org/sig/ont/fma/fma84050"},{"id":"A4","pred":"fma_id","subj":"T4","obj":"http://purl.org/sig/ont/fma/fma84050"},{"id":"A5","pred":"fma_id","subj":"T5","obj":"http://purl.org/sig/ont/fma/fma86578"},{"id":"A6","pred":"fma_id","subj":"T6","obj":"http://purl.org/sig/ont/fma/fma86578"},{"id":"A7","pred":"fma_id","subj":"T7","obj":"http://purl.org/sig/ont/fma/fma86578"},{"id":"A8","pred":"fma_id","subj":"T8","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A9","pred":"fma_id","subj":"T9","obj":"http://purl.org/sig/ont/fma/fma84070"},{"id":"A10","pred":"fma_id","subj":"T10","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A11","pred":"fma_id","subj":"T11","obj":"http://purl.org/sig/ont/fma/fma7195"},{"subj":"T1","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T2","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T3","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T4","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T5","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T6","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T7","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T8","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T9","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T10","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T11","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T1","span":{"begin":48,"end":52},"obj":"Body_part"},{"id":"T2","span":{"begin":688,"end":692},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"uberon_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/UBERON_0015875"},{"id":"A2","pred":"uberon_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"subj":"T1","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T2","pred":"source","obj":"LitCovid-PD-UBERON"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T1","span":{"begin":56,"end":64},"obj":"Disease"},{"id":"T2","span":{"begin":109,"end":117},"obj":"Disease"},{"id":"T3","span":{"begin":320,"end":328},"obj":"Disease"},{"id":"T4","span":{"begin":615,"end":662},"obj":"Disease"},{"id":"T5","span":{"begin":615,"end":648},"obj":"Disease"},{"id":"T6","span":{"begin":688,"end":700},"obj":"Disease"}],"attributes":[{"id":"A1","pred":"mondo_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A2","pred":"mondo_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A3","pred":"mondo_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A4","pred":"mondo_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A5","pred":"mondo_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A6","pred":"mondo_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/MONDO_0005275"},{"subj":"T1","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T2","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T3","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T4","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T5","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T6","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T1","span":{"begin":208,"end":209},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T2","span":{"begin":282,"end":283},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T3","span":{"begin":482,"end":487},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T4","span":{"begin":547,"end":565},"obj":"http://purl.obolibrary.org/obo/CL_0000815"},{"id":"T5","span":{"begin":688,"end":692},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"T6","span":{"begin":688,"end":692},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"}],"attributes":[{"subj":"T1","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T2","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T3","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T4","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T5","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T6","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T1","span":{"begin":271,"end":273},"obj":"Chemical"},{"id":"T3","span":{"begin":439,"end":441},"obj":"Chemical"}],"attributes":[{"id":"A1","pred":"chebi_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A2","pred":"chebi_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A3","pred":"chebi_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A4","pred":"chebi_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"subj":"T1","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T3","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PD-HP","denotations":[{"id":"T1","span":{"begin":688,"end":700},"obj":"Phenotype"}],"attributes":[{"id":"A1","pred":"hp_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/HP_0002088"},{"subj":"T1","pred":"source","obj":"LitCovid-PD-HP"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T1","span":{"begin":0,"end":65},"obj":"Sentence"},{"id":"T2","span":{"begin":67,"end":75},"obj":"Sentence"},{"id":"T3","span":{"begin":76,"end":190},"obj":"Sentence"},{"id":"T4","span":{"begin":191,"end":410},"obj":"Sentence"},{"id":"T5","span":{"begin":411,"end":701},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T1","pred":"source","obj":"LitCovid-sentences"},{"subj":"T2","pred":"source","obj":"LitCovid-sentences"},{"subj":"T3","pred":"source","obj":"LitCovid-sentences"},{"subj":"T4","pred":"source","obj":"LitCovid-sentences"},{"subj":"T5","pred":"source","obj":"LitCovid-sentences"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"2","span":{"begin":20,"end":34},"obj":"Gene"},{"id":"3","span":{"begin":56,"end":64},"obj":"Disease"},{"id":"23","span":{"begin":258,"end":277},"obj":"Gene"},{"id":"24","span":{"begin":439,"end":444},"obj":"Gene"},{"id":"25","span":{"begin":514,"end":535},"obj":"Gene"},{"id":"33","span":{"begin":615,"end":662},"obj":"Species"},{"id":"36","span":{"begin":109,"end":117},"obj":"Disease"},{"id":"37","span":{"begin":320,"end":328},"obj":"Disease"},{"id":"38","span":{"begin":671,"end":700},"obj":"Disease"}],"attributes":[{"id":"A2","pred":"tao:has_database_id","subj":"2","obj":"Gene:90865"},{"id":"A3","pred":"tao:has_database_id","subj":"3","obj":"MESH:C000657245"},{"id":"A23","pred":"tao:has_database_id","subj":"23","obj":"Gene:90865"},{"id":"A24","pred":"tao:has_database_id","subj":"24","obj":"Gene:90865"},{"id":"A25","pred":"tao:has_database_id","subj":"25","obj":"Gene:2625"},{"id":"A33","pred":"tao:has_database_id","subj":"33","obj":"Tax:2697049"},{"id":"A36","pred":"tao:has_database_id","subj":"36","obj":"MESH:C000657245"},{"id":"A37","pred":"tao:has_database_id","subj":"37","obj":"MESH:C000657245"},{"id":"A38","pred":"tao:has_database_id","subj":"38","obj":"MESH:D008171"},{"subj":"2","pred":"source","obj":"LitCovid-PubTator"},{"subj":"3","pred":"source","obj":"LitCovid-PubTator"},{"subj":"23","pred":"source","obj":"LitCovid-PubTator"},{"subj":"24","pred":"source","obj":"LitCovid-PubTator"},{"subj":"25","pred":"source","obj":"LitCovid-PubTator"},{"subj":"33","pred":"source","obj":"LitCovid-PubTator"},{"subj":"36","pred":"source","obj":"LitCovid-PubTator"},{"subj":"37","pred":"source","obj":"LitCovid-PubTator"},{"subj":"38","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PD-FMA-UBERON","color":"#9396ec","default":true},{"id":"LitCovid-PD-UBERON","color":"#b0ec93"},{"id":"LitCovid-PD-MONDO","color":"#ec93ca"},{"id":"LitCovid-PD-CLO","color":"#93e4ec"},{"id":"LitCovid-PD-CHEBI","color":"#ecd993"},{"id":"LitCovid-PD-HP","color":"#bf93ec"},{"id":"LitCovid-sentences","color":"#93eca5"},{"id":"LitCovid-PubTator","color":"#ec939a"}]}]}}