PMC:7546130 / 7523-8364 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7546130","sourcedb":"PMC","sourceid":"7546130","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7546130","text":"First, the multiple supratentorial ischemic lesions seen on DWI, with corpus callosum involvement, do not depict a territorial distribution, inconsistent with COVID-19-associated large vessel occlusion [5]. Instead, they might reflect diffuse local thrombosis or, less likely, embolism. In this setting, high D-dimer values may reflect thrombus formation, but they can also act as acute-phase enhancer of the inflammatory cascade and stimulates monocyte synthesis and release of proinflammatory cytokines, which can contribute to the occurrence of stroke [6]. We cannot ascertain a specific correlation of the DWI findings with SARS-CoV2 infection in our patient. Nevertheless, similar MRI findings of bilateral supratentorial and corpus callosum DWI lesions have been described in COVID-19 patients with similar clinical manifestations 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