PMC:7546130 / 7523-8364 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T52","span":{"begin":70,"end":85},"obj":"Body_part"},{"id":"T53","span":{"begin":445,"end":453},"obj":"Body_part"},{"id":"T54","span":{"begin":495,"end":504},"obj":"Body_part"},{"id":"T55","span":{"begin":731,"end":746},"obj":"Body_part"}],"attributes":[{"id":"A52","pred":"fma_id","subj":"T52","obj":"http://purl.org/sig/ont/fma/fma86464"},{"id":"A53","pred":"fma_id","subj":"T53","obj":"http://purl.org/sig/ont/fma/fma62864"},{"id":"A54","pred":"fma_id","subj":"T54","obj":"http://purl.org/sig/ont/fma/fma84050"},{"id":"A55","pred":"fma_id","subj":"T55","obj":"http://purl.org/sig/ont/fma/fma86464"}],"text":"First, the multiple supratentorial ischemic lesions seen on DWI, with corpus callosum involvement, do not depict a territorial distribution, inconsistent with COVID-19-associated large vessel occlusion [5]. Instead, they might reflect diffuse local thrombosis or, less likely, embolism. In this setting, high D-dimer values may reflect thrombus formation, but they can also act as acute-phase enhancer of the inflammatory cascade and stimulates monocyte synthesis and release of proinflammatory cytokines, which can contribute to the occurrence of stroke [6]. We cannot ascertain a specific correlation of the DWI findings with SARS-CoV2 infection in our patient. Nevertheless, similar MRI findings of bilateral supratentorial and corpus callosum DWI lesions have been described in COVID-19 patients with similar clinical manifestations [2]."}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T36","span":{"begin":70,"end":85},"obj":"Body_part"},{"id":"T37","span":{"begin":70,"end":76},"obj":"Body_part"},{"id":"T38","span":{"begin":185,"end":191},"obj":"Body_part"},{"id":"T39","span":{"begin":731,"end":746},"obj":"Body_part"},{"id":"T40","span":{"begin":731,"end":737},"obj":"Body_part"}],"attributes":[{"id":"A36","pred":"uberon_id","subj":"T36","obj":"http://purl.obolibrary.org/obo/UBERON_0002336"},{"id":"A37","pred":"uberon_id","subj":"T37","obj":"http://purl.obolibrary.org/obo/UBERON_3000645"},{"id":"A38","pred":"uberon_id","subj":"T38","obj":"http://purl.obolibrary.org/obo/UBERON_0000055"},{"id":"A39","pred":"uberon_id","subj":"T39","obj":"http://purl.obolibrary.org/obo/UBERON_0002336"},{"id":"A40","pred":"uberon_id","subj":"T40","obj":"http://purl.obolibrary.org/obo/UBERON_3000645"}],"text":"First, the multiple supratentorial ischemic lesions seen on DWI, with corpus callosum involvement, do not depict a territorial distribution, inconsistent with COVID-19-associated large vessel occlusion [5]. Instead, they might reflect diffuse local thrombosis or, less likely, embolism. In this setting, high D-dimer values may reflect thrombus formation, but they can also act as acute-phase enhancer of the inflammatory cascade and stimulates monocyte synthesis and release of proinflammatory cytokines, which can contribute to the occurrence of stroke [6]. We cannot ascertain a specific correlation of the DWI findings with SARS-CoV2 infection in our patient. Nevertheless, similar MRI findings of bilateral supratentorial and corpus callosum DWI lesions have been described in COVID-19 patients with similar clinical manifestations [2]."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T31","span":{"begin":159,"end":167},"obj":"Disease"},{"id":"T32","span":{"begin":249,"end":259},"obj":"Disease"},{"id":"T33","span":{"begin":336,"end":344},"obj":"Disease"},{"id":"T34","span":{"begin":548,"end":554},"obj":"Disease"},{"id":"T36","span":{"begin":628,"end":632},"obj":"Disease"},{"id":"T37","span":{"begin":638,"end":647},"obj":"Disease"},{"id":"T38","span":{"begin":782,"end":790},"obj":"Disease"}],"attributes":[{"id":"A31","pred":"mondo_id","subj":"T31","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A32","pred":"mondo_id","subj":"T32","obj":"http://purl.obolibrary.org/obo/MONDO_0000831"},{"id":"A33","pred":"mondo_id","subj":"T33","obj":"http://purl.obolibrary.org/obo/MONDO_0000831"},{"id":"A34","pred":"mondo_id","subj":"T34","obj":"http://purl.obolibrary.org/obo/MONDO_0005098"},{"id":"A35","pred":"mondo_id","subj":"T34","obj":"http://purl.obolibrary.org/obo/MONDO_0011057"},{"id":"A36","pred":"mondo_id","subj":"T36","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A37","pred":"mondo_id","subj":"T37","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A38","pred":"mondo_id","subj":"T38","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"}],"text":"First, the multiple supratentorial ischemic lesions seen on DWI, with corpus callosum involvement, do not depict a territorial distribution, inconsistent with COVID-19-associated large vessel occlusion [5]. Instead, they might reflect diffuse local thrombosis or, less likely, embolism. In this setting, high D-dimer values may reflect thrombus formation, but they can also act as acute-phase enhancer of the inflammatory cascade and stimulates monocyte synthesis and release of proinflammatory cytokines, which can contribute to the occurrence of stroke [6]. We cannot ascertain a specific correlation of the DWI findings with SARS-CoV2 infection in our patient. Nevertheless, similar MRI findings of bilateral supratentorial and corpus callosum DWI lesions have been described in COVID-19 patients with similar clinical manifestations [2]."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T65","span":{"begin":113,"end":114},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T66","span":{"begin":185,"end":191},"obj":"http://purl.obolibrary.org/obo/UBERON_0000055"},{"id":"T67","span":{"begin":445,"end":453},"obj":"http://purl.obolibrary.org/obo/CL_0000576"},{"id":"T68","span":{"begin":580,"end":581},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"text":"First, the multiple supratentorial ischemic lesions seen on DWI, with corpus callosum involvement, do not depict a territorial distribution, inconsistent with COVID-19-associated large vessel occlusion [5]. Instead, they might reflect diffuse local thrombosis or, less likely, embolism. In this setting, high D-dimer values may reflect thrombus formation, but they can also act as acute-phase enhancer of the inflammatory cascade and stimulates monocyte synthesis and release of proinflammatory cytokines, which can contribute to the occurrence of stroke [6]. We cannot ascertain a specific correlation of the DWI findings with SARS-CoV2 infection in our patient. Nevertheless, similar MRI findings of bilateral supratentorial and corpus callosum DWI lesions have been described in COVID-19 patients with similar clinical manifestations [2]."}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T13","span":{"begin":548,"end":554},"obj":"Phenotype"}],"attributes":[{"id":"A13","pred":"hp_id","subj":"T13","obj":"http://purl.obolibrary.org/obo/HP_0001297"}],"text":"First, the multiple supratentorial ischemic lesions seen on DWI, with corpus callosum involvement, do not depict a territorial distribution, inconsistent with COVID-19-associated large vessel occlusion [5]. Instead, they might reflect diffuse local thrombosis or, less likely, embolism. In this setting, high D-dimer values may reflect thrombus formation, but they can also act as acute-phase enhancer of the inflammatory cascade and stimulates monocyte synthesis and release of proinflammatory cytokines, which can contribute to the occurrence of stroke [6]. We cannot ascertain a specific correlation of the DWI findings with SARS-CoV2 infection in our patient. Nevertheless, similar MRI findings of bilateral supratentorial and corpus callosum DWI lesions have been described in COVID-19 patients with similar clinical manifestations [2]."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T4","span":{"begin":345,"end":354},"obj":"http://purl.obolibrary.org/obo/GO_0009058"},{"id":"T5","span":{"begin":454,"end":463},"obj":"http://purl.obolibrary.org/obo/GO_0009058"}],"text":"First, the multiple supratentorial ischemic lesions seen on DWI, with corpus callosum involvement, do not depict a territorial distribution, inconsistent with COVID-19-associated large vessel occlusion [5]. Instead, they might reflect diffuse local thrombosis or, less likely, embolism. In this setting, high D-dimer values may reflect thrombus formation, but they can also act as acute-phase enhancer of the inflammatory cascade and stimulates monocyte synthesis and release of proinflammatory cytokines, which can contribute to the occurrence of stroke [6]. We cannot ascertain a specific correlation of the DWI findings with SARS-CoV2 infection in our patient. Nevertheless, similar MRI findings of bilateral supratentorial and corpus callosum DWI lesions have been described in COVID-19 patients with similar clinical manifestations [2]."}

{"project":"LitCovid-sentences","denotations":[{"id":"T67","span":{"begin":0,"end":206},"obj":"Sentence"},{"id":"T68","span":{"begin":207,"end":286},"obj":"Sentence"},{"id":"T69","span":{"begin":287,"end":559},"obj":"Sentence"},{"id":"T70","span":{"begin":560,"end":663},"obj":"Sentence"},{"id":"T71","span":{"begin":664,"end":841},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"First, the multiple supratentorial ischemic lesions seen on DWI, with corpus callosum involvement, do not depict a territorial distribution, inconsistent with COVID-19-associated large vessel occlusion [5]. Instead, they might reflect diffuse local thrombosis or, less likely, embolism. In this setting, high D-dimer values may reflect thrombus formation, but they can also act as acute-phase enhancer of the inflammatory cascade and stimulates monocyte synthesis and release of proinflammatory cytokines, which can contribute to the occurrence of stroke [6]. We cannot ascertain a specific correlation of the DWI findings with SARS-CoV2 infection in our patient. Nevertheless, similar MRI findings of bilateral supratentorial and corpus callosum DWI lesions have been described in COVID-19 patients with similar clinical manifestations [2]."}

{"project":"LitCovid-PubTator","denotations":[{"id":"155","span":{"begin":628,"end":637},"obj":"Species"},{"id":"156","span":{"begin":655,"end":662},"obj":"Species"},{"id":"157","span":{"begin":791,"end":799},"obj":"Species"},{"id":"158","span":{"begin":35,"end":43},"obj":"Disease"},{"id":"159","span":{"begin":159,"end":167},"obj":"Disease"},{"id":"160","span":{"begin":249,"end":259},"obj":"Disease"},{"id":"161","span":{"begin":277,"end":285},"obj":"Disease"},{"id":"162","span":{"begin":336,"end":344},"obj":"Disease"},{"id":"163","span":{"begin":548,"end":554},"obj":"Disease"},{"id":"164","span":{"begin":638,"end":647},"obj":"Disease"},{"id":"165","span":{"begin":782,"end":790},"obj":"Disease"}],"attributes":[{"id":"A155","pred":"tao:has_database_id","subj":"155","obj":"Tax:2697049"},{"id":"A156","pred":"tao:has_database_id","subj":"156","obj":"Tax:9606"},{"id":"A157","pred":"tao:has_database_id","subj":"157","obj":"Tax:9606"},{"id":"A158","pred":"tao:has_database_id","subj":"158","obj":"MESH:D007511"},{"id":"A159","pred":"tao:has_database_id","subj":"159","obj":"MESH:C000657245"},{"id":"A160","pred":"tao:has_database_id","subj":"160","obj":"MESH:D013927"},{"id":"A161","pred":"tao:has_database_id","subj":"161","obj":"MESH:D004617"},{"id":"A162","pred":"tao:has_database_id","subj":"162","obj":"MESH:D013927"},{"id":"A163","pred":"tao:has_database_id","subj":"163","obj":"MESH:D020521"},{"id":"A164","pred":"tao:has_database_id","subj":"164","obj":"MESH:D007239"},{"id":"A165","pred":"tao:has_database_id","subj":"165","obj":"MESH:C000657245"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"First, the multiple supratentorial ischemic lesions seen on DWI, with corpus callosum involvement, do not depict a territorial distribution, inconsistent with COVID-19-associated large vessel occlusion [5]. Instead, they might reflect diffuse local thrombosis or, less likely, embolism. In this setting, high D-dimer values may reflect thrombus formation, but they can also act as acute-phase enhancer of the inflammatory cascade and stimulates monocyte synthesis and release of proinflammatory cytokines, which can contribute to the occurrence of stroke [6]. We cannot ascertain a specific correlation of the DWI findings with SARS-CoV2 infection in our patient. Nevertheless, similar MRI findings of bilateral supratentorial and corpus callosum DWI lesions have been described in COVID-19 patients with similar clinical manifestations [2]."}

{"project":"2_test","denotations":[{"id":"33034804-32343504-75886969","span":{"begin":203,"end":204},"obj":"32343504"},{"id":"33034804-31331288-75886970","span":{"begin":556,"end":557},"obj":"31331288"}],"text":"First, the multiple supratentorial ischemic lesions seen on DWI, with corpus callosum involvement, do not depict a territorial distribution, inconsistent with COVID-19-associated large vessel occlusion [5]. Instead, they might reflect diffuse local thrombosis or, less likely, embolism. In this setting, high D-dimer values may reflect thrombus formation, but they can also act as acute-phase enhancer of the inflammatory cascade and stimulates monocyte synthesis and release of proinflammatory cytokines, which can contribute to the occurrence of stroke [6]. We cannot ascertain a specific correlation of the DWI findings with SARS-CoV2 infection in our patient. Nevertheless, similar MRI findings of bilateral supratentorial and corpus callosum DWI lesions have been described in COVID-19 patients with similar clinical manifestations [2]."}