> top > docs > PMC:7544934 > spans > 26436-27243 > annotations

PMC:7544934 / 26436-27243 JSONTXT

Annnotations TAB JSON ListView MergeView

LitCovid_Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T65 250-253 https://glytoucan.org/Structures/Glycans/G00057MO denotes LDN
T66 250-253 https://glytoucan.org/Structures/Glycans/G31736BK denotes LDN
T67 675-678 https://glytoucan.org/Structures/Glycans/G00057MO denotes LDN
T68 675-678 https://glytoucan.org/Structures/Glycans/G31736BK denotes LDN

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
622 50-55 Gene denotes spike Gene:43740568
623 112-116 Gene denotes ACE2 Gene:59272
624 130-134 Gene denotes ACE2 Gene:59272
625 269-273 Gene denotes ACE2 Gene:59272
626 350-354 Gene denotes ACE2 Gene:59272
627 568-572 Gene denotes ACE2 Gene:59272
628 767-771 Gene denotes ACE2 Gene:59272
629 72-82 Species denotes SARS-CoV-2 Tax:2697049
630 331-341 Species denotes SARS-CoV-2 Tax:2697049
631 706-716 Species denotes SARS-CoV-2 Tax:2697049
632 275-285 Chemical denotes Naltrexone MESH:D009271
633 365-371 Chemical denotes Tyr505
634 376-382 Chemical denotes Glu406
635 409-417 Chemical denotes hydrogen MESH:D006859
636 433-443 Chemical denotes naltrexone MESH:D009271
637 493-499 Chemical denotes Arg403
638 540-545 Chemical denotes His34
639 547-552 Chemical denotes Glu37
640 558-564 Chemical denotes Phe390
641 641-651 Chemical denotes naltrexone MESH:D009271

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T184 0-213 Sentence denotes The latest research further strengthened that the spike-RBD sequence of SARS-CoV-2 interacts with host receptor ACE2 and this RBD-ACE2 complex plays a key role in virus invasion and virulence (Walls et al., 2020).
T185 214-274 Sentence denotes Based on virtual screening results, LDN interacts with ACE2.
T186 275-364 Sentence denotes Naltrexone prefers to bind in the central cavity formed SARS-CoV-2 RBD and ACE2 receptor.
T187 365-529 Sentence denotes Tyr505 and Glu406 of RBD formed two crucial hydrogen bonds with the naltrexone with an atomic distance of 2.08 and 1.80, while, Arg403 formed electrostatic contact.
T188 530-652 Sentence denotes While the His34, Glu37, and Phe390 of ACE2 displayed some hydrophobic contacts (mostly pi-alkyl contacts) with naltrexone.
T189 653-807 Sentence denotes Overall this suggests LDN can strongly interact with SARS-CoV-2 RBD, including its RBM may further influence RDB- ACE2 binding, and host cell infectivity.

2_test

Id Subject Object Predicate Lexical cue
32930058-32155444-56195705 207-211 32155444 denotes 2020