PMC:7544934 / 2425-3269 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7544934","sourcedb":"PMC","sourceid":"7544934","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7544934","text":"Several preclinical and clinical trials data have indicated an elevated cytokine/chemokine response in severe COVID-19 patients and identifies cytokine storm as the most potentially dangerous event for mortality (Coperchini et al., 2020; Rahmati \u0026 Moosavi, 2020; Zhang et al., 2020). Several kinases in the MAPK/ERK (mitogen-activated protein kinases/extracellular signal-regulated kinases) pathway are essential for viral replication. ERK1 and ERK2 phosphorylate HIV-1 proteins and enhance viral infectivity (Cai et al., 2007). The phosphorylation status of ERK1/2 is positively correlated with virus load and ERK1/2 inhibition suppressed viral replication and viral infectivity (Cai et al., 2007). Some preclinical findings have suggested targeting the ERK1/2 pathway to halt the viral replication and severity of SARS-COV-2 (Mizutani, 2010).","tracks":[{"project":"LitCovid-PD-HP","denotations":[{"id":"T4","span":{"begin":143,"end":157},"obj":"Phenotype"}],"attributes":[{"id":"A4","pred":"hp_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/HP_0033041"},{"subj":"T4","pred":"source","obj":"LitCovid-PD-HP"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"86","span":{"begin":307,"end":311},"obj":"Gene"},{"id":"87","span":{"begin":312,"end":315},"obj":"Gene"},{"id":"88","span":{"begin":436,"end":440},"obj":"Gene"},{"id":"89","span":{"begin":445,"end":449},"obj":"Gene"},{"id":"90","span":{"begin":559,"end":565},"obj":"Gene"},{"id":"91","span":{"begin":611,"end":617},"obj":"Gene"},{"id":"92","span":{"begin":755,"end":761},"obj":"Gene"},{"id":"93","span":{"begin":119,"end":127},"obj":"Species"},{"id":"94","span":{"begin":464,"end":469},"obj":"Species"},{"id":"95","span":{"begin":816,"end":826},"obj":"Species"},{"id":"96","span":{"begin":110,"end":118},"obj":"Disease"},{"id":"97","span":{"begin":202,"end":211},"obj":"Disease"}],"attributes":[{"id":"A87","pred":"tao:has_database_id","subj":"87","obj":"Gene:5594"},{"id":"A88","pred":"tao:has_database_id","subj":"88","obj":"Gene:5595"},{"id":"A89","pred":"tao:has_database_id","subj":"89","obj":"Gene:5594"},{"id":"A90","pred":"tao:has_database_id","subj":"90","obj":"Gene:5595"},{"id":"A91","pred":"tao:has_database_id","subj":"91","obj":"Gene:5595"},{"id":"A92","pred":"tao:has_database_id","subj":"92","obj":"Gene:5595"},{"id":"A93","pred":"tao:has_database_id","subj":"93","obj":"Tax:9606"},{"id":"A94","pred":"tao:has_database_id","subj":"94","obj":"Tax:11676"},{"id":"A95","pred":"tao:has_database_id","subj":"95","obj":"Tax:2697049"},{"id":"A96","pred":"tao:has_database_id","subj":"96","obj":"MESH:C000657245"},{"id":"A97","pred":"tao:has_database_id","subj":"97","obj":"MESH:D003643"},{"subj":"86","pred":"source","obj":"LitCovid-PubTator"},{"subj":"87","pred":"source","obj":"LitCovid-PubTator"},{"subj":"88","pred":"source","obj":"LitCovid-PubTator"},{"subj":"89","pred":"source","obj":"LitCovid-PubTator"},{"subj":"90","pred":"source","obj":"LitCovid-PubTator"},{"subj":"91","pred":"source","obj":"LitCovid-PubTator"},{"subj":"92","pred":"source","obj":"LitCovid-PubTator"},{"subj":"93","pred":"source","obj":"LitCovid-PubTator"},{"subj":"94","pred":"source","obj":"LitCovid-PubTator"},{"subj":"95","pred":"source","obj":"LitCovid-PubTator"},{"subj":"96","pred":"source","obj":"LitCovid-PubTator"},{"subj":"97","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T25","span":{"begin":0,"end":283},"obj":"Sentence"},{"id":"T26","span":{"begin":284,"end":435},"obj":"Sentence"},{"id":"T27","span":{"begin":436,"end":528},"obj":"Sentence"},{"id":"T28","span":{"begin":529,"end":699},"obj":"Sentence"},{"id":"T29","span":{"begin":700,"end":844},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T25","pred":"source","obj":"LitCovid-sentences"},{"subj":"T26","pred":"source","obj":"LitCovid-sentences"},{"subj":"T27","pred":"source","obj":"LitCovid-sentences"},{"subj":"T28","pred":"source","obj":"LitCovid-sentences"},{"subj":"T29","pred":"source","obj":"LitCovid-sentences"}]},{"project":"2_test","denotations":[{"id":"32930058-17079328-56195685","span":{"begin":522,"end":526},"obj":"17079328"},{"id":"32930058-17079328-56195686","span":{"begin":693,"end":697},"obj":"17079328"}],"attributes":[{"subj":"32930058-17079328-56195685","pred":"source","obj":"2_test"},{"subj":"32930058-17079328-56195686","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PD-HP","color":"#93ecb5","default":true},{"id":"LitCovid-PubTator","color":"#ec9b93"},{"id":"LitCovid-sentences","color":"#93a4ec"},{"id":"2_test","color":"#beec93"}]}]}}