| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T25 |
0-283 |
Sentence |
denotes |
Several preclinical and clinical trials data have indicated an elevated cytokine/chemokine response in severe COVID-19 patients and identifies cytokine storm as the most potentially dangerous event for mortality (Coperchini et al., 2020; Rahmati & Moosavi, 2020; Zhang et al., 2020). |
| T26 |
284-435 |
Sentence |
denotes |
Several kinases in the MAPK/ERK (mitogen-activated protein kinases/extracellular signal-regulated kinases) pathway are essential for viral replication. |
| T27 |
436-528 |
Sentence |
denotes |
ERK1 and ERK2 phosphorylate HIV-1 proteins and enhance viral infectivity (Cai et al., 2007). |
| T28 |
529-699 |
Sentence |
denotes |
The phosphorylation status of ERK1/2 is positively correlated with virus load and ERK1/2 inhibition suppressed viral replication and viral infectivity (Cai et al., 2007). |
| T29 |
700-844 |
Sentence |
denotes |
Some preclinical findings have suggested targeting the ERK1/2 pathway to halt the viral replication and severity of SARS-COV-2 (Mizutani, 2010). |