PMC:7543426 / 6780-9884 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T42","span":{"begin":893,"end":899},"obj":"Body_part"},{"id":"T43","span":{"begin":1254,"end":1259},"obj":"Body_part"},{"id":"T44","span":{"begin":1361,"end":1383},"obj":"Body_part"},{"id":"T45","span":{"begin":1434,"end":1440},"obj":"Body_part"},{"id":"T46","span":{"begin":1840,"end":1856},"obj":"Body_part"},{"id":"T47","span":{"begin":2135,"end":2141},"obj":"Body_part"},{"id":"T48","span":{"begin":2444,"end":2447},"obj":"Body_part"},{"id":"T49","span":{"begin":2570,"end":2578},"obj":"Body_part"},{"id":"T50","span":{"begin":2750,"end":2758},"obj":"Body_part"}],"attributes":[{"id":"A42","pred":"fma_id","subj":"T42","obj":"http://purl.org/sig/ont/fma/fma7203"},{"id":"A43","pred":"fma_id","subj":"T43","obj":"http://purl.org/sig/ont/fma/fma7088"},{"id":"A44","pred":"fma_id","subj":"T44","obj":"http://purl.org/sig/ont/fma/fma7233"},{"id":"A45","pred":"fma_id","subj":"T45","obj":"http://purl.org/sig/ont/fma/fma7203"},{"id":"A46","pred":"fma_id","subj":"T46","obj":"http://purl.org/sig/ont/fma/fma66326"},{"id":"A47","pred":"fma_id","subj":"T47","obj":"http://purl.org/sig/ont/fma/fma7203"},{"id":"A48","pred":"fma_id","subj":"T48","obj":"http://purl.org/sig/ont/fma/fma278683"},{"id":"A49","pred":"fma_id","subj":"T49","obj":"http://purl.org/sig/ont/fma/fma9600"},{"id":"A50","pred":"fma_id","subj":"T50","obj":"http://purl.org/sig/ont/fma/fma9600"}],"text":"Patient Demographics and Clinical Characteristics\nTable 1 and Table 2 depict the demographic and clinical characteristics of 22 COVID-19 patients on whom postmortem examinations were performed. Of these, 18 had other medical comorbidities (designated group 1). Four patients were healthy prior to hospital admission and had no known medical comorbidities or any cause of immunosuppression (designated group 2).\nTable 1. Summary of Patient Demographics at Baseline\nCharacteristic Group 1 With Comorbidities Group 2 Without Comorbidities\nNumber of patients 18 4\nDemography\n Age, y, median ± SD (range) 76 ± 15.7 (27–92) 48.5 ± 13.07 (35–65)\n Men 12 (66.7) 3 (75)\n Women 6 (33.3) 1 (25)\nComorbidity\n Chronic obstructive pulmonary disease 6 (33.3) …\n Cardiac disease 8 (44.5) …\n Malignancy 5 (27.8) …\n Hypertension 4 (22.3) …\n Diabetes 4 (22.3) …\n Schizophrenia 1 (5.6) …\n Kidney disease 2 (11.2) …\nData are No. (%) except where indicated.\nTable 2. Demographics, Comorbidities, Duration of Hospital Stay, and Autopsy Cause of Death\nPatient Number Sex, M/F Age, y Onset of Symptoms, d Comorbidities Days in Hospital Before Death Postmortem Cause of Death\n1 M 81 Not known Hypertension Aortomyocardial sclerosis Ischemic heart disease Cardiomyopathy Aortic aneurysm 4 Cardiorespiratory failure\n2 F 82 Not known Diabetes Atrioventricular valve prothesis Atrial fibrillation COPD Malignancy Kidney disease 3 Cardiorespiratory failure\n3 M 92 7 COPD 1 Cardiorespiratory failure\n4 F 69 Not known Schizophrenia 28 Cardiorespiratory failure\n5 F 80 Not known Cardiovascular disease Senile dementia 38 Cardiorespiratory failure\n6 M 92 Not known Cardiovascular disease COPD 3 Cardiorespiratory failure\n7 F 64 4 Malignancy 2 Cardiorespiratory failure\n8 M 58 Not known Pulmonary artery thrombosis 4 Cardiorespiratory failure\n9 M 64 Not known Myelodysplasia 4 Cardiorespiratory failure\n10 M 82 3 Aortic aneurysm COPD 5 Cardiorespiratory failure\n11 M 76 Not known Malignancy 30 Cardiorespiratory failure\n12 M 60 6 Malignancy Hypertension Kidney disease Diabetes COPD Obesity 29 Cardiorespiratory failure\n13 F 70 Not known Cardiovascular disease Diabetes Psychiatric disorder 43 Cardiorespiratory failure\n14 M 76 Not known Malignancy COPD Hypertension Cardiovascular disease 33 Cardiorespiratory failure\n15 F 27 Not known HIV infection 6 Cardiorespiratory failure\n16 M 82 Not known Parkinson disease Hypertension Transient ischemic attack Prostate hypertrophy 14 Cardiorespiratory failure\n17 M 57 Not known Diabetes 1 Cardiorespiratory failure\n18 M 86 Not known Endocarditis caused by Staphylococcus aureus Prostate hypertrophy Aortic aneurysm Atrial fibrillation 1 Cardiorespiratory failure\n19 M 54 4 NONE 16 Cardiorespiratory failure\n20 M 35 5 NONE 7 Cardiorespiratory failure\n21 M 65 7 NONE 12 Cardiorespiratory failure\n22 F 43 Not known NONE 25 Cardiorespiratory failure\nAbbreviation: COPD, chronic obstructive pulmonary disease."}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T35","span":{"begin":893,"end":899},"obj":"Body_part"},{"id":"T36","span":{"begin":1254,"end":1259},"obj":"Body_part"},{"id":"T37","span":{"begin":1361,"end":1383},"obj":"Body_part"},{"id":"T38","span":{"begin":1378,"end":1383},"obj":"Body_part"},{"id":"T39","span":{"begin":1434,"end":1440},"obj":"Body_part"},{"id":"T40","span":{"begin":1840,"end":1856},"obj":"Body_part"},{"id":"T41","span":{"begin":1850,"end":1856},"obj":"Body_part"},{"id":"T42","span":{"begin":2135,"end":2141},"obj":"Body_part"}],"attributes":[{"id":"A35","pred":"uberon_id","subj":"T35","obj":"http://purl.obolibrary.org/obo/UBERON_0002113"},{"id":"A36","pred":"uberon_id","subj":"T36","obj":"http://purl.obolibrary.org/obo/UBERON_0000948"},{"id":"A37","pred":"uberon_id","subj":"T37","obj":"http://purl.obolibrary.org/obo/UBERON_0002133"},{"id":"A38","pred":"uberon_id","subj":"T38","obj":"http://purl.obolibrary.org/obo/UBERON_0003978"},{"id":"A39","pred":"uberon_id","subj":"T39","obj":"http://purl.obolibrary.org/obo/UBERON_0002113"},{"id":"A40","pred":"uberon_id","subj":"T40","obj":"http://purl.obolibrary.org/obo/UBERON_0002012"},{"id":"A41","pred":"uberon_id","subj":"T41","obj":"http://purl.obolibrary.org/obo/UBERON_0001637"},{"id":"A42","pred":"uberon_id","subj":"T42","obj":"http://purl.obolibrary.org/obo/UBERON_0002113"}],"text":"Patient Demographics and Clinical Characteristics\nTable 1 and Table 2 depict the demographic and clinical characteristics of 22 COVID-19 patients on whom postmortem examinations were performed. Of these, 18 had other medical comorbidities (designated group 1). Four patients were healthy prior to hospital admission and had no known medical comorbidities or any cause of immunosuppression (designated group 2).\nTable 1. Summary of Patient Demographics at Baseline\nCharacteristic Group 1 With Comorbidities Group 2 Without Comorbidities\nNumber of patients 18 4\nDemography\n Age, y, median ± SD (range) 76 ± 15.7 (27–92) 48.5 ± 13.07 (35–65)\n Men 12 (66.7) 3 (75)\n Women 6 (33.3) 1 (25)\nComorbidity\n Chronic obstructive pulmonary disease 6 (33.3) …\n Cardiac disease 8 (44.5) …\n Malignancy 5 (27.8) …\n Hypertension 4 (22.3) …\n Diabetes 4 (22.3) …\n Schizophrenia 1 (5.6) …\n Kidney disease 2 (11.2) …\nData are No. (%) except where indicated.\nTable 2. Demographics, Comorbidities, Duration of Hospital Stay, and Autopsy Cause of Death\nPatient Number Sex, M/F Age, y Onset of Symptoms, d Comorbidities Days in Hospital Before Death Postmortem Cause of Death\n1 M 81 Not known Hypertension Aortomyocardial sclerosis Ischemic heart disease Cardiomyopathy Aortic aneurysm 4 Cardiorespiratory failure\n2 F 82 Not known Diabetes Atrioventricular valve prothesis Atrial fibrillation COPD Malignancy Kidney disease 3 Cardiorespiratory failure\n3 M 92 7 COPD 1 Cardiorespiratory failure\n4 F 69 Not known Schizophrenia 28 Cardiorespiratory failure\n5 F 80 Not known Cardiovascular disease Senile dementia 38 Cardiorespiratory failure\n6 M 92 Not known Cardiovascular disease COPD 3 Cardiorespiratory failure\n7 F 64 4 Malignancy 2 Cardiorespiratory failure\n8 M 58 Not known Pulmonary artery thrombosis 4 Cardiorespiratory failure\n9 M 64 Not known Myelodysplasia 4 Cardiorespiratory failure\n10 M 82 3 Aortic aneurysm COPD 5 Cardiorespiratory failure\n11 M 76 Not known Malignancy 30 Cardiorespiratory failure\n12 M 60 6 Malignancy Hypertension Kidney disease Diabetes COPD Obesity 29 Cardiorespiratory failure\n13 F 70 Not known Cardiovascular disease Diabetes Psychiatric disorder 43 Cardiorespiratory failure\n14 M 76 Not known Malignancy COPD Hypertension Cardiovascular disease 33 Cardiorespiratory failure\n15 F 27 Not known HIV infection 6 Cardiorespiratory failure\n16 M 82 Not known Parkinson disease Hypertension Transient ischemic attack Prostate hypertrophy 14 Cardiorespiratory failure\n17 M 57 Not known Diabetes 1 Cardiorespiratory failure\n18 M 86 Not known Endocarditis caused by Staphylococcus aureus Prostate hypertrophy Aortic aneurysm Atrial fibrillation 1 Cardiorespiratory failure\n19 M 54 4 NONE 16 Cardiorespiratory failure\n20 M 35 5 NONE 7 Cardiorespiratory failure\n21 M 65 7 NONE 12 Cardiorespiratory failure\n22 F 43 Not known NONE 25 Cardiorespiratory failure\nAbbreviation: COPD, chronic obstructive pulmonary disease."}

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Demographics and Clinical Characteristics\nTable 1 and Table 2 depict the demographic and clinical characteristics of 22 COVID-19 patients on whom postmortem examinations were performed. Of these, 18 had other medical comorbidities (designated group 1). Four patients were healthy prior to hospital admission and had no known medical comorbidities or any cause of immunosuppression (designated group 2).\nTable 1. Summary of Patient Demographics at Baseline\nCharacteristic Group 1 With Comorbidities Group 2 Without Comorbidities\nNumber of patients 18 4\nDemography\n Age, y, median ± SD (range) 76 ± 15.7 (27–92) 48.5 ± 13.07 (35–65)\n Men 12 (66.7) 3 (75)\n Women 6 (33.3) 1 (25)\nComorbidity\n Chronic obstructive pulmonary disease 6 (33.3) …\n Cardiac disease 8 (44.5) …\n Malignancy 5 (27.8) …\n Hypertension 4 (22.3) …\n Diabetes 4 (22.3) …\n Schizophrenia 1 (5.6) …\n Kidney disease 2 (11.2) …\nData are No. (%) except where indicated.\nTable 2. Demographics, Comorbidities, Duration of Hospital Stay, and Autopsy Cause of Death\nPatient Number Sex, M/F Age, y Onset of Symptoms, d Comorbidities Days in Hospital Before Death Postmortem Cause of Death\n1 M 81 Not known Hypertension Aortomyocardial sclerosis Ischemic heart disease Cardiomyopathy Aortic aneurysm 4 Cardiorespiratory failure\n2 F 82 Not known Diabetes Atrioventricular valve prothesis Atrial fibrillation COPD Malignancy Kidney disease 3 Cardiorespiratory failure\n3 M 92 7 COPD 1 Cardiorespiratory failure\n4 F 69 Not known Schizophrenia 28 Cardiorespiratory failure\n5 F 80 Not known Cardiovascular disease Senile dementia 38 Cardiorespiratory failure\n6 M 92 Not known Cardiovascular disease COPD 3 Cardiorespiratory failure\n7 F 64 4 Malignancy 2 Cardiorespiratory failure\n8 M 58 Not known Pulmonary artery thrombosis 4 Cardiorespiratory failure\n9 M 64 Not known Myelodysplasia 4 Cardiorespiratory failure\n10 M 82 3 Aortic aneurysm COPD 5 Cardiorespiratory failure\n11 M 76 Not known Malignancy 30 Cardiorespiratory failure\n12 M 60 6 Malignancy Hypertension Kidney disease Diabetes COPD Obesity 29 Cardiorespiratory failure\n13 F 70 Not known Cardiovascular disease Diabetes Psychiatric disorder 43 Cardiorespiratory failure\n14 M 76 Not known Malignancy COPD Hypertension Cardiovascular disease 33 Cardiorespiratory failure\n15 F 27 Not known HIV infection 6 Cardiorespiratory failure\n16 M 82 Not known Parkinson disease Hypertension Transient ischemic attack Prostate hypertrophy 14 Cardiorespiratory failure\n17 M 57 Not known Diabetes 1 Cardiorespiratory failure\n18 M 86 Not known Endocarditis caused by Staphylococcus aureus Prostate hypertrophy Aortic aneurysm Atrial fibrillation 1 Cardiorespiratory failure\n19 M 54 4 NONE 16 Cardiorespiratory failure\n20 M 35 5 NONE 7 Cardiorespiratory failure\n21 M 65 7 NONE 12 Cardiorespiratory failure\n22 F 43 Not known NONE 25 Cardiorespiratory failure\nAbbreviation: COPD, chronic obstructive pulmonary disease."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T95","span":{"begin":125,"end":127},"obj":"http://purl.obolibrary.org/obo/CLO_0050507"},{"id":"T96","span":{"begin":204,"end":206},"obj":"http://purl.obolibrary.org/obo/CLO_0050510"},{"id":"T97","span":{"begin":559,"end":561},"obj":"http://purl.obolibrary.org/obo/CLO_0050510"},{"id":"T98","span":{"begin":618,"end":620},"obj":"http://purl.obolibrary.org/obo/CLO_0050509"},{"id":"T99","span":{"begin":640,"end":642},"obj":"http://purl.obolibrary.org/obo/CLO_0001000"},{"id":"T100","span":{"begin":893,"end":899},"obj":"http://purl.obolibrary.org/obo/UBERON_0002113"},{"id":"T101","span":{"begin":893,"end":899},"obj":"http://www.ebi.ac.uk/efo/EFO_0000927"},{"id":"T102","span":{"begin":893,"end":899},"obj":"http://www.ebi.ac.uk/efo/EFO_0000929"},{"id":"T103","span":{"begin":1254,"end":1259},"obj":"http://purl.obolibrary.org/obo/UBERON_0000948"},{"id":"T104","span":{"begin":1254,"end":1259},"obj":"http://purl.obolibrary.org/obo/UBERON_0007100"},{"id":"T105","span":{"begin":1254,"end":1259},"obj":"http://purl.obolibrary.org/obo/UBERON_0015228"},{"id":"T106","span":{"begin":1254,"end":1259},"obj":"http://www.ebi.ac.uk/efo/EFO_0000815"},{"id":"T107","span":{"begin":1284,"end":1290},"obj":"http://www.ebi.ac.uk/efo/EFO_0000265"},{"id":"T108","span":{"begin":1378,"end":1383},"obj":"http://www.ebi.ac.uk/efo/EFO_0000825"},{"id":"T109","span":{"begin":1434,"end":1440},"obj":"http://purl.obolibrary.org/obo/UBERON_0002113"},{"id":"T110","span":{"begin":1434,"end":1440},"obj":"http://www.ebi.ac.uk/efo/EFO_0000927"},{"id":"T111","span":{"begin":1434,"end":1440},"obj":"http://www.ebi.ac.uk/efo/EFO_0000929"},{"id":"T112","span":{"begin":1840,"end":1856},"obj":"http://purl.obolibrary.org/obo/UBERON_0002012"},{"id":"T113","span":{"begin":1840,"end":1856},"obj":"http://www.ebi.ac.uk/efo/EFO_0001399"},{"id":"T114","span":{"begin":1979,"end":1985},"obj":"http://www.ebi.ac.uk/efo/EFO_0000265"},{"id":"T115","span":{"begin":2031,"end":2033},"obj":"http://purl.obolibrary.org/obo/CLO_0053733"},{"id":"T116","span":{"begin":2135,"end":2141},"obj":"http://purl.obolibrary.org/obo/UBERON_0002113"},{"id":"T117","span":{"begin":2135,"end":2141},"obj":"http://www.ebi.ac.uk/efo/EFO_0000927"},{"id":"T118","span":{"begin":2135,"end":2141},"obj":"http://www.ebi.ac.uk/efo/EFO_0000929"},{"id":"T119","span":{"begin":2429,"end":2431},"obj":"http://purl.obolibrary.org/obo/CLO_0050509"},{"id":"T120","span":{"begin":2683,"end":2685},"obj":"http://purl.obolibrary.org/obo/CLO_0050510"},{"id":"T121","span":{"begin":2687,"end":2692},"obj":"http://purl.obolibrary.org/obo/CLO_0007489"},{"id":"T122","span":{"begin":2772,"end":2778},"obj":"http://www.ebi.ac.uk/efo/EFO_0000265"},{"id":"T123","span":{"begin":2896,"end":2898},"obj":"http://purl.obolibrary.org/obo/CLO_0001000"},{"id":"T124","span":{"begin":2988,"end":2990},"obj":"http://purl.obolibrary.org/obo/CLO_0050507"}],"text":"Patient Demographics and Clinical Characteristics\nTable 1 and Table 2 depict the demographic and clinical characteristics of 22 COVID-19 patients on whom postmortem examinations were performed. Of these, 18 had other medical comorbidities (designated group 1). Four patients were healthy prior to hospital admission and had no known medical comorbidities or any cause of immunosuppression (designated group 2).\nTable 1. Summary of Patient Demographics at Baseline\nCharacteristic Group 1 With Comorbidities Group 2 Without Comorbidities\nNumber of patients 18 4\nDemography\n Age, y, median ± SD (range) 76 ± 15.7 (27–92) 48.5 ± 13.07 (35–65)\n Men 12 (66.7) 3 (75)\n Women 6 (33.3) 1 (25)\nComorbidity\n Chronic obstructive pulmonary disease 6 (33.3) …\n Cardiac disease 8 (44.5) …\n Malignancy 5 (27.8) …\n Hypertension 4 (22.3) …\n Diabetes 4 (22.3) …\n Schizophrenia 1 (5.6) …\n Kidney disease 2 (11.2) …\nData are No. (%) except where indicated.\nTable 2. Demographics, Comorbidities, Duration of Hospital Stay, and Autopsy Cause of Death\nPatient Number Sex, M/F Age, y Onset of Symptoms, d Comorbidities Days in Hospital Before Death Postmortem Cause of Death\n1 M 81 Not known Hypertension Aortomyocardial sclerosis Ischemic heart disease Cardiomyopathy Aortic aneurysm 4 Cardiorespiratory failure\n2 F 82 Not known Diabetes Atrioventricular valve prothesis Atrial fibrillation COPD Malignancy Kidney disease 3 Cardiorespiratory failure\n3 M 92 7 COPD 1 Cardiorespiratory failure\n4 F 69 Not known Schizophrenia 28 Cardiorespiratory failure\n5 F 80 Not known Cardiovascular disease Senile dementia 38 Cardiorespiratory failure\n6 M 92 Not known Cardiovascular disease COPD 3 Cardiorespiratory failure\n7 F 64 4 Malignancy 2 Cardiorespiratory failure\n8 M 58 Not known Pulmonary artery thrombosis 4 Cardiorespiratory failure\n9 M 64 Not known Myelodysplasia 4 Cardiorespiratory failure\n10 M 82 3 Aortic aneurysm COPD 5 Cardiorespiratory failure\n11 M 76 Not known Malignancy 30 Cardiorespiratory failure\n12 M 60 6 Malignancy Hypertension Kidney disease Diabetes COPD Obesity 29 Cardiorespiratory failure\n13 F 70 Not known Cardiovascular disease Diabetes Psychiatric disorder 43 Cardiorespiratory failure\n14 M 76 Not known Malignancy COPD Hypertension Cardiovascular disease 33 Cardiorespiratory failure\n15 F 27 Not known HIV infection 6 Cardiorespiratory failure\n16 M 82 Not known Parkinson disease Hypertension Transient ischemic attack Prostate hypertrophy 14 Cardiorespiratory failure\n17 M 57 Not known Diabetes 1 Cardiorespiratory failure\n18 M 86 Not known Endocarditis caused by Staphylococcus aureus Prostate hypertrophy Aortic aneurysm Atrial fibrillation 1 Cardiorespiratory failure\n19 M 54 4 NONE 16 Cardiorespiratory failure\n20 M 35 5 NONE 7 Cardiorespiratory failure\n21 M 65 7 NONE 12 Cardiorespiratory failure\n22 F 43 Not known NONE 25 Cardiorespiratory failure\nAbbreviation: COPD, chronic obstructive pulmonary disease."}

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Demographics and Clinical Characteristics\nTable 1 and Table 2 depict the demographic and clinical characteristics of 22 COVID-19 patients on whom postmortem examinations were performed. Of these, 18 had other medical comorbidities (designated group 1). Four patients were healthy prior to hospital admission and had no known medical comorbidities or any cause of immunosuppression (designated group 2).\nTable 1. Summary of Patient Demographics at Baseline\nCharacteristic Group 1 With Comorbidities Group 2 Without Comorbidities\nNumber of patients 18 4\nDemography\n Age, y, median ± SD (range) 76 ± 15.7 (27–92) 48.5 ± 13.07 (35–65)\n Men 12 (66.7) 3 (75)\n Women 6 (33.3) 1 (25)\nComorbidity\n Chronic obstructive pulmonary disease 6 (33.3) …\n Cardiac disease 8 (44.5) …\n Malignancy 5 (27.8) …\n Hypertension 4 (22.3) …\n Diabetes 4 (22.3) …\n Schizophrenia 1 (5.6) …\n Kidney disease 2 (11.2) …\nData are No. (%) except where indicated.\nTable 2. Demographics, Comorbidities, Duration of Hospital Stay, and Autopsy Cause of Death\nPatient Number Sex, M/F Age, y Onset of Symptoms, d Comorbidities Days in Hospital Before Death Postmortem Cause of Death\n1 M 81 Not known Hypertension Aortomyocardial sclerosis Ischemic heart disease Cardiomyopathy Aortic aneurysm 4 Cardiorespiratory failure\n2 F 82 Not known Diabetes Atrioventricular valve prothesis Atrial fibrillation COPD Malignancy Kidney disease 3 Cardiorespiratory failure\n3 M 92 7 COPD 1 Cardiorespiratory failure\n4 F 69 Not known Schizophrenia 28 Cardiorespiratory failure\n5 F 80 Not known Cardiovascular disease Senile dementia 38 Cardiorespiratory failure\n6 M 92 Not known Cardiovascular disease COPD 3 Cardiorespiratory failure\n7 F 64 4 Malignancy 2 Cardiorespiratory failure\n8 M 58 Not known Pulmonary artery thrombosis 4 Cardiorespiratory failure\n9 M 64 Not known Myelodysplasia 4 Cardiorespiratory failure\n10 M 82 3 Aortic aneurysm COPD 5 Cardiorespiratory failure\n11 M 76 Not known Malignancy 30 Cardiorespiratory failure\n12 M 60 6 Malignancy Hypertension Kidney disease Diabetes COPD Obesity 29 Cardiorespiratory failure\n13 F 70 Not known Cardiovascular disease Diabetes Psychiatric disorder 43 Cardiorespiratory failure\n14 M 76 Not known Malignancy COPD Hypertension Cardiovascular disease 33 Cardiorespiratory failure\n15 F 27 Not known HIV infection 6 Cardiorespiratory failure\n16 M 82 Not known Parkinson disease Hypertension Transient ischemic attack Prostate hypertrophy 14 Cardiorespiratory failure\n17 M 57 Not known Diabetes 1 Cardiorespiratory failure\n18 M 86 Not known Endocarditis caused by Staphylococcus aureus Prostate hypertrophy Aortic aneurysm Atrial fibrillation 1 Cardiorespiratory failure\n19 M 54 4 NONE 16 Cardiorespiratory failure\n20 M 35 5 NONE 7 Cardiorespiratory failure\n21 M 65 7 NONE 12 Cardiorespiratory failure\n22 F 43 Not known NONE 25 Cardiorespiratory failure\nAbbreviation: COPD, chronic obstructive pulmonary disease."}

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Demographics and Clinical Characteristics\nTable 1 and Table 2 depict the demographic and clinical characteristics of 22 COVID-19 patients on whom postmortem examinations were performed. Of these, 18 had other medical comorbidities (designated group 1). Four patients were healthy prior to hospital admission and had no known medical comorbidities or any cause of immunosuppression (designated group 2).\nTable 1. Summary of Patient Demographics at Baseline\nCharacteristic Group 1 With Comorbidities Group 2 Without Comorbidities\nNumber of patients 18 4\nDemography\n Age, y, median ± SD (range) 76 ± 15.7 (27–92) 48.5 ± 13.07 (35–65)\n Men 12 (66.7) 3 (75)\n Women 6 (33.3) 1 (25)\nComorbidity\n Chronic obstructive pulmonary disease 6 (33.3) …\n Cardiac disease 8 (44.5) …\n Malignancy 5 (27.8) …\n Hypertension 4 (22.3) …\n Diabetes 4 (22.3) …\n Schizophrenia 1 (5.6) …\n Kidney disease 2 (11.2) …\nData are No. (%) except where indicated.\nTable 2. Demographics, Comorbidities, Duration of Hospital Stay, and Autopsy Cause of Death\nPatient Number Sex, M/F Age, y Onset of Symptoms, d Comorbidities Days in Hospital Before Death Postmortem Cause of Death\n1 M 81 Not known Hypertension Aortomyocardial sclerosis Ischemic heart disease Cardiomyopathy Aortic aneurysm 4 Cardiorespiratory failure\n2 F 82 Not known Diabetes Atrioventricular valve prothesis Atrial fibrillation COPD Malignancy Kidney disease 3 Cardiorespiratory failure\n3 M 92 7 COPD 1 Cardiorespiratory failure\n4 F 69 Not known Schizophrenia 28 Cardiorespiratory failure\n5 F 80 Not known Cardiovascular disease Senile dementia 38 Cardiorespiratory failure\n6 M 92 Not known Cardiovascular disease COPD 3 Cardiorespiratory failure\n7 F 64 4 Malignancy 2 Cardiorespiratory failure\n8 M 58 Not known Pulmonary artery thrombosis 4 Cardiorespiratory failure\n9 M 64 Not known Myelodysplasia 4 Cardiorespiratory failure\n10 M 82 3 Aortic aneurysm COPD 5 Cardiorespiratory failure\n11 M 76 Not known Malignancy 30 Cardiorespiratory failure\n12 M 60 6 Malignancy Hypertension Kidney disease Diabetes COPD Obesity 29 Cardiorespiratory failure\n13 F 70 Not known Cardiovascular disease Diabetes Psychiatric disorder 43 Cardiorespiratory failure\n14 M 76 Not known Malignancy COPD Hypertension Cardiovascular disease 33 Cardiorespiratory failure\n15 F 27 Not known HIV infection 6 Cardiorespiratory failure\n16 M 82 Not known Parkinson disease Hypertension Transient ischemic attack Prostate hypertrophy 14 Cardiorespiratory failure\n17 M 57 Not known Diabetes 1 Cardiorespiratory failure\n18 M 86 Not known Endocarditis caused by Staphylococcus aureus Prostate hypertrophy Aortic aneurysm Atrial fibrillation 1 Cardiorespiratory failure\n19 M 54 4 NONE 16 Cardiorespiratory failure\n20 M 35 5 NONE 7 Cardiorespiratory failure\n21 M 65 7 NONE 12 Cardiorespiratory failure\n22 F 43 Not known NONE 25 Cardiorespiratory failure\nAbbreviation: COPD, chronic obstructive pulmonary disease."}

{"project":"LitCovid-sentences","denotations":[{"id":"T61","span":{"begin":0,"end":49},"obj":"Sentence"},{"id":"T62","span":{"begin":50,"end":193},"obj":"Sentence"},{"id":"T63","span":{"begin":194,"end":260},"obj":"Sentence"},{"id":"T64","span":{"begin":261,"end":410},"obj":"Sentence"},{"id":"T65","span":{"begin":411,"end":419},"obj":"Sentence"},{"id":"T66","span":{"begin":421,"end":464},"obj":"Sentence"},{"id":"T67","span":{"begin":465,"end":538},"obj":"Sentence"},{"id":"T68","span":{"begin":539,"end":564},"obj":"Sentence"},{"id":"T69","span":{"begin":565,"end":575},"obj":"Sentence"},{"id":"T70","span":{"begin":576,"end":646},"obj":"Sentence"},{"id":"T71","span":{"begin":647,"end":670},"obj":"Sentence"},{"id":"T72","span":{"begin":671,"end":695},"obj":"Sentence"},{"id":"T73","span":{"begin":696,"end":707},"obj":"Sentence"},{"id":"T74","span":{"begin":708,"end":759},"obj":"Sentence"},{"id":"T75","span":{"begin":760,"end":789},"obj":"Sentence"},{"id":"T76","span":{"begin":790,"end":814},"obj":"Sentence"},{"id":"T77","span":{"begin":815,"end":841},"obj":"Sentence"},{"id":"T78","span":{"begin":842,"end":864},"obj":"Sentence"},{"id":"T79","span":{"begin":865,"end":891},"obj":"Sentence"},{"id":"T80","span":{"begin":892,"end":920},"obj":"Sentence"},{"id":"T81","span":{"begin":921,"end":961},"obj":"Sentence"},{"id":"T82","span":{"begin":962,"end":970},"obj":"Sentence"},{"id":"T83","span":{"begin":972,"end":1054},"obj":"Sentence"},{"id":"T84","span":{"begin":1055,"end":1182},"obj":"Sentence"},{"id":"T85","span":{"begin":1183,"end":1329},"obj":"Sentence"},{"id":"T86","span":{"begin":1330,"end":1478},"obj":"Sentence"},{"id":"T87","span":{"begin":1479,"end":1526},"obj":"Sentence"},{"id":"T88","span":{"begin":1527,"end":1592},"obj":"Sentence"},{"id":"T89","span":{"begin":1593,"end":1684},"obj":"Sentence"},{"id":"T90","span":{"begin":1685,"end":1764},"obj":"Sentence"},{"id":"T91","span":{"begin":1765,"end":1818},"obj":"Sentence"},{"id":"T92","span":{"begin":1819,"end":1898},"obj":"Sentence"},{"id":"T93","span":{"begin":1899,"end":1964},"obj":"Sentence"},{"id":"T94","span":{"begin":1965,"end":2030},"obj":"Sentence"},{"id":"T95","span":{"begin":2031,"end":2094},"obj":"Sentence"},{"id":"T96","span":{"begin":2095,"end":2205},"obj":"Sentence"},{"id":"T97","span":{"begin":2206,"end":2313},"obj":"Sentence"},{"id":"T98","span":{"begin":2314,"end":2421},"obj":"Sentence"},{"id":"T99","span":{"begin":2422,"end":2487},"obj":"Sentence"},{"id":"T100","span":{"begin":2488,"end":2621},"obj":"Sentence"},{"id":"T101","span":{"begin":2622,"end":2682},"obj":"Sentence"},{"id":"T102","span":{"begin":2683,"end":2838},"obj":"Sentence"},{"id":"T103","span":{"begin":2839,"end":2888},"obj":"Sentence"},{"id":"T104","span":{"begin":2889,"end":2937},"obj":"Sentence"},{"id":"T105","span":{"begin":2938,"end":2987},"obj":"Sentence"},{"id":"T106","span":{"begin":2988,"end":3045},"obj":"Sentence"},{"id":"T107","span":{"begin":3046,"end":3104},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Patient Demographics and Clinical Characteristics\nTable 1 and Table 2 depict the demographic and clinical characteristics of 22 COVID-19 patients on whom postmortem examinations were performed. Of these, 18 had other medical comorbidities (designated group 1). Four patients were healthy prior to hospital admission and had no known medical comorbidities or any cause of immunosuppression (designated group 2).\nTable 1. Summary of Patient Demographics at Baseline\nCharacteristic Group 1 With Comorbidities Group 2 Without Comorbidities\nNumber of patients 18 4\nDemography\n Age, y, median ± SD (range) 76 ± 15.7 (27–92) 48.5 ± 13.07 (35–65)\n Men 12 (66.7) 3 (75)\n Women 6 (33.3) 1 (25)\nComorbidity\n Chronic obstructive pulmonary disease 6 (33.3) …\n Cardiac disease 8 (44.5) …\n Malignancy 5 (27.8) …\n Hypertension 4 (22.3) …\n Diabetes 4 (22.3) …\n Schizophrenia 1 (5.6) …\n Kidney disease 2 (11.2) …\nData are No. (%) except where indicated.\nTable 2. Demographics, Comorbidities, Duration of Hospital Stay, and Autopsy Cause of Death\nPatient Number Sex, M/F Age, y Onset of Symptoms, d Comorbidities Days in Hospital Before Death Postmortem Cause of Death\n1 M 81 Not known Hypertension Aortomyocardial sclerosis Ischemic heart disease Cardiomyopathy Aortic aneurysm 4 Cardiorespiratory failure\n2 F 82 Not known Diabetes Atrioventricular valve prothesis Atrial fibrillation COPD Malignancy Kidney disease 3 Cardiorespiratory failure\n3 M 92 7 COPD 1 Cardiorespiratory failure\n4 F 69 Not known Schizophrenia 28 Cardiorespiratory failure\n5 F 80 Not known Cardiovascular disease Senile dementia 38 Cardiorespiratory failure\n6 M 92 Not known Cardiovascular disease COPD 3 Cardiorespiratory failure\n7 F 64 4 Malignancy 2 Cardiorespiratory failure\n8 M 58 Not known Pulmonary artery thrombosis 4 Cardiorespiratory failure\n9 M 64 Not known Myelodysplasia 4 Cardiorespiratory failure\n10 M 82 3 Aortic aneurysm COPD 5 Cardiorespiratory failure\n11 M 76 Not known Malignancy 30 Cardiorespiratory failure\n12 M 60 6 Malignancy Hypertension Kidney disease Diabetes COPD Obesity 29 Cardiorespiratory failure\n13 F 70 Not known Cardiovascular disease Diabetes Psychiatric disorder 43 Cardiorespiratory failure\n14 M 76 Not known Malignancy COPD Hypertension Cardiovascular disease 33 Cardiorespiratory failure\n15 F 27 Not known HIV infection 6 Cardiorespiratory failure\n16 M 82 Not known Parkinson disease Hypertension Transient ischemic attack Prostate hypertrophy 14 Cardiorespiratory failure\n17 M 57 Not known Diabetes 1 Cardiorespiratory failure\n18 M 86 Not known Endocarditis caused by Staphylococcus aureus Prostate hypertrophy Aortic aneurysm Atrial fibrillation 1 Cardiorespiratory failure\n19 M 54 4 NONE 16 Cardiorespiratory failure\n20 M 35 5 NONE 7 Cardiorespiratory failure\n21 M 65 7 NONE 12 Cardiorespiratory failure\n22 F 43 Not known NONE 25 Cardiorespiratory failure\nAbbreviation: COPD, chronic obstructive pulmonary disease."}