PMC:7543426 / 3701-6769 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7543426","sourcedb":"PMC","sourceid":"7543426","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7543426","text":"METHODS\n\nStudy Site and Ethical Approval\nAutopsies were performed at the National Institute for Infectious Diseases Lazzaro Spallanzani-IRCCS Hospital, Rome, Italy. The study was approved by the local ethics committee (approval number 9/2020).\n\nStudy Cohort and Clinical Information\nPatient demographic and clinical information was extracted from case records of 22 consecutive patients with COVID-19 who died and were autopsied.\n\nAutopsy Procedures\nAutopsies were performed using the specific guidance for post mortem, and collection according to submission of specimens and biosafety practices [11] to reduce the risk of transmission of infectious pathogens during and after postmortem examination. Because SARS-CoV-2 is classified as a biosafety level 3 (BSL3) organism, specific operating procedures for BSL3 pathogens were also followed. Autopsies were performed in a specific COVID-19 designated autopsy room with airflow control and airborne infection control procedures, including use of appropriated personal protective equipment (ie, National Institute for Occupational Safety and Health-certified disposable N-95 respirator).\n\nSARS-CoV-2 RT-PCR\nSARS-CoV-2 qualitative reverse transcriptase polymerase chain reaction (RT-PCR) testing for SARS-CoV-2 infection was performed on the following samples: ocular, nasopharyngeal, oropharyngeal, lung, and rectal swabs.\n\nTissues Sampled and Histological Stains\nTissues from the lung, heart, liver, kidney, spleen, and bone marrow were placed in formalin at room temperature for 72 hours before macroscopic analysis and processing for histological examination. The brain was not examined. Tissue samples were processed using hematoxylin and eosin staining (H\u0026E), Masson trichrome stain, Perls stain, reticulin stain, periodic acid-Schiff reaction (PAS) and diastase-PAS. Giemsa and/or Grocott methenamine silver stains were performed where necessary.\n\nImmunohistochemistry\nDeparaffinized and rehydrated sections were used for immunohistochemistry. Organ sections were immersed in 10 mM sodium citrate, pH 6.0, and microwaved for antigen retrieval and stained on a BenchMark ULTRA system fully automated instrument (Roche) with an antibody directed against CD3 (2GV6; Ventana), CD4 (SP35; Ventana), CD8 (SP57; Ventana), CD15 (MMA; Ventana) CD26 (ab28340; Abcam), CD183 (1C6/CXCR3; BD Pharmigen), CD61 (ZfZ; Leica), CD20 (LZ6; Ventana), and CD68 (KP-1; Ventana).\n\nTransmission Electron Microscopy\nWe only looked for evidence of SARS-CoV-2 in lung samples. Nonlung samples were not subject to transmission electron microscopy. Lung tissues were fixed with 2.5% glutaraldehyde in 0.1 M cacodylate buffer for 4 hours at 4°C. Fixation was performed with 1% OsO4. Samples were then dehydrated in graded ethanol and embedded in Epon resin, as previously described [14, 15]. Ultrathin sections were stained with 2% uranyl acetate and examined under a transmission electron microscope (JEOL JEM 2100 Plus; Japan Electron Optics Laboratory). Images were captured with a digital camera (Tietz Video and Image Processing Systems).","divisions":[{"label":"title","span":{"begin":0,"end":7}},{"label":"sec","span":{"begin":9,"end":243}},{"label":"title","span":{"begin":9,"end":40}},{"label":"p","span":{"begin":41,"end":243}},{"label":"sec","span":{"begin":245,"end":429}},{"label":"title","span":{"begin":245,"end":282}},{"label":"p","span":{"begin":283,"end":429}},{"label":"sec","span":{"begin":431,"end":1136}},{"label":"title","span":{"begin":431,"end":449}},{"label":"p","span":{"begin":450,"end":1136}},{"label":"sec","span":{"begin":1138,"end":1371}},{"label":"title","span":{"begin":1138,"end":1155}},{"label":"p","span":{"begin":1156,"end":1371}},{"label":"sec","span":{"begin":1373,"end":1901}},{"label":"title","span":{"begin":1373,"end":1412}},{"label":"p","span":{"begin":1413,"end":1901}},{"label":"sec","span":{"begin":1903,"end":2411}},{"label":"title","span":{"begin":1903,"end":1923}},{"label":"p","span":{"begin":1924,"end":2411}},{"label":"title","span":{"begin":2413,"end":2445}}],"tracks":[{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T26","span":{"begin":1348,"end":1352},"obj":"Body_part"},{"id":"T27","span":{"begin":1373,"end":1380},"obj":"Body_part"},{"id":"T28","span":{"begin":1413,"end":1420},"obj":"Body_part"},{"id":"T29","span":{"begin":1430,"end":1434},"obj":"Body_part"},{"id":"T30","span":{"begin":1436,"end":1441},"obj":"Body_part"},{"id":"T31","span":{"begin":1443,"end":1448},"obj":"Body_part"},{"id":"T32","span":{"begin":1450,"end":1456},"obj":"Body_part"},{"id":"T33","span":{"begin":1458,"end":1464},"obj":"Body_part"},{"id":"T34","span":{"begin":1470,"end":1481},"obj":"Body_part"},{"id":"T35","span":{"begin":1616,"end":1621},"obj":"Body_part"},{"id":"T36","span":{"begin":1640,"end":1646},"obj":"Body_part"},{"id":"T37","span":{"begin":1999,"end":2004},"obj":"Body_part"},{"id":"T38","span":{"begin":2181,"end":2189},"obj":"Body_part"},{"id":"T39","span":{"begin":2491,"end":2495},"obj":"Body_part"},{"id":"T40","span":{"begin":2575,"end":2579},"obj":"Body_part"},{"id":"T41","span":{"begin":2580,"end":2587},"obj":"Body_part"}],"attributes":[{"id":"A26","pred":"fma_id","subj":"T26","obj":"http://purl.org/sig/ont/fma/fma7195"},{"id":"A27","pred":"fma_id","subj":"T27","obj":"http://purl.org/sig/ont/fma/fma9637"},{"id":"A28","pred":"fma_id","subj":"T28","obj":"http://purl.org/sig/ont/fma/fma9637"},{"id":"A29","pred":"fma_id","subj":"T29","obj":"http://purl.org/sig/ont/fma/fma7195"},{"id":"A30","pred":"fma_id","subj":"T30","obj":"http://purl.org/sig/ont/fma/fma7088"},{"id":"A31","pred":"fma_id","subj":"T31","obj":"http://purl.org/sig/ont/fma/fma7197"},{"id":"A32","pred":"fma_id","subj":"T32","obj":"http://purl.org/sig/ont/fma/fma7203"},{"id":"A33","pred":"fma_id","subj":"T33","obj":"http://purl.org/sig/ont/fma/fma7196"},{"id":"A34","pred":"fma_id","subj":"T34","obj":"http://purl.org/sig/ont/fma/fma9608"},{"id":"A35","pred":"fma_id","subj":"T35","obj":"http://purl.org/sig/ont/fma/fma50801"},{"id":"A36","pred":"fma_id","subj":"T36","obj":"http://purl.org/sig/ont/fma/fma9637"},{"id":"A37","pred":"fma_id","subj":"T37","obj":"http://purl.org/sig/ont/fma/fma67498"},{"id":"A38","pred":"fma_id","subj":"T38","obj":"http://purl.org/sig/ont/fma/fma62871"},{"id":"A39","pred":"fma_id","subj":"T39","obj":"http://purl.org/sig/ont/fma/fma7195"},{"id":"A40","pred":"fma_id","subj":"T40","obj":"http://purl.org/sig/ont/fma/fma7195"},{"id":"A41","pred":"fma_id","subj":"T41","obj":"http://purl.org/sig/ont/fma/fma9637"},{"subj":"T26","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T27","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T28","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T29","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T30","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T31","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T32","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T33","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T34","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T35","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T36","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T37","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T38","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T39","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T40","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T41","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T23","span":{"begin":1348,"end":1352},"obj":"Body_part"},{"id":"T24","span":{"begin":1430,"end":1434},"obj":"Body_part"},{"id":"T25","span":{"begin":1436,"end":1441},"obj":"Body_part"},{"id":"T26","span":{"begin":1443,"end":1448},"obj":"Body_part"},{"id":"T27","span":{"begin":1450,"end":1456},"obj":"Body_part"},{"id":"T28","span":{"begin":1458,"end":1464},"obj":"Body_part"},{"id":"T29","span":{"begin":1470,"end":1481},"obj":"Body_part"},{"id":"T30","span":{"begin":1616,"end":1621},"obj":"Body_part"},{"id":"T31","span":{"begin":1640,"end":1646},"obj":"Body_part"},{"id":"T32","span":{"begin":1999,"end":2004},"obj":"Body_part"},{"id":"T33","span":{"begin":2491,"end":2495},"obj":"Body_part"},{"id":"T34","span":{"begin":2575,"end":2579},"obj":"Body_part"}],"attributes":[{"id":"A23","pred":"uberon_id","subj":"T23","obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"A24","pred":"uberon_id","subj":"T24","obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"A25","pred":"uberon_id","subj":"T25","obj":"http://purl.obolibrary.org/obo/UBERON_0000948"},{"id":"A26","pred":"uberon_id","subj":"T26","obj":"http://purl.obolibrary.org/obo/UBERON_0002107"},{"id":"A27","pred":"uberon_id","subj":"T27","obj":"http://purl.obolibrary.org/obo/UBERON_0002113"},{"id":"A28","pred":"uberon_id","subj":"T28","obj":"http://purl.obolibrary.org/obo/UBERON_0002106"},{"id":"A29","pred":"uberon_id","subj":"T29","obj":"http://purl.obolibrary.org/obo/UBERON_0002371"},{"id":"A30","pred":"uberon_id","subj":"T30","obj":"http://purl.obolibrary.org/obo/UBERON_0000955"},{"id":"A31","pred":"uberon_id","subj":"T31","obj":"http://purl.obolibrary.org/obo/UBERON_0000479"},{"id":"A32","pred":"uberon_id","subj":"T32","obj":"http://purl.obolibrary.org/obo/UBERON_0000062"},{"id":"A33","pred":"uberon_id","subj":"T33","obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"A34","pred":"uberon_id","subj":"T34","obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"subj":"T23","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T24","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T25","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T26","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T27","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T28","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T29","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T30","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T31","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T32","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T33","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T34","pred":"source","obj":"LitCovid-PD-UBERON"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T39","span":{"begin":96,"end":106},"obj":"Disease"},{"id":"T40","span":{"begin":392,"end":400},"obj":"Disease"},{"id":"T41","span":{"begin":639,"end":649},"obj":"Disease"},{"id":"T42","span":{"begin":709,"end":717},"obj":"Disease"},{"id":"T43","span":{"begin":882,"end":890},"obj":"Disease"},{"id":"T44","span":{"begin":949,"end":958},"obj":"Disease"},{"id":"T45","span":{"begin":1138,"end":1146},"obj":"Disease"},{"id":"T46","span":{"begin":1156,"end":1164},"obj":"Disease"},{"id":"T47","span":{"begin":1248,"end":1256},"obj":"Disease"},{"id":"T48","span":{"begin":1259,"end":1268},"obj":"Disease"},{"id":"T49","span":{"begin":1799,"end":1802},"obj":"Disease"},{"id":"T50","span":{"begin":1817,"end":1820},"obj":"Disease"},{"id":"T51","span":{"begin":2331,"end":2333},"obj":"Disease"},{"id":"T52","span":{"begin":2396,"end":2398},"obj":"Disease"},{"id":"T53","span":{"begin":2477,"end":2485},"obj":"Disease"}],"attributes":[{"id":"A39","pred":"mondo_id","subj":"T39","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A40","pred":"mondo_id","subj":"T40","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A41","pred":"mondo_id","subj":"T41","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A42","pred":"mondo_id","subj":"T42","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A43","pred":"mondo_id","subj":"T43","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A44","pred":"mondo_id","subj":"T44","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A45","pred":"mondo_id","subj":"T45","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A46","pred":"mondo_id","subj":"T46","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A47","pred":"mondo_id","subj":"T47","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A48","pred":"mondo_id","subj":"T48","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A49","pred":"mondo_id","subj":"T49","obj":"http://purl.obolibrary.org/obo/MONDO_0004277"},{"id":"A50","pred":"mondo_id","subj":"T50","obj":"http://purl.obolibrary.org/obo/MONDO_0004277"},{"id":"A51","pred":"mondo_id","subj":"T51","obj":"http://purl.obolibrary.org/obo/MONDO_0007191"},{"id":"A52","pred":"mondo_id","subj":"T52","obj":"http://purl.obolibrary.org/obo/MONDO_0021036"},{"id":"A53","pred":"mondo_id","subj":"T53","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"subj":"T39","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T40","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T41","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T42","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T43","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T44","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T45","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T46","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T47","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T48","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T49","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T50","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T51","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T52","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T53","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T53","span":{"begin":363,"end":365},"obj":"http://purl.obolibrary.org/obo/CLO_0050507"},{"id":"T54","span":{"begin":597,"end":599},"obj":"http://purl.obolibrary.org/obo/CLO_0053733"},{"id":"T55","span":{"begin":737,"end":738},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T56","span":{"begin":764,"end":772},"obj":"http://purl.obolibrary.org/obo/OBI_0100026"},{"id":"T57","span":{"begin":764,"end":772},"obj":"http://purl.obolibrary.org/obo/UBERON_0000468"},{"id":"T58","span":{"begin":871,"end":872},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T59","span":{"begin":1236,"end":1243},"obj":"http://purl.obolibrary.org/obo/UBERON_0000473"},{"id":"T60","span":{"begin":1348,"end":1352},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"T61","span":{"begin":1348,"end":1352},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"},{"id":"T62","span":{"begin":1430,"end":1434},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"T63","span":{"begin":1430,"end":1434},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"},{"id":"T64","span":{"begin":1436,"end":1441},"obj":"http://purl.obolibrary.org/obo/UBERON_0000948"},{"id":"T65","span":{"begin":1436,"end":1441},"obj":"http://purl.obolibrary.org/obo/UBERON_0007100"},{"id":"T66","span":{"begin":1436,"end":1441},"obj":"http://purl.obolibrary.org/obo/UBERON_0015228"},{"id":"T67","span":{"begin":1436,"end":1441},"obj":"http://www.ebi.ac.uk/efo/EFO_0000815"},{"id":"T68","span":{"begin":1443,"end":1448},"obj":"http://purl.obolibrary.org/obo/UBERON_0002107"},{"id":"T69","span":{"begin":1443,"end":1448},"obj":"http://www.ebi.ac.uk/efo/EFO_0000887"},{"id":"T70","span":{"begin":1450,"end":1456},"obj":"http://purl.obolibrary.org/obo/UBERON_0002113"},{"id":"T71","span":{"begin":1450,"end":1456},"obj":"http://www.ebi.ac.uk/efo/EFO_0000927"},{"id":"T72","span":{"begin":1450,"end":1456},"obj":"http://www.ebi.ac.uk/efo/EFO_0000929"},{"id":"T73","span":{"begin":1458,"end":1464},"obj":"http://purl.obolibrary.org/obo/UBERON_0002106"},{"id":"T74","span":{"begin":1470,"end":1474},"obj":"http://purl.obolibrary.org/obo/UBERON_0002481"},{"id":"T75","span":{"begin":1616,"end":1621},"obj":"http://purl.obolibrary.org/obo/UBERON_0000955"},{"id":"T76","span":{"begin":1616,"end":1621},"obj":"http://www.ebi.ac.uk/efo/EFO_0000302"},{"id":"T77","span":{"begin":1999,"end":2004},"obj":"http://purl.obolibrary.org/obo/UBERON_0003103"},{"id":"T78","span":{"begin":2113,"end":2114},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T79","span":{"begin":2154,"end":2164},"obj":"http://purl.obolibrary.org/obo/OBI_0000968"},{"id":"T80","span":{"begin":2207,"end":2210},"obj":"http://purl.obolibrary.org/obo/CLO_0052882"},{"id":"T81","span":{"begin":2207,"end":2210},"obj":"http://purl.obolibrary.org/obo/CLO_0053434"},{"id":"T82","span":{"begin":2228,"end":2231},"obj":"http://purl.obolibrary.org/obo/PR_000001004"},{"id":"T83","span":{"begin":2249,"end":2252},"obj":"http://purl.obolibrary.org/obo/CLO_0053438"},{"id":"T84","span":{"begin":2276,"end":2279},"obj":"http://purl.obolibrary.org/obo/CLO_0007803"},{"id":"T85","span":{"begin":2320,"end":2323},"obj":"http://purl.obolibrary.org/obo/CLO_0001159"},{"id":"T86","span":{"begin":2390,"end":2394},"obj":"http://purl.obolibrary.org/obo/PR_000002064"},{"id":"T87","span":{"begin":2491,"end":2495},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"T88","span":{"begin":2491,"end":2495},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"},{"id":"T89","span":{"begin":2575,"end":2579},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"T90","span":{"begin":2575,"end":2579},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"},{"id":"T91","span":{"begin":2666,"end":2669},"obj":"http://purl.obolibrary.org/obo/CLO_0001387"},{"id":"T92","span":{"begin":2891,"end":2892},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T93","span":{"begin":3008,"end":3009},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T94","span":{"begin":3010,"end":3017},"obj":"http://www.ebi.ac.uk/efo/EFO_0000881"}],"attributes":[{"subj":"T53","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T54","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T55","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T56","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T57","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T58","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T59","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T60","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T61","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T62","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T63","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T64","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T65","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T66","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T67","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T68","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T69","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T70","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T71","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T72","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T73","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T74","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T75","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T76","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T77","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T78","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T79","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T80","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T81","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T82","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T83","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T84","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T85","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T86","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T87","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T88","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T89","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T90","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T91","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T92","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T93","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T94","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"123","span":{"begin":96,"end":115},"obj":"Disease"},{"id":"128","span":{"begin":283,"end":290},"obj":"Species"},{"id":"129","span":{"begin":378,"end":386},"obj":"Species"},{"id":"130","span":{"begin":392,"end":400},"obj":"Disease"},{"id":"131","span":{"begin":405,"end":409},"obj":"Disease"},{"id":"135","span":{"begin":709,"end":719},"obj":"Species"},{"id":"136","span":{"begin":882,"end":890},"obj":"Disease"},{"id":"137","span":{"begin":949,"end":958},"obj":"Disease"},{"id":"139","span":{"begin":1138,"end":1148},"obj":"Species"},{"id":"142","span":{"begin":1156,"end":1166},"obj":"Species"},{"id":"143","span":{"begin":1248,"end":1268},"obj":"Disease"},{"id":"149","span":{"begin":1497,"end":1505},"obj":"Chemical"},{"id":"150","span":{"begin":1676,"end":1687},"obj":"Chemical"},{"id":"151","span":{"begin":1692,"end":1697},"obj":"Chemical"},{"id":"152","span":{"begin":1768,"end":1781},"obj":"Chemical"},{"id":"153","span":{"begin":1844,"end":1862},"obj":"Chemical"},{"id":"163","span":{"begin":2228,"end":2231},"obj":"Gene"},{"id":"164","span":{"begin":2249,"end":2252},"obj":"Gene"},{"id":"165","span":{"begin":2270,"end":2274},"obj":"Gene"},{"id":"166","span":{"begin":2290,"end":2294},"obj":"Gene"},{"id":"167","span":{"begin":2313,"end":2318},"obj":"Gene"},{"id":"168","span":{"begin":2324,"end":2329},"obj":"Gene"},{"id":"169","span":{"begin":2346,"end":2350},"obj":"Gene"},{"id":"170","span":{"begin":2365,"end":2369},"obj":"Gene"},{"id":"171","span":{"begin":2390,"end":2394},"obj":"Gene"},{"id":"178","span":{"begin":2477,"end":2487},"obj":"Species"},{"id":"179","span":{"begin":2609,"end":2623},"obj":"Chemical"},{"id":"180","span":{"begin":2633,"end":2650},"obj":"Chemical"},{"id":"181","span":{"begin":2702,"end":2706},"obj":"Chemical"},{"id":"182","span":{"begin":2747,"end":2754},"obj":"Chemical"},{"id":"183","span":{"begin":2857,"end":2871},"obj":"Chemical"}],"attributes":[{"id":"A123","pred":"tao:has_database_id","subj":"123","obj":"MESH:D003141"},{"id":"A128","pred":"tao:has_database_id","subj":"128","obj":"Tax:9606"},{"id":"A129","pred":"tao:has_database_id","subj":"129","obj":"Tax:9606"},{"id":"A130","pred":"tao:has_database_id","subj":"130","obj":"MESH:C000657245"},{"id":"A131","pred":"tao:has_database_id","subj":"131","obj":"MESH:D003643"},{"id":"A135","pred":"tao:has_database_id","subj":"135","obj":"Tax:2697049"},{"id":"A136","pred":"tao:has_database_id","subj":"136","obj":"MESH:C000657245"},{"id":"A137","pred":"tao:has_database_id","subj":"137","obj":"MESH:D007239"},{"id":"A139","pred":"tao:has_database_id","subj":"139","obj":"Tax:2697049"},{"id":"A142","pred":"tao:has_database_id","subj":"142","obj":"Tax:2697049"},{"id":"A143","pred":"tao:has_database_id","subj":"143","obj":"MESH:C000657245"},{"id":"A149","pred":"tao:has_database_id","subj":"149","obj":"MESH:D005557"},{"id":"A150","pred":"tao:has_database_id","subj":"150","obj":"MESH:D006416"},{"id":"A151","pred":"tao:has_database_id","subj":"151","obj":"MESH:D004801"},{"id":"A152","pred":"tao:has_database_id","subj":"152","obj":"MESH:D010504"},{"id":"A153","pred":"tao:has_database_id","subj":"153","obj":"MESH:D008709"},{"id":"A163","pred":"tao:has_database_id","subj":"163","obj":"Gene:920"},{"id":"A164","pred":"tao:has_database_id","subj":"164","obj":"Gene:925"},{"id":"A165","pred":"tao:has_database_id","subj":"165","obj":"Gene:2526"},{"id":"A166","pred":"tao:has_database_id","subj":"166","obj":"Gene:1803"},{"id":"A167","pred":"tao:has_database_id","subj":"167","obj":"Gene:2833"},{"id":"A168","pred":"tao:has_database_id","subj":"168","obj":"Gene:2833"},{"id":"A169","pred":"tao:has_database_id","subj":"169","obj":"Gene:3690"},{"id":"A170","pred":"tao:has_database_id","subj":"170","obj":"Gene:54474"},{"id":"A171","pred":"tao:has_database_id","subj":"171","obj":"Gene:968"},{"id":"A178","pred":"tao:has_database_id","subj":"178","obj":"Tax:2697049"},{"id":"A179","pred":"tao:has_database_id","subj":"179","obj":"MESH:D005976"},{"id":"A182","pred":"tao:has_database_id","subj":"182","obj":"MESH:D000431"},{"id":"A183","pred":"tao:has_database_id","subj":"183","obj":"MESH:C005460"},{"subj":"123","pred":"source","obj":"LitCovid-PubTator"},{"subj":"128","pred":"source","obj":"LitCovid-PubTator"},{"subj":"129","pred":"source","obj":"LitCovid-PubTator"},{"subj":"130","pred":"source","obj":"LitCovid-PubTator"},{"subj":"131","pred":"source","obj":"LitCovid-PubTator"},{"subj":"135","pred":"source","obj":"LitCovid-PubTator"},{"subj":"136","pred":"source","obj":"LitCovid-PubTator"},{"subj":"137","pred":"source","obj":"LitCovid-PubTator"},{"subj":"139","pred":"source","obj":"LitCovid-PubTator"},{"subj":"142","pred":"source","obj":"LitCovid-PubTator"},{"subj":"143","pred":"source","obj":"LitCovid-PubTator"},{"subj":"149","pred":"source","obj":"LitCovid-PubTator"},{"subj":"150","pred":"source","obj":"LitCovid-PubTator"},{"subj":"151","pred":"source","obj":"LitCovid-PubTator"},{"subj":"152","pred":"source","obj":"LitCovid-PubTator"},{"subj":"153","pred":"source","obj":"LitCovid-PubTator"},{"subj":"163","pred":"source","obj":"LitCovid-PubTator"},{"subj":"164","pred":"source","obj":"LitCovid-PubTator"},{"subj":"165","pred":"source","obj":"LitCovid-PubTator"},{"subj":"166","pred":"source","obj":"LitCovid-PubTator"},{"subj":"167","pred":"source","obj":"LitCovid-PubTator"},{"subj":"168","pred":"source","obj":"LitCovid-PubTator"},{"subj":"169","pred":"source","obj":"LitCovid-PubTator"},{"subj":"170","pred":"source","obj":"LitCovid-PubTator"},{"subj":"171","pred":"source","obj":"LitCovid-PubTator"},{"subj":"178","pred":"source","obj":"LitCovid-PubTator"},{"subj":"179","pred":"source","obj":"LitCovid-PubTator"},{"subj":"180","pred":"source","obj":"LitCovid-PubTator"},{"subj":"181","pred":"source","obj":"LitCovid-PubTator"},{"subj":"182","pred":"source","obj":"LitCovid-PubTator"},{"subj":"183","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T2","span":{"begin":1187,"end":1200},"obj":"http://purl.obolibrary.org/obo/GO_0003968"},{"id":"T3","span":{"begin":1187,"end":1200},"obj":"http://purl.obolibrary.org/obo/GO_0003899"}],"attributes":[{"subj":"T2","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T3","pred":"source","obj":"LitCovid-PD-GO-BP"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T32","span":{"begin":0,"end":7},"obj":"Sentence"},{"id":"T33","span":{"begin":9,"end":40},"obj":"Sentence"},{"id":"T34","span":{"begin":41,"end":164},"obj":"Sentence"},{"id":"T35","span":{"begin":165,"end":243},"obj":"Sentence"},{"id":"T36","span":{"begin":245,"end":282},"obj":"Sentence"},{"id":"T37","span":{"begin":283,"end":429},"obj":"Sentence"},{"id":"T38","span":{"begin":431,"end":449},"obj":"Sentence"},{"id":"T39","span":{"begin":450,"end":700},"obj":"Sentence"},{"id":"T40","span":{"begin":701,"end":842},"obj":"Sentence"},{"id":"T41","span":{"begin":843,"end":1136},"obj":"Sentence"},{"id":"T42","span":{"begin":1138,"end":1155},"obj":"Sentence"},{"id":"T43","span":{"begin":1156,"end":1371},"obj":"Sentence"},{"id":"T44","span":{"begin":1373,"end":1412},"obj":"Sentence"},{"id":"T45","span":{"begin":1413,"end":1611},"obj":"Sentence"},{"id":"T46","span":{"begin":1612,"end":1639},"obj":"Sentence"},{"id":"T47","span":{"begin":1640,"end":1821},"obj":"Sentence"},{"id":"T48","span":{"begin":1822,"end":1901},"obj":"Sentence"},{"id":"T49","span":{"begin":1903,"end":1923},"obj":"Sentence"},{"id":"T50","span":{"begin":1924,"end":1998},"obj":"Sentence"},{"id":"T51","span":{"begin":1999,"end":2411},"obj":"Sentence"},{"id":"T52","span":{"begin":2413,"end":2445},"obj":"Sentence"},{"id":"T53","span":{"begin":2446,"end":2504},"obj":"Sentence"},{"id":"T54","span":{"begin":2505,"end":2574},"obj":"Sentence"},{"id":"T55","span":{"begin":2575,"end":2670},"obj":"Sentence"},{"id":"T56","span":{"begin":2671,"end":2707},"obj":"Sentence"},{"id":"T57","span":{"begin":2708,"end":2816},"obj":"Sentence"},{"id":"T58","span":{"begin":2817,"end":2981},"obj":"Sentence"},{"id":"T59","span":{"begin":2982,"end":3068},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T32","pred":"source","obj":"LitCovid-sentences"},{"subj":"T33","pred":"source","obj":"LitCovid-sentences"},{"subj":"T34","pred":"source","obj":"LitCovid-sentences"},{"subj":"T35","pred":"source","obj":"LitCovid-sentences"},{"subj":"T36","pred":"source","obj":"LitCovid-sentences"},{"subj":"T37","pred":"source","obj":"LitCovid-sentences"},{"subj":"T38","pred":"source","obj":"LitCovid-sentences"},{"subj":"T39","pred":"source","obj":"LitCovid-sentences"},{"subj":"T40","pred":"source","obj":"LitCovid-sentences"},{"subj":"T41","pred":"source","obj":"LitCovid-sentences"},{"subj":"T42","pred":"source","obj":"LitCovid-sentences"},{"subj":"T43","pred":"source","obj":"LitCovid-sentences"},{"subj":"T44","pred":"source","obj":"LitCovid-sentences"},{"subj":"T45","pred":"source","obj":"LitCovid-sentences"},{"subj":"T46","pred":"source","obj":"LitCovid-sentences"},{"subj":"T47","pred":"source","obj":"LitCovid-sentences"},{"subj":"T48","pred":"source","obj":"LitCovid-sentences"},{"subj":"T49","pred":"source","obj":"LitCovid-sentences"},{"subj":"T50","pred":"source","obj":"LitCovid-sentences"},{"subj":"T51","pred":"source","obj":"LitCovid-sentences"},{"subj":"T52","pred":"source","obj":"LitCovid-sentences"},{"subj":"T53","pred":"source","obj":"LitCovid-sentences"},{"subj":"T54","pred":"source","obj":"LitCovid-sentences"},{"subj":"T55","pred":"source","obj":"LitCovid-sentences"},{"subj":"T56","pred":"source","obj":"LitCovid-sentences"},{"subj":"T57","pred":"source","obj":"LitCovid-sentences"},{"subj":"T58","pred":"source","obj":"LitCovid-sentences"},{"subj":"T59","pred":"source","obj":"LitCovid-sentences"}]},{"project":"2_test","denotations":[{"id":"32914853-32198191-61098654","span":{"begin":597,"end":599},"obj":"32198191"},{"id":"32914853-31217430-61098655","span":{"begin":2808,"end":2810},"obj":"31217430"},{"id":"32914853-24813622-61098656","span":{"begin":2812,"end":2814},"obj":"24813622"}],"attributes":[{"subj":"32914853-32198191-61098654","pred":"source","obj":"2_test"},{"subj":"32914853-31217430-61098655","pred":"source","obj":"2_test"},{"subj":"32914853-24813622-61098656","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PD-FMA-UBERON","color":"#93cfec","default":true},{"id":"LitCovid-PD-UBERON","color":"#e9ec93"},{"id":"LitCovid-PD-MONDO","color":"#d593ec"},{"id":"LitCovid-PD-CLO","color":"#93ecbb"},{"id":"LitCovid-PubTator","color":"#eca193"},{"id":"LitCovid-PD-GO-BP","color":"#939eec"},{"id":"LitCovid-sentences","color":"#b8ec93"},{"id":"2_test","color":"#ec93d2"}]}]}}