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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T1 554-562 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T2 785-790 Body_part denotes lungs http://purl.org/sig/ont/fma/fma68877
T3 908-913 Body_part denotes organ http://purl.org/sig/ont/fma/fma67498
T4 1210-1216 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T5 2887-2891 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T6 2911-2916 Body_part denotes lungs http://purl.org/sig/ont/fma/fma68877
T7 2986-2995 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T8 3740-3747 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T9 3796-3800 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T10 3801-3812 Body_part denotes capillaries http://purl.org/sig/ont/fma/fma63194
T11 4026-4036 Body_part denotes neutrophil http://purl.org/sig/ont/fma/fma62860
T12 4379-4406 Body_part denotes surface of epithelial cells http://purl.org/sig/ont/fma/fma82998
T13 4401-4406 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T14 4408-4430 Body_part denotes mononuclear phagocytes http://purl.org/sig/ont/fma/fma273563
T15 4441-4445 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T16 4647-4652 Body_part denotes organ http://purl.org/sig/ont/fma/fma67498
T17 4754-4758 Body_part denotes body http://purl.org/sig/ont/fma/fma256135
T18 4973-4979 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T19 4991-4996 Body_part denotes organ http://purl.org/sig/ont/fma/fma67498
T20 5239-5250 Body_part denotes endothelium http://purl.org/sig/ont/fma/fma63916
T21 5426-5431 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T22 5654-5664 Body_part denotes lymphocyte http://purl.org/sig/ont/fma/fma62863
T23 5855-5864 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T24 5908-5921 Body_part denotes interleukin-6 http://purl.org/sig/ont/fma/fma264829
T25 5970-5976 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T26 6151-6158 Body_part denotes tissues http://purl.org/sig/ont/fma/fma9637
T27 6207-6211 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T28 6994-6999 Body_part denotes lungs http://purl.org/sig/ont/fma/fma68877
T29 7052-7058 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T30 8123-8128 Body_part denotes lungs http://purl.org/sig/ont/fma/fma68877
T31 8237-8243 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T32 8517-8526 Body_part denotes platelets http://purl.org/sig/ont/fma/fma62851
T33 8720-8737 Body_part denotes endothelial cells http://purl.org/sig/ont/fma/fma66772
T34 8732-8737 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T35 8939-8947 Body_part denotes alveolar http://purl.org/sig/ont/fma/fma264783
T36 8997-9004 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T37 9105-9111 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T38 9142-9153 Body_part denotes interleukin http://purl.org/sig/ont/fma/fma86578
T39 9188-9196 Body_part denotes monocyte http://purl.org/sig/ont/fma/fma62864
T40 9213-9220 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T41 9266-9272 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T42 9362-9369 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T43 9517-9523 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T44 9634-9646 Body_part denotes glycoprotein http://purl.org/sig/ont/fma/fma62925
T45 9672-9677 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T46 9679-9696 Body_part denotes endothelial cells http://purl.org/sig/ont/fma/fma66772
T47 9691-9696 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T48 9698-9709 Body_part denotes fibroblasts http://purl.org/sig/ont/fma/fma63877
T49 9711-9739 Body_part denotes vascular smooth muscle cells http://purl.org/sig/ont/fma/fma284560
T50 9734-9739 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T51 9744-9769 Body_part denotes alveolar epithelial cells http://purl.org/sig/ont/fma/fma62499
T52 9764-9769 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T53 9829-9833 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T54 9877-9882 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T55 9967-9972 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T56 10888-10894 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T57 11109-11113 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T58 11115-11121 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203
T59 11126-11131 Body_part denotes liver http://purl.org/sig/ont/fma/fma7197
T60 11526-11532 Body_part denotes Tissue http://purl.org/sig/ont/fma/fma9637
T61 11652-11664 Body_part denotes glycoprotein http://purl.org/sig/ont/fma/fma62925
T62 11688-11705 Body_part denotes endothelial cells http://purl.org/sig/ont/fma/fma66772
T63 11700-11705 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T64 11710-11719 Body_part denotes platelets http://purl.org/sig/ont/fma/fma62851
T65 12013-12017 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T66 12233-12241 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T67 12656-12663 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T68 12896-12903 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T69 12965-12971 Body_part denotes Tissue http://purl.org/sig/ont/fma/fma9637
T70 13289-13298 Body_part denotes capillary http://purl.org/sig/ont/fma/fma63194
T71 13661-13668 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T72 13786-13790 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T73 13874-13884 Body_part denotes neutrophil http://purl.org/sig/ont/fma/fma62860
T74 14144-14148 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T75 14275-14279 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T76 14527-14534 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T77 14630-14637 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T78 14711-14718 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T79 15344-15351 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T80 15353-15360 Body_part denotes Heparin http://purl.org/sig/ont/fma/fma82839
T81 15628-15635 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T82 15688-15695 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T83 15750-15757 Body_part denotes Heparin http://purl.org/sig/ont/fma/fma82839
T84 15863-15870 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T85 15907-15914 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T86 16054-16061 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T87 16210-16217 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T88 16506-16513 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T89 16533-16540 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T90 16617-16624 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T91 16647-16654 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T92 16949-16955 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T93 17009-17013 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T94 17072-17076 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T95 17110-17128 Body_part denotes lipopolysaccharide http://purl.org/sig/ont/fma/fma82785
T96 17141-17145 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T97 17473-17492 Body_part denotes alveolar epithelium http://purl.org/sig/ont/fma/fma63915
T98 17482-17492 Body_part denotes epithelium http://purl.org/sig/ont/fma/fma9639
T99 18185-18189 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T100 20122-20127 Body_part denotes liver http://purl.org/sig/ont/fma/fma7197
T101 20162-20168 Body_part denotes serine http://purl.org/sig/ont/fma/fma82764
T102 20181-20187 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T103 20826-20830 Body_part denotes axis http://purl.org/sig/ont/fma/fma12520
T104 20889-20900 Body_part denotes neutrophils http://purl.org/sig/ont/fma/fma62860
T105 20930-20940 Body_part denotes neutrophil http://purl.org/sig/ont/fma/fma62860
T106 21009-21013 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T107 21049-21057 Body_part denotes alveolar http://purl.org/sig/ont/fma/fma264783
T108 21369-21373 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T109 21443-21451 Body_part denotes alveolar http://purl.org/sig/ont/fma/fma264783
T110 22049-22053 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T111 22435-22439 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T112 22486-22495 Body_part denotes G-protein http://purl.org/sig/ont/fma/fma61788
T113 22707-22711 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T114 22721-22726 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T115 22738-22742 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T116 22743-22759 Body_part denotes epithelial cells http://purl.org/sig/ont/fma/fma66768
T117 22754-22759 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T118 22761-22778 Body_part denotes endothelial cells http://purl.org/sig/ont/fma/fma66772
T119 22773-22778 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T120 22783-22794 Body_part denotes fibroblasts http://purl.org/sig/ont/fma/fma63877
T121 22820-22829 Body_part denotes monocytes http://purl.org/sig/ont/fma/fma62864
T122 22834-22845 Body_part denotes neutrophils http://purl.org/sig/ont/fma/fma62860
T123 22856-22862 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T124 23235-23244 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T125 23246-23256 Body_part denotes chemokines http://purl.org/sig/ont/fma/fma241981
T126 23304-23308 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T127 23322-23331 Body_part denotes leukocyte http://purl.org/sig/ont/fma/fma62852
T128 25027-25031 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T129 25043-25053 Body_part denotes neutrophil http://purl.org/sig/ont/fma/fma62860
T130 25160-25172 Body_part denotes neutrophilic http://purl.org/sig/ont/fma/fma62860
T131 25192-25196 Body_part denotes IL-1 http://purl.org/sig/ont/fma/fma86583
T132 25209-25218 Body_part denotes chemokine http://purl.org/sig/ont/fma/fma241981
T133 25303-25311 Body_part denotes alveolar http://purl.org/sig/ont/fma/fma264783
T134 25783-25791 Body_part denotes alveolar http://purl.org/sig/ont/fma/fma264783
T135 26329-26336 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T136 27279-27286 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T137 28079-28086 Body_part denotes stomach http://purl.org/sig/ont/fma/fma7148
T138 28417-28424 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T139 29512-29516 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T140 29885-29893 Body_part denotes platelet http://purl.org/sig/ont/fma/fma62851
T141 29961-29967 Body_part denotes artery http://purl.org/sig/ont/fma/fma50720
T142 30123-30127 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T143 30259-30267 Body_part denotes alveolar http://purl.org/sig/ont/fma/fma264783
T144 30612-30621 Body_part denotes platelets http://purl.org/sig/ont/fma/fma62851
T145 30916-30924 Body_part denotes platelet http://purl.org/sig/ont/fma/fma62851
T146 31273-31277 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T147 31563-31569 Body_part denotes Tissue http://purl.org/sig/ont/fma/fma9637
T148 31996-32004 Body_part denotes Alveolar http://purl.org/sig/ont/fma/fma264783
T149 32196-32203 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T150 32275-32283 Body_part denotes Alveolar http://purl.org/sig/ont/fma/fma264783
T151 32343-32350 Body_part denotes Heparin http://purl.org/sig/ont/fma/fma82839
T152 32560-32568 Body_part denotes Alveolar http://purl.org/sig/ont/fma/fma264783
T153 32767-32771 Body_part denotes Lung http://purl.org/sig/ont/fma/fma7195
T154 32799-32807 Body_part denotes Alveolar http://purl.org/sig/ont/fma/fma264783
T155 33085-33093 Body_part denotes Alveolar http://purl.org/sig/ont/fma/fma264783
T156 33261-33269 Body_part denotes Alveolar http://purl.org/sig/ont/fma/fma264783
T157 33341-33347 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T158 33389-33396 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T159 33435-33441 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T160 33684-33691 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T161 33813-33820 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T162 34027-34034 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T163 34233-34237 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T164 34407-34411 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T165 34972-34976 Body_part denotes body http://purl.org/sig/ont/fma/fma256135

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 908-913 Body_part denotes organ http://purl.obolibrary.org/obo/UBERON_0000062
T2 1210-1216 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T3 3796-3800 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T4 4140-4147 Body_part denotes vessels http://purl.obolibrary.org/obo/UBERON_0000055
T5 4647-4652 Body_part denotes organ http://purl.obolibrary.org/obo/UBERON_0000062
T6 4973-4979 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T7 4991-4996 Body_part denotes organ http://purl.obolibrary.org/obo/UBERON_0000062
T8 5239-5250 Body_part denotes endothelium http://purl.obolibrary.org/obo/UBERON_0001986
T9 5450-5474 Body_part denotes renin–angiotensin system http://purl.obolibrary.org/obo/UBERON_0018229
T10 5970-5976 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T11 6207-6211 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T12 7052-7058 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T13 8237-8243 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T14 9105-9111 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T15 9266-9272 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T16 9517-9523 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T17 9967-9972 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T18 10888-10894 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T19 11087-11093 Body_part denotes organs http://purl.obolibrary.org/obo/UBERON_0000062
T20 11109-11113 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T21 11115-11121 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T22 11126-11131 Body_part denotes liver http://purl.obolibrary.org/obo/UBERON_0002107
T23 11526-11532 Body_part denotes Tissue http://purl.obolibrary.org/obo/UBERON_0000479
T24 12013-12017 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T25 12965-12971 Body_part denotes Tissue http://purl.obolibrary.org/obo/UBERON_0000479
T26 13289-13298 Body_part denotes capillary http://purl.obolibrary.org/obo/UBERON_0001982
T27 13786-13790 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T28 14144-14148 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T29 14275-14279 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T30 16949-16955 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T31 17009-17013 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T32 17072-17076 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T33 17141-17145 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T34 17482-17492 Body_part denotes epithelium http://purl.obolibrary.org/obo/UBERON_0000483
T35 18185-18189 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T36 20122-20127 Body_part denotes liver http://purl.obolibrary.org/obo/UBERON_0002107
T37 20181-20187 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T38 21009-21013 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T39 21369-21373 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T40 22049-22053 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T41 22707-22711 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T42 22738-22742 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T43 22856-22862 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T44 25027-25031 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T45 28067-28071 Body_part denotes tube http://purl.obolibrary.org/obo/UBERON_0000025
T46 28079-28086 Body_part denotes stomach http://purl.obolibrary.org/obo/UBERON_0000945
T47 29512-29516 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T48 29952-29967 Body_part denotes cerebral artery http://purl.obolibrary.org/obo/UBERON_0004449
T49 29961-29967 Body_part denotes artery http://purl.obolibrary.org/obo/UBERON_0001637
T50 31273-31277 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T51 31563-31569 Body_part denotes Tissue http://purl.obolibrary.org/obo/UBERON_0000479
T52 32767-32771 Body_part denotes Lung http://purl.obolibrary.org/obo/UBERON_0002048
T53 33341-33347 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T54 33435-33441 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T55 34233-34237 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T56 34407-34411 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 43-51 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T2 52-61 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T3 76-95 Disease denotes bacterial pneumonia http://purl.obolibrary.org/obo/MONDO_0004652
T4 86-95 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T5 140-148 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T6 149-158 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T7 175-199 Disease denotes coronavirus disease 2019 http://purl.obolibrary.org/obo/MONDO_0100096
T8 201-209 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T9 222-269 Disease denotes severe acute respiratory syndrome-coronavirus-2 http://purl.obolibrary.org/obo/MONDO_0100096
T10 222-255 Disease denotes severe acute respiratory syndrome http://purl.obolibrary.org/obo/MONDO_0005091
T11 271-279 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T12 433-441 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T13 531-543 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T14 579-587 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T15 588-597 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T16 648-667 Disease denotes bacterial pneumonia http://purl.obolibrary.org/obo/MONDO_0004652
T17 658-667 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T18 859-897 Disease denotes disseminated intravascular coagulation http://purl.obolibrary.org/obo/MONDO_0001243
T19 902-921 Disease denotes multi-organ failure http://purl.obolibrary.org/obo/MONDO_0043726
T20 1041-1060 Disease denotes bacterial pneumonia http://purl.obolibrary.org/obo/MONDO_0004652
T21 1051-1060 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T22 1217-1223 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T23 1438-1447 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T24 1460-1495 Disease denotes acute respiratory distress syndrome http://purl.obolibrary.org/obo/MONDO_0006502
T25 1466-1495 Disease denotes respiratory distress syndrome http://purl.obolibrary.org/obo/MONDO_0009971
T26 1685-1704 Disease denotes bacterial pneumonia http://purl.obolibrary.org/obo/MONDO_0004652
T27 1695-1704 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T28 1780-1788 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T29 2084-2108 Disease denotes coronavirus disease 2019 http://purl.obolibrary.org/obo/MONDO_0100096
T30 2110-2118 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T31 2192-2200 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T32 2214-2261 Disease denotes severe acute respiratory syndrome-coronavirus-2 http://purl.obolibrary.org/obo/MONDO_0100096
T33 2214-2247 Disease denotes severe acute respiratory syndrome http://purl.obolibrary.org/obo/MONDO_0005091
T34 2263-2271 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T35 2452-2460 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T36 2687-2695 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T37 2696-2705 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T38 2743-2762 Disease denotes bacterial pneumonia http://purl.obolibrary.org/obo/MONDO_0004652
T39 2753-2762 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T40 3022-3030 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T41 3031-3040 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T42 3052-3071 Disease denotes bacterial pneumonia http://purl.obolibrary.org/obo/MONDO_0004652
T43 3062-3071 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T44 3366-3404 Disease denotes disseminated intravascular coagulation http://purl.obolibrary.org/obo/MONDO_0001243
T45 3468-3476 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T46 3492-3500 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T47 3626-3647 Disease denotes venous thromboembolic http://purl.obolibrary.org/obo/MONDO_0005399
T48 3649-3652 Disease denotes VTE http://purl.obolibrary.org/obo/MONDO_0005399
T49 3663-3669 Disease denotes stroke http://purl.obolibrary.org/obo/MONDO_0005098|http://purl.obolibrary.org/obo/MONDO_0011057
T51 3674-3698 Disease denotes acute coronary syndromes http://purl.obolibrary.org/obo/MONDO_0005542
T52 3888-3896 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T53 4101-4109 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T54 4239-4258 Disease denotes bacterial pneumonia http://purl.obolibrary.org/obo/MONDO_0004652
T55 4249-4258 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T56 4277-4296 Disease denotes bacterial infection http://purl.obolibrary.org/obo/MONDO_0005113
T57 4287-4296 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T58 4608-4624 Disease denotes bacterial sepsis http://purl.obolibrary.org/obo/MONDO_0005229
T59 4772-4784 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T60 4980-4986 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T61 5131-5150 Disease denotes bacterial pneumonia http://purl.obolibrary.org/obo/MONDO_0004652
T62 5141-5150 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T63 5183-5191 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T64 5198-5206 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T65 5341-5349 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T66 5777-5787 Disease denotes thrombosis http://purl.obolibrary.org/obo/MONDO_0000831
T67 5794-5802 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T68 5803-5812 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T69 5876-5881 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T70 6134-6146 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T71 6292-6327 Disease denotes acute respiratory distress syndrome http://purl.obolibrary.org/obo/MONDO_0006502
T72 6298-6327 Disease denotes respiratory distress syndrome http://purl.obolibrary.org/obo/MONDO_0009971
T73 6329-6333 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T74 6409-6417 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T75 6442-6454 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T76 6559-6571 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T77 6880-6888 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T78 6897-6916 Disease denotes bacterial pneumonia http://purl.obolibrary.org/obo/MONDO_0004652
T79 6907-6916 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T80 7059-7065 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T81 7257-7276 Disease denotes bacterial pneumonia http://purl.obolibrary.org/obo/MONDO_0004652
T82 7267-7276 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T83 7347-7356 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T84 7369-7373 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T85 7520-7532 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T86 7555-7563 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T87 7740-7759 Disease denotes bacterial pneumonia http://purl.obolibrary.org/obo/MONDO_0004652
T88 7750-7759 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T89 7829-7837 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T90 7838-7847 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T91 7992-8004 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T92 9160-9165 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T93 9301-9304 Disease denotes uPA http://purl.obolibrary.org/obo/MONDO_0004041
T94 9524-9530 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T95 9535-9547 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T96 9583-9592 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T97 9597-9601 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T98 10024-10030 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T99 10964-10976 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T100 11197-11207 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T101 11331-11340 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T102 12018-12030 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T103 12263-12271 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T104 12272-12281 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T105 12608-12620 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T106 12827-12836 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T107 13026-13035 Disease denotes Pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T108 13324-13336 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T109 13421-13430 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T110 13435-13439 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T111 13707-13716 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T112 13721-13725 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T113 13791-13797 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T114 14149-14155 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T115 14280-14286 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T116 15010-15019 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T117 15112-15121 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T118 15204-15212 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T119 15213-15222 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T120 15499-15507 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T121 15508-15517 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T122 15652-15656 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T123 15740-15743 Disease denotes VTE http://purl.obolibrary.org/obo/MONDO_0005399
T124 15933-15945 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T125 15967-15976 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T126 16038-16042 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T127 16956-16962 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T128 17014-17020 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T129 17077-17083 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T130 17146-17152 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T131 17154-17188 Disease denotes Streptococcus pneumoniae infection http://purl.obolibrary.org/obo/MONDO_0005114
T132 17179-17188 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T133 17946-17965 Disease denotes respiratory failure http://purl.obolibrary.org/obo/MONDO_0021113
T134 17993-18003 Disease denotes Infectious http://purl.obolibrary.org/obo/MONDO_0005550
T135 18190-18196 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T136 18235-18239 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T137 18339-18343 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T138 19108-19116 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T139 19117-19126 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T140 19567-19575 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T141 20262-20265 Disease denotes uPA http://purl.obolibrary.org/obo/MONDO_0004041
T142 20355-20364 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T143 20441-20444 Disease denotes uPA http://purl.obolibrary.org/obo/MONDO_0004041
T144 20465-20474 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T145 20536-20557 Disease denotes Klebsiella pneumoniae http://purl.obolibrary.org/obo/MONDO_0030602
T146 20558-20567 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T147 20714-20724 Disease denotes pneumoniae http://purl.obolibrary.org/obo/MONDO_0005249
T148 20756-20765 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T149 20864-20874 Disease denotes pneumoniae http://purl.obolibrary.org/obo/MONDO_0005249
T150 21001-21008 Disease denotes sterile http://purl.obolibrary.org/obo/MONDO_0005047
T151 21014-21020 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T152 21094-21106 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T153 21173-21194 Disease denotes respiratory infection http://purl.obolibrary.org/obo/MONDO_0024355
T154 21185-21194 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T155 21220-21229 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T156 21232-21241 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T157 21278-21290 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T158 21363-21380 Disease denotes acute lung injury http://purl.obolibrary.org/obo/MONDO_0006502|http://purl.obolibrary.org/obo/MONDO_0015796
T160 21374-21380 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T161 21426-21438 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T162 21584-21594 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T163 21598-21602 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T164 21627-21631 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T165 21713-21716 Disease denotes uPA http://purl.obolibrary.org/obo/MONDO_0004041
T166 21904-21908 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T167 22032-22040 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T168 22054-22060 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T169 22267-22279 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T170 22863-22869 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T171 23886-23895 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T172 24550-24559 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T173 24954-24964 Disease denotes pneumoniae http://purl.obolibrary.org/obo/MONDO_0005249
T174 24965-24974 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T175 25032-25038 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T176 25173-25185 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T177 25385-25400 Disease denotes viral infection http://purl.obolibrary.org/obo/MONDO_0005108
T178 25391-25400 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T179 25412-25421 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T180 25559-25571 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T181 25964-25972 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T182 26007-26015 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T183 26206-26210 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T184 26217-26226 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T185 26405-26413 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T186 26574-26586 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T187 26885-26893 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T188 27010-27018 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T189 27127-27135 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T190 28234-28242 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T191 28531-28539 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T192 28582-28586 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T193 29045-29053 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T194 29127-29135 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T195 29290-29294 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T196 29357-29365 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T197 29517-29523 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T198 29771-29774 Disease denotes VTE http://purl.obolibrary.org/obo/MONDO_0005399
T199 29813-29821 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T200 29822-29831 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T201 29968-29978 Disease denotes thrombosis http://purl.obolibrary.org/obo/MONDO_0000831
T202 30184-30188 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T203 30189-30207 Disease denotes pulmonary fibrosis http://purl.obolibrary.org/obo/MONDO_0002771
T204 30369-30381 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T205 30785-30809 Disease denotes acute coronary syndromes http://purl.obolibrary.org/obo/MONDO_0005542
T206 31262-31271 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T207 31278-31284 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T208 31547-31555 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T209 31674-31686 Disease denotes Inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T210 31732-31744 Disease denotes Inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T211 31932-31944 Disease denotes Inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T212 32209-32221 Disease denotes Inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T213 32527-32539 Disease denotes Inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T214 32725-32737 Disease denotes Inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T215 32772-32778 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T216 33040-33052 Disease denotes Inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T217 33229-33241 Disease denotes Inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T218 33470-33473 Disease denotes uPA http://purl.obolibrary.org/obo/MONDO_0004041
T219 33632-33641 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T220 34219-34228 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T221 34238-34244 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T222 34344-34356 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T223 34385-34394 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T224 34412-34418 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T225 34605-34614 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T226 34706-34714 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T227 34743-34758 Disease denotes hypercoagulable http://purl.obolibrary.org/obo/MONDO_0002305
T228 35094-35102 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T229 35103-35112 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T230 35164-35176 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T231 35188-35191 Disease denotes VTE http://purl.obolibrary.org/obo/MONDO_0005399

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T1 22-32 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T2 119-129 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T3 284-287 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T4 338-339 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T5 477-484 http://purl.obolibrary.org/obo/CLO_0009985 denotes focused
T6 749-750 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T7 785-790 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lungs
T8 908-913 http://purl.obolibrary.org/obo/UBERON_0003103 denotes organ
T9 989-999 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T10 1328-1331 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T11 1562-1568 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes humans
T12 1791-1792 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T13 2155-2158 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T14 2417-2418 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T15 2508-2511 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T16 2633-2634 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T17 2706-2709 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T18 2887-2891 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T19 2911-2916 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lungs
T20 2918-2919 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T21 3008-3012 http://purl.obolibrary.org/obo/CLO_0053799 denotes 4, 5
T22 3108-3118 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T23 3168-3177 http://purl.obolibrary.org/obo/CLO_0001658 denotes activated
T24 3217-3228 http://purl.obolibrary.org/obo/PR_000007299 denotes prothrombin
T25 3528-3538 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T26 3581-3582 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T27 3756-3758 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T28 3796-3800 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T29 3796-3800 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T30 4140-4147 http://purl.obolibrary.org/obo/UBERON_0000055 denotes vessels
T31 4390-4400 http://purl.obolibrary.org/obo/CL_0000066 denotes epithelial
T32 4401-4406 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T33 4408-4430 http://purl.obolibrary.org/obo/CL_0000113 denotes mononuclear phagocytes
T34 4441-4451 http://purl.obolibrary.org/obo/CL_0000000 denotes cell types
T35 4647-4652 http://purl.obolibrary.org/obo/UBERON_0003103 denotes organ
T36 4991-4996 http://purl.obolibrary.org/obo/UBERON_0003103 denotes organ
T37 5216-5217 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T38 5239-5250 http://purl.obolibrary.org/obo/UBERON_0001986 denotes endothelium
T39 5309-5314 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T40 5426-5431 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T41 5436-5445 http://purl.obolibrary.org/obo/CLO_0001658 denotes activates
T42 5493-5494 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T43 5572-5577 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T44 5587-5597 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T45 5908-5921 http://purl.obolibrary.org/obo/PR_000001393 denotes interleukin-6
T46 5952-5962 http://purl.obolibrary.org/obo/CLO_0001658 denotes activators
T47 6028-6038 http://purl.obolibrary.org/obo/CLO_0001658 denotes Activation
T48 6164-6165 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T49 6207-6211 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T50 6340-6342 http://purl.obolibrary.org/obo/CLO_0050507 denotes 22
T51 6359-6369 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T52 6504-6505 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T53 6576-6577 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T54 6953-6963 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T55 6994-6999 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lungs
T56 7121-7122 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T57 7193-7203 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T58 7450-7456 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes humans
T59 7894-7904 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T60 8037-8047 http://purl.obolibrary.org/obo/CLO_0001658 denotes Activation
T61 8123-8128 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lungs
T62 8191-8192 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T63 8316-8325 http://purl.obolibrary.org/obo/CLO_0001658 denotes activates
T64 8365-8366 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T65 8397-8408 http://purl.obolibrary.org/obo/PR_000007299 denotes prothrombin
T66 8720-8737 http://purl.obolibrary.org/obo/CL_0000115 denotes endothelial cells
T67 8742-8751 http://purl.obolibrary.org/obo/CLO_0001658 denotes activates
T68 8763-8772 http://purl.obolibrary.org/obo/CLO_0001658 denotes activated
T69 8821-8831 http://purl.obolibrary.org/obo/CLO_0001658 denotes Activation
T70 8872-8882 http://purl.obolibrary.org/obo/SO_0000418 denotes signalling
T71 8965-8975 http://purl.obolibrary.org/obo/CLO_0001658 denotes Activation
T72 8987-8996 http://purl.obolibrary.org/obo/CLO_0001658 denotes activated
T73 9022-9032 http://purl.obolibrary.org/obo/SO_0000418 denotes signalling
T74 9038-9041 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T75 9188-9196 http://purl.obolibrary.org/obo/CL_0000576 denotes monocyte
T76 9227-9238 http://purl.obolibrary.org/obo/PR_000012867 denotes plasminogen
T77 9239-9248 http://purl.obolibrary.org/obo/CLO_0001658 denotes activator
T78 9261-9264 http://purl.obolibrary.org/obo/CLO_0053275 denotes tPA
T79 9261-9264 http://purl.obolibrary.org/obo/CLO_0053276 denotes tPA
T80 9261-9264 http://purl.obolibrary.org/obo/CLO_0053277 denotes tPA
T81 9278-9289 http://purl.obolibrary.org/obo/PR_000012867 denotes plasminogen
T82 9290-9299 http://purl.obolibrary.org/obo/CLO_0001658 denotes activator
T83 9321-9332 http://purl.obolibrary.org/obo/PR_000012867 denotes plasminogen
T84 9333-9342 http://purl.obolibrary.org/obo/CLO_0001658 denotes activator
T85 9495-9503 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T86 9618-9619 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T87 9660-9677 http://purl.obolibrary.org/obo/CL_0000842 denotes mononuclear cells
T88 9679-9696 http://purl.obolibrary.org/obo/CL_0000115 denotes endothelial cells
T89 9698-9709 http://purl.obolibrary.org/obo/CL_0000057 denotes fibroblasts
T90 9720-9739 http://purl.obolibrary.org/obo/CL_0000192 denotes smooth muscle cells
T91 9753-9763 http://purl.obolibrary.org/obo/CL_0000066 denotes epithelial
T92 9764-9769 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T93 9829-9833 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T94 9867-9882 http://purl.obolibrary.org/obo/CLO_0001658 denotes activated cells
T95 9884-9886 http://purl.obolibrary.org/obo/CLO_0050509 denotes 27
T96 9967-9972 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T97 9967-9972 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T98 10099-10108 http://purl.obolibrary.org/obo/CLO_0001658 denotes activates
T99 10229-10239 http://purl.obolibrary.org/obo/CLO_0001658 denotes activating
T100 10374-10385 http://purl.obolibrary.org/obo/PR_000007299 denotes prothrombin
T101 10424-10425 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T102 10509-10519 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T103 10594-10602 http://purl.obolibrary.org/obo/CLO_0001658 denotes activate
T104 10728-10737 http://purl.obolibrary.org/obo/CLO_0001658 denotes activator
T105 10752-10761 http://purl.obolibrary.org/obo/CLO_0001658 denotes activated
T106 11007-11017 http://purl.obolibrary.org/obo/CL_0000066 denotes epithelial
T107 11087-11093 http://purl.obolibrary.org/obo/UBERON_0003103 denotes organs
T108 11109-11113 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T109 11109-11113 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T110 11115-11121 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidney
T111 11115-11121 http://www.ebi.ac.uk/efo/EFO_0000927 denotes kidney
T112 11115-11121 http://www.ebi.ac.uk/efo/EFO_0000929 denotes kidney
T113 11126-11131 http://purl.obolibrary.org/obo/UBERON_0002107 denotes liver
T114 11126-11131 http://www.ebi.ac.uk/efo/EFO_0000887 denotes liver
T115 11133-11135 http://purl.obolibrary.org/obo/CLO_0001302 denotes 34
T116 11514-11524 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T117 11568-11569 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T118 11613-11621 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T119 11688-11705 http://purl.obolibrary.org/obo/CL_0000115 denotes endothelial cells
T120 11850-11855 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T121 11856-11863 http://purl.obolibrary.org/obo/NCBITaxon_9443 denotes primate
T122 11915-11916 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T123 12013-12017 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T124 12013-12017 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T125 12057-12059 http://purl.obolibrary.org/obo/CLO_0001000 denotes 35
T126 12061-12063 http://purl.obolibrary.org/obo/CLO_0001313 denotes 36
T127 12066-12067 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T128 12107-12112 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T129 12286-12287 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T130 12492-12493 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T131 12727-12728 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T132 13055-13057 http://purl.obolibrary.org/obo/CLO_0053794 denotes 41
T133 13440-13450 http://purl.obolibrary.org/obo/CLO_0001658 denotes Activation
T134 13579-13580 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T135 13651-13660 http://purl.obolibrary.org/obo/CLO_0001658 denotes activated
T136 13786-13790 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T137 13786-13790 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T138 13814-13820 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes animal
T139 13963-13966 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T140 14144-14148 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T141 14144-14148 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T142 14252-14253 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T143 14275-14279 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T144 14275-14279 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T145 14541-14542 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T146 14642-14646 http://purl.obolibrary.org/obo/CLO_0001557 denotes a 15
T147 14733-14734 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T148 14765-14766 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T149 14900-14902 http://purl.obolibrary.org/obo/CLO_0053799 denotes 45
T150 14966-14972 http://purl.obolibrary.org/obo/UBERON_0000473 denotes tested
T151 15055-15058 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T152 15146-15147 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T153 15415-15425 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T154 15547-15548 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T155 15580-15581 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T156 15745-15747 http://purl.obolibrary.org/obo/CLO_0001382 denotes 48
T157 15949-15950 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T158 16113-16114 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T159 16200-16209 http://purl.obolibrary.org/obo/CLO_0001658 denotes Activated
T160 16230-16231 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T161 16331-16334 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T162 16426-16435 http://purl.obolibrary.org/obo/CLO_0001658 denotes activated
T163 16546-16555 http://purl.obolibrary.org/obo/CLO_0001658 denotes activated
T164 16876-16877 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T165 17009-17013 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T166 17009-17013 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T167 17072-17076 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T168 17072-17076 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T169 17141-17145 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T170 17141-17145 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T171 17349-17357 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T172 17482-17492 http://purl.obolibrary.org/obo/UBERON_0000483 denotes epithelium
T173 17548-17558 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T174 17664-17667 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T175 17791-17800 http://purl.obolibrary.org/obo/CLO_0001658 denotes activated
T176 17967-17969 http://purl.obolibrary.org/obo/CLO_0050507 denotes 22
T177 18170-18180 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T178 18185-18189 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T179 18185-18189 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T180 18207-18208 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T181 18218-18220 http://purl.obolibrary.org/obo/CLO_0050509 denotes 27
T182 18253-18254 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T183 18429-18430 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T184 18913-18916 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T185 18948-18949 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T186 19046-19047 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T187 19057-19058 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T188 19413-19421 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T189 19547-19548 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T190 19564-19566 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T191 19932-19940 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T192 20001-20012 http://purl.obolibrary.org/obo/PR_000012867 denotes plasminogen
T193 20013-20023 http://purl.obolibrary.org/obo/CLO_0001658 denotes activators
T194 20028-20039 http://purl.obolibrary.org/obo/PR_000012867 denotes plasminogen
T195 20040-20049 http://purl.obolibrary.org/obo/CLO_0001658 denotes activator
T196 20081-20092 http://purl.obolibrary.org/obo/PR_000012867 denotes Plasminogen
T197 20122-20127 http://purl.obolibrary.org/obo/UBERON_0002107 denotes liver
T198 20122-20127 http://www.ebi.ac.uk/efo/EFO_0000887 denotes liver
T199 20193-20204 http://purl.obolibrary.org/obo/PR_000012867 denotes plasminogen
T200 20205-20214 http://purl.obolibrary.org/obo/CLO_0001658 denotes activator
T201 20216-20219 http://purl.obolibrary.org/obo/CLO_0053275 denotes tPA
T202 20216-20219 http://purl.obolibrary.org/obo/CLO_0053276 denotes tPA
T203 20216-20219 http://purl.obolibrary.org/obo/CLO_0053277 denotes tPA
T204 20239-20250 http://purl.obolibrary.org/obo/PR_000012867 denotes plasminogen
T205 20251-20260 http://purl.obolibrary.org/obo/CLO_0001658 denotes activator
T206 20370-20372 http://purl.obolibrary.org/obo/CLO_0054055 denotes 71
T207 20433-20436 http://purl.obolibrary.org/obo/CLO_0053275 denotes tPA
T208 20433-20436 http://purl.obolibrary.org/obo/CLO_0053276 denotes tPA
T209 20433-20436 http://purl.obolibrary.org/obo/CLO_0053277 denotes tPA
T210 20534-20535 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T211 20685-20686 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T212 20695-20700 http://purl.obolibrary.org/obo/CLO_0007836 denotes mouse
T213 20795-20806 http://purl.obolibrary.org/obo/PR_000012867 denotes plasminogen
T214 20807-20816 http://purl.obolibrary.org/obo/CLO_0001658 denotes activator
T215 20990-20991 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T216 21009-21013 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T217 21009-21013 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T218 21022-21025 http://purl.obolibrary.org/obo/CLO_0053275 denotes tPA
T219 21022-21025 http://purl.obolibrary.org/obo/CLO_0053276 denotes tPA
T220 21022-21025 http://purl.obolibrary.org/obo/CLO_0053277 denotes tPA
T221 21209-21210 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T222 21230-21231 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T223 21258-21269 http://purl.obolibrary.org/obo/PR_000012867 denotes plasminogen
T224 21297-21298 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T225 21369-21373 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T226 21369-21373 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T227 21652-21653 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T228 21717-21725 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T229 21827-21828 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T230 22049-22053 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T231 22049-22053 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T232 22147-22150 http://purl.obolibrary.org/obo/CLO_0053275 denotes tPA
T233 22147-22150 http://purl.obolibrary.org/obo/CLO_0053276 denotes tPA
T234 22147-22150 http://purl.obolibrary.org/obo/CLO_0053277 denotes tPA
T235 22326-22327 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T236 22435-22439 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T237 22486-22513 http://purl.obolibrary.org/obo/PR_000030035 denotes G-protein-coupled receptors
T238 22545-22555 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T239 22637-22638 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T240 22707-22711 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T241 22707-22711 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T242 22721-22726 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T243 22738-22759 http://purl.obolibrary.org/obo/CL_0000082 denotes lung epithelial cells
T244 22761-22778 http://purl.obolibrary.org/obo/CL_0000115 denotes endothelial cells
T245 22783-22794 http://purl.obolibrary.org/obo/CL_0000057 denotes fibroblasts
T246 22820-22829 http://purl.obolibrary.org/obo/CL_0000576 denotes monocytes
T247 22883-22884 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T248 22891-22900 http://purl.obolibrary.org/obo/CLO_0001658 denotes activator
T249 22979-22987 http://purl.obolibrary.org/obo/CLO_0001658 denotes activate
T250 23025-23034 http://purl.obolibrary.org/obo/CLO_0001658 denotes activated
T251 23147-23155 http://purl.obolibrary.org/obo/CLO_0001658 denotes activate
T252 23167-23177 http://purl.obolibrary.org/obo/CLO_0001658 denotes Activation
T253 23212-23213 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T254 23304-23308 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T255 23332-23342 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T256 23407-23417 http://purl.obolibrary.org/obo/SO_0000418 denotes signalling
T257 23519-23529 http://purl.obolibrary.org/obo/CLO_0001658 denotes activating
T258 23680-23690 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T259 23703-23713 http://purl.obolibrary.org/obo/SO_0000418 denotes signalling
T260 23821-23831 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T261 23836-23846 http://purl.obolibrary.org/obo/SO_0000418 denotes signalling
T262 23927-23937 http://purl.obolibrary.org/obo/SO_0000418 denotes signalling
T263 23995-24005 http://purl.obolibrary.org/obo/SO_0000418 denotes signalling
T264 24067-24070 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T265 24194-24204 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T266 24783-24793 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T267 24832-24833 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T268 25027-25031 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T269 25027-25031 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T270 25109-25111 http://purl.obolibrary.org/obo/CLO_0001527 denotes 94
T271 25264-25274 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T272 25477-25482 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T273 26086-26096 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T274 26098-26099 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T275 26551-26561 http://purl.obolibrary.org/obo/SO_0000418 denotes signalling
T276 26936-26937 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T277 27652-27660 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T278 28053-28054 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T279 28067-28071 http://purl.obolibrary.org/obo/UBERON_0000025 denotes tube
T280 28317-28318 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T281 28332-28335 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T282 28426-28429 http://purl.obolibrary.org/obo/CLO_0054060 denotes 102
T283 28923-28924 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T284 28986-28989 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T285 29246-29249 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T286 29421-29424 http://purl.obolibrary.org/obo/CLO_0053275 denotes tPA
T287 29421-29424 http://purl.obolibrary.org/obo/CLO_0053276 denotes tPA
T288 29421-29424 http://purl.obolibrary.org/obo/CLO_0053277 denotes tPA
T289 29512-29516 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T290 29512-29516 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T291 29652-29662 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T292 29961-29967 http://purl.obolibrary.org/obo/UBERON_0001637 denotes artery
T293 29961-29967 http://www.ebi.ac.uk/efo/EFO_0000814 denotes artery
T294 30016-30026 http://purl.obolibrary.org/obo/SO_0000418 denotes signalling
T295 30123-30127 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T296 30346-30356 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T297 30440-30443 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T298 30506-30507 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T299 30626-30628 http://purl.obolibrary.org/obo/CLO_0001382 denotes 48
T300 30714-30715 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T301 30979-30980 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T302 31184-31185 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T303 31273-31277 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T304 31273-31277 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T305 31486-31492 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes Animal
T306 31596-31606 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T307 31644-31654 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T308 31697-31699 http://purl.obolibrary.org/obo/CLO_0001313 denotes 36
T309 31855-31857 http://purl.obolibrary.org/obo/CLO_0053794 denotes 41
T310 32085-32095 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T311 32133-32135 http://purl.obolibrary.org/obo/CLO_0053799 denotes 45
T312 32364-32374 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T313 32658-32668 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T314 32700-32710 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T315 32767-32771 http://purl.obolibrary.org/obo/UBERON_0002048 denotes Lung
T316 32767-32771 http://www.ebi.ac.uk/efo/EFO_0000934 denotes Lung
T317 32848-32850 http://purl.obolibrary.org/obo/CLO_0050507 denotes 22
T318 32964-32974 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T319 33203-33213 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T320 33224-33227 http://purl.obolibrary.org/obo/CLO_0053001 denotes 114
T321 33252-33254 http://purl.obolibrary.org/obo/CLO_0001527 denotes 94
T322 33285-33287 http://purl.obolibrary.org/obo/CLO_0001527 denotes 94
T323 33326-33328 http://purl.obolibrary.org/obo/CLO_0001527 denotes 94
T324 33379-33388 http://purl.obolibrary.org/obo/CLO_0001658 denotes activated
T325 33419-33424 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T326 33430-33433 http://purl.obolibrary.org/obo/CLO_0053275 denotes tPA
T327 33430-33433 http://purl.obolibrary.org/obo/CLO_0053276 denotes tPA
T328 33430-33433 http://purl.obolibrary.org/obo/CLO_0053277 denotes tPA
T329 33447-33458 http://purl.obolibrary.org/obo/PR_000012867 denotes plasminogen
T330 33459-33468 http://purl.obolibrary.org/obo/CLO_0001658 denotes activator
T331 33490-33501 http://purl.obolibrary.org/obo/PR_000012867 denotes plasminogen
T332 33502-33511 http://purl.obolibrary.org/obo/CLO_0001658 denotes activator
T333 33531-33540 http://purl.obolibrary.org/obo/CLO_0001658 denotes activated
T334 34233-34237 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T335 34233-34237 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T336 34407-34411 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T337 34407-34411 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T338 34529-34534 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T339 34732-34733 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T340 35243-35244 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T341 35512-35516 http://purl.obolibrary.org/obo/CLO_0008416 denotes peer
T342 35512-35516 http://purl.obolibrary.org/obo/CLO_0050081 denotes peer
T343 35559-35562 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T344 35606-35607 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T345 35618-35621 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T346 35665-35666 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T347 35675-35678 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T348 35733-35736 http://purl.obolibrary.org/obo/CLO_0051582 denotes has

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
3 43-61 Disease denotes COVID-19 pneumonia MESH:C000657245
4 76-95 Disease denotes bacterial pneumonia MESH:D016920
5 100-106 Disease denotes sepsis MESH:D018805
29 222-269 Species denotes severe acute respiratory syndrome-coronavirus-2 Tax:2697049
30 271-281 Species denotes SARS-CoV-2 Tax:2697049
31 1424-1432 Species denotes patients Tax:9606
32 1562-1568 Species denotes humans Tax:9606
33 169-194 Disease denotes Novel coronavirus disease MESH:C000657245
34 201-209 Disease denotes COVID-19 MESH:C000657245
35 359-368 Disease denotes mortality MESH:D003643
36 433-441 Disease denotes COVID-19 MESH:C000657245
37 525-543 Disease denotes hyper-inflammation MESH:D007249
38 579-597 Disease denotes COVID-19 pneumonia MESH:C000657245
39 648-667 Disease denotes bacterial pneumonia MESH:D016920
40 672-678 Disease denotes sepsis MESH:D018805
41 859-897 Disease denotes disseminated intravascular coagulation MESH:D004211
42 902-921 Disease denotes multi-organ failure MESH:D009102
43 1051-1060 Disease denotes pneumonia MESH:D011014
44 1065-1071 Disease denotes sepsis MESH:D018805
45 1210-1223 Disease denotes tissue injury MESH:D017695
46 1438-1447 Disease denotes pneumonia MESH:D011014
47 1449-1455 Disease denotes sepsis MESH:D018805
48 1460-1495 Disease denotes acute respiratory distress syndrome MESH:D012128
49 1685-1704 Disease denotes bacterial pneumonia MESH:D016920
50 1709-1715 Disease denotes sepsis MESH:D018805
51 1780-1788 Disease denotes COVID-19 MESH:C000657245
62 2214-2261 Species denotes severe acute respiratory syndrome-coronavirus-2 Tax:2697049
63 2263-2273 Species denotes SARS-CoV-2 Tax:2697049
64 2464-2477 Chemical denotes dexamethasone MESH:D003907
65 2497-2507 Chemical denotes remdesivir MESH:C000606551
66 2078-2103 Disease denotes Novel coronavirus disease MESH:C000657245
67 2110-2118 Disease denotes COVID-19 MESH:C000657245
68 2192-2200 Disease denotes COVID-19 MESH:C000657245
69 2362-2368 Disease denotes deaths MESH:D003643
70 2432-2441 Disease denotes mortality MESH:D003643
71 2452-2460 Disease denotes COVID-19 MESH:C000657245
92 3427-3435 Species denotes patients Tax:9606
93 3708-3716 Species denotes patients Tax:9606
94 3874-3882 Species denotes patients Tax:9606
95 4080-4088 Species denotes patients Tax:9606
96 3740-3747 Chemical denotes heparin MESH:D006493
97 2687-2705 Disease denotes COVID-19 pneumonia MESH:C000657245
98 2743-2762 Disease denotes bacterial pneumonia MESH:D016920
99 2789-2796 Disease denotes hypoxia MESH:D000860
100 3022-3040 Disease denotes COVID-19 pneumonia MESH:C000657245
101 3052-3071 Disease denotes bacterial pneumonia MESH:D016920
102 3366-3404 Disease denotes disseminated intravascular coagulation MESH:D004211
103 3457-3462 Disease denotes death MESH:D003643
104 3468-3476 Disease denotes COVID-19 MESH:C000657245
105 3492-3500 Disease denotes COVID-19 MESH:C000657245
106 3601-3661 Disease denotes pulmonary and peripheral venous thromboembolic (VTE) disease MESH:D054556
107 3663-3669 Disease denotes stroke MESH:D020521
108 3853-3860 Disease denotes hypoxia MESH:D000860
109 3888-3896 Disease denotes COVID-19 MESH:C000657245
110 4101-4109 Disease denotes COVID-19 MESH:C000657245
111 4161-4176 Disease denotes microthrombosis
120 4583-4591 Species denotes patients Tax:9606
121 5015-5023 Species denotes patients Tax:9606
122 4239-4258 Disease denotes bacterial pneumonia MESH:D016920
123 4277-4296 Disease denotes bacterial infection MESH:D001424
124 4618-4624 Disease denotes sepsis MESH:D018805
125 4647-4664 Disease denotes organ dysfunction MESH:D009102
126 4772-4784 Disease denotes inflammation MESH:D007249
127 4973-5004 Disease denotes tissue injury and organ failure MESH:D009102
135 5198-5208 Species denotes SARS-CoV-2 Tax:2697049
136 5341-5351 Species denotes SARS-CoV-2 Tax:2697049
137 5131-5150 Disease denotes bacterial pneumonia MESH:D016920
138 5155-5161 Disease denotes sepsis MESH:D018805
139 5183-5191 Disease denotes COVID-19 MESH:C000657245
140 5319-5334 Disease denotes microangiopathy MESH:D000783
141 5777-5787 Disease denotes thrombosis MESH:D013927
156 5876-5897 Gene denotes tumor necrosis factor Gene:7124
157 5899-5902 Gene denotes TNF Gene:7124
158 5908-5921 Gene denotes interleukin-6 Gene:3569
159 5923-5927 Gene denotes IL-6 Gene:3569
160 5970-5983 Gene denotes tissue factor Gene:2152
161 5985-5987 Gene denotes TF Gene:2152
162 6388-6396 Species denotes patients Tax:9606
163 5794-5812 Disease denotes COVID-19 pneumonia MESH:C000657245
164 6134-6146 Disease denotes inflammation MESH:D007249
165 6292-6327 Disease denotes acute respiratory distress syndrome MESH:D012128
166 6329-6333 Disease denotes ARDS MESH:D012128
167 6409-6417 Disease denotes COVID-19 MESH:C000657245
168 6442-6454 Disease denotes inflammation MESH:D007249
169 6559-6571 Disease denotes inflammation MESH:D007249
183 7450-7456 Species denotes humans Tax:9606
184 6880-6888 Disease denotes COVID-19 MESH:C000657245
185 6897-6916 Disease denotes bacterial pneumonia MESH:D016920
186 6921-6927 Disease denotes sepsis MESH:D018805
187 7059-7065 Disease denotes injury MESH:D014947
188 7257-7276 Disease denotes bacterial pneumonia MESH:D016920
189 7281-7287 Disease denotes sepsis MESH:D018805
190 7347-7356 Disease denotes pneumonia MESH:D011014
191 7358-7364 Disease denotes sepsis MESH:D018805
192 7369-7373 Disease denotes ARDS MESH:D012128
193 7480-7505 Disease denotes coagulation abnormalities MESH:D025861
194 7520-7532 Disease denotes inflammation MESH:D007249
195 7555-7563 Disease denotes COVID-19 MESH:C000657245
201 7915-7923 Gene denotes thrombin Gene:2147
202 7740-7759 Disease denotes bacterial pneumonia MESH:D016920
203 7764-7770 Disease denotes sepsis MESH:D018805
204 7829-7847 Disease denotes COVID-19 pneumonia MESH:C000657245
205 7980-8004 Disease denotes coagulation–inflammation MESH:D001778
229 8531-8540 Gene denotes factor Xa Gene:2159
230 8664-8672 Gene denotes Thrombin Gene:2147
231 8702-8716 Gene denotes thrombomodulin Gene:7056
232 8752-8783 Gene denotes proteinase-activated receptor-1 Gene:2149
233 8785-8789 Gene denotes PAR1 Gene:2149
234 8835-8839 Gene denotes PAR1 Gene:2149
235 8843-8851 Gene denotes thrombin Gene:2147
236 8979-8983 Gene denotes PAR1 Gene:2149
237 8987-9006 Gene denotes activated protein C Gene:324
238 9008-9011 Gene denotes APC Gene:324
239 9105-9118 Gene denotes tissue factor Gene:2152
240 9266-9299 Gene denotes tissue-type plasminogen activator Gene:5327
241 9301-9304 Gene denotes uPA Gene:5328
242 9306-9342 Gene denotes urokinase-type plasminogen activator Gene:5328
243 9344-9348 Gene denotes EPCR Gene:10544
244 9350-9380 Gene denotes endothelial protein C receptor Gene:10544
245 9261-9264 Gene denotes tPA Gene:100128998
246 8349-8351 Gene denotes TF Gene:2152
247 8308-8310 Gene denotes TF Gene:2152
248 8304-8306 Gene denotes TF Gene:2152
249 8618-8626 Gene denotes thrombin Gene:2147
250 9099-9103 Gene denotes TFPI Gene:7035
251 9160-9174 Disease denotes tumor necrosis MESH:D009336
253 9421-9423 Gene denotes TF Gene:2152
275 9446-9448 Gene denotes TF Gene:2152
276 10240-10260 Gene denotes coagulation factor X Gene:2159
277 10284-10293 Gene denotes factor Xa Gene:2159
278 10549-10553 Gene denotes VIII Gene:1351
279 10622-10630 Gene denotes Thrombin Gene:2147
280 10741-10772 Gene denotes proteinase-activated receptor-1 Gene:2149
281 10774-10778 Gene denotes PAR1 Gene:2149
282 10640-10650 Gene denotes fibrinogen Gene:2244
283 10190-10192 Gene denotes TF Gene:2152
284 10083-10085 Gene denotes TF Gene:2152
285 9931-9933 Gene denotes TF Gene:2152
286 9612-9614 Gene denotes TF Gene:2152
287 10401-10409 Gene denotes thrombin Gene:2147
288 9524-9530 Disease denotes injury MESH:D014947
289 9535-9547 Disease denotes inflammation MESH:D007249
290 9583-9592 Disease denotes pneumonia MESH:D011014
291 9597-9601 Disease denotes ARDS MESH:D012128
292 10015-10030 Disease denotes vascular injury MESH:D057772
293 10964-10976 Disease denotes inflammation MESH:D007249
294 11066-11074 Disease denotes fibrosis MESH:D005355
295 11197-11207 Disease denotes infections MESH:D007239
297 11210-11212 Gene denotes TF Gene:2152
337 11526-11557 Gene denotes Tissue factor pathway inhibitor Gene:7035
338 11559-11563 Gene denotes TFPI Gene:7035
339 11626-11634 Gene denotes thrombin Gene:2147
340 11752-11761 Gene denotes factor Xa Gene:2159
341 11770-11774 Gene denotes TFPI Gene:7035
342 11990-11992 Gene denotes TF Gene:2152
343 12113-12117 Gene denotes TFPI Gene:7035
344 12197-12201 Gene denotes IL-6 Gene:3569
345 12965-12996 Gene denotes Tissue Factor Pathway Inhibitor Gene:7035
346 13156-13160 Gene denotes TFPI Gene:7035
347 13245-13247 Gene denotes TF Gene:2152
348 11942-11944 Gene denotes TF Gene:2152
349 11900-11902 Gene denotes TF Gene:2152
350 11602-11604 Gene denotes TF Gene:2152
351 11366-11368 Gene denotes TF Gene:2152
352 11232-11234 Gene denotes TF Gene:2152
353 11310-11318 Species denotes patients Tax:9606
354 11850-11855 Species denotes human Tax:9606
355 12107-12112 Species denotes human Tax:9606
356 12141-12149 Species denotes patients Tax:9606
357 12459-12467 Species denotes patients Tax:9606
358 12787-12795 Species denotes patients Tax:9606
359 13101-13109 Species denotes patients Tax:9606
360 12656-12663 Chemical denotes heparin MESH:D006493
361 12896-12903 Chemical denotes heparin MESH:D006493
362 11331-11340 Disease denotes pneumonia MESH:D011014
363 11874-11886 Disease denotes endotoxaemia
364 12013-12030 Disease denotes lung inflammation MESH:D011014
365 12162-12168 Disease denotes sepsis MESH:D018805
366 12263-12281 Disease denotes COVID-19 pneumonia MESH:C000657245
367 12421-12427 Disease denotes Sepsis MESH:D018805
368 12480-12486 Disease denotes sepsis MESH:D018805
369 12568-12577 Disease denotes mortality MESH:D003643
370 12608-12620 Disease denotes inflammation MESH:D007249
371 12708-12716 Disease denotes bleeding MESH:D006470
372 12827-12836 Disease denotes pneumonia MESH:D011014
373 13026-13035 Disease denotes Pneumonia MESH:D011014
374 13205-13211 Disease denotes sepsis MESH:D018805
375 13324-13336 Disease denotes inflammation MESH:D007249
378 13421-13430 Disease denotes pneumonia MESH:D011014
379 13435-13439 Disease denotes ARDS MESH:D012128
386 13633-13641 Gene denotes thrombin Gene:2147
387 13651-13670 Gene denotes activated protein C Gene:324
388 13672-13675 Gene denotes APC Gene:324
389 13707-13716 Disease denotes pneumonia MESH:D011014
390 13721-13725 Disease denotes ARDS MESH:D012128
391 13786-13797 Disease denotes lung injury MESH:D055370
432 13936-13944 Gene denotes thrombin Gene:2147
433 14106-14114 Gene denotes thrombin Gene:2147
434 14932-14940 Gene denotes thrombin Gene:2147
435 13949-13958 Gene denotes factor Xa Gene:2159
436 14453-14465 Species denotes participants Tax:9606
437 14810-14818 Species denotes patients Tax:9606
438 15951-15957 Species denotes murine Tax:10090
439 16010-16018 Species denotes patients Tax:9606
440 15647-15651 Species denotes H1N1 Tax:114727
441 14527-14534 Chemical denotes heparin MESH:D006493
442 14630-14637 Chemical denotes heparin MESH:D006493
443 14711-14718 Chemical denotes heparin MESH:D006493
444 15344-15351 Chemical denotes heparin MESH:D006493
445 15353-15360 Chemical denotes Heparin MESH:D006493
446 15607-15635 Chemical denotes low molecular weight heparin MESH:D006495
447 15637-15641 Chemical denotes LMWH MESH:D006495
448 15688-15695 Chemical denotes heparin MESH:D006493
449 15750-15757 Chemical denotes Heparin MESH:D006493
450 15863-15870 Chemical denotes heparin MESH:D006493
451 15907-15914 Chemical denotes heparin MESH:D006493
452 16054-16061 Chemical denotes heparin MESH:D006493
453 14144-14155 Disease denotes lung injury MESH:D055370
454 14275-14286 Disease denotes lung injury MESH:D055370
455 14344-14350 Disease denotes sepsis MESH:D018805
456 14383-14392 Disease denotes mortality MESH:D003643
457 14419-14427 Disease denotes bleeding MESH:D006470
458 14670-14679 Disease denotes mortality MESH:D003643
459 14795-14809 Disease denotes critically ill MESH:D016638
460 14876-14898 Disease denotes bleeding complications MESH:D006470
461 15010-15019 Disease denotes pneumonia MESH:D011014
462 15095-15101 Disease denotes sepsis MESH:D018805
463 15112-15121 Disease denotes pneumonia MESH:D011014
464 15204-15222 Disease denotes COVID-19 pneumonia MESH:C000657245
465 15499-15517 Disease denotes COVID-19 pneumonia MESH:C000657245
466 15652-15656 Disease denotes ARDS MESH:D012128
467 15740-15743 Disease denotes VTE MESH:D054556
468 15933-15945 Disease denotes inflammation MESH:D007249
469 15967-15976 Disease denotes pneumonia MESH:D011014
470 16038-16042 Disease denotes ARDS MESH:D012128
471 16136-16145 Disease denotes mortality MESH:D003643
495 16220-16223 Gene denotes APC Gene:324
496 16437-16445 Gene denotes thrombin Gene:2147
497 16455-16469 Gene denotes thrombomodulin Gene:7056
498 16494-16524 Gene denotes endothelial protein C receptor Gene:10544
499 16526-16530 Gene denotes EPCR Gene:10544
500 16557-16560 Gene denotes APC Gene:324
501 16579-16583 Gene denotes EPCR Gene:10544
502 16754-16762 Gene denotes thrombin Gene:2147
503 16899-16902 Gene denotes APC Gene:324
504 17313-17321 Gene denotes thrombin Gene:2147
505 17250-17258 Gene denotes thrombin Gene:2147
506 16775-16778 Gene denotes APC Gene:324
507 17046-17052 Species denotes murine Tax:10090
508 16643-16646 Gene denotes APC Gene:324
509 16638-16642 Gene denotes EPCR Gene:10544
510 17110-17128 Chemical denotes lipopolysaccharide MESH:D008070
511 16378-16384 Disease denotes sepsis MESH:D018805
512 16932-16962 Disease denotes rhAPC attenuates tissue injury MESH:C538265
513 16998-17004 Disease denotes sepsis MESH:D018805
514 17009-17020 Disease denotes lung injury MESH:D055370
515 17072-17083 Disease denotes lung injury MESH:D055370
516 17141-17152 Disease denotes lung injury MESH:D055370
517 17154-17188 Disease denotes Streptococcus pneumoniae infection MESH:D011008
551 17660-17663 Gene denotes APC Gene:324
552 18504-18507 Gene denotes APC Gene:324
553 19487-19490 Gene denotes APC Gene:11789
554 18294-18297 Gene denotes APC Gene:324
555 18146-18149 Gene denotes APC Gene:324
556 18071-18074 Gene denotes APC Gene:324
557 17864-17872 Species denotes patients Tax:9606
558 18221-18229 Species denotes patients Tax:9606
559 18344-18352 Species denotes patients Tax:9606
560 18364-18372 Species denotes patients Tax:9606
561 18476-18488 Species denotes participants Tax:9606
562 18578-18586 Species denotes patients Tax:9606
563 18722-18730 Species denotes patients Tax:9606
564 18862-18869 Species denotes patient Tax:9606
565 19516-19520 Species denotes mice Tax:10090
566 17851-17860 Disease denotes mortality MESH:D003643
567 17878-17884 Disease denotes sepsis MESH:D018805
568 17946-17965 Disease denotes respiratory failure MESH:D012131
569 17993-18012 Disease denotes Infectious Diseases MESH:D003141
570 18107-18119 Disease denotes septic shock MESH:D012772
571 18185-18196 Disease denotes lung injury MESH:D055370
572 18235-18239 Disease denotes ARDS MESH:D012128
573 18339-18343 Disease denotes ARDS MESH:D012128
574 18378-18384 Disease denotes sepsis MESH:D018805
575 18404-18409 Disease denotes death MESH:D003643
576 18543-18551 Disease denotes bleeding MESH:D006470
577 18599-18605 Disease denotes sepsis MESH:D018805
578 18609-18621 Disease denotes septic shock MESH:D012772
579 18736-18748 Disease denotes septic shock MESH:D012772
580 19108-19126 Disease denotes COVID-19 pneumonia MESH:C000657245
581 19209-19217 Disease denotes bleeding MESH:D006470
582 19333-19341 Disease denotes bleeding MESH:D006470
583 19524-19530 Disease denotes sepsis MESH:D018805
592 19616-19619 Gene denotes APC Gene:324
593 19666-19669 Gene denotes APC Gene:324
594 19576-19584 Species denotes patients Tax:9606
595 19647-19655 Species denotes patients Tax:9606
596 19701-19709 Species denotes patients Tax:9606
597 19567-19575 Disease denotes COVID-19 MESH:C000657245
598 19735-19747 Disease denotes septic shock MESH:D012772
599 19767-19772 Disease denotes death MESH:D003643
633 20028-20079 Gene denotes plasminogen activator inhibitors (PAI)-1, -2 and -3 Gene:5054
634 20147-20154 Gene denotes plasmin Gene:5340
635 20181-20214 Gene denotes tissue-type plasminogen activator Gene:5327
636 20224-20260 Gene denotes urokinase-type plasminogen activator Gene:5328
637 20262-20265 Gene denotes uPA Gene:5328
638 20346-20351 Gene denotes PAI-1 Gene:5054
639 20426-20431 Gene denotes PAI-1 Gene:18787
640 20433-20436 Gene denotes tPA Gene:18791
641 20441-20444 Gene denotes uPA Gene:18792
642 20575-20580 Gene denotes PAI-1 Gene:5054
643 20650-20655 Gene denotes PAI-1 Gene:5054
644 20660-20667 Gene denotes plasmin Gene:5340
645 21022-21025 Gene denotes tPA Gene:100128998
646 20216-20219 Gene denotes tPA Gene:100128998
647 19924-19931 Gene denotes plasmin Gene:5340
648 20448-20454 Species denotes murine Tax:10090
649 20695-20700 Species denotes mouse Tax:10090
650 20711-20724 Species denotes S. pneumoniae Tax:1313
651 20861-20874 Species denotes S. pneumoniae Tax:1313
652 21220-21229 Species denotes influenza Tax:11320
653 20162-20168 Chemical denotes serine MESH:D012694
654 20355-20364 Disease denotes pneumonia MESH:D011014
655 20465-20474 Disease denotes pneumonia MESH:D011014
656 20536-20567 Disease denotes Klebsiella pneumoniae pneumonia MESH:D011014
657 20622-20631 Disease denotes mortality MESH:D003643
658 20745-20765 Disease denotes aeruginosa pneumonia MESH:D011552
659 21009-21020 Disease denotes lung injury MESH:D055370
660 21084-21106 Disease denotes pulmonary inflammation MESH:D011014
661 21167-21194 Disease denotes viral respiratory infection
662 21232-21241 Disease denotes infection MESH:D007239
663 21278-21290 Disease denotes inflammation MESH:D007249
664 21369-21380 Disease denotes lung injury MESH:D055370
665 21426-21438 Disease denotes inflammation MESH:D007249
678 21740-21745 Gene denotes PAI-1 Gene:5054
679 21713-21716 Gene denotes uPA Gene:5328
680 22147-22150 Gene denotes tPA Gene:100128998
681 21563-21571 Species denotes patients Tax:9606
682 21613-21621 Species denotes patients Tax:9606
683 21909-21917 Species denotes patients Tax:9606
684 21584-21594 Disease denotes infections MESH:D007239
685 21598-21602 Disease denotes ARDS MESH:D012128
686 21627-21631 Disease denotes ARDS MESH:D012128
687 21904-21908 Disease denotes ARDS MESH:D012128
688 22032-22040 Disease denotes COVID-19 MESH:C000657245
689 22049-22060 Disease denotes lung injury MESH:D055370
691 22267-22279 Disease denotes inflammation MESH:D007249
707 22667-22671 Gene denotes PAR1 Gene:2149
708 22871-22879 Gene denotes Thrombin Gene:2147
709 22904-22908 Gene denotes PAR1 Gene:2149
710 22913-22917 Gene denotes PAR3 Gene:2151
711 22927-22936 Gene denotes factor Xa Gene:2159
712 22988-22992 Gene denotes PAR1 Gene:2149
713 22997-23001 Gene denotes PAR2 Gene:2150
714 23008-23012 Gene denotes PAR1 Gene:2149
715 23066-23073 Gene denotes plasmin Gene:5340
716 23083-23107 Gene denotes matrix metalloprotease-1 Gene:4312
717 23156-23160 Gene denotes PAR2 Gene:2150
718 22952-22954 Gene denotes TF Gene:2152
719 23048-23051 Gene denotes APC Gene:324
720 23042-23046 Gene denotes EPCR Gene:10544
721 22856-22869 Disease denotes tissue injury MESH:D017695
754 23181-23185 Gene denotes PAR1 Gene:2149
755 23391-23395 Gene denotes PAR1 Gene:2149
756 23630-23638 Gene denotes thrombin Gene:2147
757 23675-23679 Gene denotes PAR1 Gene:2149
758 23753-23756 Gene denotes APC Gene:324
759 23766-23774 Gene denotes thrombin Gene:2147
760 23816-23820 Gene denotes PAR1 Gene:2149
761 23912-23920 Gene denotes thrombin Gene:2147
762 23922-23926 Gene denotes PAR1 Gene:2149
763 23986-23994 Gene denotes APC-PAR1 Gene:324
764 24035-24038 Gene denotes APC Gene:324
765 24124-24128 Gene denotes PAR1 Gene:2149
766 24141-24149 Gene denotes thrombin Gene:2147
767 24188-24193 Gene denotes PAR-1 Gene:2149
768 24208-24211 Gene denotes APC Gene:324
769 24215-24223 Gene denotes thrombin Gene:2147
770 24275-24279 Gene denotes PAR1 Gene:2149
771 24309-24313 Gene denotes PAR1 Gene:2149
772 24344-24348 Gene denotes PAR1 Gene:2149
773 24455-24458 Gene denotes APC Gene:324
774 24505-24513 Gene denotes thrombin Gene:2147
775 24612-24615 Gene denotes APC Gene:324
776 24669-24677 Gene denotes thrombin Gene:2147
777 24686-24690 Gene denotes PAR1 Gene:2149
778 24332-24335 Gene denotes APC Gene:324
779 24063-24066 Gene denotes APC Gene:324
780 24292-24300 Gene denotes Thrombin Gene:2147
781 24317-24322 Chemical denotes Arg41
782 24352-24357 Chemical denotes Arg41
783 24362-24367 Chemical denotes Arg46
784 23886-23895 Disease denotes infection MESH:D007239
785 24550-24559 Disease denotes pneumonia MESH:D011014
814 24797-24801 Gene denotes PAR1 Gene:14062
815 24834-24838 Gene denotes PAR1 Gene:14062
816 24907-24915 Gene denotes thrombin Gene:14061
817 24978-24982 Gene denotes PAR1 Gene:2149
818 25126-25130 Gene denotes PAR1 Gene:14062
819 25187-25190 Gene denotes TNF Gene:21926
820 25192-25197 Gene denotes IL-1β Gene:16175
821 25199-25227 Gene denotes C-C motif chemokine ligand 2 Gene:20296
822 25229-25233 Gene denotes CCL2 Gene:20296
823 25239-25243 Gene denotes CCL7 Gene:20306
824 25440-25444 Gene denotes PAR1 Gene:2149
825 25545-25549 Gene denotes PAR1 Gene:2149
826 25663-25667 Gene denotes PAR1 Gene:2149
827 24808-24812 Species denotes mice Tax:10090
828 24951-24964 Species denotes S. pneumoniae Tax:1313
829 24992-24996 Species denotes mice Tax:10090
830 25367-25373 Species denotes Murine Tax:10090
831 25412-25421 Species denotes influenza Tax:11320
832 25142-25151 Chemical denotes vorapaxar MESH:C530299
833 24739-24745 Disease denotes sepsis MESH:D018805
834 24873-24890 Disease denotes thrombocytopaenia
835 24965-24974 Disease denotes pneumonia MESH:D011014
836 25027-25038 Disease denotes lung injury MESH:D055370
837 25160-25185 Disease denotes neutrophilic inflammation MESH:D007249
838 25385-25400 Disease denotes viral infection MESH:D001102
839 25559-25571 Disease denotes inflammation MESH:D007249
840 25586-25595 Disease denotes mortality MESH:D003643
841 25718-25736 Disease denotes hyper-inflammatory MESH:D007249
843 25964-25972 Disease denotes COVID-19 MESH:C000657245
868 26447-26455 Gene denotes thrombin Gene:2147
869 27311-27320 Gene denotes factor Xa Gene:2159
870 26127-26135 Species denotes patients Tax:9606
871 26206-26216 Species denotes SARS-COV-2 Tax:2697049
872 26370-26378 Species denotes patients Tax:9606
873 26502-26510 Species denotes patients Tax:9606
874 27113-27121 Species denotes patients Tax:9606
875 27148-27156 Species denotes patients Tax:9606
876 27345-27353 Species denotes patients Tax:9606
877 26329-26336 Chemical denotes heparin MESH:D006493
878 26477-26481 Chemical denotes LMWH MESH:D006495
879 26699-26703 Chemical denotes LMWH MESH:D006495
880 27028-27032 Chemical denotes LMWH MESH:D006495
881 27248-27252 Chemical denotes LMWH MESH:D006495
882 27279-27286 Chemical denotes heparin MESH:D006493
883 26007-26015 Disease denotes COVID-19 MESH:C000657245
884 26217-26226 Disease denotes infection MESH:D007239
885 26280-26304 Disease denotes thrombotic complications MESH:D013927
886 26405-26413 Disease denotes COVID-19 MESH:C000657245
887 26574-26586 Disease denotes inflammation MESH:D007249
888 26601-26609 Disease denotes bleeding MESH:D006470
889 26885-26893 Disease denotes COVID-19 MESH:C000657245
890 27010-27018 Disease denotes COVID-19 MESH:C000657245
891 27127-27135 Disease denotes COVID-19 MESH:C000657245
917 27753-27761 Gene denotes thrombin Gene:2147
918 27766-27775 Gene denotes factor Xa Gene:2159
919 27838-27846 Species denotes patients Tax:9606
920 27962-27970 Species denotes patients Tax:9606
921 28398-28406 Species denotes patients Tax:9606
922 28490-28498 Species denotes patients Tax:9606
923 28007-28018 Chemical denotes rivaroxaban MESH:D000069552
924 28023-28031 Chemical denotes apixaban MESH:C522181
925 28151-28155 Chemical denotes LMWH MESH:D006495
926 28417-28424 Chemical denotes heparin MESH:D006493
927 28601-28613 Chemical denotes idarucizumab MESH:C000594745
928 28671-28681 Chemical denotes dabigatran MESH:D000069604
929 28686-28697 Chemical denotes rivaroxaban MESH:D000069552
930 28698-28706 Chemical denotes apixaban MESH:C522181
931 28186-28194 Disease denotes bleeding MESH:D006470
932 28234-28242 Disease denotes COVID-19 MESH:C000657245
933 28269-28277 Disease denotes bleeding MESH:D006470
934 28367-28375 Disease denotes bleeding MESH:D006470
935 28383-28397 Disease denotes critically ill MESH:D016638
936 28450-28472 Disease denotes bleeding complications MESH:D006470
937 28520-28525 Disease denotes death MESH:D003643
938 28531-28539 Disease denotes COVID-19 MESH:C000657245
939 28575-28581 Disease denotes sepsis MESH:D018805
940 28582-28586 Disease denotes ARDS MESH:D012128
941 28801-28809 Disease denotes bleeding MESH:D006470
959 28817-28820 Gene denotes APC Gene:324
960 29217-29220 Gene denotes APC Gene:324
961 29019-29022 Gene denotes APC Gene:324
962 29421-29424 Gene denotes tPA Gene:100128998
963 28901-28909 Species denotes patients Tax:9606
964 28966-28973 Species denotes patient Tax:9606
965 29064-29072 Species denotes patients Tax:9606
966 29295-29303 Species denotes patients Tax:9606
967 28938-28943 Disease denotes death MESH:D003643
968 29045-29053 Disease denotes COVID-19 MESH:C000657245
969 29127-29135 Disease denotes COVID-19 MESH:C000657245
970 29181-29186 Disease denotes death MESH:D003643
971 29264-29273 Disease denotes mortality MESH:D003643
972 29290-29294 Disease denotes ARDS MESH:D012128
973 29357-29365 Disease denotes COVID-19 MESH:C000657245
974 29485-29507 Disease denotes pulmonary microthrombi MESH:D008171
975 29512-29523 Disease denotes lung injury MESH:D055370
1000 29535-29539 Gene denotes PAR1 Gene:2149
1001 29629-29637 Gene denotes thrombin Gene:2147
1002 29728-29732 Gene denotes PAR1 Gene:2149
1003 30050-30058 Gene denotes thrombin Gene:2147
1004 30391-30395 Gene denotes PAR1 Gene:2149
1005 30540-30544 Gene denotes PAR1 Gene:2149
1006 30937-30941 Gene denotes PAR1 Gene:2149
1007 30683-30691 Species denotes patients Tax:9606
1008 30889-30897 Species denotes patients Tax:9606
1009 31051-31059 Species denotes patients Tax:9606
1010 30470-30479 Chemical denotes vorapaxar MESH:C530299
1011 30493-30502 Chemical denotes Vorapaxar MESH:C530299
1012 29771-29774 Disease denotes VTE MESH:D054556
1013 29813-29831 Disease denotes COVID-19 pneumonia MESH:C000657245
1014 29952-29978 Disease denotes cerebral artery thrombosis MESH:D020767
1015 30184-30207 Disease denotes ARDS pulmonary fibrosis MESH:D011658
1016 30286-30302 Disease denotes pulmonary oedema MESH:D011654
1017 30369-30381 Disease denotes inflammation MESH:D007249
1018 30668-30682 Disease denotes critically ill MESH:D016638
1019 30854-30862 Disease denotes bleeding MESH:D006470
1020 31071-31087 Disease denotes critical illness MESH:D016638
1021 31262-31271 Disease denotes pneumonia MESH:D011014
1022 31273-31284 Disease denotes lung injury MESH:D055370
1023 31289-31295 Disease denotes sepsis MESH:D018805
1051 31578-31582 Gene denotes TFPI Gene:7035
1052 33164-33169 Gene denotes PAR-1 Gene:2149
1053 32932-32942 Gene denotes Fibrinogen Gene:2244
1054 31563-31576 Gene denotes Tissue factor Gene:2152
1055 32025-32033 Gene denotes Thrombin Gene:2147
1056 32196-32203 Chemical denotes heparin MESH:D006493
1057 32343-32350 Chemical denotes Heparin MESH:D006493
1058 31547-31555 Disease denotes COVID-19 MESH:C000657245
1059 31674-31686 Disease denotes Inflammation MESH:D007249
1060 31732-31744 Disease denotes Inflammation MESH:D007249
1061 31812-31821 Disease denotes Mortality MESH:D003643
1062 31870-31878 Disease denotes bleeding MESH:D006470
1063 31900-31944 Disease denotes Factor X RivaroxabanApixabanƒ Inflammation MESH:D007249
1064 32111-32120 Disease denotes Mortality MESH:D003643
1065 32148-32157 Disease denotes mortality MESH:D003643
1066 32209-32221 Disease denotes Inflammation MESH:D007249
1067 32249-32257 Disease denotes bleeding MESH:D006470
1068 32404-32413 Disease denotes Mortality MESH:D003643
1069 32527-32539 Disease denotes Inflammation MESH:D007249
1070 32634-32657 Disease denotes APC rhAPC Coagulation MESH:D001778
1071 32725-32737 Disease denotes Inflammation MESH:D007249
1072 32767-32778 Disease denotes Lung injury MESH:D055370
1073 32828-32837 Disease denotes Mortality MESH:D003643
1074 32873-32881 Disease denotes Fibrosis MESH:D005355
1075 32992-33001 Disease denotes Mortality MESH:D003643
1076 33040-33052 Disease denotes Inflammation MESH:D007249
1077 33229-33241 Disease denotes Inflammation MESH:D007249
1101 33335-33339 Gene denotes TFPI Gene:7035
1102 33341-33354 Gene denotes tissue factor Gene:2152
1103 33425-33428 Gene denotes APC Gene:324
1104 33435-33468 Gene denotes tissue-type plasminogen activator Gene:5327
1105 33470-33473 Gene denotes uPA Gene:5328
1106 33475-33511 Gene denotes urokinase-type plasminogen activator Gene:5328
1107 33513-33518 Gene denotes PAR-1 Gene:2149
1108 33520-33551 Gene denotes proteinase-activated receptor-1 Gene:2149
1109 33591-33595 Gene denotes TFPI Gene:7035
1110 33776-33780 Gene denotes TFPI Gene:7035
1111 33865-33869 Gene denotes TFPI Gene:7035
1112 33430-33433 Gene denotes tPA Gene:100128998
1113 33419-33424 Species denotes human Tax:9606
1114 33642-33650 Species denotes patients Tax:9606
1115 33684-33691 Chemical denotes heparin MESH:D006493
1116 33813-33820 Chemical denotes heparin MESH:D006493
1117 34027-34034 Chemical denotes heparin MESH:D006493
1118 33578-33587 Disease denotes mortality MESH:D003643
1119 33632-33641 Disease denotes pneumonia MESH:D011014
1120 33763-33772 Disease denotes mortality MESH:D003643
1121 33852-33861 Disease denotes mortality MESH:D003643
1122 33909-33918 Disease denotes mortality MESH:D003643
1123 33957-33965 Disease denotes bleeding MESH:D006470
1141 34529-34534 Species denotes human Tax:9606
1142 35080-35088 Species denotes patients Tax:9606
1143 34219-34228 Disease denotes pneumonia MESH:D011014
1144 34233-34244 Disease denotes lung injury MESH:D055370
1145 34344-34356 Disease denotes inflammation MESH:D007249
1146 34375-34394 Disease denotes pulmonary infection MESH:D012141
1147 34396-34402 Disease denotes sepsis MESH:D018805
1148 34407-34418 Disease denotes lung injury MESH:D055370
1149 34605-34614 Disease denotes pneumonia MESH:D011014
1150 34622-34628 Disease denotes sepsis MESH:D018805
1151 34668-34677 Disease denotes mortality MESH:D003643
1152 34706-34714 Disease denotes COVID-19 MESH:C000657245
1153 34803-34832 Disease denotes macrothrombi and microthrombi
1154 35008-35014 Disease denotes sepsis MESH:D018805
1155 35094-35112 Disease denotes COVID-19 pneumonia MESH:C000657245
1156 35164-35176 Disease denotes inflammation MESH:D007249
1157 35188-35191 Disease denotes VTE MESH:D054556
1159 35609-35617 Disease denotes Williams MESH:D018980

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T1 10-21 http://purl.obolibrary.org/obo/GO_0050817 denotes coagulation
T2 107-118 http://purl.obolibrary.org/obo/GO_0050817 denotes Coagulation
T3 531-543 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T4 832-841 http://purl.obolibrary.org/obo/GO_0009058 denotes formation
T5 886-897 http://purl.obolibrary.org/obo/GO_0050817 denotes coagulation
T6 962-984 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammatory responses
T7 989-1014 http://purl.obolibrary.org/obo/GO_0050820 denotes activation of coagulation
T8 1003-1014 http://purl.obolibrary.org/obo/GO_0050817 denotes coagulation
T9 1153-1168 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T10 2664-2676 http://purl.obolibrary.org/obo/GO_0009405 denotes pathogenesis
T11 3108-3137 http://purl.obolibrary.org/obo/GO_0050820 denotes activation of the coagulation
T12 3126-3137 http://purl.obolibrary.org/obo/GO_0050817 denotes coagulation
T13 3393-3404 http://purl.obolibrary.org/obo/GO_0050817 denotes coagulation
T14 3528-3557 http://purl.obolibrary.org/obo/GO_0050820 denotes activation of the coagulation
T15 3546-3557 http://purl.obolibrary.org/obo/GO_0050817 denotes coagulation
T16 4530-4551 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammatory response
T17 4772-4784 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T18 4918-4940 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammatory responses
T19 5543-5564 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammatory response
T20 5587-5612 http://purl.obolibrary.org/obo/GO_0050820 denotes activation of coagulation
T21 5601-5612 http://purl.obolibrary.org/obo/GO_0050817 denotes coagulation
T22 5625-5637 http://purl.obolibrary.org/obo/GO_0042730 denotes fibrinolysis
T23 5882-5890 http://purl.obolibrary.org/obo/GO_0070265 denotes necrosis
T24 5882-5890 http://purl.obolibrary.org/obo/GO_0019835 denotes necrosis
T25 5882-5890 http://purl.obolibrary.org/obo/GO_0008219 denotes necrosis
T26 5882-5890 http://purl.obolibrary.org/obo/GO_0001906 denotes necrosis
T27 5999-6010 http://purl.obolibrary.org/obo/GO_0050817 denotes coagulation
T28 6028-6057 http://purl.obolibrary.org/obo/GO_0050820 denotes Activation of the coagulation
T29 6046-6057 http://purl.obolibrary.org/obo/GO_0050817 denotes coagulation
T30 6134-6146 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T31 6259-6267 http://purl.obolibrary.org/obo/GO_0015297 denotes exchange
T32 6359-6384 http://purl.obolibrary.org/obo/GO_0050820 denotes activation of coagulation
T33 6373-6384 http://purl.obolibrary.org/obo/GO_0050817 denotes coagulation
T34 6442-6454 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T35 6559-6571 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T36 6691-6699 http://purl.obolibrary.org/obo/GO_0050817 denotes clotting
T37 6711-6722 http://purl.obolibrary.org/obo/GO_0050817 denotes coagulation
T38 6743-6765 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammatory responses
T39 6953-6978 http://purl.obolibrary.org/obo/GO_0050820 denotes activation of coagulation
T40 6967-6978 http://purl.obolibrary.org/obo/GO_0050817 denotes coagulation
T41 7160-7182 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammatory responses
T42 7193-7218 http://purl.obolibrary.org/obo/GO_0050820 denotes activation of coagulation
T43 7207-7218 http://purl.obolibrary.org/obo/GO_0050817 denotes coagulation
T44 7480-7491 http://purl.obolibrary.org/obo/GO_0050817 denotes coagulation
T45 7520-7532 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T46 7980-7991 http://purl.obolibrary.org/obo/GO_0050817 denotes coagulation
T47 7992-8004 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T48 8037-8066 http://purl.obolibrary.org/obo/GO_0050820 denotes Activation of the coagulation
T49 8055-8066 http://purl.obolibrary.org/obo/GO_0050817 denotes coagulation
T50 8197-8218 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammatory response
T51 8653-8662 http://purl.obolibrary.org/obo/GO_0009058 denotes formation
T52 8720-8751 http://purl.obolibrary.org/obo/GO_0042118 denotes endothelial cells and activates
T53 8752-8762 http://purl.obolibrary.org/obo/GO_0004175 denotes proteinase
T54 8872-8882 http://purl.obolibrary.org/obo/GO_0023052 denotes signalling
T55 9022-9032 http://purl.obolibrary.org/obo/GO_0023052 denotes signalling
T56 9166-9174 http://purl.obolibrary.org/obo/GO_0070265 denotes necrosis
T57 9166-9174 http://purl.obolibrary.org/obo/GO_0019835 denotes necrosis
T58 9166-9174 http://purl.obolibrary.org/obo/GO_0008219 denotes necrosis
T59 9166-9174 http://purl.obolibrary.org/obo/GO_0001906 denotes necrosis
T60 9227-9248 http://purl.obolibrary.org/obo/GO_0031639 denotes plasminogen activator
T61 9278-9299 http://purl.obolibrary.org/obo/GO_0031639 denotes plasminogen activator
T62 9321-9342 http://purl.obolibrary.org/obo/GO_0031639 denotes plasminogen activator
T63 9394-9405 http://purl.obolibrary.org/obo/GO_0009056 denotes degradation
T64 9535-9547 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T65 9988-9999 http://purl.obolibrary.org/obo/GO_0050817 denotes coagulation
T66 10099-10120 http://purl.obolibrary.org/obo/GO_0050820 denotes activates coagulation
T67 10109-10120 http://purl.obolibrary.org/obo/GO_0050817 denotes coagulation
T68 10214-10225 http://purl.obolibrary.org/obo/GO_0050817 denotes coagulation
T69 10229-10251 http://purl.obolibrary.org/obo/GO_0050820 denotes activating coagulation
T70 10240-10251 http://purl.obolibrary.org/obo/GO_0050817 denotes coagulation
T71 10509-10534 http://purl.obolibrary.org/obo/GO_0050820 denotes activation of coagulation
T72 10523-10534 http://purl.obolibrary.org/obo/GO_0050817 denotes coagulation
T73 10741-10751 http://purl.obolibrary.org/obo/GO_0004175 denotes proteinase
T74 10964-10976 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T75 11170-11182 http://purl.obolibrary.org/obo/GO_0009405 denotes pathogenesis
T76 11384-11395 http://purl.obolibrary.org/obo/GO_0050817 denotes coagulation
T77 11502-11513 http://purl.obolibrary.org/obo/GO_0050817 denotes coagulation
T78 12018-12030 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T79 12608-12620 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T80 13324-13336 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T81 13440-13469 http://purl.obolibrary.org/obo/GO_0050820 denotes Activation of the coagulation
T82 13458-13469 http://purl.obolibrary.org/obo/GO_0050817 denotes coagulation
T83 13566-13577 http://purl.obolibrary.org/obo/GO_0050817 denotes coagulation
T84 15043-15054 http://purl.obolibrary.org/obo/GO_0006412 denotes translation
T85 15933-15945 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T86 16261-16272 http://purl.obolibrary.org/obo/GO_0050817 denotes coagulation
T87 16403-16414 http://purl.obolibrary.org/obo/GO_0050817 denotes coagulation
T88 17536-17547 http://purl.obolibrary.org/obo/GO_0050817 denotes coagulation
T89 18158-18169 http://purl.obolibrary.org/obo/GO_0050817 denotes coagulation
T90 19399-19421 http://purl.obolibrary.org/obo/GO_0050819 denotes anticoagulant activity
T91 20001-20023 http://purl.obolibrary.org/obo/GO_0031639 denotes plasminogen activators
T92 20028-20049 http://purl.obolibrary.org/obo/GO_0031639 denotes plasminogen activator
T93 20169-20180 http://purl.obolibrary.org/obo/GO_0004175 denotes proteinases
T94 20193-20214 http://purl.obolibrary.org/obo/GO_0031639 denotes plasminogen activator
T95 20239-20260 http://purl.obolibrary.org/obo/GO_0031639 denotes plasminogen activator
T96 20785-20825 http://purl.obolibrary.org/obo/GO_0030377 denotes urokinase plasminogen activator receptor
T97 21094-21106 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T98 21278-21290 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T99 21401-21413 http://purl.obolibrary.org/obo/GO_0042730 denotes fibrinolysis
T100 21426-21438 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T101 21547-21559 http://purl.obolibrary.org/obo/GO_0042730 denotes fibrinolysis
T102 21674-21686 http://purl.obolibrary.org/obo/GO_0042730 denotes fibrinolysis
T103 22251-22262 http://purl.obolibrary.org/obo/GO_0050817 denotes coagulation
T104 22267-22279 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T105 22392-22403 http://purl.obolibrary.org/obo/GO_0050817 denotes coagulation
T106 22404-22415 http://purl.obolibrary.org/obo/GO_0004175 denotes proteinases
T107 22580-22591 http://purl.obolibrary.org/obo/GO_0006508 denotes proteolysis
T108 23261-23267 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T109 23322-23342 http://purl.obolibrary.org/obo/GO_0045321 denotes leukocyte activation
T110 23407-23417 http://purl.obolibrary.org/obo/GO_0023052 denotes signalling
T111 23530-23541 http://purl.obolibrary.org/obo/GO_0004175 denotes proteinases
T112 23602-23613 http://purl.obolibrary.org/obo/GO_0004175 denotes proteinases
T113 23703-23713 http://purl.obolibrary.org/obo/GO_0023052 denotes signalling
T114 23836-23846 http://purl.obolibrary.org/obo/GO_0023052 denotes signalling
T115 23927-23937 http://purl.obolibrary.org/obo/GO_0023052 denotes signalling
T116 23995-24005 http://purl.obolibrary.org/obo/GO_0023052 denotes signalling
T117 25173-25185 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T118 25252-25263 http://purl.obolibrary.org/obo/GO_0050817 denotes coagulation
T119 25264-25301 http://purl.obolibrary.org/obo/GO_0043117 denotes activation; and vascular permeability
T120 25385-25400 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infection
T121 25506-25523 http://purl.obolibrary.org/obo/GO_0019079 denotes viral replication
T122 25506-25523 http://purl.obolibrary.org/obo/GO_0019058 denotes viral replication
T123 25559-25571 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T124 25724-25746 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammatory responses
T125 25949-25960 http://purl.obolibrary.org/obo/GO_0050817 denotes coagulation
T126 26074-26085 http://purl.obolibrary.org/obo/GO_0050817 denotes coagulation
T127 26551-26561 http://purl.obolibrary.org/obo/GO_0023052 denotes signalling
T128 26574-26586 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T129 26947-26968 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammatory response
T130 27455-27466 http://purl.obolibrary.org/obo/GO_0050817 denotes coagulation
T131 27467-27478 http://purl.obolibrary.org/obo/GO_0004175 denotes proteinases
T132 29313-29325 http://purl.obolibrary.org/obo/GO_0042730 denotes fibrinolysis
T133 29638-29647 http://purl.obolibrary.org/obo/GO_0009058 denotes formation
T134 29699-29710 http://purl.obolibrary.org/obo/GO_0050817 denotes coagulation
T135 30016-30035 http://purl.obolibrary.org/obo/GO_0007165 denotes signalling pathways
T136 30016-30026 http://purl.obolibrary.org/obo/GO_0023052 denotes signalling
T137 30083-30105 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammatory responses
T138 30334-30345 http://purl.obolibrary.org/obo/GO_0050817 denotes coagulation
T139 30369-30381 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T140 31235-31246 http://purl.obolibrary.org/obo/GO_0050817 denotes coagulation
T141 31247-31258 http://purl.obolibrary.org/obo/GO_0004175 denotes proteinases
T142 31398-31409 http://purl.obolibrary.org/obo/GO_0050817 denotes coagulation
T143 31584-31595 http://purl.obolibrary.org/obo/GO_0050817 denotes Coagulation
T144 31632-31643 http://purl.obolibrary.org/obo/GO_0050817 denotes Coagulation
T145 31674-31686 http://purl.obolibrary.org/obo/GO_0006954 denotes Inflammation
T146 31732-31744 http://purl.obolibrary.org/obo/GO_0006954 denotes Inflammation
T147 31932-31944 http://purl.obolibrary.org/obo/GO_0006954 denotes Inflammation
T148 32073-32084 http://purl.obolibrary.org/obo/GO_0050817 denotes Coagulation
T149 32209-32221 http://purl.obolibrary.org/obo/GO_0006954 denotes Inflammation
T150 32352-32363 http://purl.obolibrary.org/obo/GO_0050817 denotes Coagulation
T151 32527-32539 http://purl.obolibrary.org/obo/GO_0006954 denotes Inflammation
T152 32646-32657 http://purl.obolibrary.org/obo/GO_0050817 denotes Coagulation
T153 32688-32699 http://purl.obolibrary.org/obo/GO_0050817 denotes Coagulation
T154 32725-32737 http://purl.obolibrary.org/obo/GO_0006954 denotes Inflammation
T155 32952-32963 http://purl.obolibrary.org/obo/GO_0050817 denotes Coagulation
T156 33040-33052 http://purl.obolibrary.org/obo/GO_0006954 denotes Inflammation
T157 33131-33143 http://purl.obolibrary.org/obo/GO_0042730 denotes Fibrinolysis
T158 33191-33202 http://purl.obolibrary.org/obo/GO_0050817 denotes Coagulation
T159 33229-33241 http://purl.obolibrary.org/obo/GO_0006954 denotes Inflammation
T160 33447-33468 http://purl.obolibrary.org/obo/GO_0031639 denotes plasminogen activator
T161 33490-33511 http://purl.obolibrary.org/obo/GO_0031639 denotes plasminogen activator
T162 33520-33530 http://purl.obolibrary.org/obo/GO_0004175 denotes proteinase
T163 34182-34193 http://purl.obolibrary.org/obo/GO_0050817 denotes coagulation
T164 34194-34205 http://purl.obolibrary.org/obo/GO_0004175 denotes proteinases
T165 34328-34339 http://purl.obolibrary.org/obo/GO_0050817 denotes coagulation
T166 34344-34356 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T167 34502-34513 http://purl.obolibrary.org/obo/GO_0006412 denotes translation
T168 34936-34947 http://purl.obolibrary.org/obo/GO_0050817 denotes coagulation
T169 34992-35003 http://purl.obolibrary.org/obo/GO_0050817 denotes coagulation
T170 35141-35152 http://purl.obolibrary.org/obo/GO_0050817 denotes coagulation
T171 35164-35176 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation

MyTest

Id Subject Object Predicate Lexical cue
33004529-19608588-29392975 3011-3012 19608588 denotes 5
33004529-32007143-29392976 3348-3349 32007143 denotes 6
33004529-32171076-29392976 3348-3349 32171076 denotes 6
33004529-32073213-29392976 3348-3349 32073213 denotes 6
33004529-21454038-29392976 3348-3349 21454038 denotes 6
33004529-32073213-29392977 3478-3479 32073213 denotes 8
33004529-32073213-29392978 3749-3750 32073213 denotes 8
33004529-32353746-29392979 3756-3758 32353746 denotes 11
33004529-32437596-29392980 3814-3816 32437596 denotes 12
33004529-32745993-29392981 4178-4180 32745993 denotes 13
33004529-32437596-29392982 5336-5338 32437596 denotes 12
33004529-32607467-29392983 5516-5518 32607467 denotes 14
33004529-32361250-29392984 5930-5932 32361250 denotes 16
33004529-2050700-29392985 6020-6022 2050700 denotes 17
33004529-11722403-29392985 6020-6022 11722403 denotes 17
33004529-15115872-29392986 6269-6271 15115872 denotes 20
33004529-22417886-29392987 6336-6338 22417886 denotes 21
33004529-15891319-29392988 6340-6342 15891319 denotes 22
33004529-21454038-29392989 7106-7107 21454038 denotes 9
33004529-17041861-29392990 7109-7111 17041861 denotes 23
33004529-14760153-29392991 9603-9605 14760153 denotes 25
33004529-17356058-29392992 9607-9609 17356058 denotes 26
33004529-19700643-29392993 9884-9886 19700643 denotes 27
33004529-10051638-29392993 9884-9886 10051638 denotes 27
33004529-22728467-29392993 9884-9886 22728467 denotes 27
33004529-10673185-29392994 10074-10076 10673185 denotes 30
33004529-18403723-29392995 10078-10080 18403723 denotes 31
33004529-17567444-29392996 10613-10615 17567444 denotes 32
33004529-17951326-29392997 10617-10619 17951326 denotes 33
33004529-22802281-29392998 11133-11135 22802281 denotes 34
33004529-11734456-29392999 12057-12059 11734456 denotes 35
33004529-12034563-29393000 12061-12063 12034563 denotes 36
33004529-11700399-29393001 12329-12331 11700399 denotes 37
33004529-32253759-29393002 12333-12335 32253759 denotes 38
33004529-12851279-29393003 12622-12624 12851279 denotes 39
33004529-19284881-29393004 12924-12926 19284881 denotes 40
33004529-21297074-29393005 13055-13057 21297074 denotes 41
33004529-18090375-29393006 13898-13900 18090375 denotes 42
33004529-2221583-29393006 13898-13900 2221583 denotes 42
33004529-8726231-29393006 13898-13900 8726231 denotes 42
33004529-19740417-29393006 13898-13900 19740417 denotes 42
33004529-18090375-29393007 14179-14181 18090375 denotes 42
33004529-19740417-29393008 14183-14185 19740417 denotes 46
33004529-11597289-29393009 14352-14354 11597289 denotes 47
33004529-30477976-29393010 15745-15747 30477976 denotes 48
33004529-27975101-29393011 15814-15816 27975101 denotes 49
33004529-21887302-29393012 15818-15820 21887302 denotes 50
33004529-18090375-29393013 15978-15980 18090375 denotes 42
33004529-18460218-29393014 16191-16193 18460218 denotes 51
33004529-20937093-29393014 16191-16193 20937093 denotes 51
33004529-26673586-29393014 16191-16193 26673586 denotes 51
33004529-15550023-29393015 16386-16388 15550023 denotes 54
33004529-16215381-29393015 16386-16388 16215381 denotes 54
33004529-9198130-29393016 16717-16719 9198130 denotes 57
33004529-9198130-29393017 16839-16841 9198130 denotes 57
33004529-14592828-29393018 16843-16845 14592828 denotes 58
33004529-3102560-29393019 17022-17024 3102560 denotes 59
33004529-8555486-29393019 17022-17024 8555486 denotes 59
33004529-11401891-29393019 17022-17024 11401891 denotes 59
33004529-19740417-29393020 17359-17361 19740417 denotes 46
33004529-19740417-29393021 17416-17418 19740417 denotes 46
33004529-15891319-29393022 17967-17969 15891319 denotes 22
33004529-17278083-29393023 18132-18134 17278083 denotes 62
33004529-23433188-29393024 18241-18243 23433188 denotes 63
33004529-24632673-29393025 18245-18247 24632673 denotes 64
33004529-18565951-29393026 18354-18356 18565951 denotes 65
33004529-16192478-29393027 18411-18413 16192478 denotes 66
33004529-23826709-29393028 19018-19020 23826709 denotes 68
33004529-17893198-29393029 19423-19425 17893198 denotes 69
33004529-17893198-29393030 19539-19541 17893198 denotes 69
33004529-32302438-29393031 19628-19630 32302438 denotes 70
33004529-10673185-29393032 20366-20368 10673185 denotes 30
33004529-15516673-29393033 20370-20372 15516673 denotes 71
33004529-12702502-29393034 20374-20376 12702502 denotes 72
33004529-17032919-29393035 20633-20635 17032919 denotes 73
33004529-12702502-29393036 20726-20728 12702502 denotes 72
33004529-23408962-29393037 20767-20769 23408962 denotes 74
33004529-11907112-29393038 20969-20971 11907112 denotes 75
33004529-9667494-29393039 21108-21110 9667494 denotes 76
33004529-23555246-29393040 21292-21294 23555246 denotes 77
33004529-30177934-29393041 21481-21483 30177934 denotes 78
33004529-10673185-29393042 21786-21788 10673185 denotes 30
33004529-31262641-29393043 21956-21958 31262641 denotes 79
33004529-24186921-29393044 23003-23005 24186921 denotes 80
33004529-12052963-29393045 23061-23063 12052963 denotes 81
33004529-10194379-29393046 23075-23077 10194379 denotes 82
33004529-15707890-29393047 23109-23111 15707890 denotes 83
33004529-24186921-29393048 23162-23164 24186921 denotes 80
33004529-11888681-29393049 23373-23375 11888681 denotes 84
33004529-11359654-29393050 23377-23379 11359654 denotes 85
33004529-19141861-29393051 23543-23545 19141861 denotes 86
33004529-17395891-29393052 23736-23738 17395891 denotes 87
33004529-19141861-29393053 23870-23872 19141861 denotes 86
33004529-15626732-29393054 23874-23876 15626732 denotes 88
33004529-15665002-29393055 24151-24153 15665002 denotes 89
33004529-19350118-29393056 24155-24157 19350118 denotes 90
33004529-22712885-29393057 24460-24462 22712885 denotes 91
33004529-23149848-29393058 24464-24466 23149848 denotes 92
33004529-17965715-29393059 24803-24805 17965715 denotes 93
33004529-17965715-29393060 24946-24948 17965715 denotes 93
33004529-25948816-29393061 25109-25111 25948816 denotes 94
33004529-23391721-29393062 25423-25425 23391721 denotes 95
33004529-23202729-29393063 25427-25429 23202729 denotes 96
33004529-32407672-29393064 26415-26417 32407672 denotes 98
33004529-32073213-29393065 27020-27021 32073213 denotes 8
33004529-32302438-29393066 27023-27025 32302438 denotes 70
33004529-32407672-29393067 27401-27403 32407672 denotes 98
33004529-20973685-29393068 27694-27697 20973685 denotes 100
33004529-31262641-29393069 29305-29307 31262641 denotes 79
33004529-22443427-29393070 29980-29983 22443427 denotes 103
33004529-15855637-29393071 30209-30212 15855637 denotes 104
33004529-19286091-29393072 30633-30636 19286091 denotes 105
33004529-22742648-29393073 30638-30641 22742648 denotes 106

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T1 52-61 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T2 86-95 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T3 100-106 Phenotype denotes sepsis http://purl.obolibrary.org/obo/HP_0100806
T4 149-158 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T5 588-597 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T6 658-667 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T7 672-678 Phenotype denotes sepsis http://purl.obolibrary.org/obo/HP_0100806
T8 859-897 Phenotype denotes disseminated intravascular coagulation http://purl.obolibrary.org/obo/HP_0005521
T9 1051-1060 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T10 1065-1071 Phenotype denotes sepsis http://purl.obolibrary.org/obo/HP_0100806
T11 1438-1447 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T12 1449-1455 Phenotype denotes sepsis http://purl.obolibrary.org/obo/HP_0100806
T13 1466-1486 Phenotype denotes respiratory distress http://purl.obolibrary.org/obo/HP_0002098
T14 1695-1704 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T15 1709-1715 Phenotype denotes sepsis http://purl.obolibrary.org/obo/HP_0100806
T16 2696-2705 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T17 2753-2762 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T18 2789-2796 Phenotype denotes hypoxia http://purl.obolibrary.org/obo/HP_0012418
T19 3031-3040 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T20 3062-3071 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T21 3252-3268 Phenotype denotes elevated D-dimer http://purl.obolibrary.org/obo/HP_0033106
T22 3366-3404 Phenotype denotes disseminated intravascular coagulation http://purl.obolibrary.org/obo/HP_0005521
T23 3633-3647 Phenotype denotes thromboembolic http://purl.obolibrary.org/obo/HP_0001907
T24 3663-3669 Phenotype denotes stroke http://purl.obolibrary.org/obo/HP_0001297
T25 3853-3860 Phenotype denotes hypoxia http://purl.obolibrary.org/obo/HP_0012418
T26 4249-4258 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T27 4618-4624 Phenotype denotes sepsis http://purl.obolibrary.org/obo/HP_0100806
T28 5097-5120 Phenotype denotes endothelial dysfunction http://purl.obolibrary.org/obo/HP_0032654
T29 5141-5150 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T30 5155-5161 Phenotype denotes sepsis http://purl.obolibrary.org/obo/HP_0100806
T31 5672-5684 Phenotype denotes prolonged PT http://purl.obolibrary.org/obo/HP_0008151
T32 5803-5812 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T33 5876-5881 Phenotype denotes tumor http://purl.obolibrary.org/obo/HP_0002664
T34 6298-6318 Phenotype denotes respiratory distress http://purl.obolibrary.org/obo/HP_0002098
T35 6816-6837 Phenotype denotes pulmonary infiltrates http://purl.obolibrary.org/obo/HP_0002113
T36 6907-6916 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T37 6921-6927 Phenotype denotes sepsis http://purl.obolibrary.org/obo/HP_0100806
T38 7267-7276 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T39 7281-7287 Phenotype denotes sepsis http://purl.obolibrary.org/obo/HP_0100806
T40 7347-7356 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T41 7358-7364 Phenotype denotes sepsis http://purl.obolibrary.org/obo/HP_0100806
T42 7480-7505 Phenotype denotes coagulation abnormalities http://purl.obolibrary.org/obo/HP_0001928
T43 7750-7759 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T44 7764-7770 Phenotype denotes sepsis http://purl.obolibrary.org/obo/HP_0100806
T45 7838-7847 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T46 9160-9165 Phenotype denotes tumor http://purl.obolibrary.org/obo/HP_0002664
T47 9583-9592 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T48 11190-11207 Phenotype denotes severe infections http://purl.obolibrary.org/obo/HP_0032169
T49 11331-11340 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T50 12162-12168 Phenotype denotes sepsis http://purl.obolibrary.org/obo/HP_0100806
T51 12272-12281 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T52 12421-12427 Phenotype denotes Sepsis http://purl.obolibrary.org/obo/HP_0100806
T53 12480-12486 Phenotype denotes sepsis http://purl.obolibrary.org/obo/HP_0100806
T54 12827-12836 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T55 13026-13035 Phenotype denotes Pneumonia http://purl.obolibrary.org/obo/HP_0002090
T56 13205-13211 Phenotype denotes sepsis http://purl.obolibrary.org/obo/HP_0100806
T57 13421-13430 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T58 13707-13716 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T59 14344-14350 Phenotype denotes sepsis http://purl.obolibrary.org/obo/HP_0100806
T60 15010-15019 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T61 15095-15101 Phenotype denotes sepsis http://purl.obolibrary.org/obo/HP_0100806
T62 15112-15121 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T63 15213-15222 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T64 15508-15517 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T65 15967-15976 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T66 16378-16384 Phenotype denotes sepsis http://purl.obolibrary.org/obo/HP_0100806
T67 16998-17004 Phenotype denotes sepsis http://purl.obolibrary.org/obo/HP_0100806
T68 17168-17178 Phenotype denotes pneumoniae http://purl.obolibrary.org/obo/HP_0002090
T69 17878-17884 Phenotype denotes sepsis http://purl.obolibrary.org/obo/HP_0100806
T70 17946-17965 Phenotype denotes respiratory failure http://purl.obolibrary.org/obo/HP_0002878
T71 18114-18119 Phenotype denotes shock http://purl.obolibrary.org/obo/HP_0031273
T72 18378-18384 Phenotype denotes sepsis http://purl.obolibrary.org/obo/HP_0100806
T73 18599-18605 Phenotype denotes sepsis http://purl.obolibrary.org/obo/HP_0100806
T74 18616-18621 Phenotype denotes shock http://purl.obolibrary.org/obo/HP_0031273
T75 18653-18658 Phenotype denotes Shock http://purl.obolibrary.org/obo/HP_0031273
T76 18743-18748 Phenotype denotes shock http://purl.obolibrary.org/obo/HP_0031273
T77 19117-19126 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T78 19524-19530 Phenotype denotes sepsis http://purl.obolibrary.org/obo/HP_0100806
T79 19742-19747 Phenotype denotes shock http://purl.obolibrary.org/obo/HP_0031273
T80 20355-20364 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T81 20465-20474 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T82 20547-20557 Phenotype denotes pneumoniae http://purl.obolibrary.org/obo/HP_0002090
T83 20558-20567 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T84 20714-20724 Phenotype denotes pneumoniae http://purl.obolibrary.org/obo/HP_0002090
T85 20756-20765 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T86 20864-20874 Phenotype denotes pneumoniae http://purl.obolibrary.org/obo/HP_0002090
T87 21173-21194 Phenotype denotes respiratory infection http://purl.obolibrary.org/obo/HP_0011947
T88 21363-21380 Phenotype denotes acute lung injury http://www.orpha.net/ORDO/Orphanet_178320
T89 21577-21594 Phenotype denotes severe infections http://purl.obolibrary.org/obo/HP_0032169
T90 24550-24559 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T91 24739-24745 Phenotype denotes sepsis http://purl.obolibrary.org/obo/HP_0100806
T92 24954-24964 Phenotype denotes pneumoniae http://purl.obolibrary.org/obo/HP_0002090
T93 24965-24974 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T94 28575-28581 Phenotype denotes sepsis http://purl.obolibrary.org/obo/HP_0100806
T95 29822-29831 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T96 29961-29978 Phenotype denotes artery thrombosis http://purl.obolibrary.org/obo/HP_0004420
T97 30189-30207 Phenotype denotes pulmonary fibrosis http://purl.obolibrary.org/obo/HP_0002206
T98 30286-30302 Phenotype denotes pulmonary oedema http://purl.obolibrary.org/obo/HP_0100598
T99 31262-31271 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T100 31289-31295 Phenotype denotes sepsis http://purl.obolibrary.org/obo/HP_0100806
T101 33632-33641 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T102 34219-34228 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T103 34375-34394 Phenotype denotes pulmonary infection http://purl.obolibrary.org/obo/HP_0006532
T104 34396-34402 Phenotype denotes sepsis http://purl.obolibrary.org/obo/HP_0100806
T105 34605-34614 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T106 34622-34628 Phenotype denotes sepsis http://purl.obolibrary.org/obo/HP_0100806
T107 35008-35014 Phenotype denotes sepsis http://purl.obolibrary.org/obo/HP_0100806
T108 35103-35112 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090

2_test

Id Subject Object Predicate Lexical cue
33004529-19608588-29392975 3011-3012 19608588 denotes 5
33004529-32007143-29392976 3348-3349 32007143 denotes 6
33004529-32171076-29392976 3348-3349 32171076 denotes 6
33004529-32073213-29392976 3348-3349 32073213 denotes 6
33004529-21454038-29392976 3348-3349 21454038 denotes 6
33004529-32073213-29392977 3478-3479 32073213 denotes 8
33004529-32073213-29392978 3749-3750 32073213 denotes 8
33004529-32353746-29392979 3756-3758 32353746 denotes 11
33004529-32437596-29392980 3814-3816 32437596 denotes 12
33004529-32745993-29392981 4178-4180 32745993 denotes 13
33004529-32437596-29392982 5336-5338 32437596 denotes 12
33004529-32607467-29392983 5516-5518 32607467 denotes 14
33004529-32361250-29392984 5930-5932 32361250 denotes 16
33004529-2050700-29392985 6020-6022 2050700 denotes 17
33004529-11722403-29392985 6020-6022 11722403 denotes 17
33004529-15115872-29392986 6269-6271 15115872 denotes 20
33004529-22417886-29392987 6336-6338 22417886 denotes 21
33004529-15891319-29392988 6340-6342 15891319 denotes 22
33004529-21454038-29392989 7106-7107 21454038 denotes 9
33004529-17041861-29392990 7109-7111 17041861 denotes 23
33004529-14760153-29392991 9603-9605 14760153 denotes 25
33004529-17356058-29392992 9607-9609 17356058 denotes 26
33004529-19700643-29392993 9884-9886 19700643 denotes 27
33004529-10051638-29392993 9884-9886 10051638 denotes 27
33004529-22728467-29392993 9884-9886 22728467 denotes 27
33004529-10673185-29392994 10074-10076 10673185 denotes 30
33004529-18403723-29392995 10078-10080 18403723 denotes 31
33004529-17567444-29392996 10613-10615 17567444 denotes 32
33004529-17951326-29392997 10617-10619 17951326 denotes 33
33004529-22802281-29392998 11133-11135 22802281 denotes 34
33004529-11734456-29392999 12057-12059 11734456 denotes 35
33004529-12034563-29393000 12061-12063 12034563 denotes 36
33004529-11700399-29393001 12329-12331 11700399 denotes 37
33004529-32253759-29393002 12333-12335 32253759 denotes 38
33004529-12851279-29393003 12622-12624 12851279 denotes 39
33004529-19284881-29393004 12924-12926 19284881 denotes 40
33004529-21297074-29393005 13055-13057 21297074 denotes 41
33004529-18090375-29393006 13898-13900 18090375 denotes 42
33004529-2221583-29393006 13898-13900 2221583 denotes 42
33004529-8726231-29393006 13898-13900 8726231 denotes 42
33004529-19740417-29393006 13898-13900 19740417 denotes 42
33004529-18090375-29393007 14179-14181 18090375 denotes 42
33004529-19740417-29393008 14183-14185 19740417 denotes 46
33004529-11597289-29393009 14352-14354 11597289 denotes 47
33004529-30477976-29393010 15745-15747 30477976 denotes 48
33004529-27975101-29393011 15814-15816 27975101 denotes 49
33004529-21887302-29393012 15818-15820 21887302 denotes 50
33004529-18090375-29393013 15978-15980 18090375 denotes 42
33004529-18460218-29393014 16191-16193 18460218 denotes 51
33004529-20937093-29393014 16191-16193 20937093 denotes 51
33004529-26673586-29393014 16191-16193 26673586 denotes 51
33004529-15550023-29393015 16386-16388 15550023 denotes 54
33004529-16215381-29393015 16386-16388 16215381 denotes 54
33004529-9198130-29393016 16717-16719 9198130 denotes 57
33004529-9198130-29393017 16839-16841 9198130 denotes 57
33004529-14592828-29393018 16843-16845 14592828 denotes 58
33004529-3102560-29393019 17022-17024 3102560 denotes 59
33004529-8555486-29393019 17022-17024 8555486 denotes 59
33004529-11401891-29393019 17022-17024 11401891 denotes 59
33004529-19740417-29393020 17359-17361 19740417 denotes 46
33004529-19740417-29393021 17416-17418 19740417 denotes 46
33004529-15891319-29393022 17967-17969 15891319 denotes 22
33004529-17278083-29393023 18132-18134 17278083 denotes 62
33004529-23433188-29393024 18241-18243 23433188 denotes 63
33004529-24632673-29393025 18245-18247 24632673 denotes 64
33004529-18565951-29393026 18354-18356 18565951 denotes 65
33004529-16192478-29393027 18411-18413 16192478 denotes 66
33004529-23826709-29393028 19018-19020 23826709 denotes 68
33004529-17893198-29393029 19423-19425 17893198 denotes 69
33004529-17893198-29393030 19539-19541 17893198 denotes 69
33004529-32302438-29393031 19628-19630 32302438 denotes 70
33004529-10673185-29393032 20366-20368 10673185 denotes 30
33004529-15516673-29393033 20370-20372 15516673 denotes 71
33004529-12702502-29393034 20374-20376 12702502 denotes 72
33004529-17032919-29393035 20633-20635 17032919 denotes 73
33004529-12702502-29393036 20726-20728 12702502 denotes 72
33004529-23408962-29393037 20767-20769 23408962 denotes 74
33004529-11907112-29393038 20969-20971 11907112 denotes 75
33004529-9667494-29393039 21108-21110 9667494 denotes 76
33004529-23555246-29393040 21292-21294 23555246 denotes 77
33004529-30177934-29393041 21481-21483 30177934 denotes 78
33004529-10673185-29393042 21786-21788 10673185 denotes 30
33004529-31262641-29393043 21956-21958 31262641 denotes 79
33004529-24186921-29393044 23003-23005 24186921 denotes 80
33004529-12052963-29393045 23061-23063 12052963 denotes 81
33004529-10194379-29393046 23075-23077 10194379 denotes 82
33004529-15707890-29393047 23109-23111 15707890 denotes 83
33004529-24186921-29393048 23162-23164 24186921 denotes 80
33004529-11888681-29393049 23373-23375 11888681 denotes 84
33004529-11359654-29393050 23377-23379 11359654 denotes 85
33004529-19141861-29393051 23543-23545 19141861 denotes 86
33004529-17395891-29393052 23736-23738 17395891 denotes 87
33004529-19141861-29393053 23870-23872 19141861 denotes 86
33004529-15626732-29393054 23874-23876 15626732 denotes 88
33004529-15665002-29393055 24151-24153 15665002 denotes 89
33004529-19350118-29393056 24155-24157 19350118 denotes 90
33004529-22712885-29393057 24460-24462 22712885 denotes 91
33004529-23149848-29393058 24464-24466 23149848 denotes 92
33004529-17965715-29393059 24803-24805 17965715 denotes 93
33004529-17965715-29393060 24946-24948 17965715 denotes 93
33004529-25948816-29393061 25109-25111 25948816 denotes 94
33004529-23391721-29393062 25423-25425 23391721 denotes 95
33004529-23202729-29393063 25427-25429 23202729 denotes 96
33004529-32407672-29393064 26415-26417 32407672 denotes 98
33004529-32073213-29393065 27020-27021 32073213 denotes 8
33004529-32302438-29393066 27023-27025 32302438 denotes 70
33004529-32407672-29393067 27401-27403 32407672 denotes 98
33004529-20973685-29393068 27694-27697 20973685 denotes 100
33004529-31262641-29393069 29305-29307 31262641 denotes 79
33004529-22443427-29393070 29980-29983 22443427 denotes 103
33004529-15855637-29393071 30209-30212 15855637 denotes 104
33004529-19286091-29393072 30633-30636 19286091 denotes 105
33004529-22742648-29393073 30638-30641 22742648 denotes 106

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T1 0-106 Sentence denotes Targeting coagulation activation in severe COVID-19 pneumonia: lessons from bacterial pneumonia and sepsis
T2 107-158 Sentence denotes Coagulation activation in severe COVID-19 pneumonia
T3 160-168 Sentence denotes Abstract
T4 169-369 Sentence denotes Novel coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2), has rapidly spread throughout the world, resulting in a pandemic with high mortality.
T5 370-571 Sentence denotes There are no effective treatments for the management of severe COVID-19 and current therapeutic trials are focused on antiviral therapy and attenuation of hyper-inflammation with anti-cytokine therapy.
T6 572-679 Sentence denotes Severe COVID-19 pneumonia shares some pathological similarities with severe bacterial pneumonia and sepsis.
T7 680-808 Sentence denotes In particular, it disrupts the haemostatic balance, which results in a procoagulant state locally in the lungs and systemically.
T8 809-922 Sentence denotes This culminates in the formation of microthrombi, disseminated intravascular coagulation and multi-organ failure.
T9 923-1268 Sentence denotes The deleterious effects of exaggerated inflammatory responses and activation of coagulation have been investigated in bacterial pneumonia and sepsis and there is recognition that although these pathways are important for the host immune response to pathogens, they can lead to bystander tissue injury and are negatively associated with survival.
T10 1269-1569 Sentence denotes In the past two decades, evidence from preclinical studies has led to the emergence of potential anticoagulant therapeutic strategies for the treatment of patients with pneumonia, sepsis and acute respiratory distress syndrome, and some of these anticoagulant approaches have been trialled in humans.
T11 1570-1789 Sentence denotes Here, we review the evidence from preclinical studies and clinical trials of anticoagulant treatment strategies in bacterial pneumonia and sepsis, and discuss the importance of these findings in the context of COVID-19.
T12 1791-2063 Sentence denotes A large armamentarium of potentially beneficial anticoagulant agents exists, and well-designed randomised clinical trials are now needed to investigate the wide range of anticoagulant and anti-fibrinolytic therapies to determine the optimal strategy https://bit.ly/2CI459q
T13 2065-2077 Sentence denotes Introduction
T14 2078-2191 Sentence denotes Novel coronavirus disease 2019 (COVID-19) first emerged in Wuhan, China, and has rapidly spread across the globe.
T15 2192-2373 Sentence denotes COVID-19 is caused by severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) and, as of August 7, 2020, there have been ∼19 million reported cases and 700 thousand deaths [1].
T16 2374-2482 Sentence denotes The only treatment thus far to demonstrate a reduction in mortality of severe COVID-19 is dexamethasone [2].
T17 2483-2561 Sentence denotes The antiviral remdesivir has been shown to reduce hospital length of stay [3].
T18 2562-2659 Sentence denotes Therefore, identifying successful therapeutic strategies still remains a major ongoing challenge.
T19 2660-2837 Sentence denotes The pathogenesis of severe COVID-19 pneumonia has similarities with that of severe bacterial pneumonia, with both causing severe hypoxia that often requires ventilatory support.
T20 2838-3014 Sentence denotes Both are characterised by extensive inflammatory cell recruitment to the lungs, a potent acute phase reaction and raised levels of pro-inflammatory cytokines (figure 1) [4, 5].
T21 3015-3353 Sentence denotes Severe COVID-19 pneumonia and severe bacterial pneumonia are both associated with widespread activation of the coagulation system, evidenced by elevated activated partial thromboplastin time (APPT) and prothrombin time (PT) and markedly elevated D-dimer levels, with raised levels of the latter being associated with poor prognosis [6–9].
T22 3354-3481 Sentence denotes Evidence of disseminated intravascular coagulation is seen frequently in patients at increased risk of death from COVID-19 [8].
T23 3482-3760 Sentence denotes In severe COVID-19, the clinical relevance of activation of the coagulation system is evidenced by a high incidence of pulmonary and peripheral venous thromboembolic (VTE) disease, stroke and acute coronary syndromes, even in patients receiving prophylactic heparin [8, 10, 11].
T24 3761-3971 Sentence denotes The development of microthrombi in lung capillaries [12] may partially explain the profound hypoxia seen in some patients with COVID-19, and similar microthrombi may contribute to renal and cardiac involvement.
T25 3972-4182 Sentence denotes Recent studies suggest that the rapid accumulation of neutrophil extracellular traps in the microvessels of patients with severe COVID-19 results in occlusion of these vessels and promotes microthrombosis [13].
T26 4183-4259 Sentence denotes FIGURE 1 Similarity in progression of severe viral and bacterial pneumonia.
T27 4260-4568 Sentence denotes During viral and bacterial infection, the pathogens are recognised by host pathogen recognition receptors (PRR) on the surface of epithelial cells, mononuclear phagocytes and other cell types, resulting in initiation of various inflammatory cascades triggering systemic inflammatory response syndrome (SIRS).
T28 4569-4665 Sentence denotes At this stage patients will have viral/bacterial sepsis with life-threatening organ dysfunction.
T29 4666-4785 Sentence denotes Most individuals will clear the pathogen (with antimicrobial/antiviral therapy) and the body resolves the inflammation.
T30 4786-5005 Sentence denotes Others, however, will not be able to clear the pathogen, or despite clearance of the pathogen will continue to exhibit dysregulated inflammatory responses that are unabated, resulting in tissue injury and organ failure.
T31 5006-5087 Sentence denotes Of these patients, some receiving supportive care will recover and some will die.
T32 5088-5251 Sentence denotes Although endothelial dysfunction occurs in bacterial pneumonia and sepsis, it is pronounced in COVID-19, with SARS-CoV-2 having a direct effect on the endothelium.
T33 5252-5340 Sentence denotes Post mortem studies have shown evidence of intracellular virus and microangiopathy [12].
T34 5341-5520 Sentence denotes SARS-CoV-2 uses the angiotensin-converting enzyme (ACE)-2 receptor to enter the host cells and activates the renin–angiotensin system, which can induce a prothrombotic state [14].
T35 5521-5638 Sentence denotes Furthermore, the host inflammatory response to the virus promotes activation of coagulation and reduced fibrinolysis.
T36 5639-5793 Sentence denotes Older age, low lymphocyte count, prolonged PT and APPT, and admission to the intensive care unit have been identified as risk factors for thrombosis [15].
T37 5794-6027 Sentence denotes COVID-19 pneumonia is characterised by increases in multiple cytokines, including tumor necrosis factor (TNF) and interleukin-6 (IL-6) [16], which are potent activators of the tissue factor (TF)-dependent coagulation cascade [17–19].
T38 6028-6344 Sentence denotes Activation of the coagulation system is known to be pro-inflammatory and could drive further increases in inflammation; in tissues with a delicate architecture such as the distal lung, this can be highly detrimental, impairing gas exchange [20] and culminating in acute respiratory distress syndrome (ARDS) [21, 22].
T39 6345-6595 Sentence denotes The extensive activation of coagulation in patients with severe COVID-19 could stimulate further inflammation via the mechanisms described below, resulting in a positive feedback loop that maintains high levels of inflammation for a prolonged period.
T40 6596-6838 Sentence denotes Hence, effective anticoagulation strategies may prevent complications associated with aberrant clotting, attenuate coagulation-induced exaggerated inflammatory responses and potentially reduce the severity and extent of pulmonary infiltrates.
T41 6839-7117 Sentence denotes Although less clinically evident than in COVID-19, severe bacterial pneumonia and sepsis are also associated with activation of coagulation locally in the lungs and systemically, and are associated with bystander tissue injury and correlate negatively with survival [9, 23, 24].
T42 7118-7288 Sentence denotes As a consequence, therapies that modulate inflammatory responses caused by activation of coagulation have been extensively investigated in bacterial pneumonia and sepsis.
T43 7289-7457 Sentence denotes Several anticoagulant therapeutic strategies for treating pneumonia, sepsis and ARDS have been identified and some of these anticoagulants have been trialled in humans.
T44 7458-7624 Sentence denotes The high frequency of coagulation abnormalities and prolonged inflammation that occurs in severe COVID-19 suggests these therapies are attractive potential therapies.
T45 7625-7848 Sentence denotes Here, we review the evidence from preclinical studies and clinical trials of anticoagulant treatment strategies in bacterial pneumonia and sepsis and discuss how these data could be relevant for managing COVID-19 pneumonia.
T46 7849-8026 Sentence denotes The data will be discussed in relation to 1) activation of the TF–thrombin generation pathway, 2) endogenous anticoagulants and 3) coagulation–inflammation crosstalk (figure 2).
T47 8027-8105 Sentence denotes FIGURE 2 Activation of the coagulation cascade and endogenous anticoagulants.
T48 8106-8307 Sentence denotes Pathogens in the lungs are recognised by pattern recognition receptors that initiate a pro-inflammatory response and expression of tissue factor (TF) allowing factor VIIa to come in to contact with TF.
T49 8308-8435 Sentence denotes TF-VIIa activates factor X that binds to TF-VIIa to form a ternary complex that converts prothrombin to thromobin (factor IIa).
T50 8436-8663 Sentence denotes Factor Va binds to the ternary complex to form the prothrombinase complex and to platelets and factor Xa to form the major prothrombinase complex that generates the large amounts of thrombin necessary for fibrin clot formation.
T51 8664-8820 Sentence denotes Thrombin also increases expression of thrombomodulin on endothelial cells and activates proteinase-activated receptor-1 (PAR1), the major thrombin receptor.
T52 8821-8964 Sentence denotes Activation of PAR1 by thrombin leads to downstream signalling that is pro-inflammatory and leads to disruption of the alveolar barrier (brown).
T53 8965-9098 Sentence denotes Activation of PAR1 by activated protein C (APC) leads to signalling that has barrier-protective and anti-inflammatory effects (blue).
T54 9099-9415 Sentence denotes TFPI: tissue factor pathway inhibitor; IL: interleukin; TNF: tumor necrosis factor; MCP: monocyte chemoattractant protein; PAI: plasminogen activator inhibitors; tPA: tissue-type plasminogen activator; uPA: urokinase-type plasminogen activator; EPCR: endothelial protein C receptor; FDP: fibrin degradation products.
T55 9417-9441 Sentence denotes The TF-dependent pathway
T56 9442-9611 Sentence denotes The TF pathway is the main initiator of procoagulant activity secondary to tissue injury and inflammation, and it plays an important role in pneumonia and ARDS [25, 26].
T57 9612-9891 Sentence denotes TF is a transmembrane glycoprotein expressed by mononuclear cells, endothelial cells, fibroblasts, vascular smooth muscle cells and alveolar epithelial cells but it can also be detected in extracellular fluids and in cell-derived microparticles shed from activated cells [27–29].
T58 9892-10082 Sentence denotes Under normal physiological conditions, TF will only come into contact with blood or circulating coagulation zymogens after vascular injury and disruption of the endothelial barrier [30, 31].
T59 10083-10170 Sentence denotes TF binds to and activates coagulation factors VII to VIIa, forming the TF-VIIa complex.
T60 10171-10333 Sentence denotes This initiates the TF-dependent pathway of coagulation by activating coagulation factor X to Xa and then binding factor Xa to form the TF-VIIa-Xa ternary complex.
T61 10334-10621 Sentence denotes The TF-VIIa-Xa ternary complex converts prothrombin (factor II) to thrombin (factor IIa), a process that is sustained and increased in efficiency by positive feedback through activation of coagulation factors V and VIII, which are non-enzymatic cofactors that activate factor X [32, 33].
T62 10622-10902 Sentence denotes Thrombin converts fibrinogen to fibrin, the main constituent of clots, and is also the main physiological activator of proteinase-activated receptor-1 (PAR1), the major high-affinity thrombin receptor that promotes multiple downstream cellular responses involved in tissue repair.
T63 10903-11208 Sentence denotes However, when dysregulated, these cellular responses promote inflammation and lead to disruption of the epithelial and endothelial barriers and the development of fibrosis in multiple organs, including the lung, kidney and liver [34], thereby contributing to disease pathogenesis during severe infections.
T64 11210-11231 Sentence denotes TF pathway inhibitors
T65 11232-11525 Sentence denotes TF and factor VIIa levels are elevated in the bronchoalveolar lavage fluid of patients with severe pneumonia, and the central role of TF for initiating coagulation makes it an attractive target for therapeutic intervention against the potential negative consequences of coagulation activation.
T66 11526-11646 Sentence denotes Tissue factor pathway inhibitor (TFPI) is a central endogenous regulator of TF pathway activity and thrombin generation.
T67 11647-11762 Sentence denotes This glycoprotein is mainly expressed by endothelial cells and platelets and acts by directly inhibiting factor Xa.
T68 11763-11830 Sentence denotes The Xa-TFPI complex subsequently also inhibits the TF-VIIa complex.
T69 11831-12065 Sentence denotes In preclinical non-human primate models of endotoxaemia, blockade of TF-VIIa, using a competitive inhibitor of TF (site-inactivated factor VIIa), inhibits the TF pathway and reduces lung inflammation and deposition of fibrin [35, 36].
T70 12066-12337 Sentence denotes A phase II clinical trial of recombinant human TFPI (rhTFPI; Tifacogin) in patients with severe sepsis decreased concentrations of IL-6, an important pro-inflammatory cytokine that is increased in COVID-19 pneumonia and a major target in ongoing clinical trials [37, 38].
T71 12338-12626 Sentence denotes However, in the Optimised Phase III Tifacogin (rTFPI) in Multicenter International Sepsis Trial (OPTIMIST phase III) for patients with severe sepsis with a high international normalised ratio (≥1.2), rhTFPI did not improve 28-day mortality, despite reducing evidence of inflammation [39].
T72 12627-12928 Sentence denotes Administration of rhTFPI and heparin concomitantly was associated with increased bleeding, although a post hoc analysis did suggest rhTFPI improved survival in patients with severe community-acquired pneumonia (CAP) for whom the microbiological aetiology was known and heparin had not been given [40].
T73 12929-13146 Sentence denotes However, the subsequent Recombinant Tissue Factor Pathway Inhibitor in Severe Community-Acquired Pneumonia (CAPTIVATE) trial [41] did not demonstrate improved survival for patients with severe CAP treated with rhTFPI.
T74 13147-13369 Sentence denotes Although TFPI was largely disappointing in the setting of sepsis, the advantages of targeting the TF pathway in preventing the development of capillary microthrombi, as well as inflammation, might outweigh potential risks.
T75 13371-13439 Sentence denotes Endogenous anticoagulants and treatment of severe pneumonia and ARDS
T76 13440-13578 Sentence denotes Activation of the coagulation system is countered by endogenous anticoagulants, which act either alone or in concert to limit coagulation.
T77 13579-13905 Sentence denotes A number of endogenous anticoagulants, including anti-thrombin (AT) and activated protein C (APC), have been trialled in severe pneumonia and ARDS, on the basis that they were shown to be protective against lung injury in experimental animal models by reducing fibrin generation and attenuating neutrophil recruitment [42–46].
T78 13907-13920 Sentence denotes Anti-thrombin
T79 13921-14187 Sentence denotes AT inactivates thrombin and factor Xa and has been shown to reduce systemic (after intravenous administration) and bronchoalveolar (after both intravenous and nebulised administration) thrombin and fibrin levels and reduce lung injury in preclinical models [42, 46].
T80 14188-14287 Sentence denotes However, the clinical data currently do not support using AT as a treatment to improve lung injury.
T81 14288-14535 Sentence denotes The KyperSept trial of high-dose AT treatment in severe sepsis [47] showed no effect on 28-day mortality, and an increased risk of bleeding events in the AT-treated participants was observed, particularly in those who received concomitant heparin.
T82 14536-14719 Sentence denotes Yet, a subgroup analysis revealed that the AT-treated group that had not received concomitant heparin had a 15% improvement in 90-day mortality compared to those treated with heparin.
T83 14720-14904 Sentence denotes Nonetheless, a meta-analysis of 20 trials of a heterogeneous population of critically ill patients concluded that AT should be avoided owing to the risk of bleeding complications [45].
T84 14905-15174 Sentence denotes Natural or pharmacological thrombin inhibitors have not been tested in clinical trials in the setting of pneumonia and potential clinical translation has been inferred from studies of AT in sepsis, in which pneumonia is the leading cause in a large proportion of cases.
T85 15175-15352 Sentence denotes In terms of extrapolation to COVID-19 pneumonia, we would propose that the current evidence would also argue against the use of AT, particularly if co-administered with heparin.
T86 15353-15518 Sentence denotes Heparin alone, which exerts its anticoagulant effects via the activation of AT, is currently being evaluated in multiple trials in the context of COVID-19 pneumonia.
T87 15519-15643 Sentence denotes This includes evaluation of a systemic prophylactic dose and a full therapeutic dose of low molecular weight heparin (LMWH).
T88 15644-15749 Sentence denotes In H1N1 ARDS, anticoagulation with systemic heparin significantly reduced the high incidence of VTE [48].
T89 15750-15822 Sentence denotes Heparin also exerts anti-inflammatory and antiviral properties [49, 50].
T90 15823-15896 Sentence denotes However, the route of administration of heparin is likely to be critical.
T91 15897-16198 Sentence denotes Nebulised heparin did not attenuate inflammation in a murine model of pneumonia [42], and, in clinical trials in patients with or at risk of ARDS, nebulised heparin had no major impact on physiological variables nor a beneficial effect on mortality, although it increased ventilator-free days [51–53].
T92 16200-16219 Sentence denotes Activated protein C
T93 16220-16393 Sentence denotes APC plays a critical role in terminating coagulation by proteolytically inactivating factors Va and VIIIa, and has been widely investigated in the context of sepsis [54–56].
T94 16394-16556 Sentence denotes Once the coagulation cascade is activated, thrombin binds to thrombomodulin and, facilitated by the endothelial protein C receptor (EPCR), protein C is activated.
T95 16557-16774 Sentence denotes APC then binds to the EPCR and, together with its co-factor protein S, forms the EPCR-APC-protein S complex that binds and degrades factor Va and factor VIIIa [57], providing negative feedback for thrombin generation.
T96 16775-16847 Sentence denotes APC also exerts pro-fibrinolytic and anti-inflammatory effects [57, 58].
T97 16848-17029 Sentence denotes Preclinical studies support a beneficial effect of APC administration, showing that rhAPC attenuates tissue injury and improves survival in models of sepsis and lung injury [59–61].
T98 17030-17420 Sentence denotes For example, in murine models of indirect lung injury (intravenous injection of lipopolysaccharide) and direct lung injury (Streptococcus pneumoniae infection), nebulised rhAPC specifically reduced local bronchoalveolar thrombin and fibrin generation without affecting intravascular thrombin generation or fibrinolytic activity [46] and without adversely affecting bacterial clearance [46].
T99 17421-17593 Sentence denotes This provides proof-of-principle that targeting the alveolar epithelium locally with nebulised rhAPC can attenuate coagulation activation without compromising host defence.
T100 17594-17700 Sentence denotes In clinical studies, systemic, rather than nebulised, delivery of APC has had initially promising results.
T101 17701-17971 Sentence denotes In the original landmark PROWESS study, intravenous infusion of rhAPC (drotrecogin alpha (activated) (DrotAA)) significantly reduced 28-day all-cause mortality in patients with sepsis (secondary to CAP) by 28% and reduced the resolution time of respiratory failure [22].
T102 17972-18136 Sentence denotes This resulted in the Infectious Diseases Society of America/American Thoracic Society recommending APC for the treatment of refractory septic shock due to CAP [62].
T103 18137-18415 Sentence denotes Although APC reduced coagulation activation and lung injury scores in a study of 27 patients with ARDS [63, 64], in a subsequent randomised controlled trial APC did not improve the clinical outcomes of ARDS patients [65] or of patients with sepsis and low of risk of death [66].
T104 18416-18627 Sentence denotes Furthermore, a meta-analysis of five studies involving 5101 participants concluded that APC was associated with higher risk of bleeding and should not be used in patients with severe sepsis or septic shock [67].
T105 18628-18821 Sentence denotes Importantly, the PROWESS-Shock study [55] failed to demonstrate an improvement in survival in patients with septic shock and eventually led to the withdrawal of DrotAA (Xigris) from the market.
T106 18822-19127 Sentence denotes However, the significant differences in patient characteristics between the PROWESS trials has led to the recommendation that a trial of DrotAA should be repeated using an optimised study design [68], and this could include a trial in a less heterogeneous high-risk population, such as COVID-19 pneumonia.
T107 19128-19313 Sentence denotes The preclinical and clinical data suggest nebulised rhAPC may not carry the same bleeding liability as intravenous administration and may be an appropriate route of drug administration.
T108 19314-19543 Sentence denotes Alternatively, the bleeding risk could be mitigated using an rhAPC variant with <10% anticoagulant activity [69], which in preclinical studies was as effective as wild-type APC in improving survival of mice in sepsis models [69].
T109 19544-19834 Sentence denotes In a small study of 11 COVID-19 patients, most had increased endogenous APC levels [70]; however, four patients had lower APC levels and in this subgroup of patients, particularly those with septic shock or at high risk of death, administration of rhAPC might warrant further investigation.
T110 19836-19860 Sentence denotes Endogenous fibrinolytics
T111 19861-20080 Sentence denotes Fibrin deposition and clearance is regulated by the control of plasmin activity, which in turn is regulated by the relative balance between plasminogen activators and plasminogen activator inhibitors (PAI)-1, -2 and -3.
T112 20081-20267 Sentence denotes Plasminogen is mainly synthesised in the liver and converted into plasmin by the serine proteinases tissue-type plasminogen activator (tPA) or urokinase-type plasminogen activator (uPA).
T113 20268-20378 Sentence denotes Several preclinical and clinical studies have demonstrated elevated levels of PAI-1 in pneumonia [30, 71, 72].
T114 20379-20517 Sentence denotes However, preclinical studies on the effects of PAI-1, tPA and uPA in murine models of pneumonia suggest the outcome is pathogen dependent.
T115 20518-20771 Sentence denotes For example, in a Klebsiella pneumoniae pneumonia model, PAI-1 improved bacterial clearance and reduced mortality [73], but neither PAI-1 nor plasmin appeared to have a role in mouse models of S. pneumoniae [72] or Pseudomonas aeruginosa pneumonia [74].
T116 20772-20973 Sentence denotes Instead, the urokinase plasminogen activator receptor axis promoted host defence against S. pneumoniae by recruiting neutrophils to the alveoli and enhancing neutrophil-mediated bacterial killing [75].
T117 20974-21112 Sentence denotes Furthermore, in a model of sterile lung injury, tPA administration reduced alveolar leak but had no effect on pulmonary inflammation [76].
T118 21113-21296 Sentence denotes Data are limited regarding the role of this system in viral respiratory infection models but in a study of influenza A infection, the absence of plasminogen reduced inflammation [77].
T119 21297-21485 Sentence denotes A recent meta-analysis of preclinical studies of fibrinolytics in acute lung injury suggested increased fibrinolysis, attenuated inflammation and alveolar leak, and improved survival [78].
T120 21486-21603 Sentence denotes There are limited clinical data on the efficacy of targeting fibrinolysis in patients with severe infections or ARDS.
T121 21604-21790 Sentence denotes However, patients with ARDS display evidence of a marked reduction in fibrinolysis, with evidence of reduced uPA activity and increased PAI-1 levels in bronchoalveolar lavage fluid [30].
T122 21791-22061 Sentence denotes Furthermore, one study demonstrated a shorter length of stay in the intensive care unit and improved survival in ARDS patients treated with nebulised streptokinase [79]; this pathway may represent an interesting target for the management of COVID-19-induced lung injury.
T123 22062-22214 Sentence denotes Two trials targeting this pathway are currently underway, one in the UK (nebulised r-tPA) and another in the USA (alteplase) (NCT04356833, NCT04357730).
T124 22216-22279 Sentence denotes PARs mediate the interplay between coagulation and inflammation
T125 22280-22449 Sentence denotes The discovery of the PARs in 1991 represented a watershed moment in our understanding of the mechanism by which coagulation proteinases directly influence cell function.
T126 22450-22655 Sentence denotes PARs are seven transmembrane domain G-protein-coupled receptors that have unique mechanisms of activation, which involves limited proteolysis of their amino-terminal exodomains to unmask a tethered ligand.
T127 22656-22870 Sentence denotes Four PARs (PAR1–4) are differentially expressed on lung-resident cells, including lung epithelial cells, endothelial cells and fibroblasts, as well as on recruited monocytes and neutrophils following tissue injury.
T128 22871-23007 Sentence denotes Thrombin is a major activator of PAR1 and PAR3, whereas factor Xa and the potent TF-Xa-VIIa ternary complex activate PAR1 and PAR2 [80].
T129 23008-23166 Sentence denotes PAR1 can also be activated by the EPCR­-APC complex [81], plasmin [82] and matrix metalloprotease-1 [83], whereas trypsin and tryptase can activate PAR2 [80].
T130 23167-23381 Sentence denotes Activation of PAR1 induces the expression of a host of inflammatory cytokines, chemokines and growth factors that influence inflammatory cell trafficking, leukocyte activation and endothelial permeability [84, 85].
T131 23382-23547 Sentence denotes However, PAR1 downstream signalling is highly context dependent and influenced by both the nature and the extracellular concentration of activating proteinases [86].
T132 23548-23740 Sentence denotes For example, in vitro studies using exogenously added proteinases have shown that thrombin increases vascular permeability via PAR1 activation and coupled signalling of the S1P3 receptor [87].
T133 23741-23878 Sentence denotes Conversely, APC inhibits thrombin-mediated vascular hyper-permeability via PAR1 activation and signalling via the S1P1 receptor [86, 88].
T134 23879-24159 Sentence denotes During infection the deleterious thrombin­-PAR1 signalling responses appear to predominate over protective APC-PAR1 signalling responses because endogenous APC levels are depleted and APC has 500 times lower affinity and efficiency for cleaving PAR1 compared to thrombin [89, 90].
T135 24160-24291 Sentence denotes The differential effects of PAR-1 activation by APC or thrombin are also explained by differential cleavage of the PAR1 N-terminus.
T136 24292-24468 Sentence denotes Thrombin cleaves PAR1 at Arg41, whereas APC cleaves PAR1 at Arg41 and Arg46, with preferential cleavage at the latter site mediating the cytoprotective effects of APC [91, 92].
T137 24469-24700 Sentence denotes Hence, in the presence of increased thrombin generation, as often seen in severe pneumonia, the beneficial effects of low levels of endogenous APC may be overcome by the barrier-disruptive effects of thrombin-induced PAR1 cleavage.
T138 24701-24950 Sentence denotes In preclinical studies, survival from sepsis appears to be related to the time of activation of PAR1 [93]; mice treated early with a PAR1 antagonist were protected against thrombocytopaenia and had reduced thrombin levels and improved survival [93].
T139 24951-25366 Sentence denotes S. pneumoniae pneumonia in PAR1-knockout mice exhibited evidence of reduced lung injury and neutrophil recruitment without any effect on bacterial clearance [94], whereas the PAR1 antagonist vorapaxar reduced neutrophilic inflammation; TNF, IL-1β, C-C motif chemokine ligand 2 (CCL2) and CCL7 levels; coagulation activation; and vascular permeability (alveolar leak) without adversely affecting bacterial clearance.
T140 25367-25596 Sentence denotes Murine studies of viral infection, including influenza [95, 96], suggest PAR1 is required for host control of virus load initially, but if viral replication is left unrestricted PAR1 promotes inflammation and increases mortality.
T141 25597-25920 Sentence denotes These preclinical findings support the rationale that blockade of PAR1 may be beneficial in attenuating pathogen-induced hyper-inflammatory responses and in maintaining integrity of the alveolar endothelial barrier, but that the benefits of this treatment may differ with the timing of treatment and the causative pathogen.
T142 25922-25972 Sentence denotes The potential of targeting coagulation in COVID-19
T143 25973-26097 Sentence denotes As previously highlighted, severe COVID-19 is associated with overwhelming clinical complications of coagulation activation.
T144 26098-26310 Sentence denotes A retrospective study of 107 patients who had received at least 1 month of anticoagulation therapy prior to SARS-COV-2 infection demonstrated that none developed clinically relevant thrombotic complications [97].
T145 26311-26419 Sentence denotes Prophylactic dose heparin is therefore recommended for all patients admitted to hospital with COVID-19 [98].
T146 26420-26653 Sentence denotes The enhanced inhibition of thrombin with higher doses of LMWH may further benefit patients by subsequently reducing the downstream signalling involved in inflammation, although the bleeding risk would need to be carefully considered.
T147 26654-26894 Sentence denotes Clinical trials of low dose versus full dose LMWH are currently underway (NCT04372589, NCT04401293, NCT04367831, NCT04345848, NCT04373707, NCT04366960, NCT04359277 and NCT04397510) and will inform the future clinical management of COVID-19.
T148 26895-27054 Sentence denotes However, in the context of diseases with a profound inflammatory response and potential lower levels of AT such as COVID-19 [8, 70], LMWH may not be effective.
T149 27055-27405 Sentence denotes Indeed, anecdotal observations from clinicians caring for patients with COVID-19 report that patients continue to develop clinically identifiable clots, despite receiving prophylactic doses of LMWH, and that higher doses of heparin are needed according to factor Xa analysis, especially in patients with significantly elevated levels of D-dimer [98].
T150 27406-27553 Sentence denotes This suggests that it may be important to target coagulation proteinases that do not rely on the presence of circulating endogenous anticoagulants.
T151 27554-27699 Sentence denotes In this context, some reports suggest that bivalirudin may improve haemofilter and extracorporeal membrane oxygenation filter survival [99, 100].
T152 27700-27794 Sentence denotes Direct oral anticoagulants that specifically inhibit thrombin and factor Xa are now available.
T153 27795-27997 Sentence denotes These agents would not be suitable for all patients, particularly if drug interactions with potential antiviral medication are expected, or in mechanically ventilated patients requiring enteral feeding.
T154 27998-28142 Sentence denotes Although rivaroxaban and apixaban can be delivered via a nasogastric tube to the stomach, they should not be mixed with enteral nutrition [101].
T155 28143-28431 Sentence denotes As with LMWH there is an increased risk of bleeding with direct oral anticoagulants but in COVID-19, complications related to bleeding are anecdotally not commonly seen, but a recent study has suggested an increased risk of bleeding in non-critically ill patients receiving heparin [102].
T156 28432-28587 Sentence denotes Hence the risk of bleeding complications may be lower for patients at increased risk of death with COVID-19 compared to other causes of severe sepsis/ARDS.
T157 28588-28816 Sentence denotes Furthermore, idarucizumab and andexanet alfa are now available for the reversal of dabigatran and rivaroxaban/apixaban, respectively, mitigating the fear that the effects of these agents cannot be reversed should bleeding occur.
T158 28817-28944 Sentence denotes APC showed beneficial effects in the PROWESS study, particularly in the subgroup of patients with CAP and a high risk of death.
T159 28945-29221 Sentence denotes Heterogeneity within patient populations has hampered previous studies of APC; any future trials in COVID-19 will need patients to be carefully sub-phenotyped because the benefit in COVID-19 will likely be seen in those at high risk of death with low endogenous levels of APC.
T160 29222-29524 Sentence denotes Nebulised streptokinase has shown reduced mortality in one study of ARDS patients [79] and fibrinolysis is currently being targeted in COVID-19 with trials of nebulised and systemically administered tPA; these trials are welcomed and have the potential to reduce pulmonary microthrombi and lung injury.
T161 29525-29718 Sentence denotes Targeting PAR1 is another potential attractive approach that could counter the negative effects of both thrombin formation and activation of pro-inflammatory pathways by the coagulation system.
T162 29719-29869 Sentence denotes Although PAR1 antagonists are unlikely to impact on VTE they could have beneficial effects in COVID-19 pneumonia through several potential mechanisms:
T163 29870-30382 Sentence denotes 1) direct anti-platelet effect potentially reducing the incidence of coronary and cerebral artery thrombosis [103]; 2) inhibition of inflammatory signalling pathways downstream of thrombin resulting in attenuated inflammatory responses and inflammatory cell recruitment; 3) protection from the development of post-ARDS pulmonary fibrosis [104]; 4) maintaining integrity of the endothelial alveolar barrier, reducing pulmonary oedema; and 5) indirectly attenuating coagulation activation by reducing inflammation.
T164 30383-30492 Sentence denotes Several PAR1 antagonists are in development but only one has been clinically approved, vorapaxar (Zontivity).
T165 30493-30746 Sentence denotes Vorapaxar is a highly selective small molecule PAR1 antagonist but its long half-life (20 h) and inhibitory effects on platelets (24–48 h) [105, 106] call for cautious use in critically ill patients, particularly because a reversal agent does not exist.
T166 30747-30936 Sentence denotes Trials in the secondary prevention of acute coronary syndromes have shown that there is also potential for bleeding, although in these trials patients were on dual anti-platelet medication.
T167 30937-31088 Sentence denotes PAR1 antagonism could therefore represent a potential approach to halt progression of the disease in hospitalised patients at risk of critical illness.
T168 31089-31166 Sentence denotes Future research and carefully designed trials in this area would be welcomed.
T169 31167-31332 Sentence denotes Table 1 provides a summary of the effects of therapeutics targeting coagulation proteinases in pneumonia, lung injury and sepsis in preclinical and clinical studies.
T170 31333-31467 Sentence denotes TABLE 1 Effects of endogenous anticoagulants or drugs targeting coagulation proteases: evidence from preclinical and clinical studies
T171 31468-31562 Sentence denotes Pathway Agent Animal study outcomes Clinical study outcomes Recruiting COVID-19 trials
T172 31563-31673 Sentence denotes Tissue factor TFPI Coagulation activation Reduced [42, 107, 108] Coagulation activation Reduced [37, 109]
T173 31674-31773 Sentence denotes Inflammation Reduced [36, 110, 111]No effect [108, 112] Inflammation Reduced [37]No effect [109]
T174 31774-31861 Sentence denotes Bacterial clearance Increased [110] Mortality Reduced [40]#No effect [37, 39, 41]¶,+
T175 31862-31899 Sentence denotes Risk of bleeding Increased [37, 39]§
T176 31900-31995 Sentence denotes Factor X RivaroxabanApixabanƒ Inflammation Reduced [113] NCT04416048NCT04394377NCT04351724
T177 31996-32024 Sentence denotes Alveolar leak Reduced [113]
T178 32025-32208 Sentence denotes Thrombin Anti-thrombinDabigatranƒBivalirudinƒ Coagulation activation Reduced [46] Mortality No effect [45, 47]Reduced mortality in subgroup not receiving concomitant heparin [47]
T179 32209-32274 Sentence denotes Inflammation Reduced [42, 46] Risk of bleeding Increased [47]§
T180 32275-32306 Sentence denotes Alveolar leak Reduced [42, 46]
T181 32307-32342 Sentence denotes Bacterial clearance Increased [46]
T182 32343-32526 Sentence denotes Heparin Coagulation activation Reduced [46]No effect [42] Mortality No effect [51–53, 79] NCT04372589NCT04401293NCT04367831NCT04345848NCT04373707NCT04366960NCT04359277NCT04397510
T183 32527-32559 Sentence denotes Inflammation No effect [42, 46]
T184 32560-32593 Sentence denotes Alveolar leak No effect [42, 46]
T185 32594-32633 Sentence denotes Bacterial clearance No effect [42, 46]
T186 32634-32724 Sentence denotes APC rhAPC Coagulation activation Reduced [46, 60] Coagulation activation Reduced [63]
T187 32725-32798 Sentence denotes Inflammation Reduced [61]No effect [60] Lung injury score Reduced [63]
T188 32799-32872 Sentence denotes Alveolar leak Reduced [61] Mortality Reduced [22]No effect [55, 65–67]
T189 32873-32895 Sentence denotes Fibrosis Reduced [61]
T190 32896-32931 Sentence denotes Bacterial clearance No effect [61]
T191 32932-33039 Sentence denotes Fibrinogen tPAuPA Coagulation activation No effect [74] Mortality Reduced [79] NCT04356833NCT04357730
T192 33040-33084 Sentence denotes Inflammation Reduced [78]No effect [74, 76]
T193 33085-33130 Sentence denotes Alveolar leak Reduced [76, 78]No effect [74]
T194 33131-33163 Sentence denotes Fibrinolysis Increased [74, 78]
T195 33164-33228 Sentence denotes PAR-1 VorapaxarRWJ-58269 Coagulation activation Reduced [114]
T196 33229-33260 Sentence denotes Inflammation Reduced [94, 115]
T197 33261-33293 Sentence denotes Alveolar leak Reduced [94, 115]
T198 33294-33334 Sentence denotes Bacterial clearance No effect [94, 115]
T199 33335-34105 Sentence denotes TFPI: tissue factor pathway inhibitor; APC: activated protein C; rhAPC: recombinant human APC; tPA: tissue-type plasminogen activator; uPA: urokinase-type plasminogen activator; PAR-1: proteinase-activated receptor-1. #: trend towards reduced mortality in TFPI-treated group of community-acquired pneumonia patients who had not received concomitant heparin and in whom the pathogen was identified [40]; ¶: trend towards reduced mortality in TFPI group not receiving concomitant heparin [39]; +: trend towards reduced mortality in TFPI group (trial not powered for effect on mortality) [37]; §: difference in risk of major bleeding was not significant in those who did not receive concomitant heparin [47]; ƒ: no relevant studies were identified using this anticoagulant.
T200 34107-34118 Sentence denotes Conclusions
T201 34119-34419 Sentence denotes Preclinical studies have shown beneficial effects of targeting coagulation proteinases in models of pneumonia and lung injury and have added significant knowledge to the understanding of the crosstalk between coagulation and inflammation in the context of pulmonary infection, sepsis and lung injury.
T202 34420-34678 Sentence denotes Importantly, these preclinical studies have limitations that affect the potential translation of findings to human disease, and previous clinical trials of endogenous anticoagulants in pneumonia and in sepsis have mostly failed to show benefits on mortality.
T203 34679-34957 Sentence denotes However, in the context of COVID-19, the evidence of a profound hypercoagulable state with pathogenic contributions of both macrothrombi and microthrombi in severe disease suggest there is an improved risk/benefit ratio in targeting specific aspects of the coagulation pathways.
T204 34958-35242 Sentence denotes The extensive body of research on coagulation and sepsis provides important background for the design of future trials in patients with COVID-19 pneumonia to assess whether targeting coagulation can reduce inflammation as well as VTE and microthrombi, and potentially affect survival.
T205 35243-35479 Sentence denotes A large armamentarium of potentially beneficial agents exists, and well-designed randomised clinical trials are now needed to investigate the wide range of anticoagulant and anti-fibrinolytic therapies to determine the optimal strategy.
T206 35481-35492 Sentence denotes Provenance:
T207 35493-35526 Sentence denotes Submitted article, peer reviewed.
T208 35527-35553 Sentence denotes Conflict of interest: R.J.
T209 35554-35583 Sentence denotes José has nothing to disclose.
T210 35584-35608 Sentence denotes Conflict of interest: A.
T211 35609-35642 Sentence denotes Williams has nothing to disclose.
T212 35643-35667 Sentence denotes Conflict of interest: A.
T213 35668-35699 Sentence denotes Manuel has nothing to disclose.
T214 35700-35726 Sentence denotes Conflict of interest: J.S.
T215 35727-35757 Sentence denotes Brown has nothing to disclose.
T216 35758-35784 Sentence denotes Conflict of interest: R.C.
T217 35785-35923 Sentence denotes Chambers reports grants from The Medical Research Council UK, The Wellcome Trust and The Rosetrees Trust, during the conduct of the study.