PMC:7534795 / 82166-85693
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T393 | 172-193 | Body_part | denotes | cardiovascular system | http://purl.org/sig/ont/fma/fma7161 |
| T394 | 616-622 | Body_part | denotes | tissue | http://purl.org/sig/ont/fma/fma9637 |
| T395 | 1537-1546 | Body_part | denotes | leukocyte | http://purl.org/sig/ont/fma/fma62852 |
| T396 | 1588-1604 | Body_part | denotes | endothelial cell | http://purl.org/sig/ont/fma/fma66772 |
| T397 | 1600-1604 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T398 | 1773-1783 | Body_part | denotes | intestinal | http://purl.org/sig/ont/fma/fma7199 |
| T399 | 1801-1807 | Body_part | denotes | kidney | http://purl.org/sig/ont/fma/fma7203 |
| T400 | 1958-1962 | Body_part | denotes | lung | http://purl.org/sig/ont/fma/fma7195 |
| T401 | 1963-1969 | Body_part | denotes | tissue | http://purl.org/sig/ont/fma/fma9637 |
| T402 | 2016-2020 | Body_part | denotes | lung | http://purl.org/sig/ont/fma/fma7195 |
| T403 | 2432-2443 | Body_part | denotes | spinal cord | http://purl.org/sig/ont/fma/fma7647 |
| T404 | 2558-2568 | Body_part | denotes | fatty acid | http://purl.org/sig/ont/fma/fma82738 |
| T405 | 2777-2780 | Body_part | denotes | LPS | http://purl.org/sig/ont/fma/fma82785 |
| T406 | 2922-2927 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T407 | 2957-2960 | Body_part | denotes | LPS | http://purl.org/sig/ont/fma/fma82785 |
| T408 | 3010-3017 | Body_part | denotes | histone | http://purl.org/sig/ont/fma/fma74413 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T105 | 172-193 | Body_part | denotes | cardiovascular system | http://purl.obolibrary.org/obo/UBERON_0004535 |
| T106 | 616-622 | Body_part | denotes | tissue | http://purl.obolibrary.org/obo/UBERON_0000479 |
| T107 | 1801-1807 | Body_part | denotes | kidney | http://purl.obolibrary.org/obo/UBERON_0002113 |
| T108 | 1958-1962 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
| T109 | 1963-1969 | Body_part | denotes | tissue | http://purl.obolibrary.org/obo/UBERON_0000479 |
| T110 | 2016-2020 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
| T111 | 2432-2443 | Body_part | denotes | spinal cord | http://purl.obolibrary.org/obo/UBERON_0002240 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T481 | 56-68 | Disease | denotes | inflammation | http://purl.obolibrary.org/obo/MONDO_0021166 |
| T482 | 623-629 | Disease | denotes | injury | http://purl.obolibrary.org/obo/MONDO_0021178 |
| T483 | 770-772 | Disease | denotes | MI | http://purl.obolibrary.org/obo/MONDO_0005068 |
| T484 | 773-779 | Disease | denotes | injury | http://purl.obolibrary.org/obo/MONDO_0021178 |
| T485 | 1385-1397 | Disease | denotes | inflammation | http://purl.obolibrary.org/obo/MONDO_0021166 |
| T486 | 1764-1772 | Disease | denotes | allergic | http://purl.obolibrary.org/obo/MONDO_0004980 |
| T487 | 1773-1796 | Disease | denotes | intestinal inflammation | http://purl.obolibrary.org/obo/MONDO_0002269 |
| T488 | 1784-1796 | Disease | denotes | inflammation | http://purl.obolibrary.org/obo/MONDO_0021166 |
| T489 | 1936-1948 | Disease | denotes | inflammation | http://purl.obolibrary.org/obo/MONDO_0021166 |
| T490 | 2016-2030 | Disease | denotes | lung carcinoma | http://purl.obolibrary.org/obo/MONDO_0005138 |
| T491 | 2021-2030 | Disease | denotes | carcinoma | http://purl.obolibrary.org/obo/MONDO_0004993 |
| T492 | 2827-2833 | Disease | denotes | injury | http://purl.obolibrary.org/obo/MONDO_0021178 |
| T493 | 2985-2991 | Disease | denotes | injury | http://purl.obolibrary.org/obo/MONDO_0021178 |
| T494 | 3369-3375 | Disease | denotes | injury | http://purl.obolibrary.org/obo/MONDO_0021178 |
| T495 | 3488-3494 | Disease | denotes | injury | http://purl.obolibrary.org/obo/MONDO_0021178 |
| T496 | 3508-3516 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T497 | 3517-3526 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T533 | 172-193 | http://purl.obolibrary.org/obo/UBERON_0004535 | denotes | cardiovascular system |
| T534 | 172-193 | http://www.ebi.ac.uk/efo/EFO_0000791 | denotes | cardiovascular system |
| T535 | 738-739 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T536 | 801-802 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T537 | 886-887 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T538 | 1028-1032 | http://purl.obolibrary.org/obo/CLO_0001185 | denotes | 2018 |
| T539 | 1560-1565 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
| T540 | 1588-1604 | http://purl.obolibrary.org/obo/CL_0000115 | denotes | endothelial cell |
| T541 | 1773-1783 | http://purl.obolibrary.org/obo/UBERON_0000160 | denotes | intestinal |
| T542 | 1773-1783 | http://www.ebi.ac.uk/efo/EFO_0000834 | denotes | intestinal |
| T543 | 1801-1807 | http://purl.obolibrary.org/obo/UBERON_0002113 | denotes | kidney |
| T544 | 1801-1807 | http://www.ebi.ac.uk/efo/EFO_0000927 | denotes | kidney |
| T545 | 1801-1807 | http://www.ebi.ac.uk/efo/EFO_0000929 | denotes | kidney |
| T546 | 1834-1839 | http://purl.obolibrary.org/obo/CLO_0007836 | denotes | mouse |
| T547 | 1952-1957 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
| T548 | 1958-1962 | http://purl.obolibrary.org/obo/UBERON_0002048 | denotes | lung |
| T549 | 1958-1962 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lung |
| T550 | 2016-2020 | http://purl.obolibrary.org/obo/UBERON_0002048 | denotes | lung |
| T551 | 2016-2020 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lung |
| T552 | 2053-2054 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | B |
| T553 | 2059-2069 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
| T554 | 2241-2247 | http://purl.obolibrary.org/obo/NCBITaxon_33208 | denotes | animal |
| T555 | 2432-2443 | http://purl.obolibrary.org/obo/UBERON_0002240 | denotes | spinal cord |
| T556 | 2447-2451 | http://purl.obolibrary.org/obo/UBERON_0003101 | denotes | male |
| T557 | 2447-2451 | http://www.ebi.ac.uk/efo/EFO_0000970 | denotes | male |
| T558 | 2513-2521 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T559 | 2782-2785 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T560 | 2786-2787 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T561 | 2895-2896 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T562 | 2909-2913 | http://purl.obolibrary.org/obo/CLO_0052763 | denotes | HL-1 |
| T563 | 2922-2927 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T564 | 2995-3005 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activating |
| T565 | 3055-3065 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
| T566 | 3112-3113 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | B |
| T567 | 3287-3288 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T568 | 3309-3319 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activating |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T575 | 15-18 | Chemical | denotes | CYP | http://purl.obolibrary.org/obo/CHEBI_38559 |
| T576 | 28-39 | Chemical | denotes | metabolites | http://purl.obolibrary.org/obo/CHEBI_25212 |
| T577 | 124-139 | Chemical | denotes | cytochrome P450 | http://purl.obolibrary.org/obo/CHEBI_38559 |
| T578 | 124-134 | Chemical | denotes | cytochrome | http://purl.obolibrary.org/obo/CHEBI_4056 |
| T579 | 141-144 | Chemical | denotes | CYP | http://purl.obolibrary.org/obo/CHEBI_38559 |
| T580 | 206-209 | Chemical | denotes | EPA | http://purl.obolibrary.org/obo/CHEBI_28364 |
| T581 | 231-258 | Chemical | denotes | epoxyeicosatetraenoic acids | http://purl.obolibrary.org/obo/CHEBI_72852 |
| T582 | 253-258 | Chemical | denotes | acids | http://purl.obolibrary.org/obo/CHEBI_37527 |
| T583 | 288-297 | Chemical | denotes | 17,18-EEQ | http://purl.obolibrary.org/obo/CHEBI_72853 |
| T584 | 294-297 | Chemical | denotes | EEQ | http://purl.obolibrary.org/obo/CHEBI_144559|http://purl.obolibrary.org/obo/CHEBI_72852 |
| T586 | 303-306 | Chemical | denotes | DHA | http://purl.obolibrary.org/obo/CHEBI_16016|http://purl.obolibrary.org/obo/CHEBI_28125|http://purl.obolibrary.org/obo/CHEBI_28689|http://purl.obolibrary.org/obo/CHEBI_36005 |
| T590 | 328-355 | Chemical | denotes | epoxydocosapentaenoic acids | http://purl.obolibrary.org/obo/CHEBI_72654 |
| T591 | 350-355 | Chemical | denotes | acids | http://purl.obolibrary.org/obo/CHEBI_37527 |
| T592 | 393-402 | Chemical | denotes | 19,20-EDP | http://purl.obolibrary.org/obo/CHEBI_72653 |
| T593 | 516-525 | Chemical | denotes | 17,18-EEQ | http://purl.obolibrary.org/obo/CHEBI_72853 |
| T594 | 522-525 | Chemical | denotes | EEQ | http://purl.obolibrary.org/obo/CHEBI_144559|http://purl.obolibrary.org/obo/CHEBI_72852 |
| T596 | 530-539 | Chemical | denotes | 19,20-EDP | http://purl.obolibrary.org/obo/CHEBI_72653 |
| T597 | 589-594 | Chemical | denotes | PUFAs | http://purl.obolibrary.org/obo/CHEBI_26208 |
| T598 | 682-684 | Chemical | denotes | Lu | http://purl.obolibrary.org/obo/CHEBI_33382 |
| T599 | 744-748 | Chemical | denotes | PUFA | http://purl.obolibrary.org/obo/CHEBI_26208|http://purl.obolibrary.org/obo/CHEBI_76567 |
| T601 | 770-772 | Chemical | denotes | MI | http://purl.obolibrary.org/obo/CHEBI_53620|http://purl.obolibrary.org/obo/CHEBI_74704 |
| T603 | 814-824 | Chemical | denotes | eicosanoid | http://purl.obolibrary.org/obo/CHEBI_23899 |
| T604 | 864-874 | Chemical | denotes | metabolite | http://purl.obolibrary.org/obo/CHEBI_25212 |
| T605 | 949-958 | Chemical | denotes | 19,20-EDP | http://purl.obolibrary.org/obo/CHEBI_72653 |
| T606 | 963-972 | Chemical | denotes | 17,18-EEQ | http://purl.obolibrary.org/obo/CHEBI_72853 |
| T607 | 969-972 | Chemical | denotes | EEQ | http://purl.obolibrary.org/obo/CHEBI_144559|http://purl.obolibrary.org/obo/CHEBI_72852 |
| T609 | 1009-1013 | Chemical | denotes | PGE2 | http://purl.obolibrary.org/obo/CHEBI_15551 |
| T610 | 1071-1076 | Chemical | denotes | PUFAs | http://purl.obolibrary.org/obo/CHEBI_26208 |
| T611 | 1270-1273 | Chemical | denotes | CYP | http://purl.obolibrary.org/obo/CHEBI_38559 |
| T612 | 1282-1287 | Chemical | denotes | epoxy | http://purl.obolibrary.org/obo/CHEBI_30721 |
| T613 | 1288-1299 | Chemical | denotes | metabolites | http://purl.obolibrary.org/obo/CHEBI_25212 |
| T614 | 1368-1375 | Chemical | denotes | retinal | http://purl.obolibrary.org/obo/CHEBI_15035 |
| T615 | 1427-1436 | Chemical | denotes | 19,20-EDP | http://purl.obolibrary.org/obo/CHEBI_72653 |
| T616 | 1470-1478 | Chemical | denotes | molecule | http://purl.obolibrary.org/obo/CHEBI_25367 |
| T617 | 1506-1514 | Chemical | denotes | molecule | http://purl.obolibrary.org/obo/CHEBI_25367 |
| T618 | 1566-1573 | Chemical | denotes | retinal | http://purl.obolibrary.org/obo/CHEBI_15035 |
| T619 | 1724-1733 | Chemical | denotes | 17,18-EEQ | http://purl.obolibrary.org/obo/CHEBI_72853 |
| T620 | 1730-1733 | Chemical | denotes | EEQ | http://purl.obolibrary.org/obo/CHEBI_144559|http://purl.obolibrary.org/obo/CHEBI_72852 |
| T622 | 1738-1747 | Chemical | denotes | 19,20-EDP | http://purl.obolibrary.org/obo/CHEBI_72653 |
| T623 | 1893-1902 | Chemical | denotes | 17,18-EEQ | http://purl.obolibrary.org/obo/CHEBI_72853 |
| T624 | 1899-1902 | Chemical | denotes | EEQ | http://purl.obolibrary.org/obo/CHEBI_144559|http://purl.obolibrary.org/obo/CHEBI_72852 |
| T626 | 2049-2051 | Chemical | denotes | NF | http://purl.obolibrary.org/obo/CHEBI_141424|http://purl.obolibrary.org/obo/CHEBI_25573|http://purl.obolibrary.org/obo/CHEBI_1224 |
| T629 | 2194-2197 | Chemical | denotes | DHA | http://purl.obolibrary.org/obo/CHEBI_16016|http://purl.obolibrary.org/obo/CHEBI_28125|http://purl.obolibrary.org/obo/CHEBI_28689|http://purl.obolibrary.org/obo/CHEBI_36005 |
| T633 | 2198-2206 | Chemical | denotes | epoxides | http://purl.obolibrary.org/obo/CHEBI_32955 |
| T634 | 2349-2352 | Chemical | denotes | DHA | http://purl.obolibrary.org/obo/CHEBI_16016|http://purl.obolibrary.org/obo/CHEBI_28125|http://purl.obolibrary.org/obo/CHEBI_28689|http://purl.obolibrary.org/obo/CHEBI_36005 |
| T638 | 2353-2361 | Chemical | denotes | epoxides | http://purl.obolibrary.org/obo/CHEBI_32955 |
| T639 | 2404-2415 | Chemical | denotes | carrageenan | http://purl.obolibrary.org/obo/CHEBI_3435 |
| T640 | 2447-2451 | Chemical | denotes | male | http://purl.obolibrary.org/obo/CHEBI_30780 |
| T641 | 2558-2568 | Chemical | denotes | fatty acid | http://purl.obolibrary.org/obo/CHEBI_35366 |
| T642 | 2564-2568 | Chemical | denotes | acid | http://purl.obolibrary.org/obo/CHEBI_37527 |
| T643 | 2569-2572 | Chemical | denotes | DHA | http://purl.obolibrary.org/obo/CHEBI_16016|http://purl.obolibrary.org/obo/CHEBI_28125|http://purl.obolibrary.org/obo/CHEBI_28689|http://purl.obolibrary.org/obo/CHEBI_36005 |
| T647 | 2595-2600 | Chemical | denotes | diols | http://purl.obolibrary.org/obo/CHEBI_23824 |
| T648 | 2777-2780 | Chemical | denotes | LPS | http://purl.obolibrary.org/obo/CHEBI_16412|http://purl.obolibrary.org/obo/CHEBI_52603|http://purl.obolibrary.org/obo/CHEBI_89981 |
| T651 | 2909-2911 | Chemical | denotes | HL | http://purl.obolibrary.org/obo/CHEBI_5729 |
| T652 | 2929-2938 | Chemical | denotes | 19,20-EDP | http://purl.obolibrary.org/obo/CHEBI_72653 |
| T653 | 2957-2960 | Chemical | denotes | LPS | http://purl.obolibrary.org/obo/CHEBI_16412|http://purl.obolibrary.org/obo/CHEBI_52603|http://purl.obolibrary.org/obo/CHEBI_89981 |
| T656 | 3010-3017 | Chemical | denotes | histone | http://purl.obolibrary.org/obo/CHEBI_15358 |
| T657 | 3108-3110 | Chemical | denotes | NF | http://purl.obolibrary.org/obo/CHEBI_141424|http://purl.obolibrary.org/obo/CHEBI_25573|http://purl.obolibrary.org/obo/CHEBI_1224 |
| T660 | 3241-3244 | Chemical | denotes | CYP | http://purl.obolibrary.org/obo/CHEBI_38559 |
| T661 | 3257-3268 | Chemical | denotes | metabolites | http://purl.obolibrary.org/obo/CHEBI_25212 |
| T662 | 3276-3281 | Chemical | denotes | PUFAs | http://purl.obolibrary.org/obo/CHEBI_26208 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T185 | 56-68 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammation |
| T186 | 124-134 | http://purl.obolibrary.org/obo/GO_0045158 | denotes | cytochrome |
| T187 | 124-134 | http://purl.obolibrary.org/obo/GO_0045157 | denotes | cytochrome |
| T188 | 124-134 | http://purl.obolibrary.org/obo/GO_0045156 | denotes | cytochrome |
| T189 | 124-134 | http://purl.obolibrary.org/obo/GO_0008121 | denotes | cytochrome |
| T190 | 1385-1397 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammation |
| T191 | 1784-1796 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammation |
| T192 | 1936-1948 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammation |
| T193 | 2077-2097 | http://purl.obolibrary.org/obo/GO_0000981 | denotes | transcription factor |
| T194 | 2077-2090 | http://purl.obolibrary.org/obo/GO_0006351 | denotes | transcription |
| T195 | 3087-3107 | http://purl.obolibrary.org/obo/GO_0000981 | denotes | transcription factor |
| T196 | 3087-3100 | http://purl.obolibrary.org/obo/GO_0006351 | denotes | transcription |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T551 | 0-68 | Sentence | denotes | 8.1.4 Role of CYP-mediated metabolites in ameliorating inflammation |
| T552 | 69-485 | Sentence | denotes | CYP2J and CYP2C isoforms, the constitutively expressed cytochrome P450 (CYP) epoxygenases found in the cardiovascular system, metabolize EPA into 5 regioisomeric epoxyeicosatetraenoic acids (5,6-, 8,9-, 11,12-, 14,15-, 17,18-EEQ) and DHA into 6 regioisomeric epoxydocosapentaenoic acids (4,5-, 7,8-, 10,11-, 13,14-, 16,17-, 19,20-EDP) (Arnold et al., 2010; Konkel & Schunck, 2011; Westphal, Konkel, & Schunck, 2015). |
| T553 | 486-699 | Sentence | denotes | Recent evidence suggests that 17,18-EEQ and 19,20-EDP mediate several anti-inflammatory effects of n-3 PUFAs in various models of tissue injury (Arnold et al., 2010; Ulu et al., 2014; Wang, Chai, Lu, & Lee, 2011). |
| T554 | 700-1034 | Sentence | denotes | For example, Fang et al. demonstrated a n-3 PUFA-rich diet attenuates MI injury in mice by producing a protective eicosanoid pattern, which results in shifting the metabolite profile to a more anti-inflammatory state by increasing the levels of the 19,20-EDP and 17,18-EEQ and decreasing the pro-inflammatory PGE2 (Fang et al., 2018). |
| T555 | 1035-1222 | Sentence | denotes | The cardioprotective effects of n-3 PUFAs are also attributed to their ability to attenuate the NLRP3 inflammasome complex cascade (Darwesh, Jamieson, Wang, Samokhvalov, & Seubert, 2019). |
| T556 | 1223-1338 | Sentence | denotes | Importantly, the anti-inflammatory features of CYP-derived epoxy metabolites have been reported in numerous models. |
| T557 | 1339-1658 | Sentence | denotes | For example, in TNFα-induced retinal vascular inflammation, Capozzi et al. demonstrated 19,20-EDP can ameliorate vascular adhesion molecule and intracellular adhesion molecule expression and reduce leukocyte adherence to human retinal microvascular endothelial cell monolayers (Capozzi, Hammer, McCollum, & Penn, 2016). |
| T558 | 1659-1892 | Sentence | denotes | Additionally, evidence demonstrates intraperitoneal infusions of 17,18-EEQ and 19,20-EDP protect against allergic intestinal inflammation and kidney fibrosis in corresponding mouse models (Kunisawa et al., 2015; Sharma et al., 2016). |
| T559 | 1893-2157 | Sentence | denotes | 17,18-EEQ was able to inhibit TNFα-induced inflammation in human lung tissue obtained from patients undergoing surgery for lung carcinoma via inhibition of NF-κB and activation of the transcription factor PPAR-γ (Morin, Sirois, Echave, Albadine, & Rousseau, 2010). |
| T560 | 2158-2276 | Sentence | denotes | The anti-inflammatory properties of DHA epoxides were also well demonstrated using animal models of inflammatory pain. |
| T561 | 2277-2522 | Sentence | denotes | For example, Morisseau et al. demonstrated that direct injection of the DHA epoxides, EDPs, together with the pro-inflammatory carrageenan into the paw or spinal cord of male Sprague-Dawley rats resulted in significant antihyperalgesic activity. |
| T562 | 2523-2751 | Sentence | denotes | Surprisingly, both the parent free fatty acid DHA and the corresponding diols were inactive, supporting the hypothesis that the epoxylipids mediate many of the beneficial effects of the parent compounds (Morisseau et al., 2010). |
| T563 | 2752-2891 | Sentence | denotes | The bacterial endotoxin, LPS, has a marked role in triggering inflammatory injury which can result in several cardiovascular complications. |
| T564 | 2892-3169 | Sentence | denotes | In a study using HL-1 cardiac cells, 19,20-EDP protected against LPS-stimulated inflammatory injury by activating the histone deacetylase Sirtuin-1 inhibiting the activation the pro-inflammatory transcription factor NF-κB (Samokhvalov, Jamieson, Vriend, Quan, & Seubert, 2015). |
| T565 | 3170-3376 | Sentence | denotes | The accumulating evidence suggests the anti-inflammatory properties of CYP-epoxygenase metabolites of n-3 PUFAs have a substantial role in activating protective responses in models of cardiovascular injury. |
| T566 | 3377-3527 | Sentence | denotes | However, further investigation is required to elucidate whether the protective properties limit cardiovascular injury secondary to COVID-19 infection. |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T215 | 1801-1816 | Phenotype | denotes | kidney fibrosis | http://purl.obolibrary.org/obo/HP_0030760 |
| T216 | 2021-2030 | Phenotype | denotes | carcinoma | http://purl.obolibrary.org/obo/HP_0030731 |
| T217 | 2271-2275 | Phenotype | denotes | pain | http://purl.obolibrary.org/obo/HP_0012531 |
2_test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 33031856-20732876-84039021 | 420-424 | 20732876 | denotes | 2010 |
| 33031856-20869469-84039022 | 444-448 | 20869469 | denotes | 2011 |
| 33031856-26002735-84039023 | 479-483 | 26002735 | denotes | 2015 |
| 33031856-20732876-84039024 | 646-650 | 20732876 | denotes | 2010 |
| 33031856-24691274-84039025 | 664-668 | 24691274 | denotes | 2014 |
| 33031856-21187320-84039026 | 693-697 | 21187320 | denotes | 2011 |
| 33031856-30223037-84039027 | 1028-1032 | 30223037 | denotes | 2018 |
| 33031856-30326194-84039028 | 1216-1220 | 30326194 | denotes | 2019 |
| 33031856-26065911-84039029 | 1865-1869 | 26065911 | denotes | 2015 |
| 33031856-20008283-84039030 | 2151-2155 | 20008283 | denotes | 2010 |
| 33031856-20664072-84039031 | 2745-2749 | 20664072 | denotes | 2010 |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 2326 | 15-18 | Gene | denotes | CYP | Gene:4051 |
| 2327 | 56-68 | Disease | denotes | inflammation | MESH:D007249 |
| 2386 | 1131-1136 | Gene | denotes | NLRP3 | Gene:114548 |
| 2387 | 1270-1273 | Gene | denotes | CYP | Gene:4051 |
| 2388 | 1355-1359 | Gene | denotes | TNFα | Gene:7124 |
| 2389 | 1923-1927 | Gene | denotes | TNFα | Gene:21926 |
| 2390 | 2049-2054 | Gene | denotes | NF-κB | Gene:4790 |
| 2391 | 2098-2104 | Gene | denotes | PPAR-γ | Gene:5468 |
| 2392 | 3030-3039 | Gene | denotes | Sirtuin-1 | Gene:23411 |
| 2393 | 3108-3113 | Gene | denotes | NF-κB | Gene:4790 |
| 2394 | 3241-3244 | Gene | denotes | CYP | Gene:4051 |
| 2395 | 744-748 | Gene | denotes | PUFA | Gene:9933 |
| 2396 | 783-787 | Species | denotes | mice | Tax:10090 |
| 2397 | 1560-1565 | Species | denotes | human | Tax:9606 |
| 2398 | 1834-1839 | Species | denotes | mouse | Tax:10090 |
| 2399 | 1952-1957 | Species | denotes | human | Tax:9606 |
| 2400 | 1984-1992 | Species | denotes | patients | Tax:9606 |
| 2401 | 2452-2471 | Species | denotes | Sprague-Dawley rats | Tax:10116 |
| 2402 | 141-144 | Gene | denotes | CYP | Gene:4051 |
| 2403 | 124-139 | Gene | denotes | cytochrome P450 | Gene:4051 |
| 2404 | 516-525 | Chemical | denotes | 17,18-EEQ | |
| 2405 | 530-539 | Chemical | denotes | 19,20-EDP | |
| 2406 | 585-594 | Chemical | denotes | n-3 PUFAs | MESH:D015525 |
| 2407 | 814-824 | Chemical | denotes | eicosanoid | MESH:D015777 |
| 2408 | 949-958 | Chemical | denotes | 19,20-EDP | |
| 2409 | 963-972 | Chemical | denotes | 17,18-EEQ | |
| 2410 | 1009-1013 | Chemical | denotes | PGE2 | MESH:D015232 |
| 2411 | 1067-1076 | Chemical | denotes | n-3 PUFAs | MESH:D015525 |
| 2412 | 1432-1436 | Chemical | denotes | -EDP | |
| 2413 | 1724-1733 | Chemical | denotes | 17,18-EEQ | |
| 2414 | 1738-1747 | Chemical | denotes | 19,20-EDP | |
| 2415 | 1893-1902 | Chemical | denotes | 17,18-EEQ | |
| 2416 | 2194-2206 | Chemical | denotes | DHA epoxides | |
| 2417 | 2349-2361 | Chemical | denotes | DHA epoxides | |
| 2418 | 2363-2367 | Chemical | denotes | EDPs | |
| 2419 | 2404-2415 | Chemical | denotes | carrageenan | MESH:D002351 |
| 2420 | 2558-2568 | Chemical | denotes | fatty acid | MESH:D005227 |
| 2421 | 2569-2572 | Chemical | denotes | DHA | MESH:D004281 |
| 2422 | 2595-2600 | Chemical | denotes | diols | MESH:D011276 |
| 2423 | 2651-2662 | Chemical | denotes | epoxylipids | |
| 2424 | 2777-2780 | Chemical | denotes | LPS | MESH:D008070 |
| 2425 | 2931-2938 | Chemical | denotes | ,20-EDP | |
| 2426 | 2957-2960 | Chemical | denotes | LPS | MESH:D008070 |
| 2427 | 3272-3281 | Chemical | denotes | n-3 PUFAs | MESH:D015525 |
| 2428 | 616-629 | Disease | denotes | tissue injury | MESH:D017695 |
| 2429 | 770-779 | Disease | denotes | MI injury | MESH:D009203 |
| 2430 | 1368-1397 | Disease | denotes | retinal vascular inflammation | MESH:D007249 |
| 2431 | 1764-1796 | Disease | denotes | allergic intestinal inflammation | MESH:D007249 |
| 2432 | 1801-1816 | Disease | denotes | kidney fibrosis | MESH:D005355 |
| 2433 | 1936-1948 | Disease | denotes | inflammation | MESH:D007249 |
| 2434 | 2016-2030 | Disease | denotes | lung carcinoma | MESH:D008175 |
| 2435 | 2258-2275 | Disease | denotes | inflammatory pain | MESH:D010146 |
| 2436 | 2814-2833 | Disease | denotes | inflammatory injury | MESH:D007249 |
| 2437 | 2862-2890 | Disease | denotes | cardiovascular complications | MESH:D002318 |
| 2438 | 2972-2991 | Disease | denotes | inflammatory injury | MESH:D007249 |
| 2439 | 3354-3375 | Disease | denotes | cardiovascular injury | MESH:D002318 |
| 2440 | 3473-3494 | Disease | denotes | cardiovascular injury | MESH:D002318 |
| 2441 | 3508-3516 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 2442 | 3517-3526 | Disease | denotes | infection | MESH:D007239 |
| 2443 | 2909-2913 | CellLine | denotes | HL-1 | CVCL:0303 |