PMC:7534795 / 35823-39434 JSONTXT

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significantly more common with colchicine treatment • Colchicine may not have a significant effect on cardiac or inflammatory biomarkers, however it may be useful in stabilizing patients with severe COVID-19 infection and preventing clinical deterioration (Deftereos et al., 2020)\n• Statin therapy and impact on inflammation and patient prognosis • Retrospective cohort study\n• Primary endpoint of 28-day all-cause mortality\n• Secondary endpoint included acute cardiac injury\n• N = 1219 statin use\n• N = 12, 762 no statin • In-hospital statin use\n• Atorvastatin 83.2%,\n• Rosuvastatin 15.6%\n• Dose differences between statins were converted to a daily equivalent dose of atorvastatin ranging from 18.9–20.0 mg/day • Reduced all-cause mortality with statin use hazard ratio (HR) 0.63 (95% CI 0.48–0.84)\n• Patients on ACEi/ARB therapy in addition to statin did not have increased mortality compared to statin alone\n• Statin therapy not associated with acute cardiac injury\n• Inflammatory markers CRP, IL-6 were lower in statin treated patients while in hospital • Reduced mortality and improved prognosis associated with in-hospital statin use may be due to the anti-inflammatory and immunomodulatory effects of statins (Zhang, Qin, Cheng, et al., 2020)\n• ACEi/ARB impact on mortality in COVID-19 patients with concomitant hypertension • Retrospective, multi-centre cohort study\n• Patients with comorbid hypertension hospitalized with COVID-19\n• Age 18 to 74 years\n• Primary endpoint of 28-day all-cause mortality\n• N = 188 ACEi/ARB therapy\n• N = 940 no ACEi/ARB • ACEi/ARB for treatment of hypertension\n• individual patient dosing regimens not specified • Risk of all-cause mortality lower in ACEi/ARB treated group HR 0.42 (95% CI 0.19–0.92).\n• Use of ACEi/ARB in comparison to other anti-hypertension therapies was associated with lower mortality HR 0.30 (95% CI 0.12–0.70).\n• No difference in acute cardiac injury outcome between groups • Chronic ACEi/ARB therapy may not increase mortality of COVID-19 patients\n• May not have much benefit in acute heart injury due to COVID-19 inflammation (Zhang, Zhu, Cai, et al., 2020)\n• Statin use impact on acute myocardial injury patient outcomes • Retrospective observational cohort study\n• Patients with elevated troponin\n• History of CVD in 24% of patients\n• N = 3069\n• Objective to characterize myocardial injury and associated outcomes • 36% of patients using statins\n• Doses and regimens not specified • Statin use amongst patients with acute myocardial injury was associated with improved survival HR 0.57 (95% CI 0.47–0.69) • Statin treatment may be associated with a survival benefit in patients with CVD and elevated troponin levels\n• Exact beneficial mechanism(s) associated with statins in COVID-19 remain to be studied (Lala et al., 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