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PMC:7534795 / 35823-39434 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T177 365-373 Body_part denotes troponin http://purl.org/sig/ont/fma/fma62338
T178 401-408 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T179 659-667 Body_part denotes troponin http://purl.org/sig/ont/fma/fma62338
T180 2868-2873 Body_part denotes heart http://purl.org/sig/ont/fma/fma7088
T181 3074-3082 Body_part denotes troponin http://purl.org/sig/ont/fma/fma62338
T182 3487-3495 Body_part denotes troponin http://purl.org/sig/ont/fma/fma62338

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T64 509-514 Body_part denotes scale http://purl.obolibrary.org/obo/UBERON_0002542
T65 2868-2873 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T284 163-175 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T285 805-813 Disease denotes diarrhea http://purl.obolibrary.org/obo/MONDO_0001673
T286 1013-1021 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T287 1022-1031 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T288 1126-1138 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T289 1283-1289 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T290 1636-1639 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T291 1779-1785 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T292 2074-2077 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T293 2101-2109 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T294 2136-2148 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T295 2217-2229 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T296 2248-2256 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T297 2343-2346 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T298 2374-2377 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T299 2385-2388 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T300 2406-2418 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T301 2514-2517 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T302 2574-2577 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T303 2606-2618 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T304 2726-2732 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T305 2771-2774 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T306 2813-2821 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T307 2874-2880 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T308 2888-2896 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T309 2897-2909 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T310 2982-2988 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T311 3170-3176 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T312 3320-3326 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T313 3562-3570 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T251 219-224 http://purl.obolibrary.org/obo/CLO_0007225 denotes label
T252 892-893 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T253 1459-1460 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T254 2263-2265 http://purl.obolibrary.org/obo/CLO_0050510 denotes 18
T255 2868-2873 http://purl.obolibrary.org/obo/UBERON_0000948 denotes heart
T256 2868-2873 http://purl.obolibrary.org/obo/UBERON_0007100 denotes heart
T257 2868-2873 http://purl.obolibrary.org/obo/UBERON_0015228 denotes heart
T258 2868-2873 http://www.ebi.ac.uk/efo/EFO_0000815 denotes heart
T259 3133-3142 http://purl.obolibrary.org/obo/BFO_0000030 denotes Objective
T260 3203-3205 http://purl.obolibrary.org/obo/CLO_0001313 denotes 36
T261 3434-3435 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T274 109-119 Chemical denotes Colchicine http://purl.obolibrary.org/obo/CHEBI_27882
T275 219-224 Chemical denotes label http://purl.obolibrary.org/obo/CHEBI_35209
T276 269-279 Chemical denotes colchicine http://purl.obolibrary.org/obo/CHEBI_23359
T277 401-408 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T278 517-527 Chemical denotes Colchicine http://purl.obolibrary.org/obo/CHEBI_27882
T279 724-734 Chemical denotes colchicine http://purl.obolibrary.org/obo/CHEBI_23359
T280 845-855 Chemical denotes colchicine http://purl.obolibrary.org/obo/CHEBI_23359
T281 868-878 Chemical denotes Colchicine http://purl.obolibrary.org/obo/CHEBI_27882
T282 1302-1308 Chemical denotes statin http://purl.obolibrary.org/obo/CHEBI_87631
T283 1331-1337 Chemical denotes statin http://purl.obolibrary.org/obo/CHEBI_87631
T284 1352-1358 Chemical denotes statin http://purl.obolibrary.org/obo/CHEBI_87631
T285 1365-1377 Chemical denotes Atorvastatin http://purl.obolibrary.org/obo/CHEBI_39548
T286 1433-1440 Chemical denotes statins http://purl.obolibrary.org/obo/CHEBI_87631
T287 1486-1498 Chemical denotes atorvastatin http://purl.obolibrary.org/obo/CHEBI_39548
T288 1564-1570 Chemical denotes statin http://purl.obolibrary.org/obo/CHEBI_87631
T289 1663-1669 Chemical denotes statin http://purl.obolibrary.org/obo/CHEBI_87631
T290 1715-1721 Chemical denotes statin http://purl.obolibrary.org/obo/CHEBI_87631
T291 1814-1816 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T293 1833-1839 Chemical denotes statin http://purl.obolibrary.org/obo/CHEBI_87631
T294 1946-1952 Chemical denotes statin http://purl.obolibrary.org/obo/CHEBI_87631
T295 2025-2032 Chemical denotes statins http://purl.obolibrary.org/obo/CHEBI_87631
T296 2526-2531 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T297 3225-3232 Chemical denotes statins http://purl.obolibrary.org/obo/CHEBI_87631
T298 3551-3558 Chemical denotes statins http://purl.obolibrary.org/obo/CHEBI_87631

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T90 163-175 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T91 1126-1138 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T92 2897-2909 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T249 0-106 Sentence denotes Pharmacological intervention Sample size and criteria Treatment protocol Key findings Conclusion Reference
T250 107-258 Sentence denotes • Colchicine for the improvement of cardiac biomarkers, inflammation, and clinical outcomes • Prospective, open-label randomized controlled trial (RCT)
T251 259-295 Sentence denotes • N = 55 colchicine + standard care
T252 296-319 Sentence denotes • N = 50 standard care
T253 320-681 Sentence denotes • Primary endpoints included maximum cardiac troponin level, time for C-reactive protein (CRP) to reach 3× upper limit normal, time to deterioration by at least 2 points on clinical status scale • Colchicine 1.5 mg loading dose, 0.5 mg after 60 min, and then 0.5 mg twice daily + standard care for up to 3 weeks • No difference in cardiac troponin or CRP levels
T254 682-783 Sentence denotes • Clinical deterioration less common with colchicine treatment odd ratio (OR) 0.11 (95% CI 0.01–0.96)
T255 784-1094 Sentence denotes • Abdominal pain and diarrhea significantly more common with colchicine treatment • Colchicine may not have a significant effect on cardiac or inflammatory biomarkers, however it may be useful in stabilizing patients with severe COVID-19 infection and preventing clinical deterioration (Deftereos et al., 2020)
T256 1095-1189 Sentence denotes • Statin therapy and impact on inflammation and patient prognosis • Retrospective cohort study
T257 1190-1238 Sentence denotes • Primary endpoint of 28-day all-cause mortality
T258 1239-1289 Sentence denotes • Secondary endpoint included acute cardiac injury
T259 1290-1312 Sentence denotes • N = 1219 statin use
T260 1313-1362 Sentence denotes • N = 12, 762 no statin • In-hospital statin use
T261 1363-1384 Sentence denotes • Atorvastatin 83.2%,
T262 1385-1405 Sentence denotes • Rosuvastatin 15.6%
T263 1406-1616 Sentence denotes • Dose differences between statins were converted to a daily equivalent dose of atorvastatin ranging from 18.9–20.0 mg/day • Reduced all-cause mortality with statin use hazard ratio (HR) 0.63 (95% CI 0.48–0.84)
T264 1617-1727 Sentence denotes • Patients on ACEi/ARB therapy in addition to statin did not have increased mortality compared to statin alone
T265 1728-1785 Sentence denotes • Statin therapy not associated with acute cardiac injury
T266 1786-2066 Sentence denotes • Inflammatory markers CRP, IL-6 were lower in statin treated patients while in hospital • Reduced mortality and improved prognosis associated with in-hospital statin use may be due to the anti-inflammatory and immunomodulatory effects of statins (Zhang, Qin, Cheng, et al., 2020)
T267 2067-2191 Sentence denotes • ACEi/ARB impact on mortality in COVID-19 patients with concomitant hypertension • Retrospective, multi-centre cohort study
T268 2192-2256 Sentence denotes • Patients with comorbid hypertension hospitalized with COVID-19
T269 2257-2277 Sentence denotes • Age 18 to 74 years
T270 2278-2326 Sentence denotes • Primary endpoint of 28-day all-cause mortality
T271 2327-2354 Sentence denotes • N = 188 ACEi/ARB therapy
T272 2355-2418 Sentence denotes • N = 940 no ACEi/ARB • ACEi/ARB for treatment of hypertension
T273 2419-2559 Sentence denotes • individual patient dosing regimens not specified • Risk of all-cause mortality lower in ACEi/ARB treated group HR 0.42 (95% CI 0.19–0.92).
T274 2560-2692 Sentence denotes • Use of ACEi/ARB in comparison to other anti-hypertension therapies was associated with lower mortality HR 0.30 (95% CI 0.12–0.70).
T275 2693-2830 Sentence denotes • No difference in acute cardiac injury outcome between groups • Chronic ACEi/ARB therapy may not increase mortality of COVID-19 patients
T276 2831-2941 Sentence denotes • May not have much benefit in acute heart injury due to COVID-19 inflammation (Zhang, Zhu, Cai, et al., 2020)
T277 2942-3048 Sentence denotes • Statin use impact on acute myocardial injury patient outcomes • Retrospective observational cohort study
T278 3049-3082 Sentence denotes • Patients with elevated troponin
T279 3083-3118 Sentence denotes • History of CVD in 24% of patients
T280 3119-3130 Sentence denotes • N = 3069
T281 3131-3232 Sentence denotes • Objective to characterize myocardial injury and associated outcomes • 36% of patients using statins
T282 3233-3502 Sentence denotes • Doses and regimens not specified • Statin use amongst patients with acute myocardial injury was associated with improved survival HR 0.57 (95% CI 0.47–0.69) • Statin treatment may be associated with a survival benefit in patients with CVD and elevated troponin levels
T283 3503-3611 Sentence denotes • Exact beneficial mechanism(s) associated with statins in COVID-19 remain to be studied (Lala et al., 2020)

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T145 786-800 Phenotype denotes Abdominal pain http://purl.obolibrary.org/obo/HP_0002027
T146 805-813 Phenotype denotes diarrhea http://purl.obolibrary.org/obo/HP_0002014
T147 2136-2148 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T148 2217-2229 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T149 2406-2418 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T150 2606-2618 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822

2_test

Id Subject Object Predicate Lexical cue
33031856-32302265-84038880 2936-2940 32302265 denotes 2020
33031856-32517963-84038881 3606-3610 32517963 denotes 2020

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
1180 390-408 Gene denotes C-reactive protein Gene:1401
1181 410-413 Gene denotes CRP Gene:1401
1182 671-674 Gene denotes CRP Gene:1401
1183 1809-1812 Gene denotes CRP Gene:1401
1184 1814-1818 Gene denotes IL-6 Gene:3569
1185 992-1000 Species denotes patients Tax:9606
1186 1143-1150 Species denotes patient Tax:9606
1187 1619-1627 Species denotes Patients Tax:9606
1188 1848-1856 Species denotes patients Tax:9606
1189 2110-2118 Species denotes patients Tax:9606
1190 2432-2439 Species denotes patient Tax:9606
1191 2456-2469 Species denotes not specified Tax:32644
1192 2989-2996 Species denotes patient Tax:9606
1193 3210-3218 Species denotes patients Tax:9606
1194 3254-3267 Species denotes not specified Tax:32644
1195 3289-3297 Species denotes patients Tax:9606
1196 3456-3464 Species denotes patients Tax:9606
1197 163-175 Disease denotes inflammation MESH:D007249
1198 786-800 Disease denotes Abdominal pain MESH:D015746
1199 805-813 Disease denotes diarrhea MESH:D003967
1200 1013-1021 Disease denotes COVID-19 MESH:C000657245
1201 1022-1031 Disease denotes infection MESH:D007239
1202 1126-1138 Disease denotes inflammation MESH:D007249
1203 1275-1294 Disease denotes cardiac injury • N MESH:D006331
1204 1549-1558 Disease denotes mortality MESH:D003643
1205 1693-1702 Disease denotes mortality MESH:D003643
1206 1771-1800 Disease denotes cardiac injury • Inflammatory MESH:D006331
1207 1885-1894 Disease denotes mortality MESH:D003643
1208 2088-2097 Disease denotes mortality MESH:D003643
1209 2101-2109 Disease denotes COVID-19 MESH:C000657245
1210 2136-2148 Disease denotes hypertension MESH:D006973
1211 2217-2229 Disease denotes hypertension MESH:D006973
1212 2248-2253 Disease denotes COVID MESH:C000657245
1213 2490-2499 Disease denotes mortality MESH:D003643
1214 2606-2618 Disease denotes hypertension MESH:D006973
1215 2655-2664 Disease denotes mortality MESH:D003643
1216 2718-2732 Disease denotes cardiac injury MESH:D006331
1217 2800-2809 Disease denotes mortality MESH:D003643
1218 2813-2821 Disease denotes COVID-19 MESH:C000657245
1219 2868-2880 Disease denotes heart injury MESH:D006335
1220 2888-2896 Disease denotes COVID-19 MESH:C000657245
1221 2897-2909 Disease denotes inflammation MESH:D007249
1222 2971-2988 Disease denotes myocardial injury MESH:D009202
1223 3096-3099 Disease denotes CVD MESH:D002318
1224 3159-3176 Disease denotes myocardial injury MESH:D009202
1225 3309-3326 Disease denotes myocardial injury MESH:D009202
1226 3470-3473 Disease denotes CVD MESH:D002318
1227 3562-3570 Disease denotes COVID-19 MESH:C000657245