PMC:7534795 / 32767-33808 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7534795","sourcedb":"PMC","sourceid":"7534795","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7534795","text":"A 12-year follow-up study conducted by Wu et al. of 25 patients who recovered from SARS-CoV infection demonstrated patients were affected by various metabolic disturbances altering lipid metabolism and the cardiovascular system. These patients suffered from hyperlipidemia, increased serum concentrations of free fatty acids, abnormal glucose metabolism and other cardiovascular abnormalities (Wu et al., 2017). Considering the genetic similarities between SARS-CoV and SARS-CoV-2, Zhang et al. recently proposed the use of the lipid-lowering statins, which also possess anti-inflammatory properties, as a therapeutic option for patients with COVID-19. This study reported that amongst 13,981 cases of COVID-19, in-hospital use of statins was associated with a lower risk of death and a significantly lower inflammatory response during the entire hospitalization period (Zhang et al., 2020). Thus, suggesting the use of lipid-lowering drugs with anti-inflammatory properties can improve the cardiovascular outcomes in patients with COVID-19.","tracks":[{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T166","span":{"begin":181,"end":186},"obj":"Body_part"},{"id":"T167","span":{"begin":206,"end":227},"obj":"Body_part"},{"id":"T168","span":{"begin":284,"end":289},"obj":"Body_part"},{"id":"T169","span":{"begin":313,"end":324},"obj":"Body_part"},{"id":"T170","span":{"begin":335,"end":342},"obj":"Body_part"},{"id":"T171","span":{"begin":528,"end":533},"obj":"Body_part"},{"id":"T172","span":{"begin":920,"end":925},"obj":"Body_part"}],"attributes":[{"id":"A166","pred":"fma_id","subj":"T166","obj":"http://purl.org/sig/ont/fma/fma67264"},{"id":"A167","pred":"fma_id","subj":"T167","obj":"http://purl.org/sig/ont/fma/fma7161"},{"id":"A168","pred":"fma_id","subj":"T168","obj":"http://purl.org/sig/ont/fma/fma63083"},{"id":"A169","pred":"fma_id","subj":"T169","obj":"http://purl.org/sig/ont/fma/fma82738"},{"id":"A170","pred":"fma_id","subj":"T170","obj":"http://purl.org/sig/ont/fma/fma82743"},{"id":"A171","pred":"fma_id","subj":"T171","obj":"http://purl.org/sig/ont/fma/fma67264"},{"id":"A172","pred":"fma_id","subj":"T172","obj":"http://purl.org/sig/ont/fma/fma67264"},{"subj":"T166","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T167","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T168","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T169","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T170","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T171","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T172","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T58","span":{"begin":206,"end":227},"obj":"Body_part"},{"id":"T59","span":{"begin":284,"end":289},"obj":"Body_part"}],"attributes":[{"id":"A58","pred":"uberon_id","subj":"T58","obj":"http://purl.obolibrary.org/obo/UBERON_0004535"},{"id":"A59","pred":"uberon_id","subj":"T59","obj":"http://purl.obolibrary.org/obo/UBERON_0001977"},{"subj":"T58","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T59","pred":"source","obj":"LitCovid-PD-UBERON"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T258","span":{"begin":83,"end":101},"obj":"Disease"},{"id":"T259","span":{"begin":92,"end":101},"obj":"Disease"},{"id":"T260","span":{"begin":258,"end":272},"obj":"Disease"},{"id":"T261","span":{"begin":457,"end":465},"obj":"Disease"},{"id":"T262","span":{"begin":470,"end":478},"obj":"Disease"},{"id":"T263","span":{"begin":643,"end":651},"obj":"Disease"},{"id":"T264","span":{"begin":702,"end":710},"obj":"Disease"},{"id":"T265","span":{"begin":1032,"end":1040},"obj":"Disease"}],"attributes":[{"id":"A258","pred":"mondo_id","subj":"T258","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A259","pred":"mondo_id","subj":"T259","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A260","pred":"mondo_id","subj":"T260","obj":"http://purl.obolibrary.org/obo/MONDO_0021187"},{"id":"A261","pred":"mondo_id","subj":"T261","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A262","pred":"mondo_id","subj":"T262","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A263","pred":"mondo_id","subj":"T263","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A264","pred":"mondo_id","subj":"T264","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A265","pred":"mondo_id","subj":"T265","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"subj":"T258","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T259","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T260","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T261","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T262","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T263","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T264","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T265","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T33652","span":{"begin":0,"end":1},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T84691","span":{"begin":206,"end":227},"obj":"http://purl.obolibrary.org/obo/UBERON_0004535"},{"id":"T4742","span":{"begin":206,"end":227},"obj":"http://www.ebi.ac.uk/efo/EFO_0000791"},{"id":"T58635","span":{"begin":604,"end":605},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T95845","span":{"begin":759,"end":760},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T6069","span":{"begin":785,"end":786},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"attributes":[{"subj":"T33652","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T84691","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T4742","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T58635","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T95845","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T6069","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T250","span":{"begin":181,"end":186},"obj":"Chemical"},{"id":"T251","span":{"begin":313,"end":324},"obj":"Chemical"},{"id":"T252","span":{"begin":319,"end":324},"obj":"Chemical"},{"id":"T253","span":{"begin":335,"end":342},"obj":"Chemical"},{"id":"T255","span":{"begin":528,"end":533},"obj":"Chemical"},{"id":"T256","span":{"begin":543,"end":550},"obj":"Chemical"},{"id":"T257","span":{"begin":731,"end":738},"obj":"Chemical"},{"id":"T258","span":{"begin":920,"end":940},"obj":"Chemical"},{"id":"T259","span":{"begin":920,"end":925},"obj":"Chemical"},{"id":"T260","span":{"begin":935,"end":940},"obj":"Chemical"}],"attributes":[{"id":"A250","pred":"chebi_id","subj":"T250","obj":"http://purl.obolibrary.org/obo/CHEBI_18059"},{"id":"A251","pred":"chebi_id","subj":"T251","obj":"http://purl.obolibrary.org/obo/CHEBI_35366"},{"id":"A252","pred":"chebi_id","subj":"T252","obj":"http://purl.obolibrary.org/obo/CHEBI_37527"},{"id":"A253","pred":"chebi_id","subj":"T253","obj":"http://purl.obolibrary.org/obo/CHEBI_17234"},{"id":"A254","pred":"chebi_id","subj":"T253","obj":"http://purl.obolibrary.org/obo/CHEBI_4167"},{"id":"A255","pred":"chebi_id","subj":"T255","obj":"http://purl.obolibrary.org/obo/CHEBI_18059"},{"id":"A256","pred":"chebi_id","subj":"T256","obj":"http://purl.obolibrary.org/obo/CHEBI_87631"},{"id":"A257","pred":"chebi_id","subj":"T257","obj":"http://purl.obolibrary.org/obo/CHEBI_87631"},{"id":"A258","pred":"chebi_id","subj":"T258","obj":"http://purl.obolibrary.org/obo/CHEBI_35679"},{"id":"A259","pred":"chebi_id","subj":"T259","obj":"http://purl.obolibrary.org/obo/CHEBI_18059"},{"id":"A260","pred":"chebi_id","subj":"T260","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"},{"subj":"T250","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T251","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T252","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T253","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T255","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T256","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T257","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T258","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T259","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T260","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T81","span":{"begin":181,"end":197},"obj":"http://purl.obolibrary.org/obo/GO_0006629"},{"id":"T82","span":{"begin":187,"end":197},"obj":"http://purl.obolibrary.org/obo/GO_0008152"},{"id":"T83","span":{"begin":335,"end":353},"obj":"http://purl.obolibrary.org/obo/GO_0006006"},{"id":"T84","span":{"begin":343,"end":353},"obj":"http://purl.obolibrary.org/obo/GO_0008152"},{"id":"T85","span":{"begin":807,"end":828},"obj":"http://purl.obolibrary.org/obo/GO_0006954"}],"attributes":[{"subj":"T81","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T82","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T83","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T84","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T85","pred":"source","obj":"LitCovid-PD-GO-BP"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T234","span":{"begin":0,"end":228},"obj":"Sentence"},{"id":"T235","span":{"begin":229,"end":411},"obj":"Sentence"},{"id":"T236","span":{"begin":412,"end":652},"obj":"Sentence"},{"id":"T237","span":{"begin":653,"end":891},"obj":"Sentence"},{"id":"T238","span":{"begin":892,"end":1041},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T234","pred":"source","obj":"LitCovid-sentences"},{"subj":"T235","pred":"source","obj":"LitCovid-sentences"},{"subj":"T236","pred":"source","obj":"LitCovid-sentences"},{"subj":"T237","pred":"source","obj":"LitCovid-sentences"},{"subj":"T238","pred":"source","obj":"LitCovid-sentences"}]},{"project":"LitCovid-PD-HP","denotations":[{"id":"T136","span":{"begin":258,"end":272},"obj":"Phenotype"},{"id":"T137","span":{"begin":313,"end":334},"obj":"Phenotype"},{"id":"T138","span":{"begin":364,"end":392},"obj":"Phenotype"}],"attributes":[{"id":"A136","pred":"hp_id","subj":"T136","obj":"http://purl.obolibrary.org/obo/HP_0003077"},{"id":"A137","pred":"hp_id","subj":"T137","obj":"http://purl.obolibrary.org/obo/HP_0004359"},{"id":"A138","pred":"hp_id","subj":"T138","obj":"http://purl.obolibrary.org/obo/HP_0001626"},{"subj":"T136","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T137","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T138","pred":"source","obj":"LitCovid-PD-HP"}]},{"project":"2_test","denotations":[{"id":"33031856-28831119-84038873","span":{"begin":405,"end":409},"obj":"28831119"}],"attributes":[{"subj":"33031856-28831119-84038873","pred":"source","obj":"2_test"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"1070","span":{"begin":55,"end":63},"obj":"Species"},{"id":"1071","span":{"begin":115,"end":123},"obj":"Species"},{"id":"1072","span":{"begin":235,"end":243},"obj":"Species"},{"id":"1073","span":{"begin":457,"end":465},"obj":"Species"},{"id":"1074","span":{"begin":470,"end":480},"obj":"Species"},{"id":"1077","span":{"begin":181,"end":186},"obj":"Chemical"},{"id":"1078","span":{"begin":313,"end":324},"obj":"Chemical"},{"id":"1079","span":{"begin":528,"end":533},"obj":"Chemical"},{"id":"1080","span":{"begin":83,"end":101},"obj":"Disease"},{"id":"1081","span":{"begin":258,"end":272},"obj":"Disease"},{"id":"1082","span":{"begin":326,"end":353},"obj":"Disease"},{"id":"1083","span":{"begin":364,"end":392},"obj":"Disease"}],"attributes":[{"id":"A1070","pred":"tao:has_database_id","subj":"1070","obj":"Tax:9606"},{"id":"A1071","pred":"tao:has_database_id","subj":"1071","obj":"Tax:9606"},{"id":"A1072","pred":"tao:has_database_id","subj":"1072","obj":"Tax:9606"},{"id":"A1073","pred":"tao:has_database_id","subj":"1073","obj":"Tax:694009"},{"id":"A1074","pred":"tao:has_database_id","subj":"1074","obj":"Tax:2697049"},{"id":"A1077","pred":"tao:has_database_id","subj":"1077","obj":"MESH:D008055"},{"id":"A1078","pred":"tao:has_database_id","subj":"1078","obj":"MESH:D005227"},{"id":"A1079","pred":"tao:has_database_id","subj":"1079","obj":"MESH:D008055"},{"id":"A1080","pred":"tao:has_database_id","subj":"1080","obj":"MESH:C000657245"},{"id":"A1081","pred":"tao:has_database_id","subj":"1081","obj":"MESH:D006949"},{"id":"A1082","pred":"tao:has_database_id","subj":"1082","obj":"MESH:D044882"},{"id":"A1083","pred":"tao:has_database_id","subj":"1083","obj":"MESH:D002318"},{"subj":"1070","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1071","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1072","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1073","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1074","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1077","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1078","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1079","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1080","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1081","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1082","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1083","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PD-FMA-UBERON","color":"#ecc993","default":true},{"id":"LitCovid-PD-UBERON","color":"#af93ec"},{"id":"LitCovid-PD-MONDO","color":"#93ec95"},{"id":"LitCovid-PD-CLO","color":"#ec93ab"},{"id":"LitCovid-PD-CHEBI","color":"#93c5ec"},{"id":"LitCovid-PD-GO-BP","color":"#dfec93"},{"id":"LitCovid-sentences","color":"#df93ec"},{"id":"LitCovid-PD-HP","color":"#93ecc5"},{"id":"2_test","color":"#ecab93"},{"id":"LitCovid-PubTator","color":"#9394ec"}]}]}}