PMC:7534795 / 1971-8036
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T43090 | 735-745 | Body_part | denotes | nucleotide | http://purl.org/sig/ont/fma/fma82740 |
| T41330 | 1665-1688 | Body_part | denotes | central nervous systems | http://purl.org/sig/ont/fma/fma55675 |
| T72777 | 1760-1765 | Body_part | denotes | lungs | http://purl.org/sig/ont/fma/fma68877 |
| T16084 | 1795-1813 | Body_part | denotes | organs and systems | http://purl.org/sig/ont/fma/fma7149 |
| T80150 | 1829-1836 | Body_part | denotes | kidneys | http://purl.org/sig/ont/fma/fma7203 |
| T68146 | 1838-1843 | Body_part | denotes | heart | http://purl.org/sig/ont/fma/fma7088 |
| T74654 | 1845-1858 | Body_part | denotes | blood vessels | http://purl.org/sig/ont/fma/fma63183 |
| T81920 | 1845-1850 | Body_part | denotes | blood | http://purl.org/sig/ont/fma/fma9670 |
| T8742 | 1860-1882 | Body_part | denotes | gastrointestinal tract | http://purl.org/sig/ont/fma/fma71132 |
| T68419 | 1887-1892 | Body_part | denotes | brain | http://purl.org/sig/ont/fma/fma50801 |
| T63124 | 2036-2059 | Body_part | denotes | lower respiratory tract | http://purl.org/sig/ont/fma/fma45662 |
| T36357 | 2137-2141 | Body_part | denotes | lung | http://purl.org/sig/ont/fma/fma7195 |
| T22313 | 2229-2234 | Body_part | denotes | heart | http://purl.org/sig/ont/fma/fma7088 |
| T26828 | 3051-3060 | Body_part | denotes | Melatonin | http://purl.org/sig/ont/fma/fma74644 |
| T62683 | 3190-3195 | Body_part | denotes | heart | http://purl.org/sig/ont/fma/fma7088 |
| T69623 | 3259-3272 | Body_part | denotes | interleukin-6 | http://purl.org/sig/ont/fma/fma264829 |
| T2300 | 3405-3413 | Body_part | denotes | cytokine | http://purl.org/sig/ont/fma/fma84050 |
| T70564 | 3728-3733 | Body_part | denotes | organ | http://purl.org/sig/ont/fma/fma67498 |
| T71556 | 4076-4089 | Body_part | denotes | interleukin-1 | http://purl.org/sig/ont/fma/fma86583 |
| T41271 | 4113-4117 | Body_part | denotes | IL-1 | http://purl.org/sig/ont/fma/fma86583 |
| T45585 | 4138-4145 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T90573 | 4193-4201 | Body_part | denotes | cytokine | http://purl.org/sig/ont/fma/fma84050 |
| T84940 | 4318-4329 | Body_part | denotes | Granulocyte | http://purl.org/sig/ont/fma/fma62854 |
| T2963 | 4330-4340 | Body_part | denotes | macrophage | http://purl.org/sig/ont/fma/fma63261 |
| T89453 | 4371-4374 | Body_part | denotes | CSF | http://purl.org/sig/ont/fma/fma20935 |
| T80835 | 4392-4395 | Body_part | denotes | CSF | http://purl.org/sig/ont/fma/fma20935 |
| T16035 | 4442-4453 | Body_part | denotes | macrophages | http://purl.org/sig/ont/fma/fma63261 |
| T75061 | 4517-4520 | Body_part | denotes | CSF | http://purl.org/sig/ont/fma/fma20935 |
| T35610 | 4568-4571 | Body_part | denotes | CSF | http://purl.org/sig/ont/fma/fma20935 |
| T79976 | 4597-4606 | Body_part | denotes | cytokines | http://purl.org/sig/ont/fma/fma84050 |
| T70672 | 4646-4654 | Body_part | denotes | cytokine | http://purl.org/sig/ont/fma/fma84050 |
| T41412 | 4744-4753 | Body_part | denotes | cytokines | http://purl.org/sig/ont/fma/fma84050 |
| T31184 | 5377-5382 | Body_part | denotes | heart | http://purl.org/sig/ont/fma/fma7088 |
| T42589 | 5770-5791 | Body_part | denotes | endoplasmic reticulum | http://purl.org/sig/ont/fma/fma63842 |
| T72751 | 5793-5795 | Body_part | denotes | ER | http://purl.org/sig/ont/fma/fma63842 |
| T4655 | 5977-5988 | Body_part | denotes | fatty acids | http://purl.org/sig/ont/fma/fma82738 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T4 | 1665-1688 | Body_part | denotes | central nervous systems | http://purl.obolibrary.org/obo/UBERON_0001017 |
| T5 | 1795-1801 | Body_part | denotes | organs | http://purl.obolibrary.org/obo/UBERON_0000062 |
| T6 | 1838-1858 | Body_part | denotes | heart, blood vessels | http://purl.obolibrary.org/obo/UBERON_0003498 |
| T7 | 1838-1843 | Body_part | denotes | heart | http://purl.obolibrary.org/obo/UBERON_0000948 |
| T8 | 1845-1850 | Body_part | denotes | blood | http://purl.obolibrary.org/obo/UBERON_0000178 |
| T9 | 1851-1858 | Body_part | denotes | vessels | http://purl.obolibrary.org/obo/UBERON_0000055 |
| T10 | 1887-1892 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/UBERON_0000955 |
| T11 | 2036-2059 | Body_part | denotes | lower respiratory tract | http://purl.obolibrary.org/obo/UBERON_0001558 |
| T12 | 2042-2059 | Body_part | denotes | respiratory tract | http://purl.obolibrary.org/obo/UBERON_0000065 |
| T13 | 2137-2141 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
| T14 | 2229-2234 | Body_part | denotes | heart | http://purl.obolibrary.org/obo/UBERON_0000948 |
| T15 | 3190-3195 | Body_part | denotes | heart | http://purl.obolibrary.org/obo/UBERON_0000948 |
| T16 | 3728-3733 | Body_part | denotes | organ | http://purl.obolibrary.org/obo/UBERON_0000062 |
| T17 | 5377-5382 | Body_part | denotes | heart | http://purl.obolibrary.org/obo/UBERON_0000948 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T15 | 79-116 | Disease | denotes | severe and acute respiratory syndrome | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T16 | 130-138 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T17 | 262-270 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T18 | 288-298 | Disease | denotes | infectious | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T19 | 653-661 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T20 | 701-709 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T21 | 783-830 | Disease | denotes | severe acute respiratory syndrome coronavirus 2 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T22 | 783-816 | Disease | denotes | severe acute respiratory syndrome | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T23 | 832-840 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T24 | 1011-1019 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T25 | 1110-1119 | Disease | denotes | pneumonia | http://purl.obolibrary.org/obo/MONDO_0005249 |
| T26 | 1197-1205 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T27 | 1304-1312 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T28 | 1727-1735 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T29 | 1956-1964 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T30 | 2036-2067 | Disease | denotes | lower respiratory tract disease | http://purl.obolibrary.org/obo/MONDO_0000270 |
| T31 | 2131-2148 | Disease | denotes | acute lung injury | http://purl.obolibrary.org/obo/MONDO_0006502|http://purl.obolibrary.org/obo/MONDO_0015796 |
| T33 | 2142-2148 | Disease | denotes | injury | http://purl.obolibrary.org/obo/MONDO_0021178 |
| T34 | 2150-2153 | Disease | denotes | ALI | http://purl.obolibrary.org/obo/MONDO_0006502 |
| T35 | 2156-2191 | Disease | denotes | acute respiratory distress syndrome | http://purl.obolibrary.org/obo/MONDO_0006502 |
| T36 | 2162-2191 | Disease | denotes | respiratory distress syndrome | http://purl.obolibrary.org/obo/MONDO_0009971 |
| T37 | 2193-2197 | Disease | denotes | ARDS | http://purl.obolibrary.org/obo/MONDO_0006502 |
| T38 | 2200-2219 | Disease | denotes | respiratory failure | http://purl.obolibrary.org/obo/MONDO_0021113 |
| T39 | 2229-2242 | Disease | denotes | heart failure | http://purl.obolibrary.org/obo/MONDO_0005252 |
| T40 | 2244-2246 | Disease | denotes | HF | http://purl.obolibrary.org/obo/MONDO_0005252 |
| T41 | 2252-2273 | Disease | denotes | sudden cardiac arrest | http://purl.obolibrary.org/obo/MONDO_0007264 |
| T42 | 2259-2273 | Disease | denotes | cardiac arrest | http://purl.obolibrary.org/obo/MONDO_0000745 |
| T43 | 2612-2620 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T44 | 2826-2834 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T45 | 3006-3014 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T46 | 3105-3119 | Disease | denotes | cardiomyopathy | http://purl.obolibrary.org/obo/MONDO_0004994 |
| T47 | 3138-3159 | Disease | denotes | myocardial infarction | http://purl.obolibrary.org/obo/MONDO_0005068 |
| T48 | 3161-3175 | Disease | denotes | cardiomyopathy | http://purl.obolibrary.org/obo/MONDO_0004994 |
| T49 | 3177-3204 | Disease | denotes | hypertensive heart diseases | http://purl.obolibrary.org/obo/MONDO_0001302 |
| T50 | 3210-3232 | Disease | denotes | pulmonary hypertension | http://purl.obolibrary.org/obo/MONDO_0005149 |
| T51 | 3220-3232 | Disease | denotes | hypertension | http://purl.obolibrary.org/obo/MONDO_0005044 |
| T52 | 3674-3682 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T53 | 3765-3771 | Disease | denotes | injury | http://purl.obolibrary.org/obo/MONDO_0021178 |
| T54 | 4456-4464 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T55 | 4770-4778 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T56 | 5073-5081 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T57 | 5222-5230 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T58 | 5316-5328 | Disease | denotes | hypertension | http://purl.obolibrary.org/obo/MONDO_0005044 |
| T59 | 5330-5345 | Disease | denotes | atherosclerosis | http://purl.obolibrary.org/obo/MONDO_0005311 |
| T60 | 5357-5369 | Disease | denotes | inflammation | http://purl.obolibrary.org/obo/MONDO_0021166 |
| T61 | 5377-5390 | Disease | denotes | heart failure | http://purl.obolibrary.org/obo/MONDO_0005252 |
| T62 | 5400-5412 | Disease | denotes | inflammation | http://purl.obolibrary.org/obo/MONDO_0021166 |
| T63 | 5418-5437 | Disease | denotes | myocardial ischemia | http://purl.obolibrary.org/obo/MONDO_0024644 |
| T64 | 5429-5437 | Disease | denotes | ischemia | http://purl.obolibrary.org/obo/MONDO_0005053 |
| T65 | 5856-5868 | Disease | denotes | inflammation | http://purl.obolibrary.org/obo/MONDO_0021166 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T88816 | 559-566 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | Viruses |
| T19128 | 1098-1099 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T18892 | 1346-1358 | http://purl.obolibrary.org/obo/OBI_0000245 | denotes | Organization |
| T18621 | 1362-1363 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T5066 | 1580-1587 | http://purl.obolibrary.org/obo/NCBITaxon_33208 | denotes | animals |
| T11010 | 1592-1598 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | humans |
| T91245 | 1665-1688 | http://purl.obolibrary.org/obo/UBERON_0001017 | denotes | central nervous systems |
| T41100 | 1665-1688 | http://www.ebi.ac.uk/efo/EFO_0000302 | denotes | central nervous systems |
| T28423 | 1665-1688 | http://www.ebi.ac.uk/efo/EFO_0000908 | denotes | central nervous systems |
| T54681 | 1695-1697 | http://purl.obolibrary.org/obo/CLO_0001022 | denotes | Li |
| T54688 | 1695-1697 | http://purl.obolibrary.org/obo/CLO_0007314 | denotes | Li |
| T28843 | 1760-1765 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lungs |
| T98322 | 1795-1813 | http://purl.obolibrary.org/obo/UBERON_0000467 | denotes | organs and systems |
| T76276 | 1829-1836 | http://purl.obolibrary.org/obo/UBERON_0002113 | denotes | kidneys |
| T59650 | 1829-1836 | http://www.ebi.ac.uk/efo/EFO_0000927 | denotes | kidneys |
| T46669 | 1829-1836 | http://www.ebi.ac.uk/efo/EFO_0000929 | denotes | kidneys |
| T10398 | 1838-1843 | http://purl.obolibrary.org/obo/UBERON_0000948 | denotes | heart |
| T37309 | 1838-1843 | http://purl.obolibrary.org/obo/UBERON_0007100 | denotes | heart |
| T60359 | 1838-1843 | http://purl.obolibrary.org/obo/UBERON_0015228 | denotes | heart |
| T83927 | 1838-1843 | http://www.ebi.ac.uk/efo/EFO_0000815 | denotes | heart |
| T95767 | 1845-1858 | http://purl.obolibrary.org/obo/UBERON_0001981 | denotes | blood vessels |
| T43385 | 1845-1858 | http://www.ebi.ac.uk/efo/EFO_0000817 | denotes | blood vessels |
| T54345 | 1860-1882 | http://purl.obolibrary.org/obo/UBERON_0005409 | denotes | gastrointestinal tract |
| T58218 | 1887-1892 | http://purl.obolibrary.org/obo/UBERON_0000955 | denotes | brain |
| T72303 | 1887-1892 | http://www.ebi.ac.uk/efo/EFO_0000302 | denotes | brain |
| T28712 | 2036-2059 | http://purl.obolibrary.org/obo/UBERON_0001558 | denotes | lower respiratory tract |
| T81723 | 2137-2141 | http://purl.obolibrary.org/obo/UBERON_0002048 | denotes | lung |
| T29985 | 2137-2141 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lung |
| T97169 | 2229-2234 | http://purl.obolibrary.org/obo/UBERON_0000948 | denotes | heart |
| T97037 | 2229-2234 | http://purl.obolibrary.org/obo/UBERON_0007100 | denotes | heart |
| T58825 | 2229-2234 | http://purl.obolibrary.org/obo/UBERON_0015228 | denotes | heart |
| T17826 | 2229-2234 | http://www.ebi.ac.uk/efo/EFO_0000815 | denotes | heart |
| T25626 | 2281-2282 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T20269 | 3122-3125 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | Has |
| T32303 | 3190-3195 | http://purl.obolibrary.org/obo/UBERON_0000948 | denotes | heart |
| T86034 | 3190-3195 | http://purl.obolibrary.org/obo/UBERON_0007100 | denotes | heart |
| T68915 | 3190-3195 | http://purl.obolibrary.org/obo/UBERON_0015228 | denotes | heart |
| T41295 | 3190-3195 | http://www.ebi.ac.uk/efo/EFO_0000815 | denotes | heart |
| T78016 | 3259-3272 | http://purl.obolibrary.org/obo/PR_000001393 | denotes | interleukin-6 |
| T85990 | 3728-3733 | http://purl.obolibrary.org/obo/UBERON_0003103 | denotes | organ |
| T15304 | 3928-3937 | http://purl.obolibrary.org/obo/SO_0000418 | denotes | signaling |
| T98618 | 4076-4089 | http://purl.obolibrary.org/obo/PR_000001091 | denotes | interleukin-1 |
| T66694 | 4102-4103 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T23727 | 4405-4406 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T5199 | 4429-4438 | http://purl.obolibrary.org/obo/SO_0000418 | denotes | signaling |
| T73249 | 5377-5382 | http://purl.obolibrary.org/obo/UBERON_0000948 | denotes | heart |
| T2074 | 5377-5382 | http://purl.obolibrary.org/obo/UBERON_0007100 | denotes | heart |
| T35465 | 5377-5382 | http://purl.obolibrary.org/obo/UBERON_0015228 | denotes | heart |
| T11230 | 5377-5382 | http://www.ebi.ac.uk/efo/EFO_0000815 | denotes | heart |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T29 | 735-745 | Chemical | denotes | nucleotide | http://purl.obolibrary.org/obo/CHEBI_36976 |
| T30 | 1695-1697 | Chemical | denotes | Li | http://purl.obolibrary.org/obo/CHEBI_30145 |
| T31 | 2244-2246 | Chemical | denotes | HF | http://purl.obolibrary.org/obo/CHEBI_141438|http://purl.obolibrary.org/obo/CHEBI_29228 |
| T33 | 2481-2496 | Chemical | denotes | corticosteroids | http://purl.obolibrary.org/obo/CHEBI_50858 |
| T34 | 2498-2507 | Chemical | denotes | antiviral | http://purl.obolibrary.org/obo/CHEBI_22587 |
| T35 | 2918-2927 | Chemical | denotes | Vitamin C | http://purl.obolibrary.org/obo/CHEBI_21241|http://purl.obolibrary.org/obo/CHEBI_29073|http://purl.obolibrary.org/obo/CHEBI_38290 |
| T38 | 2918-2925 | Chemical | denotes | Vitamin | http://purl.obolibrary.org/obo/CHEBI_33229 |
| T39 | 3051-3060 | Chemical | denotes | Melatonin | http://purl.obolibrary.org/obo/CHEBI_16796 |
| T40 | 3293-3295 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T42 | 3326-3328 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T44 | 3353-3355 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T46 | 3433-3435 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T48 | 3573-3583 | Chemical | denotes | etanercept | http://purl.obolibrary.org/obo/CHEBI_4875 |
| T49 | 3817-3827 | Chemical | denotes | inhibitors | http://purl.obolibrary.org/obo/CHEBI_35222 |
| T50 | 3843-3854 | Chemical | denotes | tofacitinib | http://purl.obolibrary.org/obo/CHEBI_71200 |
| T51 | 3923-3925 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T53 | 4113-4115 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T55 | 4127-4137 | Chemical | denotes | antagonist | http://purl.obolibrary.org/obo/CHEBI_48706 |
| T56 | 4138-4145 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T57 | 4368-4370 | Chemical | denotes | GM | http://purl.obolibrary.org/obo/CHEBI_74120 |
| T58 | 4389-4391 | Chemical | denotes | GM | http://purl.obolibrary.org/obo/CHEBI_74120 |
| T59 | 4514-4516 | Chemical | denotes | GM | http://purl.obolibrary.org/obo/CHEBI_74120 |
| T60 | 4565-4567 | Chemical | denotes | GM | http://purl.obolibrary.org/obo/CHEBI_74120 |
| T61 | 4960-4971 | Chemical | denotes | antagonists | http://purl.obolibrary.org/obo/CHEBI_48706 |
| T62 | 5108-5124 | Chemical | denotes | N-acetylcysteine | http://purl.obolibrary.org/obo/CHEBI_28939 |
| T63 | 5110-5124 | Chemical | denotes | acetylcysteine | http://purl.obolibrary.org/obo/CHEBI_22198 |
| T64 | 5126-5129 | Chemical | denotes | NAC | http://purl.obolibrary.org/obo/CHEBI_28939|http://purl.obolibrary.org/obo/CHEBI_7421 |
| T66 | 5138-5145 | Chemical | denotes | oxidant | http://purl.obolibrary.org/obo/CHEBI_63248 |
| T67 | 5182-5185 | Chemical | denotes | NAC | http://purl.obolibrary.org/obo/CHEBI_28939|http://purl.obolibrary.org/obo/CHEBI_7421 |
| T69 | 5201-5209 | Chemical | denotes | adjuvant | http://purl.obolibrary.org/obo/CHEBI_60809 |
| T70 | 5295-5298 | Chemical | denotes | NAC | http://purl.obolibrary.org/obo/CHEBI_28939|http://purl.obolibrary.org/obo/CHEBI_7421 |
| T72 | 5461-5463 | Chemical | denotes | La | http://purl.obolibrary.org/obo/CHEBI_33336 |
| T73 | 5530-5537 | Chemical | denotes | epoxide | http://purl.obolibrary.org/obo/CHEBI_32955 |
| T74 | 5554-5564 | Chemical | denotes | inhibitors | http://purl.obolibrary.org/obo/CHEBI_35222 |
| T75 | 5567-5592 | Chemical | denotes | Epoxyeicosatrienoic acids | http://purl.obolibrary.org/obo/CHEBI_64007 |
| T76 | 5587-5592 | Chemical | denotes | acids | http://purl.obolibrary.org/obo/CHEBI_37527 |
| T77 | 5594-5598 | Chemical | denotes | EETs | http://purl.obolibrary.org/obo/CHEBI_64007 |
| T78 | 5739-5749 | Chemical | denotes | eicosanoid | http://purl.obolibrary.org/obo/CHEBI_23899 |
| T79 | 5932-5934 | Chemical | denotes | Co | http://purl.obolibrary.org/obo/CHEBI_27638 |
| T80 | 5954-5964 | Chemical | denotes | inhibitors | http://purl.obolibrary.org/obo/CHEBI_35222 |
| T81 | 5969-5988 | Chemical | denotes | omega-3 fatty acids | http://purl.obolibrary.org/obo/CHEBI_25681 |
| T82 | 5977-5988 | Chemical | denotes | fatty acids | http://purl.obolibrary.org/obo/CHEBI_35366 |
| T83 | 5983-5988 | Chemical | denotes | acids | http://purl.obolibrary.org/obo/CHEBI_37527 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T4456 | 3928-3937 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signaling |
| T38785 | 4429-4438 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signaling |
| T79378 | 5357-5369 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammation |
| T50858 | 5400-5412 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammation |
| T54320 | 5549-5552 | http://purl.obolibrary.org/obo/GO_0033885 | denotes | sEH |
| T86858 | 5701-5704 | http://purl.obolibrary.org/obo/GO_0033885 | denotes | sEH |
| T99650 | 5856-5868 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammation |
| T10292 | 5950-5953 | http://purl.obolibrary.org/obo/GO_0033885 | denotes | sEH |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T12 | 0-15 | Sentence | denotes | 1 Introduction |
| T13 | 16-256 | Sentence | denotes | The first outbreak of the novel coronaviruses was triggered by severe and acute respiratory syndrome coronavirus (SARS-CoV) in China in 2002, which was followed in 2012 by the Middle East respiratory syndrome-related coronavirus (MERS-CoV). |
| T14 | 257-484 | Sentence | denotes | Both SARS-CoV and MERS-CoV are infectious, lethal and accounted for thousands of deaths over the past two decades (de Wit, van Doremalen, Falzarano, & Munster, 2016; Zaki, van Boheemen, Bestebroer, Osterhaus, & Fouchier, 2012). |
| T15 | 485-987 | Sentence | denotes | The Coronavirus Study Group of the International Committee on Taxonomy of Viruses evaluated the novelty of the coronavirus responsible for the recent outbreak in 2019 (COVID-19) and formally considered it related to SARS-CoV, as they share about 79% nucleotide identity and accordingly named it as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) or 2019-novel coronavirus (Coronaviridae Study Group of the International Committee on Taxonomy of, 2020; Ren et al., 2020; Zhou et al., 2020). |
| T16 | 988-1177 | Sentence | denotes | The recent eruption of COVID-19 was first reported in Wuhan, Hubei Province, China in late December 2019 when a series of pneumonia cases of unknown cause were detected (Wang et al., 2020). |
| T17 | 1178-1274 | Sentence | denotes | Highly contagious, COVID-19 spread rapidly throughout China and most countries across the world. |
| T18 | 1275-1553 | Sentence | denotes | On March 11th, the spread of COVID-19 was declared by the World Health Organization as a global pandemic and by October 9, 2020, the cumulative number of diagnosed patients internationally was 36,577,872 with 1,062,677 global deaths (https://coronavirus.jhu.edu/map.html, 2020). |
| T19 | 1554-1712 | Sentence | denotes | Coronaviruses infect both animals and humans affecting their respiratory, gastrointestinal, cardiovascular and central nervous systems (Cui, Li, & Shi, 2019). |
| T20 | 1713-1943 | Sentence | denotes | Consistently, SARS-CoV-2 primarily targets the lungs but it can affect many other organs and systems, including the kidneys, heart, blood vessels, gastrointestinal tract and brain (Wadman, Couzin-Frankel, Kaiser, & Matacic, 2020). |
| T21 | 1944-2068 | Sentence | denotes | Symptoms of COVID-19 are manifested as myalgia, fatigue, fever and dry cough, together with lower respiratory tract disease. |
| T22 | 2069-2292 | Sentence | denotes | In some cases, the severe progression of the disease leads to acute lung injury (ALI), acute respiratory distress syndrome (ARDS), respiratory failure, sepsis, heart failure (HF) and sudden cardiac arrest within a few days. |
| T23 | 2293-2456 | Sentence | denotes | Importantly, there is significant morbidity and mortality in the elderly and individuals with underlying health conditions (Chen et al., 2020; Huang et al., 2020). |
| T24 | 2457-2731 | Sentence | denotes | Although treatment with corticosteroids, antiviral therapy and mechanical respiratory support have been employed, there is still no specific treatment for COVID-19 and therefore supportive care is of paramount importance (Huang et al., 2020; Wu & McGoogan, 2020) (Table 1 ). |
| T25 | 2732-2844 | Sentence | denotes | Table 1 Overview of some proposed pharmacological agents with potential beneficial effects in COVID-19 patients. |
| T26 | 2845-2894 | Sentence | denotes | Pharmacological intervention Conclusion Reference |
| T27 | 2895-3050 | Sentence | denotes | Antioxidants including Vitamin C and E • Antioxidant effects may ameliorate cardiac injuries of critically ill COVID-19 patients (Wang, Zhang, & Bai, 2020) |
| T28 | 3051-3119 | Sentence | denotes | Melatonin • May have preventive effect against septic cardiomyopathy |
| T29 | 3120-3253 | Sentence | denotes | • Has benefits in myocardial infarction, cardiomyopathy, hypertensive heart diseases, and pulmonary hypertension (Zhang et al., 2020) |
| T30 | 3254-3536 | Sentence | denotes | Anti-interleukin-6 • Tocilizumab (anti-IL-6 receptor), siltuximab (anti-IL-6), and sirukumab (anti-IL-6) are proposed as possible treatments to manage cytokine storm and elevated IL-6 levels (Akhmerov & Marban, 2020; Hendren, Drazner, Bozkurt, & Cooper Jr., 2020; Rizk et al., 2020) |
| T31 | 3537-3797 | Sentence | denotes | Anti-TNFα • Infliximab, adalimumab, etanercept, golimumab, certolizumab as TNFα neutralizing therapies suggested as potential agents for COVID-19 hyperinflammatory state which may ameliorate organ damage including acute cardiac injury (Convertino et al., 2020) |
| T32 | 3798-4070 | Sentence | denotes | Janus kinase (JAK) inhibitors • Ruxolitinib, tofacitinib, baricitinib are proposed to be beneficial in controlling excessive IL-6 signaling through STAT-1 and STAT-3 pathways (Alijotas-Reig et al., 2020; Convertino et al., 2020; Richardson et al., 2020; Rizk et al., 2020) |
| T33 | 4071-4317 | Sentence | denotes | Anti-interleukin-1 • Anakinra, a modified IL-1 receptor antagonist protein, is suggested to have therapeutic potential in cytokine storm, given its effectiveness on patient survival in severe sepsis (Alijotas-Reig et al., 2020; Rizk et al., 2020) |
| T34 | 4318-4453 | Sentence | denotes | Granulocyte-macrophage-colony stimulating factor (GM-CSF) inhibition • GM-CSF can play a pro-inflammatory role signaling to macrophages |
| T35 | 4454-4527 | Sentence | denotes | • COVID-19 patients have been demonstrated to have elevated GM-CSF levels |
| T36 | 4528-4680 | Sentence | denotes | • Literature proposes that targeting GM-CSF upstream of inflammatory cytokines ex. gimsilumab, may be useful to blunt cytokine storm (Rizk et al., 2020) |
| T37 | 4681-4913 | Sentence | denotes | Statins • Anti-inflammatory properties, including reduction in cytokines, may benefit in COVID-19 hyperinflammatory states in addition to their conventional cardioprotective properties (Alijotas-Reig et al., 2020; Rizk et al., 2020) |
| T38 | 4914-5107 | Sentence | denotes | ACEi/ARBs • Proposed that treatment with RAAS antagonists may theoretically be beneficial by upregulating ACE2 and compensating for ACE2 receptors lost due to COVID-19 (Akhmerov & Marban, 2020) |
| T39 | 5108-5273 | Sentence | denotes | N-acetylcysteine (NAC) • Anti-oxidant and anti-inflammatory properties of NAC proposed as an adjuvant therapy for COVID-19 and secondary cardiovascular complications |
| T40 | 5274-5505 | Sentence | denotes | • Suggested role for NAC in prevention of hypertension, atherosclerosis-associated inflammation, acute heart failure, thrombo-inflammation, and myocardial ischemia (De Flora, Balansky, & La Maestra, 2020; Guglielmetti et al., 2020) |
| T41 | 5506-5657 | Sentence | denotes | Eicosanoids and soluble epoxide hydrolase (sEH) inhibitors • Epoxyeicosatrienoic acids (EETs) are cardioprotective, anti-inflammatory and pro-resolving |
| T42 | 5658-5803 | Sentence | denotes | • Inhibition of their metabolizing enzyme, sEH, may be beneficial by maintaining eicosanoid levels and reducing endoplasmic reticulum (ER) stress |
| T43 | 5804-5929 | Sentence | denotes | • Potential to limit inflammatory storm and resolve inflammation in addition to their established cardioprotective properties |
| T44 | 5930-6065 | Sentence | denotes | • Co-treatment with sEH inhibitors and omega-3 fatty acids may provide synergistic effects (Hammock, Wang, Gilligan, & Panigrahy, 2020) |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T5 | 1110-1119 | Phenotype | denotes | pneumonia | http://purl.obolibrary.org/obo/HP_0002090 |
| T6 | 1983-1990 | Phenotype | denotes | myalgia | http://purl.obolibrary.org/obo/HP_0003326 |
| T7 | 1992-1999 | Phenotype | denotes | fatigue | http://purl.obolibrary.org/obo/HP_0012378 |
| T8 | 2001-2006 | Phenotype | denotes | fever | http://purl.obolibrary.org/obo/HP_0001945 |
| T9 | 2011-2020 | Phenotype | denotes | dry cough | http://purl.obolibrary.org/obo/HP_0031246 |
| T10 | 2131-2148 | Phenotype | denotes | acute lung injury | http://www.orpha.net/ORDO/Orphanet_178320 |
| T11 | 2150-2153 | Phenotype | denotes | ALI | http://www.orpha.net/ORDO/Orphanet_178320 |
| T12 | 2162-2182 | Phenotype | denotes | respiratory distress | http://purl.obolibrary.org/obo/HP_0002098 |
| T13 | 2200-2219 | Phenotype | denotes | respiratory failure | http://purl.obolibrary.org/obo/HP_0002878 |
| T14 | 2221-2227 | Phenotype | denotes | sepsis | http://purl.obolibrary.org/obo/HP_0100806 |
| T15 | 2229-2242 | Phenotype | denotes | heart failure | http://purl.obolibrary.org/obo/HP_0001635 |
| T16 | 2244-2246 | Phenotype | denotes | HF | http://purl.obolibrary.org/obo/HP_0001635 |
| T17 | 2252-2273 | Phenotype | denotes | sudden cardiac arrest | http://purl.obolibrary.org/obo/HP_0031628 |
| T18 | 3105-3119 | Phenotype | denotes | cardiomyopathy | http://purl.obolibrary.org/obo/HP_0001638 |
| T19 | 3138-3159 | Phenotype | denotes | myocardial infarction | http://purl.obolibrary.org/obo/HP_0001658 |
| T20 | 3161-3175 | Phenotype | denotes | cardiomyopathy | http://purl.obolibrary.org/obo/HP_0001638 |
| T21 | 3220-3232 | Phenotype | denotes | hypertension | http://purl.obolibrary.org/obo/HP_0000822 |
| T22 | 3405-3419 | Phenotype | denotes | cytokine storm | http://purl.obolibrary.org/obo/HP_0033041 |
| T23 | 4193-4207 | Phenotype | denotes | cytokine storm | http://purl.obolibrary.org/obo/HP_0033041 |
| T24 | 4263-4269 | Phenotype | denotes | sepsis | http://purl.obolibrary.org/obo/HP_0100806 |
| T25 | 4646-4660 | Phenotype | denotes | cytokine storm | http://purl.obolibrary.org/obo/HP_0033041 |
| T26 | 5316-5328 | Phenotype | denotes | hypertension | http://purl.obolibrary.org/obo/HP_0000822 |
| T27 | 5330-5345 | Phenotype | denotes | atherosclerosis | http://purl.obolibrary.org/obo/HP_0002621 |
| T28 | 5377-5390 | Phenotype | denotes | heart failure | http://purl.obolibrary.org/obo/HP_0001635 |
2_test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 33031856-27344959-84038790 | 417-421 | 27344959 | denotes | 2016 |
| 33031856-23075143-84038791 | 478-482 | 23075143 | denotes | 2012 |
| 33031856-32004165-84038792 | 962-966 | 32004165 | denotes | 2020 |
| 33031856-32015507-84038793 | 981-985 | 32015507 | denotes | 2020 |
| 33031856-32031570-84038794 | 1171-1175 | 32031570 | denotes | 2020 |
| 33031856-30531947-84038795 | 1706-1710 | 30531947 | denotes | 2019 |
| 33031856-32327580-84038796 | 1937-1941 | 32327580 | denotes | 2020 |
| 33031856-32007143-84038797 | 2430-2434 | 32007143 | denotes | 2020 |
| 33031856-31986264-84038798 | 2450-2454 | 31986264 | denotes | 2020 |
| 33031856-31986264-84038799 | 2693-2697 | 31986264 | denotes | 2020 |
| 33031856-32091533-84038800 | 2714-2718 | 32091533 | denotes | 2020 |
| 33031856-32321655-84038801 | 3045-3049 | 32321655 | denotes | 2020 |
| 33031856-32252591-84038802 | 3465-3469 | 32252591 | denotes | 2020 |
| 33031856-32297796-84038803 | 3512-3516 | 32297796 | denotes | 2020 |
| 33031856-32696108-84038804 | 3531-3535 | 32696108 | denotes | 2020 |
| 33031856-32527304-84038805 | 3792-3796 | 32527304 | denotes | 2020 |
| 33031856-32527304-84038806 | 4021-4025 | 32527304 | denotes | 2020 |
| 33031856-32032529-84038807 | 4046-4050 | 32032529 | denotes | 2020 |
| 33031856-32696108-84038808 | 4065-4069 | 32696108 | denotes | 2020 |
| 33031856-32696108-84038809 | 4312-4316 | 32696108 | denotes | 2020 |
| 33031856-32696108-84038810 | 4675-4679 | 32696108 | denotes | 2020 |
| 33031856-32696108-84038811 | 4312-4316 | 32696108 | denotes | 2020 |
| 33031856-32252591-84038812 | 5102-5106 | 32252591 | denotes | 2020 |
| 33031856-32560665-84038813 | 5500-5504 | 32560665 | denotes | 2020 |
| 33031856-32650004-84038814 | 6060-6064 | 32650004 | denotes | 2020 |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 85 | 42-61 | Species | denotes | novel coronaviruses | Tax:2697049 |
| 86 | 117-128 | Species | denotes | coronavirus | Tax:11118 |
| 87 | 130-138 | Species | denotes | SARS-CoV | Tax:694009 |
| 88 | 192-244 | Species | denotes | Middle East respiratory syndrome-related coronavirus | Tax:1335626 |
| 89 | 246-254 | Species | denotes | MERS-CoV | Tax:1335626 |
| 90 | 262-270 | Species | denotes | SARS-CoV | Tax:694009 |
| 91 | 275-283 | Species | denotes | MERS-CoV | Tax:1335626 |
| 92 | 489-500 | Species | denotes | Coronavirus | Tax:11118 |
| 93 | 596-607 | Species | denotes | coronavirus | Tax:11118 |
| 94 | 701-709 | Species | denotes | SARS-CoV | Tax:694009 |
| 95 | 783-830 | Species | denotes | severe acute respiratory syndrome coronavirus 2 | Tax:2697049 |
| 96 | 832-842 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 97 | 847-869 | Species | denotes | 2019-novel coronavirus | Tax:2697049 |
| 98 | 1439-1447 | Species | denotes | patients | Tax:9606 |
| 99 | 338-344 | Disease | denotes | deaths | MESH:D003643 |
| 100 | 653-661 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 101 | 1011-1019 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 102 | 1110-1119 | Disease | denotes | pneumonia | MESH:D011014 |
| 103 | 1197-1205 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 104 | 1304-1312 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 156 | 3259-3272 | Gene | denotes | interleukin-6 | Gene:3569 |
| 157 | 3326-3330 | Gene | denotes | IL-6 | Gene:3569 |
| 158 | 3353-3357 | Gene | denotes | IL-6 | Gene:3569 |
| 159 | 3433-3437 | Gene | denotes | IL-6 | Gene:3569 |
| 160 | 3542-3546 | Gene | denotes | TNFα | Gene:7124 |
| 161 | 3612-3616 | Gene | denotes | TNFα | Gene:7124 |
| 162 | 3923-3927 | Gene | denotes | IL-6 | Gene:3569 |
| 163 | 3946-3952 | Gene | denotes | STAT-1 | Gene:6772 |
| 164 | 3957-3963 | Gene | denotes | STAT-3 | Gene:6774 |
| 165 | 4113-4137 | Gene | denotes | IL-1 receptor antagonist | Gene:3557 |
| 166 | 4318-4366 | Gene | denotes | Granulocyte-macrophage-colony stimulating factor | Gene:1437 |
| 167 | 4368-4374 | Gene | denotes | GM-CSF | Gene:1437 |
| 168 | 4514-4520 | Gene | denotes | GM-CSF | Gene:1437 |
| 169 | 4565-4571 | Gene | denotes | GM-CSF | Gene:1437 |
| 176 | 4076-4089 | Gene | denotes | interleukin-1 | Gene:3552 |
| 177 | 3015-3023 | Species | denotes | patients | Tax:9606 |
| 178 | 4236-4243 | Species | denotes | patient | Tax:9606 |
| 179 | 4465-4473 | Species | denotes | patients | Tax:9606 |
| 180 | 4389-4395 | Gene | denotes | GM-CSF | Gene:1437 |
| 181 | 2918-2927 | Chemical | denotes | Vitamin C | MESH:D001205 |
| 182 | 3051-3060 | Chemical | denotes | Melatonin | MESH:D008550 |
| 183 | 2971-2987 | Disease | denotes | cardiac injuries | MESH:D006331 |
| 184 | 2991-3005 | Disease | denotes | critically ill | MESH:D016638 |
| 185 | 3006-3014 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 186 | 3098-3119 | Disease | denotes | septic cardiomyopathy | MESH:D009202 |
| 187 | 3138-3159 | Disease | denotes | myocardial infarction | MESH:D009203 |
| 188 | 3161-3175 | Disease | denotes | cardiomyopathy | MESH:D009202 |
| 189 | 3177-3204 | Disease | denotes | hypertensive heart diseases | MESH:D006973 |
| 190 | 3210-3232 | Disease | denotes | pulmonary hypertension | MESH:D006976 |
| 191 | 3674-3682 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 192 | 3757-3803 | Disease | denotes | cardiac injury (Convertino et al., 2020) Janus | MESH:D006331 |
| 193 | 4263-4269 | Disease | denotes | sepsis | MESH:D018805 |
| 194 | 4442-4464 | Disease | denotes | macrophages • COVID-19 | MESH:C000657245 |
| 195 | 4611-4621 | Disease | denotes | gimsilumab | |
| 208 | 2835-2843 | Species | denotes | patients | Tax:9606 |
| 209 | 2826-2834 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 228 | 1554-1567 | Species | denotes | Coronaviruses | Tax:11118 |
| 229 | 1592-1598 | Species | denotes | humans | Tax:9606 |
| 230 | 1727-1737 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 231 | 1956-1964 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 232 | 1983-1990 | Disease | denotes | myalgia | MESH:D063806 |
| 233 | 1992-1999 | Disease | denotes | fatigue | MESH:D005221 |
| 234 | 2001-2006 | Disease | denotes | fever | MESH:D005334 |
| 235 | 2011-2020 | Disease | denotes | dry cough | MESH:D003371 |
| 236 | 2042-2067 | Disease | denotes | respiratory tract disease | MESH:D012140 |
| 237 | 2137-2148 | Disease | denotes | lung injury | MESH:D055370 |
| 238 | 2156-2191 | Disease | denotes | acute respiratory distress syndrome | MESH:D012128 |
| 239 | 2193-2197 | Disease | denotes | ARDS | MESH:D012128 |
| 240 | 2200-2219 | Disease | denotes | respiratory failure | MESH:D012131 |
| 241 | 2221-2227 | Disease | denotes | sepsis | MESH:D018805 |
| 242 | 2229-2242 | Disease | denotes | heart failure | MESH:D006333 |
| 243 | 2259-2273 | Disease | denotes | cardiac arrest | MESH:D006323 |
| 244 | 2341-2350 | Disease | denotes | mortality | MESH:D003643 |
| 245 | 2612-2620 | Disease | denotes | COVID-19 | MESH:C000657245 |