PMC:7534206 / 2111-3629 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7534206","sourcedb":"PMC","sourceid":"7534206","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7534206","text":"Introduction\nIn six months, the number of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cases exceeded six million, with more than 360,000 deaths. The World Health Organization named the disease the coronavirus disease 2019 (COVID-19) and declared it a pandemic on 11 March 2020.1 Although the lung is the primary affected organ, the virus is neurovirulent and neuroinvasive with a growing recognition of neurological manifestations. The reported incidence of stroke in COVID-19 hospitalized patients is 0.9–2%,2,3 with an increased incidence in the young.4 More important than the increased incidence, is the poor outcome and high mortality rate, even with optimal treatment.5,6 A recent cross-sectional comparative study from New York identified a 7.5-fold higher rate of ischemic stroke in COVID-19 compared to influenza.3\nIn the current pandemic situation, a better understanding of the pathophysiological mechanisms associated with COVID-19 and characterization of cerebrovascular pathologies and outcomes is critical not only to estimate the risk but also to guide decision making. We present a case series of COVID-19 patients from two different health systems presenting with acute cerebrovascular pathologies. We also reviewed the literature to present a comprehensive summary of the SARS-CoV-2-induced factors that are associated with acute cerebrovascular pathologies. In addition, we performed a pooled analysis of published data on large vessel occlusion strokes in the setting of 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