PMC:7534206 / 20373-21478 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T61","span":{"begin":225,"end":242},"obj":"Body_part"},{"id":"T62","span":{"begin":237,"end":242},"obj":"Body_part"},{"id":"T63","span":{"begin":371,"end":389},"obj":"Body_part"},{"id":"T64","span":{"begin":385,"end":389},"obj":"Body_part"},{"id":"T65","span":{"begin":479,"end":487},"obj":"Body_part"},{"id":"T66","span":{"begin":540,"end":553},"obj":"Body_part"},{"id":"T67","span":{"begin":579,"end":584},"obj":"Body_part"},{"id":"T68","span":{"begin":1051,"end":1055},"obj":"Body_part"}],"attributes":[{"id":"A61","pred":"fma_id","subj":"T61","obj":"http://purl.org/sig/ont/fma/fma66772"},{"id":"A62","pred":"fma_id","subj":"T62","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A63","pred":"fma_id","subj":"T63","obj":"http://purl.org/sig/ont/fma/fma14072"},{"id":"A64","pred":"fma_id","subj":"T64","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A65","pred":"fma_id","subj":"T65","obj":"http://purl.org/sig/ont/fma/fma82768"},{"id":"A66","pred":"fma_id","subj":"T66","obj":"http://purl.org/sig/ont/fma/fma61791"},{"id":"A67","pred":"fma_id","subj":"T67","obj":"http://purl.org/sig/ont/fma/fma50801"},{"id":"A68","pred":"fma_id","subj":"T68","obj":"http://purl.org/sig/ont/fma/fma68646"}],"text":"ACE2 is a carboxypeptidase that converts angiotensin II into ANG (1–7), which is an essential component of the renin–angiotensin system.35 One of the main sites that ANG (1–7) is synthesized and has a downstream effect on is endothelial cells;36 it stimulates the release of prostaglandin and nitric oxide,37,38 enhances the metabolic actions of bradykinin, and inhibits smooth muscle cell growth.39 Additionally, ANG (1–7) enhances the vagal.40,41 It also induces a decrease in tyrosine hydroxylase expression, the rate-limiting enzyme in catecholamine biosynthesis, decreasing brain catecholaminergic activity; ANG (1–7) is neuroprotective.42 In recent rat models, central administration of ANG-(1–7) reduced neurological deficits and infarct size in ischemic stroke.43,44 Virus-mediated downregulation of ACE2 has been suggested to underlie the pathology of severe acute respiratory syndrome coronavirus infection.45,46 Therefore, binding of SARS-CoV-2 to the ACE2 receptor may similarly inhibit its downstream effect via pathway downregulation or cell lysis, ultimately decreasing ANG (1–7) synthesis."}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T60","span":{"begin":111,"end":135},"obj":"Body_part"},{"id":"T61","span":{"begin":579,"end":584},"obj":"Body_part"}],"attributes":[{"id":"A60","pred":"uberon_id","subj":"T60","obj":"http://purl.obolibrary.org/obo/UBERON_0018229"},{"id":"A61","pred":"uberon_id","subj":"T61","obj":"http://purl.obolibrary.org/obo/UBERON_0000955"}],"text":"ACE2 is a carboxypeptidase that converts angiotensin II into ANG (1–7), which is an essential component of the renin–angiotensin system.35 One of the main sites that ANG (1–7) is synthesized and has a downstream effect on is endothelial cells;36 it stimulates the release of prostaglandin and nitric oxide,37,38 enhances the metabolic actions of bradykinin, and inhibits smooth muscle cell growth.39 Additionally, ANG (1–7) enhances the vagal.40,41 It also induces a decrease in tyrosine hydroxylase expression, the rate-limiting enzyme in catecholamine biosynthesis, decreasing brain catecholaminergic activity; ANG (1–7) is neuroprotective.42 In recent rat models, central administration of ANG-(1–7) reduced neurological deficits and infarct size in ischemic stroke.43,44 Virus-mediated downregulation of ACE2 has been suggested to underlie the pathology of severe acute respiratory syndrome coronavirus infection.45,46 Therefore, binding of SARS-CoV-2 to the ACE2 receptor may similarly inhibit its downstream effect via pathway downregulation or cell lysis, ultimately decreasing ANG (1–7) synthesis."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T205","span":{"begin":762,"end":768},"obj":"Disease"},{"id":"T207","span":{"begin":861,"end":894},"obj":"Disease"},{"id":"T208","span":{"begin":907,"end":916},"obj":"Disease"},{"id":"T209","span":{"begin":945,"end":953},"obj":"Disease"}],"attributes":[{"id":"A205","pred":"mondo_id","subj":"T205","obj":"http://purl.obolibrary.org/obo/MONDO_0005098"},{"id":"A206","pred":"mondo_id","subj":"T205","obj":"http://purl.obolibrary.org/obo/MONDO_0011057"},{"id":"A207","pred":"mondo_id","subj":"T207","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A208","pred":"mondo_id","subj":"T208","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A209","pred":"mondo_id","subj":"T209","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"}],"text":"ACE2 is a carboxypeptidase that converts angiotensin II into ANG (1–7), which is an essential component of the renin–angiotensin system.35 One of the main sites that ANG (1–7) is synthesized and has a downstream effect on is endothelial cells;36 it stimulates the release of prostaglandin and nitric oxide,37,38 enhances the metabolic actions of bradykinin, and inhibits smooth muscle cell growth.39 Additionally, ANG (1–7) enhances the vagal.40,41 It also induces a decrease in tyrosine hydroxylase expression, the rate-limiting enzyme in catecholamine biosynthesis, decreasing brain catecholaminergic activity; ANG (1–7) is neuroprotective.42 In recent rat models, central administration of ANG-(1–7) reduced neurological deficits and infarct size in ischemic stroke.43,44 Virus-mediated downregulation of ACE2 has been suggested to underlie the pathology of severe acute respiratory syndrome coronavirus infection.45,46 Therefore, binding of SARS-CoV-2 to the ACE2 receptor may similarly inhibit its downstream effect via pathway downregulation or cell lysis, ultimately decreasing ANG (1–7) synthesis."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T237","span":{"begin":8,"end":9},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T238","span":{"begin":136,"end":138},"obj":"http://purl.obolibrary.org/obo/CLO_0001000"},{"id":"T239","span":{"begin":195,"end":198},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T240","span":{"begin":199,"end":200},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T241","span":{"begin":225,"end":242},"obj":"http://purl.obolibrary.org/obo/CL_0000115"},{"id":"T242","span":{"begin":243,"end":245},"obj":"http://purl.obolibrary.org/obo/CLO_0001313"},{"id":"T243","span":{"begin":371,"end":389},"obj":"http://purl.obolibrary.org/obo/CL_0000192"},{"id":"T244","span":{"begin":465,"end":466},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T245","span":{"begin":540,"end":553},"obj":"http://purl.obolibrary.org/obo/CHEBI_33567"},{"id":"T246","span":{"begin":579,"end":584},"obj":"http://purl.obolibrary.org/obo/UBERON_0000955"},{"id":"T247","span":{"begin":579,"end":584},"obj":"http://www.ebi.ac.uk/efo/EFO_0000302"},{"id":"T248","span":{"begin":603,"end":611},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T249","span":{"begin":775,"end":780},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T250","span":{"begin":813,"end":816},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T251","span":{"begin":1051,"end":1055},"obj":"http://purl.obolibrary.org/obo/GO_0005623"}],"text":"ACE2 is a carboxypeptidase that converts angiotensin II into ANG (1–7), which is an essential component of the renin–angiotensin system.35 One of the main sites that ANG (1–7) is synthesized and has a downstream effect on is endothelial cells;36 it stimulates the release of prostaglandin and nitric oxide,37,38 enhances the metabolic actions of bradykinin, and inhibits smooth muscle cell growth.39 Additionally, ANG (1–7) enhances the vagal.40,41 It also induces a decrease in tyrosine hydroxylase expression, the rate-limiting enzyme in catecholamine biosynthesis, decreasing brain catecholaminergic activity; ANG (1–7) is neuroprotective.42 In recent rat models, central administration of ANG-(1–7) reduced neurological deficits and infarct size in ischemic stroke.43,44 Virus-mediated downregulation of ACE2 has been suggested to underlie the pathology of severe acute respiratory syndrome coronavirus infection.45,46 Therefore, binding of SARS-CoV-2 to the ACE2 receptor may similarly inhibit its downstream effect via pathway downregulation or cell lysis, ultimately decreasing ANG (1–7) synthesis."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T93","span":{"begin":41,"end":55},"obj":"Chemical"},{"id":"T96","span":{"begin":41,"end":52},"obj":"Chemical"},{"id":"T97","span":{"begin":53,"end":55},"obj":"Chemical"},{"id":"T98","span":{"begin":117,"end":128},"obj":"Chemical"},{"id":"T99","span":{"begin":275,"end":288},"obj":"Chemical"},{"id":"T100","span":{"begin":293,"end":305},"obj":"Chemical"},{"id":"T101","span":{"begin":300,"end":305},"obj":"Chemical"},{"id":"T103","span":{"begin":346,"end":356},"obj":"Chemical"},{"id":"T104","span":{"begin":479,"end":487},"obj":"Chemical"},{"id":"T105","span":{"begin":540,"end":553},"obj":"Chemical"}],"attributes":[{"id":"A93","pred":"chebi_id","subj":"T93","obj":"http://purl.obolibrary.org/obo/CHEBI_2719"},{"id":"A94","pred":"chebi_id","subj":"T93","obj":"http://purl.obolibrary.org/obo/CHEBI_48432"},{"id":"A95","pred":"chebi_id","subj":"T93","obj":"http://purl.obolibrary.org/obo/CHEBI_58506"},{"id":"A96","pred":"chebi_id","subj":"T96","obj":"http://purl.obolibrary.org/obo/CHEBI_48433"},{"id":"A97","pred":"chebi_id","subj":"T97","obj":"http://purl.obolibrary.org/obo/CHEBI_74067"},{"id":"A98","pred":"chebi_id","subj":"T98","obj":"http://purl.obolibrary.org/obo/CHEBI_48433"},{"id":"A99","pred":"chebi_id","subj":"T99","obj":"http://purl.obolibrary.org/obo/CHEBI_26333"},{"id":"A100","pred":"chebi_id","subj":"T100","obj":"http://purl.obolibrary.org/obo/CHEBI_16480"},{"id":"A101","pred":"chebi_id","subj":"T101","obj":"http://purl.obolibrary.org/obo/CHEBI_25741"},{"id":"A102","pred":"chebi_id","subj":"T101","obj":"http://purl.obolibrary.org/obo/CHEBI_29356"},{"id":"A103","pred":"chebi_id","subj":"T103","obj":"http://purl.obolibrary.org/obo/CHEBI_3165"},{"id":"A104","pred":"chebi_id","subj":"T104","obj":"http://purl.obolibrary.org/obo/CHEBI_18186"},{"id":"A105","pred":"chebi_id","subj":"T105","obj":"http://purl.obolibrary.org/obo/CHEBI_33567"}],"text":"ACE2 is a carboxypeptidase that converts angiotensin II into ANG (1–7), which is an essential component of the renin–angiotensin system.35 One of the main sites that ANG (1–7) is synthesized and has a downstream effect on is endothelial cells;36 it stimulates the release of prostaglandin and nitric oxide,37,38 enhances the metabolic actions of bradykinin, and inhibits smooth muscle cell growth.39 Additionally, ANG (1–7) enhances the vagal.40,41 It also induces a decrease in tyrosine hydroxylase expression, the rate-limiting enzyme in catecholamine biosynthesis, decreasing brain catecholaminergic activity; ANG (1–7) is neuroprotective.42 In recent rat models, central administration of ANG-(1–7) reduced neurological deficits and infarct size in ischemic stroke.43,44 Virus-mediated downregulation of ACE2 has been suggested to underlie the pathology of severe acute respiratory syndrome coronavirus infection.45,46 Therefore, binding of SARS-CoV-2 to the ACE2 receptor may similarly inhibit its downstream effect via pathway downregulation or cell lysis, ultimately decreasing ANG (1–7) synthesis."}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T95","span":{"begin":753,"end":768},"obj":"Phenotype"}],"attributes":[{"id":"A95","pred":"hp_id","subj":"T95","obj":"http://purl.obolibrary.org/obo/HP_0002140"}],"text":"ACE2 is a carboxypeptidase that converts angiotensin II into ANG (1–7), which is an essential component of the renin–angiotensin system.35 One of the main sites that ANG (1–7) is synthesized and has a downstream effect on is endothelial cells;36 it stimulates the release of prostaglandin and nitric oxide,37,38 enhances the metabolic actions of bradykinin, and inhibits smooth muscle cell growth.39 Additionally, ANG (1–7) enhances the vagal.40,41 It also induces a decrease in tyrosine hydroxylase expression, the rate-limiting enzyme in catecholamine biosynthesis, decreasing brain catecholaminergic activity; ANG (1–7) is neuroprotective.42 In recent rat models, central administration of ANG-(1–7) reduced neurological deficits and infarct size in ischemic stroke.43,44 Virus-mediated downregulation of ACE2 has been suggested to underlie the pathology of severe acute respiratory syndrome coronavirus infection.45,46 Therefore, binding of SARS-CoV-2 to the ACE2 receptor may similarly inhibit its downstream effect via pathway downregulation or cell lysis, ultimately decreasing ANG (1–7) synthesis."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T6","span":{"begin":385,"end":396},"obj":"http://purl.obolibrary.org/obo/GO_0016049"},{"id":"T7","span":{"begin":390,"end":396},"obj":"http://purl.obolibrary.org/obo/GO_0040007"},{"id":"T8","span":{"begin":540,"end":566},"obj":"http://purl.obolibrary.org/obo/GO_0042423"},{"id":"T9","span":{"begin":554,"end":566},"obj":"http://purl.obolibrary.org/obo/GO_0009058"},{"id":"T10","span":{"begin":1056,"end":1061},"obj":"http://purl.obolibrary.org/obo/GO_0019835"},{"id":"T11","span":{"begin":1095,"end":1104},"obj":"http://purl.obolibrary.org/obo/GO_0009058"}],"text":"ACE2 is a carboxypeptidase that converts angiotensin II into ANG (1–7), which is an essential component of the renin–angiotensin system.35 One of the main sites that ANG (1–7) is synthesized and has a downstream effect on is endothelial cells;36 it stimulates the release of prostaglandin and nitric oxide,37,38 enhances the metabolic actions of bradykinin, and inhibits smooth muscle cell growth.39 Additionally, ANG (1–7) enhances the vagal.40,41 It also induces a decrease in tyrosine hydroxylase expression, the rate-limiting enzyme in catecholamine biosynthesis, decreasing brain catecholaminergic activity; ANG (1–7) is neuroprotective.42 In recent rat models, central administration of ANG-(1–7) reduced neurological deficits and infarct size in ischemic stroke.43,44 Virus-mediated downregulation of ACE2 has been suggested to underlie the pathology of severe acute respiratory syndrome coronavirus infection.45,46 Therefore, binding of SARS-CoV-2 to the ACE2 receptor may similarly inhibit its downstream effect via pathway downregulation or cell lysis, ultimately decreasing ANG (1–7) synthesis."}

{"project":"LitCovid-sentences","denotations":[{"id":"T199","span":{"begin":0,"end":1105},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"ACE2 is a carboxypeptidase that converts angiotensin II into ANG (1–7), which is an essential component of the renin–angiotensin system.35 One of the main sites that ANG (1–7) is synthesized and has a downstream effect on is endothelial cells;36 it stimulates the release of prostaglandin and nitric oxide,37,38 enhances the metabolic actions of bradykinin, and inhibits smooth muscle cell growth.39 Additionally, ANG (1–7) enhances the vagal.40,41 It also induces a decrease in tyrosine hydroxylase expression, the rate-limiting enzyme in catecholamine biosynthesis, decreasing brain catecholaminergic activity; ANG (1–7) is neuroprotective.42 In recent rat models, central administration of ANG-(1–7) reduced neurological deficits and infarct size in ischemic stroke.43,44 Virus-mediated downregulation of ACE2 has been suggested to underlie the pathology of severe acute respiratory syndrome coronavirus infection.45,46 Therefore, binding of SARS-CoV-2 to the ACE2 receptor may similarly inhibit its downstream effect via pathway downregulation or cell lysis, ultimately decreasing ANG (1–7) synthesis."}

{"project":"LitCovid-PubTator","denotations":[{"id":"563","span":{"begin":0,"end":4},"obj":"Gene"},{"id":"564","span":{"begin":41,"end":55},"obj":"Gene"},{"id":"565","span":{"begin":346,"end":356},"obj":"Gene"},{"id":"566","span":{"begin":808,"end":812},"obj":"Gene"},{"id":"567","span":{"begin":963,"end":967},"obj":"Gene"},{"id":"569","span":{"begin":655,"end":658},"obj":"Species"},{"id":"570","span":{"begin":945,"end":955},"obj":"Species"},{"id":"571","span":{"begin":275,"end":288},"obj":"Chemical"},{"id":"572","span":{"begin":293,"end":305},"obj":"Chemical"},{"id":"573","span":{"begin":540,"end":553},"obj":"Chemical"},{"id":"574","span":{"begin":711,"end":732},"obj":"Disease"},{"id":"575","span":{"begin":737,"end":744},"obj":"Disease"},{"id":"576","span":{"begin":753,"end":768},"obj":"Disease"},{"id":"577","span":{"begin":874,"end":916},"obj":"Disease"}],"attributes":[{"id":"A563","pred":"tao:has_database_id","subj":"563","obj":"Gene:59272"},{"id":"A564","pred":"tao:has_database_id","subj":"564","obj":"Gene:183"},{"id":"A565","pred":"tao:has_database_id","subj":"565","obj":"Gene:3827"},{"id":"A566","pred":"tao:has_database_id","subj":"566","obj":"Gene:59272"},{"id":"A567","pred":"tao:has_database_id","subj":"567","obj":"Gene:59272"},{"id":"A569","pred":"tao:has_database_id","subj":"569","obj":"Tax:10116"},{"id":"A570","pred":"tao:has_database_id","subj":"570","obj":"Tax:2697049"},{"id":"A571","pred":"tao:has_database_id","subj":"571","obj":"MESH:D011453"},{"id":"A572","pred":"tao:has_database_id","subj":"572","obj":"MESH:D009569"},{"id":"A573","pred":"tao:has_database_id","subj":"573","obj":"MESH:D002395"},{"id":"A574","pred":"tao:has_database_id","subj":"574","obj":"MESH:D009461"},{"id":"A575","pred":"tao:has_database_id","subj":"575","obj":"MESH:D007238"},{"id":"A576","pred":"tao:has_database_id","subj":"576","obj":"MESH:D002544"},{"id":"A577","pred":"tao:has_database_id","subj":"577","obj":"MESH:D018352"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"ACE2 is a carboxypeptidase that converts angiotensin II into ANG (1–7), which is an essential component of the renin–angiotensin system.35 One of the main sites that ANG (1–7) is synthesized and has a downstream effect on is endothelial cells;36 it stimulates the release of prostaglandin and nitric oxide,37,38 enhances the metabolic actions of bradykinin, and inhibits smooth muscle cell growth.39 Additionally, ANG (1–7) enhances the vagal.40,41 It also induces a decrease in tyrosine hydroxylase expression, the rate-limiting enzyme in catecholamine biosynthesis, decreasing brain catecholaminergic activity; ANG (1–7) is neuroprotective.42 In recent rat models, central administration of ANG-(1–7) reduced neurological deficits and infarct size in ischemic stroke.43,44 Virus-mediated downregulation of ACE2 has been suggested to underlie the pathology of severe acute respiratory syndrome coronavirus infection.45,46 Therefore, binding of SARS-CoV-2 to the ACE2 receptor may similarly inhibit its downstream effect via pathway downregulation or cell lysis, ultimately decreasing ANG (1–7) synthesis."}

{"project":"2_test","denotations":[{"id":"32501751-15165741-53715198","span":{"begin":136,"end":138},"obj":"15165741"},{"id":"32501751-15950155-53715199","span":{"begin":243,"end":245},"obj":"15950155"},{"id":"32501751-1735595-53715200","span":{"begin":306,"end":308},"obj":"1735595"},{"id":"32501751-8019744-53715201","span":{"begin":309,"end":311},"obj":"8019744"},{"id":"32501751-8675248-53715202","span":{"begin":397,"end":399},"obj":"8675248"},{"id":"32501751-2750946-53715203","span":{"begin":443,"end":445},"obj":"2750946"},{"id":"32501751-21178125-53715204","span":{"begin":446,"end":448},"obj":"21178125"},{"id":"32501751-19183250-53715205","span":{"begin":642,"end":644},"obj":"19183250"},{"id":"32501751-12573992-53715206","span":{"begin":769,"end":771},"obj":"12573992"},{"id":"32501751-21685445-53715207","span":{"begin":772,"end":774},"obj":"21685445"},{"id":"32501751-16001071-53715208","span":{"begin":917,"end":919},"obj":"16001071"},{"id":"32501751-16007097-53715209","span":{"begin":920,"end":922},"obj":"16007097"},{"id":"T17072","span":{"begin":136,"end":138},"obj":"15165741"},{"id":"T71290","span":{"begin":243,"end":245},"obj":"15950155"},{"id":"T79065","span":{"begin":306,"end":308},"obj":"1735595"},{"id":"T20426","span":{"begin":309,"end":311},"obj":"8019744"},{"id":"T14016","span":{"begin":397,"end":399},"obj":"8675248"},{"id":"T95083","span":{"begin":443,"end":445},"obj":"2750946"},{"id":"T64789","span":{"begin":446,"end":448},"obj":"21178125"},{"id":"T49608","span":{"begin":642,"end":644},"obj":"19183250"},{"id":"T11797","span":{"begin":769,"end":771},"obj":"12573992"},{"id":"T41059","span":{"begin":772,"end":774},"obj":"21685445"},{"id":"T31331","span":{"begin":917,"end":919},"obj":"16001071"},{"id":"T65051","span":{"begin":920,"end":922},"obj":"16007097"}],"text":"ACE2 is a carboxypeptidase that converts angiotensin II into ANG (1–7), which is an essential component of the renin–angiotensin system.35 One of the main sites that ANG (1–7) is synthesized and has a downstream effect on is endothelial cells;36 it stimulates the release of prostaglandin and nitric oxide,37,38 enhances the metabolic actions of bradykinin, and inhibits smooth muscle cell growth.39 Additionally, ANG (1–7) enhances the vagal.40,41 It also induces a decrease in tyrosine hydroxylase expression, the rate-limiting enzyme in catecholamine biosynthesis, decreasing brain catecholaminergic activity; ANG (1–7) is neuroprotective.42 In recent rat models, central administration of ANG-(1–7) reduced neurological deficits and infarct size in ischemic stroke.43,44 Virus-mediated downregulation of ACE2 has been suggested to underlie the pathology of severe acute respiratory syndrome coronavirus infection.45,46 Therefore, binding of SARS-CoV-2 to the ACE2 receptor may similarly inhibit its downstream effect via pathway downregulation or cell lysis, ultimately decreasing ANG (1–7) synthesis."}