> top > docs > PMC:7534206 > spans > 20373-21478 > annotations

PMC:7534206 / 20373-21478 JSONTXT

Annnotations TAB JSON ListView MergeView

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T61 225-242 Body_part denotes endothelial cells http://purl.org/sig/ont/fma/fma66772
T62 237-242 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T63 371-389 Body_part denotes smooth muscle cell http://purl.org/sig/ont/fma/fma14072
T64 385-389 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T65 479-487 Body_part denotes tyrosine http://purl.org/sig/ont/fma/fma82768
T66 540-553 Body_part denotes catecholamine http://purl.org/sig/ont/fma/fma61791
T67 579-584 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T68 1051-1055 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T60 111-135 Body_part denotes renin–angiotensin system http://purl.obolibrary.org/obo/UBERON_0018229
T61 579-584 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T205 762-768 Disease denotes stroke http://purl.obolibrary.org/obo/MONDO_0005098|http://purl.obolibrary.org/obo/MONDO_0011057
T207 861-894 Disease denotes severe acute respiratory syndrome http://purl.obolibrary.org/obo/MONDO_0005091
T208 907-916 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T209 945-953 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T237 8-9 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T238 136-138 http://purl.obolibrary.org/obo/CLO_0001000 denotes 35
T239 195-198 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T240 199-200 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T241 225-242 http://purl.obolibrary.org/obo/CL_0000115 denotes endothelial cells
T242 243-245 http://purl.obolibrary.org/obo/CLO_0001313 denotes 36
T243 371-389 http://purl.obolibrary.org/obo/CL_0000192 denotes smooth muscle cell
T244 465-466 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T245 540-553 http://purl.obolibrary.org/obo/CHEBI_33567 denotes catecholamine
T246 579-584 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T247 579-584 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T248 603-611 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T249 775-780 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes Virus
T250 813-816 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T251 1051-1055 http://purl.obolibrary.org/obo/GO_0005623 denotes cell

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T93 41-55 Chemical denotes angiotensin II http://purl.obolibrary.org/obo/CHEBI_2719|http://purl.obolibrary.org/obo/CHEBI_48432|http://purl.obolibrary.org/obo/CHEBI_58506
T96 41-52 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T97 53-55 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T98 117-128 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T99 275-288 Chemical denotes prostaglandin http://purl.obolibrary.org/obo/CHEBI_26333
T100 293-305 Chemical denotes nitric oxide http://purl.obolibrary.org/obo/CHEBI_16480
T101 300-305 Chemical denotes oxide http://purl.obolibrary.org/obo/CHEBI_25741|http://purl.obolibrary.org/obo/CHEBI_29356
T103 346-356 Chemical denotes bradykinin http://purl.obolibrary.org/obo/CHEBI_3165
T104 479-487 Chemical denotes tyrosine http://purl.obolibrary.org/obo/CHEBI_18186
T105 540-553 Chemical denotes catecholamine http://purl.obolibrary.org/obo/CHEBI_33567

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T95 753-768 Phenotype denotes ischemic stroke http://purl.obolibrary.org/obo/HP_0002140

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T6 385-396 http://purl.obolibrary.org/obo/GO_0016049 denotes cell growth
T7 390-396 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T8 540-566 http://purl.obolibrary.org/obo/GO_0042423 denotes catecholamine biosynthesis
T9 554-566 http://purl.obolibrary.org/obo/GO_0009058 denotes biosynthesis
T10 1056-1061 http://purl.obolibrary.org/obo/GO_0019835 denotes lysis
T11 1095-1104 http://purl.obolibrary.org/obo/GO_0009058 denotes synthesis

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T199 0-1105 Sentence denotes ACE2 is a carboxypeptidase that converts angiotensin II into ANG (1–7), which is an essential component of the renin–angiotensin system.35 One of the main sites that ANG (1–7) is synthesized and has a downstream effect on is endothelial cells;36 it stimulates the release of prostaglandin and nitric oxide,37,38 enhances the metabolic actions of bradykinin, and inhibits smooth muscle cell growth.39 Additionally, ANG (1–7) enhances the vagal.40,41 It also induces a decrease in tyrosine hydroxylase expression, the rate-limiting enzyme in catecholamine biosynthesis, decreasing brain catecholaminergic activity; ANG (1–7) is neuroprotective.42 In recent rat models, central administration of ANG-(1–7) reduced neurological deficits and infarct size in ischemic stroke.43,44 Virus-mediated downregulation of ACE2 has been suggested to underlie the pathology of severe acute respiratory syndrome coronavirus infection.45,46 Therefore, binding of SARS-CoV-2 to the ACE2 receptor may similarly inhibit its downstream effect via pathway downregulation or cell lysis, ultimately decreasing ANG (1–7) synthesis.

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
563 0-4 Gene denotes ACE2 Gene:59272
564 41-55 Gene denotes angiotensin II Gene:183
565 346-356 Gene denotes bradykinin Gene:3827
566 808-812 Gene denotes ACE2 Gene:59272
567 963-967 Gene denotes ACE2 Gene:59272
569 655-658 Species denotes rat Tax:10116
570 945-955 Species denotes SARS-CoV-2 Tax:2697049
571 275-288 Chemical denotes prostaglandin MESH:D011453
572 293-305 Chemical denotes nitric oxide MESH:D009569
573 540-553 Chemical denotes catecholamine MESH:D002395
574 711-732 Disease denotes neurological deficits MESH:D009461
575 737-744 Disease denotes infarct MESH:D007238
576 753-768 Disease denotes ischemic stroke MESH:D002544
577 874-916 Disease denotes respiratory syndrome coronavirus infection MESH:D018352

2_test

Id Subject Object Predicate Lexical cue
32501751-15165741-53715198 136-138 15165741 denotes 35
32501751-15950155-53715199 243-245 15950155 denotes 36
32501751-1735595-53715200 306-308 1735595 denotes 37
32501751-8019744-53715201 309-311 8019744 denotes 38
32501751-8675248-53715202 397-399 8675248 denotes 39
32501751-2750946-53715203 443-445 2750946 denotes 40
32501751-21178125-53715204 446-448 21178125 denotes 41
32501751-19183250-53715205 642-644 19183250 denotes 42
32501751-12573992-53715206 769-771 12573992 denotes 43
32501751-21685445-53715207 772-774 21685445 denotes 44
32501751-16001071-53715208 917-919 16001071 denotes 45
32501751-16007097-53715209 920-922 16007097 denotes 46
T17072 136-138 15165741 denotes 35
T71290 243-245 15950155 denotes 36
T79065 306-308 1735595 denotes 37
T20426 309-311 8019744 denotes 38
T14016 397-399 8675248 denotes 39
T95083 443-445 2750946 denotes 40
T64789 446-448 21178125 denotes 41
T49608 642-644 19183250 denotes 42
T11797 769-771 12573992 denotes 43
T41059 772-774 21685445 denotes 44
T31331 917-919 16001071 denotes 45
T65051 920-922 16007097 denotes 46