PMC:7534206 / 19401-20216 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7534206","sourcedb":"PMC","sourceid":"7534206","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7534206","text":"Neuroinvasion and neurovirulence\nViruses, including coronavirus, can penetrate the central nervous system (CNS) (neuroinvasion), infect neurons and glial cells (neurotropism), and contribute to, or cause neurological disease (neurovirulence).28 Access may be achieved via two main routes: hematogenous or transneuronal through the olfactory bulb.27,29 On the other hand, the hematogenous route involves directly infecting the blood–brain barrier (BBB) or access via a Trojan such as leukocytes.27,30 Human corona virus strains may infect human monocytes/macrophages,31,32 murine dendritic cells expressing the human aminopeptidase N,33 and human endothelial cells of the BBB.30 As for SARS-CoV-2, detection of the virus in the cerebrospinal fluid of COVID-19 patients has been reported in several publications.26,34","divisions":[{"label":"title","span":{"begin":0,"end":32}}],"tracks":[{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T44","span":{"begin":83,"end":105},"obj":"Body_part"},{"id":"T45","span":{"begin":107,"end":110},"obj":"Body_part"},{"id":"T46","span":{"begin":136,"end":143},"obj":"Body_part"},{"id":"T47","span":{"begin":148,"end":159},"obj":"Body_part"},{"id":"T48","span":{"begin":154,"end":159},"obj":"Body_part"},{"id":"T49","span":{"begin":331,"end":345},"obj":"Body_part"},{"id":"T50","span":{"begin":365,"end":369},"obj":"Body_part"},{"id":"T51","span":{"begin":426,"end":431},"obj":"Body_part"},{"id":"T52","span":{"begin":432,"end":437},"obj":"Body_part"},{"id":"T53","span":{"begin":483,"end":493},"obj":"Body_part"},{"id":"T54","span":{"begin":544,"end":553},"obj":"Body_part"},{"id":"T55","span":{"begin":554,"end":565},"obj":"Body_part"},{"id":"T56","span":{"begin":579,"end":594},"obj":"Body_part"},{"id":"T57","span":{"begin":589,"end":594},"obj":"Body_part"},{"id":"T58","span":{"begin":646,"end":663},"obj":"Body_part"},{"id":"T59","span":{"begin":658,"end":663},"obj":"Body_part"},{"id":"T60","span":{"begin":727,"end":746},"obj":"Body_part"}],"attributes":[{"id":"A44","pred":"fma_id","subj":"T44","obj":"http://purl.org/sig/ont/fma/fma55675"},{"id":"A45","pred":"fma_id","subj":"T45","obj":"http://purl.org/sig/ont/fma/fma55675"},{"id":"A46","pred":"fma_id","subj":"T46","obj":"http://purl.org/sig/ont/fma/fma54527"},{"id":"A47","pred":"fma_id","subj":"T47","obj":"http://purl.org/sig/ont/fma/fma54536"},{"id":"A48","pred":"fma_id","subj":"T48","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A49","pred":"fma_id","subj":"T49","obj":"http://purl.org/sig/ont/fma/fma77624"},{"id":"A50","pred":"fma_id","subj":"T50","obj":"http://purl.org/sig/ont/fma/fma9712"},{"id":"A51","pred":"fma_id","subj":"T51","obj":"http://purl.org/sig/ont/fma/fma9670"},{"id":"A52","pred":"fma_id","subj":"T52","obj":"http://purl.org/sig/ont/fma/fma50801"},{"id":"A53","pred":"fma_id","subj":"T53","obj":"http://purl.org/sig/ont/fma/fma62852"},{"id":"A54","pred":"fma_id","subj":"T54","obj":"http://purl.org/sig/ont/fma/fma62864"},{"id":"A55","pred":"fma_id","subj":"T55","obj":"http://purl.org/sig/ont/fma/fma63261"},{"id":"A56","pred":"fma_id","subj":"T56","obj":"http://purl.org/sig/ont/fma/fma273565"},{"id":"A57","pred":"fma_id","subj":"T57","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A58","pred":"fma_id","subj":"T58","obj":"http://purl.org/sig/ont/fma/fma66772"},{"id":"A59","pred":"fma_id","subj":"T59","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A60","pred":"fma_id","subj":"T60","obj":"http://purl.org/sig/ont/fma/fma20935"},{"subj":"T44","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T45","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T46","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T47","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T48","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T49","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T50","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T51","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T52","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T53","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T54","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T55","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T56","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T57","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T58","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T59","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T60","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T51","span":{"begin":83,"end":105},"obj":"Body_part"},{"id":"T52","span":{"begin":91,"end":105},"obj":"Body_part"},{"id":"T53","span":{"begin":107,"end":110},"obj":"Body_part"},{"id":"T54","span":{"begin":331,"end":345},"obj":"Body_part"},{"id":"T55","span":{"begin":365,"end":369},"obj":"Body_part"},{"id":"T56","span":{"begin":426,"end":445},"obj":"Body_part"},{"id":"T57","span":{"begin":426,"end":431},"obj":"Body_part"},{"id":"T58","span":{"begin":432,"end":437},"obj":"Body_part"},{"id":"T59","span":{"begin":727,"end":746},"obj":"Body_part"}],"attributes":[{"id":"A51","pred":"uberon_id","subj":"T51","obj":"http://purl.obolibrary.org/obo/UBERON_0001017"},{"id":"A52","pred":"uberon_id","subj":"T52","obj":"http://purl.obolibrary.org/obo/UBERON_0001016"},{"id":"A53","pred":"uberon_id","subj":"T53","obj":"http://purl.obolibrary.org/obo/UBERON_0001017"},{"id":"A54","pred":"uberon_id","subj":"T54","obj":"http://purl.obolibrary.org/obo/UBERON_0002264"},{"id":"A55","pred":"uberon_id","subj":"T55","obj":"http://purl.obolibrary.org/obo/UBERON_0002398"},{"id":"A56","pred":"uberon_id","subj":"T56","obj":"http://purl.obolibrary.org/obo/UBERON_0000120"},{"id":"A57","pred":"uberon_id","subj":"T57","obj":"http://purl.obolibrary.org/obo/UBERON_0000178"},{"id":"A58","pred":"uberon_id","subj":"T58","obj":"http://purl.obolibrary.org/obo/UBERON_0000955"},{"id":"A59","pred":"uberon_id","subj":"T59","obj":"http://purl.obolibrary.org/obo/UBERON_0001359"},{"subj":"T51","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T52","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T53","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T54","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T55","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T56","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T57","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T58","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T59","pred":"source","obj":"LitCovid-PD-UBERON"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T202","span":{"begin":204,"end":224},"obj":"Disease"},{"id":"T203","span":{"begin":685,"end":693},"obj":"Disease"},{"id":"T204","span":{"begin":750,"end":758},"obj":"Disease"}],"attributes":[{"id":"A202","pred":"mondo_id","subj":"T202","obj":"http://purl.obolibrary.org/obo/MONDO_0005071"},{"id":"A203","pred":"mondo_id","subj":"T203","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A204","pred":"mondo_id","subj":"T204","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"subj":"T202","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T203","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T204","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T213","span":{"begin":33,"end":40},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T214","span":{"begin":83,"end":105},"obj":"http://purl.obolibrary.org/obo/UBERON_0001017"},{"id":"T215","span":{"begin":83,"end":105},"obj":"http://www.ebi.ac.uk/efo/EFO_0000302"},{"id":"T216","span":{"begin":83,"end":105},"obj":"http://www.ebi.ac.uk/efo/EFO_0000908"},{"id":"T217","span":{"begin":107,"end":110},"obj":"http://www.ebi.ac.uk/efo/EFO_0000302"},{"id":"T218","span":{"begin":107,"end":110},"obj":"http://www.ebi.ac.uk/efo/EFO_0000908"},{"id":"T219","span":{"begin":107,"end":110},"obj":"http://purl.obolibrary.org/obo/UBERON_0001017"},{"id":"T220","span":{"begin":148,"end":159},"obj":"http://purl.obolibrary.org/obo/CL_0000125"},{"id":"T221","span":{"begin":426,"end":431},"obj":"http://purl.obolibrary.org/obo/UBERON_0000178"},{"id":"T222","span":{"begin":426,"end":431},"obj":"http://www.ebi.ac.uk/efo/EFO_0000296"},{"id":"T223","span":{"begin":432,"end":437},"obj":"http://purl.obolibrary.org/obo/UBERON_0000955"},{"id":"T224","span":{"begin":432,"end":437},"obj":"http://www.ebi.ac.uk/efo/EFO_0000302"},{"id":"T225","span":{"begin":466,"end":467},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T226","span":{"begin":500,"end":505},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T227","span":{"begin":513,"end":518},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T228","span":{"begin":538,"end":543},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T229","span":{"begin":544,"end":553},"obj":"http://purl.obolibrary.org/obo/CL_0000576"},{"id":"T230","span":{"begin":579,"end":594},"obj":"http://purl.obolibrary.org/obo/CL_0000451"},{"id":"T231","span":{"begin":610,"end":615},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T232","span":{"begin":640,"end":645},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T233","span":{"begin":646,"end":663},"obj":"http://purl.obolibrary.org/obo/CL_0000115"},{"id":"T234","span":{"begin":714,"end":719},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T235","span":{"begin":768,"end":771},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"}],"attributes":[{"subj":"T213","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T214","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T215","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T216","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T217","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T218","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T219","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T220","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T221","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T222","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T223","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T224","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T225","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T226","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T227","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T228","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T229","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T230","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T231","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T232","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T233","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T234","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T235","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T90","span":{"begin":245,"end":251},"obj":"Chemical"},{"id":"T91","span":{"begin":506,"end":512},"obj":"Chemical"}],"attributes":[{"id":"A90","pred":"chebi_id","subj":"T90","obj":"http://purl.obolibrary.org/obo/CHEBI_34922"},{"id":"A91","pred":"chebi_id","subj":"T91","obj":"http://purl.obolibrary.org/obo/CHEBI_37409"},{"subj":"T90","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T91","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T5","span":{"begin":697,"end":719},"obj":"http://purl.obolibrary.org/obo/GO_0009597"}],"attributes":[{"subj":"T5","pred":"source","obj":"LitCovid-PD-GO-BP"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T195","span":{"begin":0,"end":32},"obj":"Sentence"},{"id":"T196","span":{"begin":33,"end":815},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T195","pred":"source","obj":"LitCovid-sentences"},{"subj":"T196","pred":"source","obj":"LitCovid-sentences"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"532","span":{"begin":616,"end":632},"obj":"Gene"},{"id":"533","span":{"begin":52,"end":63},"obj":"Species"},{"id":"534","span":{"begin":500,"end":505},"obj":"Species"},{"id":"535","span":{"begin":506,"end":518},"obj":"Species"},{"id":"536","span":{"begin":538,"end":543},"obj":"Species"},{"id":"537","span":{"begin":572,"end":578},"obj":"Species"},{"id":"538","span":{"begin":610,"end":615},"obj":"Species"},{"id":"539","span":{"begin":640,"end":645},"obj":"Species"},{"id":"540","span":{"begin":685,"end":695},"obj":"Species"},{"id":"541","span":{"begin":759,"end":767},"obj":"Species"},{"id":"542","span":{"begin":204,"end":224},"obj":"Disease"},{"id":"543","span":{"begin":750,"end":758},"obj":"Disease"}],"attributes":[{"id":"A532","pred":"tao:has_database_id","subj":"532","obj":"Gene:290"},{"id":"A533","pred":"tao:has_database_id","subj":"533","obj":"Tax:11118"},{"id":"A534","pred":"tao:has_database_id","subj":"534","obj":"Tax:9606"},{"id":"A535","pred":"tao:has_database_id","subj":"535","obj":"Tax:11118"},{"id":"A536","pred":"tao:has_database_id","subj":"536","obj":"Tax:9606"},{"id":"A537","pred":"tao:has_database_id","subj":"537","obj":"Tax:10090"},{"id":"A538","pred":"tao:has_database_id","subj":"538","obj":"Tax:9606"},{"id":"A539","pred":"tao:has_database_id","subj":"539","obj":"Tax:9606"},{"id":"A540","pred":"tao:has_database_id","subj":"540","obj":"Tax:2697049"},{"id":"A541","pred":"tao:has_database_id","subj":"541","obj":"Tax:9606"},{"id":"A542","pred":"tao:has_database_id","subj":"542","obj":"MESH:D020271"},{"id":"A543","pred":"tao:has_database_id","subj":"543","obj":"MESH:C000657245"},{"subj":"532","pred":"source","obj":"LitCovid-PubTator"},{"subj":"533","pred":"source","obj":"LitCovid-PubTator"},{"subj":"534","pred":"source","obj":"LitCovid-PubTator"},{"subj":"535","pred":"source","obj":"LitCovid-PubTator"},{"subj":"536","pred":"source","obj":"LitCovid-PubTator"},{"subj":"537","pred":"source","obj":"LitCovid-PubTator"},{"subj":"538","pred":"source","obj":"LitCovid-PubTator"},{"subj":"539","pred":"source","obj":"LitCovid-PubTator"},{"subj":"540","pred":"source","obj":"LitCovid-PubTator"},{"subj":"541","pred":"source","obj":"LitCovid-PubTator"},{"subj":"542","pred":"source","obj":"LitCovid-PubTator"},{"subj":"543","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"2_test","denotations":[{"id":"32501751-20390431-53715189","span":{"begin":242,"end":244},"obj":"20390431"},{"id":"32501751-24619619-53715190","span":{"begin":346,"end":348},"obj":"24619619"},{"id":"32501751-24619619-53715191","span":{"begin":494,"end":496},"obj":"24619619"},{"id":"32501751-17825937-53715192","span":{"begin":497,"end":499},"obj":"17825937"},{"id":"32501751-17669539-53715193","span":{"begin":566,"end":568},"obj":"17669539"},{"id":"32501751-12414783-53715194","span":{"begin":569,"end":571},"obj":"12414783"},{"id":"32501751-15840518-53715195","span":{"begin":633,"end":635},"obj":"15840518"},{"id":"32501751-17825937-53715196","span":{"begin":675,"end":677},"obj":"17825937"},{"id":"32501751-32251791-53715197","span":{"begin":810,"end":812},"obj":"32251791"},{"id":"T35848","span":{"begin":242,"end":244},"obj":"20390431"},{"id":"T83186","span":{"begin":346,"end":348},"obj":"24619619"},{"id":"T18286","span":{"begin":494,"end":496},"obj":"24619619"},{"id":"T33219","span":{"begin":497,"end":499},"obj":"17825937"},{"id":"T81705","span":{"begin":566,"end":568},"obj":"17669539"},{"id":"T97949","span":{"begin":569,"end":571},"obj":"12414783"},{"id":"T56487","span":{"begin":633,"end":635},"obj":"15840518"},{"id":"T5106","span":{"begin":675,"end":677},"obj":"17825937"},{"id":"T8155","span":{"begin":810,"end":812},"obj":"32251791"}],"attributes":[{"subj":"32501751-20390431-53715189","pred":"source","obj":"2_test"},{"subj":"32501751-24619619-53715190","pred":"source","obj":"2_test"},{"subj":"32501751-24619619-53715191","pred":"source","obj":"2_test"},{"subj":"32501751-17825937-53715192","pred":"source","obj":"2_test"},{"subj":"32501751-17669539-53715193","pred":"source","obj":"2_test"},{"subj":"32501751-12414783-53715194","pred":"source","obj":"2_test"},{"subj":"32501751-15840518-53715195","pred":"source","obj":"2_test"},{"subj":"32501751-17825937-53715196","pred":"source","obj":"2_test"},{"subj":"32501751-32251791-53715197","pred":"source","obj":"2_test"},{"subj":"T35848","pred":"source","obj":"2_test"},{"subj":"T83186","pred":"source","obj":"2_test"},{"subj":"T18286","pred":"source","obj":"2_test"},{"subj":"T33219","pred":"source","obj":"2_test"},{"subj":"T81705","pred":"source","obj":"2_test"},{"subj":"T97949","pred":"source","obj":"2_test"},{"subj":"T56487","pred":"source","obj":"2_test"},{"subj":"T5106","pred":"source","obj":"2_test"},{"subj":"T8155","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PD-FMA-UBERON","color":"#ec9393","default":true},{"id":"LitCovid-PD-UBERON","color":"#93adec"},{"id":"LitCovid-PD-MONDO","color":"#c7ec93"},{"id":"LitCovid-PD-CLO","color":"#ec93e1"},{"id":"LitCovid-PD-CHEBI","color":"#93ecdd"},{"id":"LitCovid-PD-GO-BP","color":"#ecc393"},{"id":"LitCovid-sentences","color":"#a993ec"},{"id":"LitCovid-PubTator","color":"#97ec93"},{"id":"2_test","color":"#ec93b1"}]}]}}