PMC:7532482 / 13378-14091 JSONTXT

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T134","span":{"begin":208,"end":213},"obj":"http://purl.obolibrary.org/obo/OGG_0000000002"},{"id":"T135","span":{"begin":227,"end":228},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T136","span":{"begin":355,"end":360},"obj":"http://purl.obolibrary.org/obo/OGG_0000000002"},{"id":"T137","span":{"begin":434,"end":435},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T138","span":{"begin":472,"end":473},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T139","span":{"begin":513,"end":518},"obj":"http://purl.obolibrary.org/obo/OGG_0000000002"},{"id":"T140","span":{"begin":570,"end":571},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"text":"The ingredient-target network of SFJDC was constructed using the screened ingredients and their targets as shown in Figure 3. The network contained 117 nodes and 419 edges which indicated the compound-target genes interaction. A median of 110 candidate compouds was 5 degrees which indicating that most compounds of SFJDC were affected by multiple target genes. The top three effective ingredient according were Wogonin, licochalcone a and acacetin. Wogonin, licochalcone a and acacetin have 42, 30 and 23 target genes, respectively. And the OB of Wogonin, licochalcone a and acacetin were 30.68, 40.79 and 34.97%, respectively. Hence, they might be the crucial effective compounds of SFJDC according the network."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T84","span":{"begin":412,"end":419},"obj":"Chemical"},{"id":"T85","span":{"begin":440,"end":448},"obj":"Chemical"},{"id":"T86","span":{"begin":450,"end":457},"obj":"Chemical"},{"id":"T87","span":{"begin":478,"end":486},"obj":"Chemical"},{"id":"T88","span":{"begin":548,"end":555},"obj":"Chemical"},{"id":"T89","span":{"begin":576,"end":584},"obj":"Chemical"}],"attributes":[{"id":"A84","pred":"chebi_id","subj":"T84","obj":"http://purl.obolibrary.org/obo/CHEBI_10043"},{"id":"A85","pred":"chebi_id","subj":"T85","obj":"http://purl.obolibrary.org/obo/CHEBI_57284"},{"id":"A86","pred":"chebi_id","subj":"T86","obj":"http://purl.obolibrary.org/obo/CHEBI_10043"},{"id":"A87","pred":"chebi_id","subj":"T87","obj":"http://purl.obolibrary.org/obo/CHEBI_57284"},{"id":"A88","pred":"chebi_id","subj":"T88","obj":"http://purl.obolibrary.org/obo/CHEBI_10043"},{"id":"A89","pred":"chebi_id","subj":"T89","obj":"http://purl.obolibrary.org/obo/CHEBI_57284"}],"text":"The ingredient-target network of SFJDC was constructed using the screened ingredients and their targets as shown in Figure 3. The network contained 117 nodes and 419 edges which indicated the compound-target genes interaction. A median of 110 candidate compouds was 5 degrees which indicating that most compounds of SFJDC were affected by multiple target genes. The top three effective ingredient according were Wogonin, licochalcone a and acacetin. Wogonin, licochalcone a and acacetin have 42, 30 and 23 target genes, respectively. And the OB of Wogonin, licochalcone a and acacetin were 30.68, 40.79 and 34.97%, respectively. Hence, they might be the crucial effective compounds of SFJDC according the network."}

{"project":"LitCovid-PubTator","denotations":[{"id":"184","span":{"begin":542,"end":544},"obj":"Gene"},{"id":"185","span":{"begin":412,"end":419},"obj":"Chemical"},{"id":"186","span":{"begin":421,"end":435},"obj":"Chemical"},{"id":"187","span":{"begin":440,"end":448},"obj":"Chemical"},{"id":"188","span":{"begin":450,"end":457},"obj":"Chemical"},{"id":"189","span":{"begin":459,"end":473},"obj":"Chemical"},{"id":"190","span":{"begin":478,"end":486},"obj":"Chemical"},{"id":"191","span":{"begin":548,"end":555},"obj":"Chemical"},{"id":"192","span":{"begin":557,"end":571},"obj":"Chemical"},{"id":"193","span":{"begin":576,"end":584},"obj":"Chemical"}],"attributes":[{"id":"A184","pred":"tao:has_database_id","subj":"184","obj":"Gene:1009"},{"id":"A185","pred":"tao:has_database_id","subj":"185","obj":"MESH:C085514"},{"id":"A186","pred":"tao:has_database_id","subj":"186","obj":"MESH:C070840"},{"id":"A187","pred":"tao:has_database_id","subj":"187","obj":"MESH:C023717"},{"id":"A188","pred":"tao:has_database_id","subj":"188","obj":"MESH:C085514"},{"id":"A189","pred":"tao:has_database_id","subj":"189","obj":"MESH:C070840"},{"id":"A190","pred":"tao:has_database_id","subj":"190","obj":"MESH:C023717"},{"id":"A191","pred":"tao:has_database_id","subj":"191","obj":"MESH:C085514"},{"id":"A192","pred":"tao:has_database_id","subj":"192","obj":"MESH:C070840"},{"id":"A193","pred":"tao:has_database_id","subj":"193","obj":"MESH:C023717"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"The ingredient-target network of SFJDC was constructed using the screened ingredients and their targets as shown in Figure 3. The network contained 117 nodes and 419 edges which indicated the compound-target genes interaction. A median of 110 candidate compouds was 5 degrees which indicating that most compounds of SFJDC were affected by multiple target genes. The top three effective ingredient according were Wogonin, licochalcone a and acacetin. Wogonin, licochalcone a and acacetin have 42, 30 and 23 target genes, respectively. And the OB of Wogonin, licochalcone a and acacetin were 30.68, 40.79 and 34.97%, respectively. Hence, they might be the crucial effective compounds of SFJDC according the network."}

{"project":"LitCovid-sentences","denotations":[{"id":"T108","span":{"begin":0,"end":125},"obj":"Sentence"},{"id":"T109","span":{"begin":126,"end":226},"obj":"Sentence"},{"id":"T110","span":{"begin":227,"end":361},"obj":"Sentence"},{"id":"T111","span":{"begin":362,"end":449},"obj":"Sentence"},{"id":"T112","span":{"begin":450,"end":533},"obj":"Sentence"},{"id":"T113","span":{"begin":534,"end":628},"obj":"Sentence"},{"id":"T114","span":{"begin":629,"end":713},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"The ingredient-target network of SFJDC was constructed using the screened ingredients and their targets as shown in Figure 3. The network contained 117 nodes and 419 edges which indicated the compound-target genes interaction. A median of 110 candidate compouds was 5 degrees which indicating that most compounds of SFJDC were affected by multiple target genes. The top three effective ingredient according were Wogonin, licochalcone a and acacetin. Wogonin, licochalcone a and acacetin have 42, 30 and 23 target genes, respectively. And the OB of Wogonin, licochalcone a and acacetin were 30.68, 40.79 and 34.97%, respectively. Hence, they might be the crucial effective compounds of SFJDC according the network."}