PMC:7523471 / 52933-53720 JSONTXT

{"project":"TEST0","denotations":[{"id":"33041751-81-89-816595","span":{"begin":81,"end":85},"obj":"[\"12466113\"]"},{"id":"33041751-100-108-816596","span":{"begin":100,"end":104},"obj":"[\"23750207\"]"},{"id":"33041751-119-127-816597","span":{"begin":119,"end":123},"obj":"[\"24709310\"]"},{"id":"33041751-138-146-816598","span":{"begin":138,"end":142},"obj":"[\"24398104\"]"},{"id":"33041751-168-176-816599","span":{"begin":313,"end":317},"obj":"[\"12466113\"]"},{"id":"33041751-185-193-816600","span":{"begin":505,"end":509},"obj":"[\"24709310\"]"},{"id":"33041751-93-101-816601","span":{"begin":605,"end":609},"obj":"[\"24398104\"]"},{"id":"33041751-92-100-816602","span":{"begin":704,"end":708},"obj":"[\"25912193\"]"},{"id":"33041751-112-120-816603","span":{"begin":724,"end":728},"obj":"[\"27133194\"]"},{"id":"33041751-169-177-816604","span":{"begin":781,"end":785},"obj":"[\"25912193\"]"}],"text":"These findings are further supported by animal models of AD (Frederikse and Ren, 2002; Yang et al., 2013; Park et al., 2014; Tsai et al., 2014). In the hTgAPPtg/tg mouse lens, markers of degeneration included nuclear disorganization, organelle loss, cellular swelling, and shape irregularity (Frederikse and Ren, 2002). In the 5xFAD mouse, Aβ deposits in the retinal pigment epithelium, hypopigmentation, large vacuoles, and Bruch membrane thickening with Drusen-like deposits were observed (Park et al., 2014). Hypertrophy along with choroid changes were also detected in the TgF344-AD rat (Tsai et al., 2014). Further, in the APPSWE/PS1ΔE9 mouse, RGC density was lower than in WT controls (Gao et al., 2015; Gupta et al., 2016) and amacrine cell apoptosis was noted (Gao et al., 2015)."}

{"project":"2_test","denotations":[{"id":"33041751-12466113-38666381","span":{"begin":81,"end":85},"obj":"12466113"},{"id":"33041751-23750207-38666382","span":{"begin":100,"end":104},"obj":"23750207"},{"id":"33041751-24709310-38666383","span":{"begin":119,"end":123},"obj":"24709310"},{"id":"33041751-24398104-38666384","span":{"begin":138,"end":142},"obj":"24398104"},{"id":"33041751-12466113-38666385","span":{"begin":313,"end":317},"obj":"12466113"},{"id":"33041751-24709310-38666386","span":{"begin":505,"end":509},"obj":"24709310"},{"id":"33041751-24398104-38666387","span":{"begin":605,"end":609},"obj":"24398104"},{"id":"33041751-25912193-38666388","span":{"begin":704,"end":708},"obj":"25912193"},{"id":"33041751-27133194-38666389","span":{"begin":724,"end":728},"obj":"27133194"},{"id":"33041751-25912193-38666390","span":{"begin":781,"end":785},"obj":"25912193"}],"text":"These findings are further supported by animal models of AD (Frederikse and Ren, 2002; Yang et al., 2013; Park et al., 2014; Tsai et al., 2014). In the hTgAPPtg/tg mouse lens, markers of degeneration included nuclear disorganization, organelle loss, cellular swelling, and shape irregularity (Frederikse and Ren, 2002). In the 5xFAD mouse, Aβ deposits in the retinal pigment epithelium, hypopigmentation, large vacuoles, and Bruch membrane thickening with Drusen-like deposits were observed (Park et al., 2014). Hypertrophy along with choroid changes were also detected in the TgF344-AD rat (Tsai et al., 2014). Further, in the APPSWE/PS1ΔE9 mouse, RGC density was lower than in WT controls (Gao et al., 2015; Gupta et al., 2016) and amacrine cell apoptosis was noted (Gao et al., 2015)."}

{"project":"0_colil","denotations":[{"id":"33041751-12466113-816595","span":{"begin":81,"end":85},"obj":"12466113"},{"id":"33041751-23750207-816596","span":{"begin":100,"end":104},"obj":"23750207"},{"id":"33041751-24709310-816597","span":{"begin":119,"end":123},"obj":"24709310"},{"id":"33041751-24398104-816598","span":{"begin":138,"end":142},"obj":"24398104"},{"id":"33041751-12466113-816599","span":{"begin":313,"end":317},"obj":"12466113"},{"id":"33041751-24709310-816600","span":{"begin":505,"end":509},"obj":"24709310"},{"id":"33041751-24398104-816601","span":{"begin":605,"end":609},"obj":"24398104"},{"id":"33041751-25912193-816602","span":{"begin":704,"end":708},"obj":"25912193"},{"id":"33041751-27133194-816603","span":{"begin":724,"end":728},"obj":"27133194"},{"id":"33041751-25912193-816604","span":{"begin":781,"end":785},"obj":"25912193"}],"text":"These findings are further supported by animal models of AD (Frederikse and Ren, 2002; Yang et al., 2013; Park et al., 2014; Tsai et al., 2014). In the hTgAPPtg/tg mouse lens, markers of degeneration included nuclear disorganization, organelle loss, cellular swelling, and shape irregularity (Frederikse and Ren, 2002). In the 5xFAD mouse, Aβ deposits in the retinal pigment epithelium, hypopigmentation, large vacuoles, and Bruch membrane thickening with Drusen-like deposits were observed (Park et al., 2014). Hypertrophy along with choroid changes were also detected in the TgF344-AD rat (Tsai et al., 2014). Further, in the APPSWE/PS1ΔE9 mouse, RGC density was lower than in WT controls (Gao et al., 2015; Gupta et al., 2016) and amacrine cell apoptosis was noted (Gao et al., 2015)."}