PMC:7523471 / 36843-38568 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7523471","sourcedb":"PMC","sourceid":"7523471","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7523471","text":"TABLE 1 Alzheimer’s pathological hallmarks in retinas of animal models.\nHallmarks Animal species Models and Genotypes Retinal pathologies References\nAPP or Aβ related Drosophila AβPP, dBACE-AβPPL, pGMR-Aβ42 Increased APP, Aβ, Aβ42 toxicity Finelli et al., 2004; Greeve et al., 2004; Carmine-Simmen et al., 2009; Cutler et al., 2015\nMouse Tg2576, hTgAPPtg/tg, APPSWE/PS1ΔE9, APPSWE/PS1M146L/L286V, 3xTg, 5xFAD, Tg-SwDI Increased APP, Aβ deposits, Aβ42, Aβ40, vascular Aβ, Aβ oligomers Ning et al., 2008; Dutescu et al., 2009; Liu et al., 2009; Perez et al., 2009; Alexandrov et al., 2011; Koronyo-Hamaoui et al., 2011; Koronyo et al., 2012; Williams et al., 2013; Yang et al., 2013; Zhao et al., 2013; Edwards et al., 2014; He et al., 2014; Park et al., 2014; Gao et al., 2015; More and Vince, 2015; Parthasarathy et al., 2015; Pogue et al., 2015; Gupta et al., 2016; Oliveira-Souza et al., 2017; Criscuolo et al., 2018; Hadoux et al., 2019; Habiba et al., 2020; Sidiqi et al., 2020\nO. degus Spontaneous Increased APP, Aβ, Aβ oligomers Inestrosa et al., 2005; Ardiles et al., 2012; Du et al., 2015\nRat TgF344-AD Increased Aβ Tsai et al., 2014\nNFT or pTau related Drosophila hTau Accumulation of pTau Grammenoudi et al., 2006; Chouhan et al., 2016\nMouse Tg2576, APPSWE/PS1 ΔE9, APPSWE/PS1M146L/L286V, 3xTg, P301S, rTg4510 Accumulation of pTau, NFT Liu et al., 2009; Schön et al., 2012; Yang et al., 2013; Zhao et al., 2013; Chiasseu et al., 2017; Grimaldi et al., 2018; Harrison et al., 2019\nO. degus Spontaneous Accumulation of pTau Du et al., 2015; Chang et al., 2020\nAPP, amyloid precursor protein; Aβ, amyloid-beta; pTau, phosphorylated Tau; NFT, neurofibrillary tangle; O. degus, Octodon 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