PMC:7523471 / 36843-38568
Annnotations
TEST0
{"project":"TEST0","denotations":[{"id":"33041751-175-183-816436","span":{"begin":265,"end":269},"obj":"[\"15234342\"]"},{"id":"33041751-196-204-816437","span":{"begin":286,"end":290},"obj":"[\"15102905\"]"},{"id":"33041751-225-233-816438","span":{"begin":315,"end":319},"obj":"[\"19049874\"]"},{"id":"33041751-230-238-816439","span":{"begin":336,"end":340},"obj":"[\"26367392\"]"},{"id":"33041751-231-239-816440","span":{"begin":509,"end":513},"obj":"[\"18566467\"]"},{"id":"33041751-232-240-816441","span":{"begin":531,"end":535},"obj":"[\"19271231\"]"},{"id":"33041751-235-243-816442","span":{"begin":549,"end":553},"obj":"[\"19834067\"]"},{"id":"33041751-234-242-816443","span":{"begin":569,"end":573},"obj":"[\"18791173\"]"},{"id":"33041751-234-242-816444","span":{"begin":594,"end":598},"obj":"[\"21734608\"]"},{"id":"33041751-213-221-816445","span":{"begin":624,"end":628},"obj":"[\"20550967\"]"},{"id":"33041751-235-243-816446","span":{"begin":646,"end":650},"obj":"[\"22343730\"]"},{"id":"33041751-228-236-816447","span":{"begin":669,"end":673},"obj":"[\"23465714\"]"},{"id":"33041751-229-237-816448","span":{"begin":688,"end":692},"obj":"[\"23750207\"]"},{"id":"33041751-227-235-816449","span":{"begin":707,"end":711},"obj":"[\"23810804\"]"},{"id":"33041751-228-236-816450","span":{"begin":729,"end":733},"obj":"[\"25149907\"]"},{"id":"33041751-231-239-816451","span":{"begin":746,"end":750},"obj":"[\"24287922\"]"},{"id":"33041751-234-242-816452","span":{"begin":765,"end":769},"obj":"[\"24709310\"]"},{"id":"33041751-234-242-816453","span":{"begin":783,"end":787},"obj":"[\"25912193\"]"},{"id":"33041751-230-238-816454","span":{"begin":805,"end":809},"obj":"[\"25354367\"]"},{"id":"33041751-233-241-816455","span":{"begin":833,"end":837},"obj":"[\"26142956\"]"},{"id":"33041751-234-242-816456","span":{"begin":853,"end":857},"obj":"[\"26213226\"]"},{"id":"33041751-235-243-816457","span":{"begin":873,"end":877},"obj":"[\"27133194\"]"},{"id":"33041751-233-241-816458","span":{"begin":902,"end":906},"obj":"[\"28450267\"]"},{"id":"33041751-232-240-816459","span":{"begin":926,"end":930},"obj":"[\"29735432\"]"},{"id":"33041751-234-242-816460","span":{"begin":947,"end":951},"obj":"[\"31530809\"]"},{"id":"33041751-233-241-816461","span":{"begin":968,"end":972},"obj":"[\"32597800\"]"},{"id":"33041751-232-240-816462","span":{"begin":989,"end":993},"obj":"[\"32719582\"]"},{"id":"33041751-65-73-816463","span":{"begin":1068,"end":1072},"obj":"[\"15748782\"]"},{"id":"33041751-87-95-816464","span":{"begin":1090,"end":1094},"obj":"[\"22869717\"]"},{"id":"33041751-104-112-816465","span":{"begin":1107,"end":1111},"obj":"[\"26267479\"]"},{"id":"33041751-145-153-816466","span":{"begin":1155,"end":1159},"obj":"[\"24398104\"]"},{"id":"33041751-222-230-816467","span":{"begin":1241,"end":1245},"obj":"[\"16875690\"]"},{"id":"33041751-218-226-816468","span":{"begin":1263,"end":1267},"obj":"[\"27338814\"]"},{"id":"33041751-227-235-816469","span":{"begin":1383,"end":1387},"obj":"[\"19834067\"]"},{"id":"33041751-232-240-816470","span":{"begin":1403,"end":1407},"obj":"[\"23300938\"]"},{"id":"33041751-235-243-816471","span":{"begin":1422,"end":1426},"obj":"[\"23750207\"]"},{"id":"33041751-220-228-816472","span":{"begin":1441,"end":1445},"obj":"[\"23810804\"]"},{"id":"33041751-224-232-816473","span":{"begin":1464,"end":1468},"obj":"[\"28774322\"]"},{"id":"33041751-233-241-816474","span":{"begin":1487,"end":1491},"obj":"[\"29880901\"]"},{"id":"33041751-223-231-816475","span":{"begin":1510,"end":1514},"obj":"[\"30616676\"]"},{"id":"33041751-47-55-816476","span":{"begin":1571,"end":1575},"obj":"[\"26267479\"]"},{"id":"33041751-67-75-816477","span":{"begin":1591,"end":1595},"obj":"[\"32256305\"]"}],"text":"TABLE 1 Alzheimer’s pathological hallmarks in retinas of animal models.\nHallmarks Animal species Models and Genotypes Retinal pathologies References\nAPP or Aβ related Drosophila AβPP, dBACE-AβPPL, pGMR-Aβ42 Increased APP, Aβ, Aβ42 toxicity Finelli et al., 2004; Greeve et al., 2004; Carmine-Simmen et al., 2009; Cutler et al., 2015\nMouse Tg2576, hTgAPPtg/tg, APPSWE/PS1ΔE9, APPSWE/PS1M146L/L286V, 3xTg, 5xFAD, Tg-SwDI Increased APP, Aβ deposits, Aβ42, Aβ40, vascular Aβ, Aβ oligomers Ning et al., 2008; Dutescu et al., 2009; Liu et al., 2009; Perez et al., 2009; Alexandrov et al., 2011; Koronyo-Hamaoui et al., 2011; Koronyo et al., 2012; Williams et al., 2013; Yang et al., 2013; Zhao et al., 2013; Edwards et al., 2014; He et al., 2014; Park et al., 2014; Gao et al., 2015; More and Vince, 2015; Parthasarathy et al., 2015; Pogue et al., 2015; Gupta et al., 2016; Oliveira-Souza et al., 2017; Criscuolo et al., 2018; Hadoux et al., 2019; Habiba et al., 2020; Sidiqi et al., 2020\nO. degus Spontaneous Increased APP, Aβ, Aβ oligomers Inestrosa et al., 2005; Ardiles et al., 2012; Du et al., 2015\nRat TgF344-AD Increased Aβ Tsai et al., 2014\nNFT or pTau related Drosophila hTau Accumulation of pTau Grammenoudi et al., 2006; Chouhan et al., 2016\nMouse Tg2576, APPSWE/PS1 ΔE9, APPSWE/PS1M146L/L286V, 3xTg, P301S, rTg4510 Accumulation of pTau, NFT Liu et al., 2009; Schön et al., 2012; Yang et al., 2013; Zhao et al., 2013; Chiasseu et al., 2017; Grimaldi et al., 2018; Harrison et al., 2019\nO. degus Spontaneous Accumulation of pTau Du et al., 2015; Chang et al., 2020\nAPP, amyloid precursor protein; Aβ, amyloid-beta; pTau, phosphorylated Tau; NFT, neurofibrillary tangle; O. degus, Octodon Degus."}
2_test
{"project":"2_test","denotations":[{"id":"33041751-15234342-38666222","span":{"begin":265,"end":269},"obj":"15234342"},{"id":"33041751-15102905-38666223","span":{"begin":286,"end":290},"obj":"15102905"},{"id":"33041751-19049874-38666224","span":{"begin":315,"end":319},"obj":"19049874"},{"id":"33041751-26367392-38666225","span":{"begin":336,"end":340},"obj":"26367392"},{"id":"33041751-18566467-38666226","span":{"begin":509,"end":513},"obj":"18566467"},{"id":"33041751-19271231-38666227","span":{"begin":531,"end":535},"obj":"19271231"},{"id":"33041751-19834067-38666228","span":{"begin":549,"end":553},"obj":"19834067"},{"id":"33041751-18791173-38666229","span":{"begin":569,"end":573},"obj":"18791173"},{"id":"33041751-21734608-38666230","span":{"begin":594,"end":598},"obj":"21734608"},{"id":"33041751-20550967-38666231","span":{"begin":624,"end":628},"obj":"20550967"},{"id":"33041751-22343730-38666232","span":{"begin":646,"end":650},"obj":"22343730"},{"id":"33041751-23465714-38666233","span":{"begin":669,"end":673},"obj":"23465714"},{"id":"33041751-23750207-38666234","span":{"begin":688,"end":692},"obj":"23750207"},{"id":"33041751-23810804-38666235","span":{"begin":707,"end":711},"obj":"23810804"},{"id":"33041751-25149907-38666236","span":{"begin":729,"end":733},"obj":"25149907"},{"id":"33041751-24287922-38666237","span":{"begin":746,"end":750},"obj":"24287922"},{"id":"33041751-24709310-38666238","span":{"begin":765,"end":769},"obj":"24709310"},{"id":"33041751-25912193-38666239","span":{"begin":783,"end":787},"obj":"25912193"},{"id":"33041751-25354367-38666240","span":{"begin":805,"end":809},"obj":"25354367"},{"id":"33041751-26142956-38666241","span":{"begin":833,"end":837},"obj":"26142956"},{"id":"33041751-26213226-38666242","span":{"begin":853,"end":857},"obj":"26213226"},{"id":"33041751-27133194-38666243","span":{"begin":873,"end":877},"obj":"27133194"},{"id":"33041751-28450267-38666244","span":{"begin":902,"end":906},"obj":"28450267"},{"id":"33041751-29735432-38666245","span":{"begin":926,"end":930},"obj":"29735432"},{"id":"33041751-31530809-38666246","span":{"begin":947,"end":951},"obj":"31530809"},{"id":"33041751-32597800-38666247","span":{"begin":968,"end":972},"obj":"32597800"},{"id":"33041751-32719582-38666248","span":{"begin":989,"end":993},"obj":"32719582"},{"id":"33041751-15748782-38666249","span":{"begin":1068,"end":1072},"obj":"15748782"},{"id":"33041751-22869717-38666250","span":{"begin":1090,"end":1094},"obj":"22869717"},{"id":"33041751-26267479-38666251","span":{"begin":1107,"end":1111},"obj":"26267479"},{"id":"33041751-24398104-38666252","span":{"begin":1155,"end":1159},"obj":"24398104"},{"id":"33041751-16875690-38666253","span":{"begin":1241,"end":1245},"obj":"16875690"},{"id":"33041751-27338814-38666254","span":{"begin":1263,"end":1267},"obj":"27338814"},{"id":"33041751-19834067-38666255","span":{"begin":1383,"end":1387},"obj":"19834067"},{"id":"33041751-23300938-38666256","span":{"begin":1403,"end":1407},"obj":"23300938"},{"id":"33041751-23750207-38666257","span":{"begin":1422,"end":1426},"obj":"23750207"},{"id":"33041751-23810804-38666258","span":{"begin":1441,"end":1445},"obj":"23810804"},{"id":"33041751-28774322-38666259","span":{"begin":1464,"end":1468},"obj":"28774322"},{"id":"33041751-29880901-38666260","span":{"begin":1487,"end":1491},"obj":"29880901"},{"id":"33041751-30616676-38666261","span":{"begin":1510,"end":1514},"obj":"30616676"},{"id":"33041751-26267479-38666262","span":{"begin":1571,"end":1575},"obj":"26267479"},{"id":"33041751-32256305-38666263","span":{"begin":1591,"end":1595},"obj":"32256305"}],"text":"TABLE 1 Alzheimer’s pathological hallmarks in retinas of animal models.\nHallmarks Animal species Models and Genotypes Retinal pathologies References\nAPP or Aβ related Drosophila AβPP, dBACE-AβPPL, pGMR-Aβ42 Increased APP, Aβ, Aβ42 toxicity Finelli et al., 2004; Greeve et al., 2004; Carmine-Simmen et al., 2009; Cutler et al., 2015\nMouse Tg2576, hTgAPPtg/tg, APPSWE/PS1ΔE9, APPSWE/PS1M146L/L286V, 3xTg, 5xFAD, Tg-SwDI Increased APP, Aβ deposits, Aβ42, Aβ40, vascular Aβ, Aβ oligomers Ning et al., 2008; Dutescu et al., 2009; Liu et al., 2009; Perez et al., 2009; Alexandrov et al., 2011; Koronyo-Hamaoui et al., 2011; Koronyo et al., 2012; Williams et al., 2013; Yang et al., 2013; Zhao et al., 2013; Edwards et al., 2014; He et al., 2014; Park et al., 2014; Gao et al., 2015; More and Vince, 2015; Parthasarathy et al., 2015; Pogue et al., 2015; Gupta et al., 2016; Oliveira-Souza et al., 2017; Criscuolo et al., 2018; Hadoux et al., 2019; Habiba et al., 2020; Sidiqi et al., 2020\nO. degus Spontaneous Increased APP, Aβ, Aβ oligomers Inestrosa et al., 2005; Ardiles et al., 2012; Du et al., 2015\nRat TgF344-AD Increased Aβ Tsai et al., 2014\nNFT or pTau related Drosophila hTau Accumulation of pTau Grammenoudi et al., 2006; Chouhan et al., 2016\nMouse Tg2576, APPSWE/PS1 ΔE9, APPSWE/PS1M146L/L286V, 3xTg, P301S, rTg4510 Accumulation of pTau, NFT Liu et al., 2009; Schön et al., 2012; Yang et al., 2013; Zhao et al., 2013; Chiasseu et al., 2017; Grimaldi et al., 2018; Harrison et al., 2019\nO. degus Spontaneous Accumulation of pTau Du et al., 2015; Chang et al., 2020\nAPP, amyloid precursor protein; Aβ, amyloid-beta; pTau, phosphorylated Tau; NFT, neurofibrillary tangle; O. degus, Octodon Degus."}
0_colil
{"project":"0_colil","denotations":[{"id":"33041751-15234342-816436","span":{"begin":265,"end":269},"obj":"15234342"},{"id":"33041751-15102905-816437","span":{"begin":286,"end":290},"obj":"15102905"},{"id":"33041751-19049874-816438","span":{"begin":315,"end":319},"obj":"19049874"},{"id":"33041751-26367392-816439","span":{"begin":336,"end":340},"obj":"26367392"},{"id":"33041751-18566467-816440","span":{"begin":509,"end":513},"obj":"18566467"},{"id":"33041751-19271231-816441","span":{"begin":531,"end":535},"obj":"19271231"},{"id":"33041751-19834067-816442","span":{"begin":549,"end":553},"obj":"19834067"},{"id":"33041751-18791173-816443","span":{"begin":569,"end":573},"obj":"18791173"},{"id":"33041751-21734608-816444","span":{"begin":594,"end":598},"obj":"21734608"},{"id":"33041751-20550967-816445","span":{"begin":624,"end":628},"obj":"20550967"},{"id":"33041751-22343730-816446","span":{"begin":646,"end":650},"obj":"22343730"},{"id":"33041751-23465714-816447","span":{"begin":669,"end":673},"obj":"23465714"},{"id":"33041751-23750207-816448","span":{"begin":688,"end":692},"obj":"23750207"},{"id":"33041751-23810804-816449","span":{"begin":707,"end":711},"obj":"23810804"},{"id":"33041751-25149907-816450","span":{"begin":729,"end":733},"obj":"25149907"},{"id":"33041751-24287922-816451","span":{"begin":746,"end":750},"obj":"24287922"},{"id":"33041751-24709310-816452","span":{"begin":765,"end":769},"obj":"24709310"},{"id":"33041751-25912193-816453","span":{"begin":783,"end":787},"obj":"25912193"},{"id":"33041751-25354367-816454","span":{"begin":805,"end":809},"obj":"25354367"},{"id":"33041751-26142956-816455","span":{"begin":833,"end":837},"obj":"26142956"},{"id":"33041751-26213226-816456","span":{"begin":853,"end":857},"obj":"26213226"},{"id":"33041751-27133194-816457","span":{"begin":873,"end":877},"obj":"27133194"},{"id":"33041751-28450267-816458","span":{"begin":902,"end":906},"obj":"28450267"},{"id":"33041751-29735432-816459","span":{"begin":926,"end":930},"obj":"29735432"},{"id":"33041751-31530809-816460","span":{"begin":947,"end":951},"obj":"31530809"},{"id":"33041751-32597800-816461","span":{"begin":968,"end":972},"obj":"32597800"},{"id":"33041751-32719582-816462","span":{"begin":989,"end":993},"obj":"32719582"},{"id":"33041751-15748782-816463","span":{"begin":1068,"end":1072},"obj":"15748782"},{"id":"33041751-22869717-816464","span":{"begin":1090,"end":1094},"obj":"22869717"},{"id":"33041751-26267479-816465","span":{"begin":1107,"end":1111},"obj":"26267479"},{"id":"33041751-24398104-816466","span":{"begin":1155,"end":1159},"obj":"24398104"},{"id":"33041751-16875690-816467","span":{"begin":1241,"end":1245},"obj":"16875690"},{"id":"33041751-27338814-816468","span":{"begin":1263,"end":1267},"obj":"27338814"},{"id":"33041751-19834067-816469","span":{"begin":1383,"end":1387},"obj":"19834067"},{"id":"33041751-23300938-816470","span":{"begin":1403,"end":1407},"obj":"23300938"},{"id":"33041751-23750207-816471","span":{"begin":1422,"end":1426},"obj":"23750207"},{"id":"33041751-23810804-816472","span":{"begin":1441,"end":1445},"obj":"23810804"},{"id":"33041751-28774322-816473","span":{"begin":1464,"end":1468},"obj":"28774322"},{"id":"33041751-29880901-816474","span":{"begin":1487,"end":1491},"obj":"29880901"},{"id":"33041751-30616676-816475","span":{"begin":1510,"end":1514},"obj":"30616676"},{"id":"33041751-26267479-816476","span":{"begin":1571,"end":1575},"obj":"26267479"},{"id":"33041751-32256305-816477","span":{"begin":1591,"end":1595},"obj":"32256305"}],"text":"TABLE 1 Alzheimer’s pathological hallmarks in retinas of animal models.\nHallmarks Animal species Models and Genotypes Retinal pathologies References\nAPP or Aβ related Drosophila AβPP, dBACE-AβPPL, pGMR-Aβ42 Increased APP, Aβ, Aβ42 toxicity Finelli et al., 2004; Greeve et al., 2004; Carmine-Simmen et al., 2009; Cutler et al., 2015\nMouse Tg2576, hTgAPPtg/tg, APPSWE/PS1ΔE9, APPSWE/PS1M146L/L286V, 3xTg, 5xFAD, Tg-SwDI Increased APP, Aβ deposits, Aβ42, Aβ40, vascular Aβ, Aβ oligomers Ning et al., 2008; Dutescu et al., 2009; Liu et al., 2009; Perez et al., 2009; Alexandrov et al., 2011; Koronyo-Hamaoui et al., 2011; Koronyo et al., 2012; Williams et al., 2013; Yang et al., 2013; Zhao et al., 2013; Edwards et al., 2014; He et al., 2014; Park et al., 2014; Gao et al., 2015; More and Vince, 2015; Parthasarathy et al., 2015; Pogue et al., 2015; Gupta et al., 2016; Oliveira-Souza et al., 2017; Criscuolo et al., 2018; Hadoux et al., 2019; Habiba et al., 2020; Sidiqi et al., 2020\nO. degus Spontaneous Increased APP, Aβ, Aβ oligomers Inestrosa et al., 2005; Ardiles et al., 2012; Du et al., 2015\nRat TgF344-AD Increased Aβ Tsai et al., 2014\nNFT or pTau related Drosophila hTau Accumulation of pTau Grammenoudi et al., 2006; Chouhan et al., 2016\nMouse Tg2576, APPSWE/PS1 ΔE9, APPSWE/PS1M146L/L286V, 3xTg, P301S, rTg4510 Accumulation of pTau, NFT Liu et al., 2009; Schön et al., 2012; Yang et al., 2013; Zhao et al., 2013; Chiasseu et al., 2017; Grimaldi et al., 2018; Harrison et al., 2019\nO. degus Spontaneous Accumulation of pTau Du et al., 2015; Chang et al., 2020\nAPP, amyloid precursor protein; Aβ, amyloid-beta; pTau, phosphorylated Tau; NFT, neurofibrillary tangle; O. degus, Octodon Degus."}