PMC:7523471 / 18043-18777
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7523471","sourcedb":"PMC","sourceid":"7523471","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7523471","text":"This and two subsequent studies on human cohorts of over 50 patients and control donor eyes, examining retinal flatmounts and cross-sections with Aβ-specific monoclonal antibodies (12F4, 11A5-B10, 6E10, 4G8), anti-Aβ dyes (i.e., Curcumin, Thioflavin-S, Congo-Red) and Gallyas silver stain, showed that all neuropathologically confirmed AD patients exhibited Aβ deposits in the retina (Koronyo-Hamaoui et al., 2011; La Morgia et al., 2016; Koronyo et al., 2017). Interestingly, through scanning of retinal flatmounts, the team discovered a non-uniform manifestation of Aβ deposits across the human retina. Plaques were more often detected in peripheral regions, especially in the superior and inferior quadrants (Koronyo et al., 2017).","tracks":[{"project":"TEST0","denotations":[{"id":"33041751-229-237-816333","span":{"begin":409,"end":413},"obj":"[\"20550967\"]"},{"id":"33041751-230-238-816334","span":{"begin":433,"end":437},"obj":"[\"26505992\"]"},{"id":"33041751-233-241-816335","span":{"begin":455,"end":459},"obj":"[\"28814675\"]"},{"id":"33041751-123-131-816336","span":{"begin":728,"end":732},"obj":"[\"28814675\"]"}],"attributes":[{"subj":"33041751-229-237-816333","pred":"source","obj":"TEST0"},{"subj":"33041751-230-238-816334","pred":"source","obj":"TEST0"},{"subj":"33041751-233-241-816335","pred":"source","obj":"TEST0"},{"subj":"33041751-123-131-816336","pred":"source","obj":"TEST0"}]},{"project":"2_test","denotations":[{"id":"33041751-20550967-38666119","span":{"begin":409,"end":413},"obj":"20550967"},{"id":"33041751-26505992-38666120","span":{"begin":433,"end":437},"obj":"26505992"},{"id":"33041751-28814675-38666121","span":{"begin":455,"end":459},"obj":"28814675"},{"id":"33041751-28814675-38666122","span":{"begin":728,"end":732},"obj":"28814675"}],"attributes":[{"subj":"33041751-20550967-38666119","pred":"source","obj":"2_test"},{"subj":"33041751-26505992-38666120","pred":"source","obj":"2_test"},{"subj":"33041751-28814675-38666121","pred":"source","obj":"2_test"},{"subj":"33041751-28814675-38666122","pred":"source","obj":"2_test"}]},{"project":"0_colil","denotations":[{"id":"33041751-20550967-816333","span":{"begin":409,"end":413},"obj":"20550967"},{"id":"33041751-26505992-816334","span":{"begin":433,"end":437},"obj":"26505992"},{"id":"33041751-28814675-816335","span":{"begin":455,"end":459},"obj":"28814675"},{"id":"33041751-28814675-816336","span":{"begin":728,"end":732},"obj":"28814675"}],"attributes":[{"subj":"33041751-20550967-816333","pred":"source","obj":"0_colil"},{"subj":"33041751-26505992-816334","pred":"source","obj":"0_colil"},{"subj":"33041751-28814675-816335","pred":"source","obj":"0_colil"},{"subj":"33041751-28814675-816336","pred":"source","obj":"0_colil"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"TEST0","color":"#d893ec","default":true},{"id":"2_test","color":"#93ecbe"},{"id":"0_colil","color":"#eca493"}]}]}}