This and two subsequent studies on human cohorts of over 50 patients and control donor eyes, examining retinal flatmounts and cross-sections with Aβ-specific monoclonal antibodies (12F4, 11A5-B10, 6E10, 4G8), anti-Aβ dyes (i.e., Curcumin, Thioflavin-S, Congo-Red) and Gallyas silver stain, showed that all neuropathologically confirmed AD patients exhibited Aβ deposits in the retina (Koronyo-Hamaoui et al., 2011; La Morgia et al., 2016; Koronyo et al., 2017). Interestingly, through scanning of retinal flatmounts, the team discovered a non-uniform manifestation of Aβ deposits across the human retina. Plaques were more often detected in peripheral regions, especially in the superior and inferior quadrants (Koronyo et al., 2017).