PMC:7519301 / 32112-33015 JSONTXT

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T161","span":{"begin":192,"end":200},"obj":"Disease"},{"id":"T162","span":{"begin":192,"end":196},"obj":"Disease"},{"id":"T163","span":{"begin":513,"end":523},"obj":"Disease"}],"attributes":[{"id":"A161","pred":"mondo_id","subj":"T161","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A162","pred":"mondo_id","subj":"T162","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A163","pred":"mondo_id","subj":"T163","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"}],"text":"These data indicate that epidemiologic factors could be sufficient to explain the global spread of mutations such as D614G. A founder effect means that these mutations were likely exported to SARS-CoV-2 naive areas early in the outbreak and therefore given the opportunity to spread widely. As such, on January 28, 2020, a virus carrying the D614G mutation, which was rare among sequences from China, was identified in Germany. Host and environmental factors permitted the establishment of a sustained cluster of infections that propagated this mutation until it became dominant among European sequences and then globally (Fig. 2). We found no evidence that the frequent identification of this mutation was caused by convergent selection events that would have occurred in multiple individuals. Further analyses are needed to characterize the biologic mechanisms behind the spread of the D614G mutation."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T258","span":{"begin":124,"end":125},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T259","span":{"begin":321,"end":322},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T260","span":{"begin":323,"end":328},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T261","span":{"begin":490,"end":491},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"text":"These data indicate that epidemiologic factors could be sufficient to explain the global spread of mutations such as D614G. A founder effect means that these mutations were likely exported to SARS-CoV-2 naive areas early in the outbreak and therefore given the opportunity to spread widely. As such, on January 28, 2020, a virus carrying the D614G mutation, which was rare among sequences from China, was identified in Germany. Host and environmental factors permitted the establishment of a sustained cluster of infections that propagated this mutation until it became dominant among European sequences and then globally (Fig. 2). We found no evidence that the frequent identification of this mutation was caused by convergent selection events that would have occurred in multiple individuals. Further analyses are needed to characterize the biologic mechanisms behind the spread of the D614G mutation."}

{"project":"LitCovid-PubTator","denotations":[{"id":"463","span":{"begin":192,"end":202},"obj":"Species"},{"id":"464","span":{"begin":513,"end":523},"obj":"Disease"},{"id":"465","span":{"begin":888,"end":893},"obj":"Mutation"},{"id":"466","span":{"begin":342,"end":347},"obj":"Mutation"},{"id":"467","span":{"begin":117,"end":122},"obj":"Mutation"}],"attributes":[{"id":"A463","pred":"tao:has_database_id","subj":"463","obj":"Tax:2697049"},{"id":"A464","pred":"tao:has_database_id","subj":"464","obj":"MESH:D007239"},{"id":"A465","pred":"tao:has_standard_notation","subj":"465","obj":"p.D614G"},{"id":"A466","pred":"tao:has_standard_notation","subj":"466","obj":"p.D614G"},{"id":"A467","pred":"tao:has_standard_notation","subj":"467","obj":"p.D614G"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"These data indicate that epidemiologic factors could be sufficient to explain the global spread of mutations such as D614G. A founder effect means that these mutations were likely exported to SARS-CoV-2 naive areas early in the outbreak and therefore given the opportunity to spread widely. As such, on January 28, 2020, a virus carrying the D614G mutation, which was rare among sequences from China, was identified in Germany. Host and environmental factors permitted the establishment of a sustained cluster of infections that propagated this mutation until it became dominant among European sequences and then globally (Fig. 2). We found no evidence that the frequent identification of this mutation was caused by convergent selection events that would have occurred in multiple individuals. Further analyses are needed to characterize the biologic mechanisms behind the spread of the D614G mutation."}

{"project":"LitCovid-sentences","denotations":[{"id":"T194","span":{"begin":0,"end":123},"obj":"Sentence"},{"id":"T195","span":{"begin":124,"end":290},"obj":"Sentence"},{"id":"T196","span":{"begin":291,"end":427},"obj":"Sentence"},{"id":"T197","span":{"begin":428,"end":631},"obj":"Sentence"},{"id":"T198","span":{"begin":632,"end":794},"obj":"Sentence"},{"id":"T199","span":{"begin":795,"end":903},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"These data indicate that epidemiologic factors could be sufficient to explain the global spread of mutations such as D614G. A founder effect means that these mutations were likely exported to SARS-CoV-2 naive areas early in the outbreak and therefore given the opportunity to spread widely. As such, on January 28, 2020, a virus carrying the D614G mutation, which was rare among sequences from China, was identified in Germany. Host and environmental factors permitted the establishment of a sustained cluster of infections that propagated this mutation until it became dominant among European sequences and then globally (Fig. 2). We found no evidence that the frequent identification of this mutation was caused by convergent selection events that would have occurred in multiple individuals. Further analyses are needed to characterize the biologic mechanisms behind the spread of the D614G mutation."}