PMC:7519301 / 29126-30373 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7519301","sourcedb":"PMC","sourceid":"7519301","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7519301","text":"In the context of rare SARS-CoV-2 mutations, the rapid spread of the D614G mutation is singular and has led authors to hypothesize that viruses with D614G may have enhanced fitness (24). The strongest evidence of a biological effect for this mutation comes from recent reports of an increase in in vitro infectivity or cell entry for pseudoviruses with D614G (25–28). Additional work is needed to evaluate whether the increase in infectivity in vitro translates to increased transmissibility (spread) of SARS-CoV-2 across humans, as there is not necessarily a linear relationship between the two. For example, SARS-CoV mediates cell entry more efficiently than SARS-CoV-2 (with or without the D614G S mutation) (26). Hence, it would be important to understand whether, controlling for epidemiological factors, there are higher reproduction numbers associated with viruses carrying the D614G mutation. While a preliminary comparison of the lineages with either D or G in Washington State did not indicate an obvious advantage for D614G mutants, as they found similar maximal values for the effective reproduction number (https://github.com/blab/ncov-wa-phylodynamics), additional comparisons in different geographic locations should be informative.","tracks":[{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T101","span":{"begin":319,"end":323},"obj":"Body_part"},{"id":"T102","span":{"begin":628,"end":632},"obj":"Body_part"}],"attributes":[{"id":"A101","pred":"fma_id","subj":"T101","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A102","pred":"fma_id","subj":"T102","obj":"http://purl.org/sig/ont/fma/fma68646"},{"subj":"T101","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T102","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T150","span":{"begin":23,"end":31},"obj":"Disease"},{"id":"T151","span":{"begin":23,"end":27},"obj":"Disease"},{"id":"T152","span":{"begin":504,"end":512},"obj":"Disease"},{"id":"T153","span":{"begin":504,"end":508},"obj":"Disease"},{"id":"T154","span":{"begin":610,"end":618},"obj":"Disease"},{"id":"T155","span":{"begin":610,"end":614},"obj":"Disease"},{"id":"T156","span":{"begin":661,"end":669},"obj":"Disease"},{"id":"T157","span":{"begin":661,"end":665},"obj":"Disease"}],"attributes":[{"id":"A150","pred":"mondo_id","subj":"T150","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A151","pred":"mondo_id","subj":"T151","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A152","pred":"mondo_id","subj":"T152","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A153","pred":"mondo_id","subj":"T153","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A154","pred":"mondo_id","subj":"T154","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A155","pred":"mondo_id","subj":"T155","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A156","pred":"mondo_id","subj":"T156","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A157","pred":"mondo_id","subj":"T157","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"subj":"T150","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T151","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T152","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T153","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T154","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T155","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T156","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T157","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T235","span":{"begin":100,"end":103},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T236","span":{"begin":136,"end":143},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T237","span":{"begin":213,"end":214},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T238","span":{"begin":319,"end":323},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T239","span":{"begin":522,"end":528},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T240","span":{"begin":558,"end":559},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T241","span":{"begin":628,"end":632},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T242","span":{"begin":864,"end":871},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T243","span":{"begin":907,"end":908},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"attributes":[{"subj":"T235","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T236","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T237","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T238","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T239","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T240","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T241","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T242","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T243","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"430","span":{"begin":699,"end":700},"obj":"Gene"},{"id":"431","span":{"begin":23,"end":33},"obj":"Species"},{"id":"432","span":{"begin":504,"end":514},"obj":"Species"},{"id":"433","span":{"begin":522,"end":528},"obj":"Species"},{"id":"434","span":{"begin":610,"end":618},"obj":"Species"},{"id":"435","span":{"begin":661,"end":671},"obj":"Species"},{"id":"436","span":{"begin":1144,"end":1148},"obj":"Species"},{"id":"437","span":{"begin":173,"end":180},"obj":"Disease"},{"id":"438","span":{"begin":1029,"end":1034},"obj":"Mutation"},{"id":"439","span":{"begin":885,"end":890},"obj":"Mutation"},{"id":"440","span":{"begin":693,"end":698},"obj":"Mutation"},{"id":"441","span":{"begin":353,"end":358},"obj":"Mutation"},{"id":"442","span":{"begin":149,"end":154},"obj":"Mutation"},{"id":"443","span":{"begin":69,"end":74},"obj":"Mutation"}],"attributes":[{"id":"A430","pred":"tao:has_database_id","subj":"430","obj":"Gene:43740568"},{"id":"A431","pred":"tao:has_database_id","subj":"431","obj":"Tax:2697049"},{"id":"A432","pred":"tao:has_database_id","subj":"432","obj":"Tax:2697049"},{"id":"A433","pred":"tao:has_database_id","subj":"433","obj":"Tax:9606"},{"id":"A434","pred":"tao:has_database_id","subj":"434","obj":"Tax:694009"},{"id":"A435","pred":"tao:has_database_id","subj":"435","obj":"Tax:2697049"},{"id":"A436","pred":"tao:has_database_id","subj":"436","obj":"Tax:2697049"},{"id":"A437","pred":"tao:has_database_id","subj":"437","obj":"MESH:D012640"},{"id":"A438","pred":"tao:has_standard_notation","subj":"438","obj":"p.D614G"},{"id":"A439","pred":"tao:has_standard_notation","subj":"439","obj":"p.D614G"},{"id":"A440","pred":"tao:has_standard_notation","subj":"440","obj":"p.D614G"},{"id":"A441","pred":"tao:has_standard_notation","subj":"441","obj":"p.D614G"},{"id":"A442","pred":"tao:has_standard_notation","subj":"442","obj":"p.D614G"},{"id":"A443","pred":"tao:has_standard_notation","subj":"443","obj":"p.D614G"},{"subj":"430","pred":"source","obj":"LitCovid-PubTator"},{"subj":"431","pred":"source","obj":"LitCovid-PubTator"},{"subj":"432","pred":"source","obj":"LitCovid-PubTator"},{"subj":"433","pred":"source","obj":"LitCovid-PubTator"},{"subj":"434","pred":"source","obj":"LitCovid-PubTator"},{"subj":"435","pred":"source","obj":"LitCovid-PubTator"},{"subj":"436","pred":"source","obj":"LitCovid-PubTator"},{"subj":"437","pred":"source","obj":"LitCovid-PubTator"},{"subj":"438","pred":"source","obj":"LitCovid-PubTator"},{"subj":"439","pred":"source","obj":"LitCovid-PubTator"},{"subj":"440","pred":"source","obj":"LitCovid-PubTator"},{"subj":"441","pred":"source","obj":"LitCovid-PubTator"},{"subj":"442","pred":"source","obj":"LitCovid-PubTator"},{"subj":"443","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T3","span":{"begin":827,"end":839},"obj":"http://purl.obolibrary.org/obo/GO_0000003"},{"id":"T4","span":{"begin":1099,"end":1111},"obj":"http://purl.obolibrary.org/obo/GO_0000003"}],"attributes":[{"subj":"T3","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T4","pred":"source","obj":"LitCovid-PD-GO-BP"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T179","span":{"begin":0,"end":186},"obj":"Sentence"},{"id":"T180","span":{"begin":187,"end":367},"obj":"Sentence"},{"id":"T181","span":{"begin":368,"end":596},"obj":"Sentence"},{"id":"T182","span":{"begin":597,"end":716},"obj":"Sentence"},{"id":"T183","span":{"begin":717,"end":900},"obj":"Sentence"},{"id":"T184","span":{"begin":901,"end":1247},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T179","pred":"source","obj":"LitCovid-sentences"},{"subj":"T180","pred":"source","obj":"LitCovid-sentences"},{"subj":"T181","pred":"source","obj":"LitCovid-sentences"},{"subj":"T182","pred":"source","obj":"LitCovid-sentences"},{"subj":"T183","pred":"source","obj":"LitCovid-sentences"},{"subj":"T184","pred":"source","obj":"LitCovid-sentences"}]},{"project":"2_test","denotations":[{"id":"32868447-32697968-132542407","span":{"begin":182,"end":184},"obj":"32697968"}],"attributes":[{"subj":"32868447-32697968-132542407","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PD-FMA-UBERON","color":"#eca693","default":true},{"id":"LitCovid-PD-MONDO","color":"#939aec"},{"id":"LitCovid-PD-CLO","color":"#b4ec93"},{"id":"LitCovid-PubTator","color":"#ec93ce"},{"id":"LitCovid-PD-GO-BP","color":"#93e8ec"},{"id":"LitCovid-sentences","color":"#ecd693"},{"id":"2_test","color":"#bc93ec"}]}]}}