PMC:7497282 / 53142-55077
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7497282","sourcedb":"PMC","sourceid":"7497282","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7497282","text":"Starting in 2006, IC began reporting on its application of advanced epidemiological methods to support the GPEI as part of its collaboration with the World Health Organization (WHO). IC focused on statistical analyses of existing data and data collected as part of prospective clinical trials or challenge studies and did not perform any economic analyses. With respect to transmission modeling, between 2000 and 2019, IC applied dynamic transmission models to explore several specific topics. In 2013, using a simple DEB and SC model on two hypothetical populations, IC explored IPV use after OPV cessation, which suggested that IPV would protect children from paralysis, and under some conditions, IPV use could potentially limit transmission [97]. The study also noted that IPV use in routine immunization could also potentially delay the detection of outbreaks and allow transmission to spread further by preventing AFP cases [97]. In 2014, IC used an SC model to explore the impact of older age groups on the transmission of polioviruses, which identified faster outbreak response as substantially more important than expanding the age range of campaigns [98]. IC applied the same SC model in 2017 to explore a statistical inference framework to epidemiological and genetic data collected during a poliovirus outbreak to estimate transmission parameters [99]. Using an SC model for Nigeria, in 2016 IC characterized the role of tOPV SIAs before OPV2 cessation and suggested that in closed populations with no routine immunization coverage, conducting tOPV SIAs with some characteristics (e.g. one SIA with low coverage) could increase cVDPV2 risks after OPV2 cessation [100]. The inclusion of low routine immunization coverage in the model suggested the need for a sufficient number of focused tOPV SIAs before OPV2 cessation in areas at risk of VDPV2 emergence to raise population immunity above the transmission threshold [100].","tracks":[{"project":"MyTest","denotations":[{"id":"32741232-24100955-29927116","span":{"begin":746,"end":748},"obj":"24100955"},{"id":"32741232-24100955-29927117","span":{"begin":931,"end":933},"obj":"24100955"},{"id":"32741232-25002465-29927118","span":{"begin":1161,"end":1163},"obj":"25002465"},{"id":"32741232-28981709-29927119","span":{"begin":1360,"end":1362},"obj":"28981709"},{"id":"32741232-27384947-29927120","span":{"begin":1675,"end":1678},"obj":"27384947"},{"id":"32741232-27384947-29927121","span":{"begin":1930,"end":1933},"obj":"27384947"}],"namespaces":[{"prefix":"_base","uri":"https://www.uniprot.org/uniprot/testbase"},{"prefix":"UniProtKB","uri":"https://www.uniprot.org/uniprot/"},{"prefix":"uniprot","uri":"https://www.uniprot.org/uniprotkb/"}],"attributes":[{"subj":"32741232-24100955-29927116","pred":"source","obj":"MyTest"},{"subj":"32741232-24100955-29927117","pred":"source","obj":"MyTest"},{"subj":"32741232-25002465-29927118","pred":"source","obj":"MyTest"},{"subj":"32741232-28981709-29927119","pred":"source","obj":"MyTest"},{"subj":"32741232-27384947-29927120","pred":"source","obj":"MyTest"},{"subj":"32741232-27384947-29927121","pred":"source","obj":"MyTest"}]},{"project":"2_test","denotations":[{"id":"32741232-24100955-29927116","span":{"begin":746,"end":748},"obj":"24100955"},{"id":"32741232-24100955-29927117","span":{"begin":931,"end":933},"obj":"24100955"},{"id":"32741232-25002465-29927118","span":{"begin":1161,"end":1163},"obj":"25002465"},{"id":"32741232-28981709-29927119","span":{"begin":1360,"end":1362},"obj":"28981709"},{"id":"32741232-27384947-29927120","span":{"begin":1675,"end":1678},"obj":"27384947"},{"id":"32741232-27384947-29927121","span":{"begin":1930,"end":1933},"obj":"27384947"}],"attributes":[{"subj":"32741232-24100955-29927116","pred":"source","obj":"2_test"},{"subj":"32741232-24100955-29927117","pred":"source","obj":"2_test"},{"subj":"32741232-25002465-29927118","pred":"source","obj":"2_test"},{"subj":"32741232-28981709-29927119","pred":"source","obj":"2_test"},{"subj":"32741232-27384947-29927120","pred":"source","obj":"2_test"},{"subj":"32741232-27384947-29927121","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"MyTest","color":"#93ecd0","default":true},{"id":"2_test","color":"#ecb693"}]}]}}