PMC:7464116 / 7146-8176 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T17","span":{"begin":120,"end":127},"obj":"Body_part"},{"id":"T18","span":{"begin":132,"end":137},"obj":"Body_part"},{"id":"T19","span":{"begin":245,"end":251},"obj":"Body_part"},{"id":"T20","span":{"begin":289,"end":294},"obj":"Body_part"},{"id":"T21","span":{"begin":392,"end":398},"obj":"Body_part"},{"id":"T22","span":{"begin":655,"end":661},"obj":"Body_part"},{"id":"T23","span":{"begin":742,"end":748},"obj":"Body_part"}],"attributes":[{"id":"A17","pred":"fma_id","subj":"T17","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A18","pred":"fma_id","subj":"T18","obj":"http://purl.org/sig/ont/fma/fma63083"},{"id":"A19","pred":"fma_id","subj":"T19","obj":"http://purl.org/sig/ont/fma/fma7203"},{"id":"A20","pred":"fma_id","subj":"T20","obj":"http://purl.org/sig/ont/fma/fma9670"},{"id":"A21","pred":"fma_id","subj":"T21","obj":"http://purl.org/sig/ont/fma/fma7203"},{"id":"A22","pred":"fma_id","subj":"T22","obj":"http://purl.org/sig/ont/fma/fma7203"},{"id":"A23","pred":"fma_id","subj":"T23","obj":"http://purl.org/sig/ont/fma/fma7203"}],"text":"Most patients also showed an inflammatory status and coagulopathies with elevated levels of high-sensitivity C-reactive protein and serum lactose dehydrogenase [8]. Interestingly, up to 15% of the hospitalized COVID-19 patients had at least one kidney abnormality represented by increased blood urea nitrogen or reduced estimated glomerular filtration rate (eGFR) which is the best marker of kidney function. Moreover, findings from different cohorts of hospitalized patients showed that 26–63% of patients presented proteinuria at admission or developed proteinuria during their stay in hospital, proteinuria being considered the most recognized sign of kidney damage [7,8]. An individual risk profile also found that COVID-19 patients with kidney abnormalities, compared with those with normal renal function at admission, were more likely to be males, with advanced age and with a worse coagulation profile [8]. In addition, a meta-analysis [21] has confirmed that CKD is associated with an enhanced risk of COVID-19 infection."}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T14","span":{"begin":132,"end":137},"obj":"Body_part"},{"id":"T15","span":{"begin":245,"end":251},"obj":"Body_part"},{"id":"T16","span":{"begin":289,"end":294},"obj":"Body_part"},{"id":"T17","span":{"begin":392,"end":398},"obj":"Body_part"},{"id":"T18","span":{"begin":655,"end":661},"obj":"Body_part"},{"id":"T19","span":{"begin":742,"end":748},"obj":"Body_part"}],"attributes":[{"id":"A14","pred":"uberon_id","subj":"T14","obj":"http://purl.obolibrary.org/obo/UBERON_0001977"},{"id":"A15","pred":"uberon_id","subj":"T15","obj":"http://purl.obolibrary.org/obo/UBERON_0002113"},{"id":"A16","pred":"uberon_id","subj":"T16","obj":"http://purl.obolibrary.org/obo/UBERON_0000178"},{"id":"A17","pred":"uberon_id","subj":"T17","obj":"http://purl.obolibrary.org/obo/UBERON_0002113"},{"id":"A18","pred":"uberon_id","subj":"T18","obj":"http://purl.obolibrary.org/obo/UBERON_0002113"},{"id":"A19","pred":"uberon_id","subj":"T19","obj":"http://purl.obolibrary.org/obo/UBERON_0002113"}],"text":"Most patients also showed an inflammatory status and coagulopathies with elevated levels of high-sensitivity C-reactive protein and serum lactose dehydrogenase [8]. Interestingly, up to 15% of the hospitalized COVID-19 patients had at least one kidney abnormality represented by increased blood urea nitrogen or reduced estimated glomerular filtration rate (eGFR) which is the best marker of kidney function. Moreover, findings from different cohorts of hospitalized patients showed that 26–63% of patients presented proteinuria at admission or developed proteinuria during their stay in hospital, proteinuria being considered the most recognized sign of kidney damage [7,8]. An individual risk profile also found that COVID-19 patients with kidney abnormalities, compared with those with normal renal function at admission, were more likely to be males, with advanced age and with a worse coagulation profile [8]. In addition, a meta-analysis [21] has confirmed that CKD is associated with an enhanced risk of COVID-19 infection."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T101","span":{"begin":210,"end":218},"obj":"Disease"},{"id":"T102","span":{"begin":517,"end":528},"obj":"Disease"},{"id":"T103","span":{"begin":555,"end":566},"obj":"Disease"},{"id":"T104","span":{"begin":598,"end":609},"obj":"Disease"},{"id":"T105","span":{"begin":719,"end":727},"obj":"Disease"},{"id":"T106","span":{"begin":968,"end":971},"obj":"Disease"},{"id":"T107","span":{"begin":1011,"end":1019},"obj":"Disease"},{"id":"T108","span":{"begin":1020,"end":1029},"obj":"Disease"}],"attributes":[{"id":"A101","pred":"mondo_id","subj":"T101","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A102","pred":"mondo_id","subj":"T102","obj":"http://purl.obolibrary.org/obo/MONDO_0003634"},{"id":"A103","pred":"mondo_id","subj":"T103","obj":"http://purl.obolibrary.org/obo/MONDO_0003634"},{"id":"A104","pred":"mondo_id","subj":"T104","obj":"http://purl.obolibrary.org/obo/MONDO_0003634"},{"id":"A105","pred":"mondo_id","subj":"T105","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A106","pred":"mondo_id","subj":"T106","obj":"http://purl.obolibrary.org/obo/MONDO_0005300"},{"id":"A107","pred":"mondo_id","subj":"T107","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A108","pred":"mondo_id","subj":"T108","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"}],"text":"Most patients also showed an inflammatory status and coagulopathies with elevated levels of high-sensitivity C-reactive protein and serum lactose dehydrogenase [8]. Interestingly, up to 15% of the hospitalized COVID-19 patients had at least one kidney abnormality represented by increased blood urea nitrogen or reduced estimated glomerular filtration rate (eGFR) which is the best marker of kidney function. Moreover, findings from different cohorts of hospitalized patients showed that 26–63% of patients presented proteinuria at admission or developed proteinuria during their stay in hospital, proteinuria being considered the most recognized sign of kidney damage [7,8]. An individual risk profile also found that COVID-19 patients with kidney abnormalities, compared with those with normal renal function at admission, were more likely to be males, with advanced age and with a worse coagulation profile [8]. In addition, a meta-analysis [21] has confirmed that CKD is associated with an enhanced risk of COVID-19 infection."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T90","span":{"begin":245,"end":251},"obj":"http://purl.obolibrary.org/obo/UBERON_0002113"},{"id":"T91","span":{"begin":245,"end":251},"obj":"http://www.ebi.ac.uk/efo/EFO_0000927"},{"id":"T92","span":{"begin":245,"end":251},"obj":"http://www.ebi.ac.uk/efo/EFO_0000929"},{"id":"T93","span":{"begin":289,"end":294},"obj":"http://purl.obolibrary.org/obo/UBERON_0000178"},{"id":"T94","span":{"begin":289,"end":294},"obj":"http://www.ebi.ac.uk/efo/EFO_0000296"},{"id":"T95","span":{"begin":392,"end":398},"obj":"http://purl.obolibrary.org/obo/UBERON_0002113"},{"id":"T96","span":{"begin":392,"end":398},"obj":"http://www.ebi.ac.uk/efo/EFO_0000927"},{"id":"T97","span":{"begin":392,"end":398},"obj":"http://www.ebi.ac.uk/efo/EFO_0000929"},{"id":"T98","span":{"begin":655,"end":661},"obj":"http://purl.obolibrary.org/obo/UBERON_0002113"},{"id":"T99","span":{"begin":655,"end":661},"obj":"http://www.ebi.ac.uk/efo/EFO_0000927"},{"id":"T100","span":{"begin":655,"end":661},"obj":"http://www.ebi.ac.uk/efo/EFO_0000929"},{"id":"T101","span":{"begin":742,"end":748},"obj":"http://purl.obolibrary.org/obo/UBERON_0002113"},{"id":"T102","span":{"begin":742,"end":748},"obj":"http://www.ebi.ac.uk/efo/EFO_0000927"},{"id":"T103","span":{"begin":742,"end":748},"obj":"http://www.ebi.ac.uk/efo/EFO_0000929"},{"id":"T104","span":{"begin":845,"end":853},"obj":"http://purl.obolibrary.org/obo/UBERON_0003101"},{"id":"T105","span":{"begin":845,"end":853},"obj":"http://www.ebi.ac.uk/efo/EFO_0000970"},{"id":"T106","span":{"begin":882,"end":883},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T107","span":{"begin":928,"end":929},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T108","span":{"begin":949,"end":952},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"}],"text":"Most patients also showed an inflammatory status and coagulopathies with elevated levels of high-sensitivity C-reactive protein and serum lactose dehydrogenase [8]. Interestingly, up to 15% of the hospitalized COVID-19 patients had at least one kidney abnormality represented by increased blood urea nitrogen or reduced estimated glomerular filtration rate (eGFR) which is the best marker of kidney function. Moreover, findings from different cohorts of hospitalized patients showed that 26–63% of patients presented proteinuria at admission or developed proteinuria during their stay in hospital, proteinuria being considered the most recognized sign of kidney damage [7,8]. An individual risk profile also found that COVID-19 patients with kidney abnormalities, compared with those with normal renal function at admission, were more likely to be males, with advanced age and with a worse coagulation profile [8]. In addition, a meta-analysis [21] has confirmed that CKD is associated with an enhanced risk of COVID-19 infection."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T1","span":{"begin":120,"end":127},"obj":"Chemical"},{"id":"T2","span":{"begin":138,"end":145},"obj":"Chemical"},{"id":"T3","span":{"begin":295,"end":299},"obj":"Chemical"},{"id":"T4","span":{"begin":300,"end":308},"obj":"Chemical"}],"attributes":[{"id":"A1","pred":"chebi_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A2","pred":"chebi_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/CHEBI_17716"},{"id":"A3","pred":"chebi_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/CHEBI_16199"},{"id":"A4","pred":"chebi_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/CHEBI_25555"}],"text":"Most patients also showed an inflammatory status and coagulopathies with elevated levels of high-sensitivity C-reactive protein and serum lactose dehydrogenase [8]. Interestingly, up to 15% of the hospitalized COVID-19 patients had at least one kidney abnormality represented by increased blood urea nitrogen or reduced estimated glomerular filtration rate (eGFR) which is the best marker of kidney function. Moreover, findings from different cohorts of hospitalized patients showed that 26–63% of patients presented proteinuria at admission or developed proteinuria during their stay in hospital, proteinuria being considered the most recognized sign of kidney damage [7,8]. An individual risk profile also found that COVID-19 patients with kidney abnormalities, compared with those with normal renal function at admission, were more likely to be males, with advanced age and with a worse coagulation profile [8]. In addition, a meta-analysis [21] has confirmed that CKD is associated with an enhanced risk of COVID-19 infection."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T3","span":{"begin":330,"end":351},"obj":"http://purl.obolibrary.org/obo/GO_0003094"},{"id":"T4","span":{"begin":358,"end":362},"obj":"http://purl.obolibrary.org/obo/GO_0005006"},{"id":"T5","span":{"begin":890,"end":901},"obj":"http://purl.obolibrary.org/obo/GO_0050817"}],"text":"Most patients also showed an inflammatory status and coagulopathies with elevated levels of high-sensitivity C-reactive protein and serum lactose dehydrogenase [8]. Interestingly, up to 15% of the hospitalized COVID-19 patients had at least one kidney abnormality represented by increased blood urea nitrogen or reduced estimated glomerular filtration rate (eGFR) which is the best marker of kidney function. Moreover, findings from different cohorts of hospitalized patients showed that 26–63% of patients presented proteinuria at admission or developed proteinuria during their stay in hospital, proteinuria being considered the most recognized sign of kidney damage [7,8]. An individual risk profile also found that COVID-19 patients with kidney abnormalities, compared with those with normal renal function at admission, were more likely to be males, with advanced age and with a worse coagulation profile [8]. In addition, a meta-analysis [21] has confirmed that CKD is associated with an enhanced risk of COVID-19 infection."}

{"project":"LitCovid-sentences","denotations":[{"id":"T49","span":{"begin":0,"end":164},"obj":"Sentence"},{"id":"T50","span":{"begin":165,"end":408},"obj":"Sentence"},{"id":"T51","span":{"begin":409,"end":675},"obj":"Sentence"},{"id":"T52","span":{"begin":676,"end":914},"obj":"Sentence"},{"id":"T53","span":{"begin":915,"end":1030},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Most patients also showed an inflammatory status and coagulopathies with elevated levels of high-sensitivity C-reactive protein and serum lactose dehydrogenase [8]. Interestingly, up to 15% of the hospitalized COVID-19 patients had at least one kidney abnormality represented by increased blood urea nitrogen or reduced estimated glomerular filtration rate (eGFR) which is the best marker of kidney function. Moreover, findings from different cohorts of hospitalized patients showed that 26–63% of patients presented proteinuria at admission or developed proteinuria during their stay in hospital, proteinuria being considered the most recognized sign of kidney damage [7,8]. An individual risk profile also found that COVID-19 patients with kidney abnormalities, compared with those with normal renal function at admission, were more likely to be males, with advanced age and with a worse coagulation profile [8]. In addition, a meta-analysis [21] has confirmed that CKD is associated with an enhanced risk of COVID-19 infection."}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T37","span":{"begin":53,"end":67},"obj":"Phenotype"},{"id":"T38","span":{"begin":279,"end":308},"obj":"Phenotype"},{"id":"T39","span":{"begin":517,"end":528},"obj":"Phenotype"},{"id":"T40","span":{"begin":555,"end":566},"obj":"Phenotype"},{"id":"T41","span":{"begin":598,"end":609},"obj":"Phenotype"},{"id":"T42","span":{"begin":655,"end":668},"obj":"Phenotype"},{"id":"T43","span":{"begin":968,"end":971},"obj":"Phenotype"}],"attributes":[{"id":"A37","pred":"hp_id","subj":"T37","obj":"http://purl.obolibrary.org/obo/HP_0003256"},{"id":"A38","pred":"hp_id","subj":"T38","obj":"http://purl.obolibrary.org/obo/HP_0003138"},{"id":"A39","pred":"hp_id","subj":"T39","obj":"http://purl.obolibrary.org/obo/HP_0000093"},{"id":"A40","pred":"hp_id","subj":"T40","obj":"http://purl.obolibrary.org/obo/HP_0000093"},{"id":"A41","pred":"hp_id","subj":"T41","obj":"http://purl.obolibrary.org/obo/HP_0000093"},{"id":"A42","pred":"hp_id","subj":"T42","obj":"http://purl.obolibrary.org/obo/HP_0000112"},{"id":"A43","pred":"hp_id","subj":"T43","obj":"http://purl.obolibrary.org/obo/HP_0012622"}],"text":"Most patients also showed an inflammatory status and coagulopathies with elevated levels of high-sensitivity C-reactive protein and serum lactose dehydrogenase [8]. Interestingly, up to 15% of the hospitalized COVID-19 patients had at least one kidney abnormality represented by increased blood urea nitrogen or reduced estimated glomerular filtration rate (eGFR) which is the best marker of kidney function. Moreover, findings from different cohorts of hospitalized patients showed that 26–63% of patients presented proteinuria at admission or developed proteinuria during their stay in hospital, proteinuria being considered the most recognized sign of kidney damage [7,8]. An individual risk profile also found that COVID-19 patients with kidney abnormalities, compared with those with normal renal function at admission, were more likely to be males, with advanced age and with a worse coagulation profile [8]. In addition, a meta-analysis [21] has confirmed that CKD is associated with an enhanced risk of COVID-19 infection."}

{"project":"LitCovid-PubTator","denotations":[{"id":"237","span":{"begin":109,"end":127},"obj":"Gene"},{"id":"238","span":{"begin":5,"end":13},"obj":"Species"},{"id":"239","span":{"begin":219,"end":227},"obj":"Species"},{"id":"240","span":{"begin":467,"end":475},"obj":"Species"},{"id":"241","span":{"begin":498,"end":506},"obj":"Species"},{"id":"242","span":{"begin":728,"end":736},"obj":"Species"},{"id":"243","span":{"begin":138,"end":145},"obj":"Chemical"},{"id":"244","span":{"begin":295,"end":299},"obj":"Chemical"},{"id":"245","span":{"begin":300,"end":308},"obj":"Chemical"},{"id":"246","span":{"begin":53,"end":67},"obj":"Disease"},{"id":"247","span":{"begin":210,"end":218},"obj":"Disease"},{"id":"248","span":{"begin":245,"end":263},"obj":"Disease"},{"id":"249","span":{"begin":517,"end":528},"obj":"Disease"},{"id":"250","span":{"begin":555,"end":566},"obj":"Disease"},{"id":"251","span":{"begin":598,"end":609},"obj":"Disease"},{"id":"252","span":{"begin":655,"end":668},"obj":"Disease"},{"id":"253","span":{"begin":719,"end":727},"obj":"Disease"},{"id":"254","span":{"begin":742,"end":762},"obj":"Disease"},{"id":"255","span":{"begin":968,"end":971},"obj":"Disease"},{"id":"256","span":{"begin":1011,"end":1019},"obj":"Disease"},{"id":"257","span":{"begin":1020,"end":1029},"obj":"Disease"}],"attributes":[{"id":"A237","pred":"tao:has_database_id","subj":"237","obj":"Gene:1401"},{"id":"A238","pred":"tao:has_database_id","subj":"238","obj":"Tax:9606"},{"id":"A239","pred":"tao:has_database_id","subj":"239","obj":"Tax:9606"},{"id":"A240","pred":"tao:has_database_id","subj":"240","obj":"Tax:9606"},{"id":"A241","pred":"tao:has_database_id","subj":"241","obj":"Tax:9606"},{"id":"A242","pred":"tao:has_database_id","subj":"242","obj":"Tax:9606"},{"id":"A243","pred":"tao:has_database_id","subj":"243","obj":"MESH:D007785"},{"id":"A244","pred":"tao:has_database_id","subj":"244","obj":"MESH:D014508"},{"id":"A245","pred":"tao:has_database_id","subj":"245","obj":"MESH:D009584"},{"id":"A246","pred":"tao:has_database_id","subj":"246","obj":"MESH:D001778"},{"id":"A247","pred":"tao:has_database_id","subj":"247","obj":"MESH:C000657245"},{"id":"A248","pred":"tao:has_database_id","subj":"248","obj":"MESH:D007674"},{"id":"A249","pred":"tao:has_database_id","subj":"249","obj":"MESH:D011507"},{"id":"A250","pred":"tao:has_database_id","subj":"250","obj":"MESH:D011507"},{"id":"A251","pred":"tao:has_database_id","subj":"251","obj":"MESH:D011507"},{"id":"A252","pred":"tao:has_database_id","subj":"252","obj":"MESH:D007674"},{"id":"A253","pred":"tao:has_database_id","subj":"253","obj":"MESH:C000657245"},{"id":"A254","pred":"tao:has_database_id","subj":"254","obj":"MESH:D007674"},{"id":"A255","pred":"tao:has_database_id","subj":"255","obj":"MESH:D012080"},{"id":"A256","pred":"tao:has_database_id","subj":"256","obj":"MESH:C000657245"},{"id":"A257","pred":"tao:has_database_id","subj":"257","obj":"MESH:D007239"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Most patients also showed an inflammatory status and coagulopathies with elevated levels of high-sensitivity C-reactive protein and serum lactose dehydrogenase [8]. Interestingly, up to 15% of the hospitalized COVID-19 patients had at least one kidney abnormality represented by increased blood urea nitrogen or reduced estimated glomerular filtration rate (eGFR) which is the best marker of kidney function. Moreover, findings from different cohorts of hospitalized patients showed that 26–63% of patients presented proteinuria at admission or developed proteinuria during their stay in hospital, proteinuria being considered the most recognized sign of kidney damage [7,8]. An individual risk profile also found that COVID-19 patients with kidney abnormalities, compared with those with normal renal function at admission, were more likely to be males, with advanced age and with a worse coagulation profile [8]. In addition, a meta-analysis [21] has confirmed that CKD is associated with an enhanced risk of COVID-19 infection."}

{"project":"2_test","denotations":[{"id":"32759645-32335410-58096149","span":{"begin":670,"end":671},"obj":"32335410"}],"text":"Most patients also showed an inflammatory status and coagulopathies with elevated levels of high-sensitivity C-reactive protein and serum lactose dehydrogenase [8]. Interestingly, up to 15% of the hospitalized COVID-19 patients had at least one kidney abnormality represented by increased blood urea nitrogen or reduced estimated glomerular filtration rate (eGFR) which is the best marker of kidney function. Moreover, findings from different cohorts of hospitalized patients showed that 26–63% of patients presented proteinuria at admission or developed proteinuria during their stay in hospital, proteinuria being considered the most recognized sign of kidney damage [7,8]. An individual risk profile also found that COVID-19 patients with kidney abnormalities, compared with those with normal renal function at admission, were more likely to be males, with advanced age and with a worse coagulation profile [8]. In addition, a meta-analysis [21] has confirmed that CKD is associated with an enhanced risk of COVID-19 infection."}