PMC:7464116 / 51335-53274 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7464116","sourcedb":"PMC","sourceid":"7464116","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7464116","text":"The standard assessment of AKI is still based on serum creatinine levels and daily urine output, but these represent only indicators of established renal damage [111]. Recently, Richardson et al. enrolled in the New York City Area (U.S.A.), the largest number of cases of sequentially hospitalized patients with confirmed COVID-19 in USA. Males and those with pre-existing hypertension and/or diabetes were highly prevalent among 5700 case series with a median age of 63 years. In this study, AKI was observed among 8.4% discharged live patients and among 63% dead patients. On hospital admission, a significant percentage of patients had renal impairment, presenting proteinuria and hematuria. AKI incidence in the overall cohort was in the range of 4.7–7.5%. A higher incidence of proteinuria and hematuria was reported in patients with severe or critically ill COVID-19 pneumonia. Among all patients with renal impairment, the patients with AKI had a higher incidence rate of proteinuria and hematuria compared with the non-AKI group. Almost 50% of the critically ill cases developed AKI during hospitalization, especially those who were in the intensive care unit (ICU). Patients were followed up for a median duration of 12 days, during which time most of the COVID-19 patients showed remission of the pneumonia. Urine dipstick testing in most of the patients with proteinuria and hematuria were reported as negative after follow-up. The mean time for AKI recovery was seen to be 6 days. The percentage of patients who developed AKI was increased in patients with diabetes. In conclusion, despite the high morbidity of kidney impairment, the short-term renal prognosis of those patients is still good: in fact 50% achieved remission in 3 weeks after the onset of their symptoms. However, adverse short-term outcomes of patients with kidney impairment are also associated with high rate of mortality in COVID-19 infected patients 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