PMC:7463108 / 9866-10776 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T70209","span":{"begin":188,"end":191},"obj":"Body_part"},{"id":"T54610","span":{"begin":208,"end":220},"obj":"Body_part"},{"id":"T92740","span":{"begin":277,"end":283},"obj":"Body_part"},{"id":"T88403","span":{"begin":324,"end":327},"obj":"Body_part"},{"id":"T91823","span":{"begin":537,"end":546},"obj":"Body_part"},{"id":"T67325","span":{"begin":577,"end":586},"obj":"Body_part"},{"id":"T63785","span":{"begin":596,"end":613},"obj":"Body_part"},{"id":"T89876","span":{"begin":615,"end":618},"obj":"Body_part"}],"attributes":[{"id":"A88653","pred":"fma_id","subj":"T70209","obj":"http://purl.org/sig/ont/fma/fma278683"},{"id":"A19954","pred":"fma_id","subj":"T54610","obj":"http://purl.org/sig/ont/fma/fma83929"},{"id":"A31994","pred":"fma_id","subj":"T92740","obj":"http://purl.org/sig/ont/fma/fma62977"},{"id":"A78119","pred":"fma_id","subj":"T88403","obj":"http://purl.org/sig/ont/fma/fma55675"},{"id":"A13757","pred":"fma_id","subj":"T91823","obj":"http://purl.org/sig/ont/fma/fma54537"},{"id":"A1293","pred":"fma_id","subj":"T67325","obj":"http://purl.org/sig/ont/fma/fma84050"},{"id":"A60748","pred":"fma_id","subj":"T63785","obj":"http://purl.org/sig/ont/fma/fma61889"},{"id":"A59669","pred":"fma_id","subj":"T89876","obj":"http://purl.org/sig/ont/fma/fma61889"}],"text":"on at the same sites (Upadhyay et al. 2010; Bora et al. 2012; Qiu et al. 2013; Alaee et al. 2014; Li et al. 2016; Shrot et al. 2017). Although a few studies have started to examine opiate-HIV interactions in white matter (see below), we predict that the interactive effects on myelin dysregulation will significantly worsen CNS outcomes.\nPreclinical studies indicate opioid-induced neuroimmune signaling alter the saliency of opioid reward and physical dependence (Narita et al. 2006; Hutchinson et al. 2008, 2009). Direct injections of astrocyte-conditioned medium containing cytokines into the nucleus accumbens (NAc) increase morphine conditioned place preference (Narita et al. 2006). Drugs reported to selectively attenuate glial inflammation block morphine conditioned place preference and attenuate symptoms of opioid withdrawal (Narita et al. 2006; Hutchinson et al. 2009; Liu et al. 2010). μ (MOR), δ "}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T22","span":{"begin":208,"end":220},"obj":"Body_part"},{"id":"T23","span":{"begin":277,"end":283},"obj":"Body_part"},{"id":"T24","span":{"begin":324,"end":327},"obj":"Body_part"},{"id":"T25","span":{"begin":596,"end":613},"obj":"Body_part"},{"id":"T26","span":{"begin":615,"end":618},"obj":"Body_part"}],"attributes":[{"id":"A22","pred":"uberon_id","subj":"T22","obj":"http://purl.obolibrary.org/obo/UBERON_0002316"},{"id":"A23","pred":"uberon_id","subj":"T23","obj":"http://purl.obolibrary.org/obo/UBERON_0000345"},{"id":"A24","pred":"uberon_id","subj":"T24","obj":"http://purl.obolibrary.org/obo/UBERON_0001017"},{"id":"A25","pred":"uberon_id","subj":"T25","obj":"http://purl.obolibrary.org/obo/UBERON_0001882"},{"id":"A26","pred":"uberon_id","subj":"T26","obj":"http://purl.obolibrary.org/obo/UBERON_0001882"}],"text":"on at the same sites (Upadhyay et al. 2010; Bora et al. 2012; Qiu et al. 2013; Alaee et al. 2014; Li et al. 2016; Shrot et al. 2017). Although a few studies have started to examine opiate-HIV interactions in white matter (see below), we predict that the interactive effects on myelin dysregulation will significantly worsen CNS outcomes.\nPreclinical studies indicate opioid-induced neuroimmune signaling alter the saliency of opioid reward and physical dependence (Narita et al. 2006; Hutchinson et al. 2008, 2009). Direct injections of astrocyte-conditioned medium containing cytokines into the nucleus accumbens (NAc) increase morphine conditioned place preference (Narita et al. 2006). Drugs reported to selectively attenuate glial inflammation block morphine conditioned place preference and attenuate symptoms of opioid withdrawal (Narita et al. 2006; Hutchinson et al. 2009; Liu et al. 2010). μ (MOR), δ "}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T18","span":{"begin":735,"end":747},"obj":"Disease"}],"attributes":[{"id":"A18","pred":"mondo_id","subj":"T18","obj":"http://purl.obolibrary.org/obo/MONDO_0021166"}],"text":"on at the same sites (Upadhyay et al. 2010; Bora et al. 2012; Qiu et al. 2013; Alaee et al. 2014; Li et al. 2016; Shrot et al. 2017). Although a few studies have started to examine opiate-HIV interactions in white matter (see below), we predict that the interactive effects on myelin dysregulation will significantly worsen CNS outcomes.\nPreclinical studies indicate opioid-induced neuroimmune signaling alter the saliency of opioid reward and physical dependence (Narita et al. 2006; Hutchinson et al. 2008, 2009). Direct injections of astrocyte-conditioned medium containing cytokines into the nucleus accumbens (NAc) increase morphine conditioned place preference (Narita et al. 2006). Drugs reported to selectively attenuate glial inflammation block morphine conditioned place preference and attenuate symptoms of opioid withdrawal (Narita et al. 2006; Hutchinson et al. 2009; Liu et al. 2010). μ (MOR), δ "}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T99017","span":{"begin":98,"end":100},"obj":"http://purl.obolibrary.org/obo/CLO_0001022"},{"id":"T26720","span":{"begin":98,"end":100},"obj":"http://purl.obolibrary.org/obo/CLO_0007314"},{"id":"T98729","span":{"begin":143,"end":144},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T8555","span":{"begin":324,"end":327},"obj":"http://www.ebi.ac.uk/efo/EFO_0000302"},{"id":"T18804","span":{"begin":324,"end":327},"obj":"http://www.ebi.ac.uk/efo/EFO_0000908"},{"id":"T44390","span":{"begin":324,"end":327},"obj":"http://purl.obolibrary.org/obo/UBERON_0001017"},{"id":"T44837","span":{"begin":394,"end":403},"obj":"http://purl.obolibrary.org/obo/SO_0000418"},{"id":"T4348","span":{"begin":537,"end":546},"obj":"http://purl.obolibrary.org/obo/CL_0000127"}],"text":"on at the same sites (Upadhyay et al. 2010; Bora et al. 2012; Qiu et al. 2013; Alaee et al. 2014; Li et al. 2016; Shrot et al. 2017). Although a few studies have started to examine opiate-HIV interactions in white matter (see below), we predict that the interactive effects on myelin dysregulation will significantly worsen CNS outcomes.\nPreclinical studies indicate opioid-induced neuroimmune signaling alter the saliency of opioid reward and physical dependence (Narita et al. 2006; Hutchinson et al. 2008, 2009). Direct injections of astrocyte-conditioned medium containing cytokines into the nucleus accumbens (NAc) increase morphine conditioned place preference (Narita et al. 2006). Drugs reported to selectively attenuate glial inflammation block morphine conditioned place preference and attenuate symptoms of opioid withdrawal (Narita et al. 2006; Hutchinson et al. 2009; Liu et al. 2010). μ (MOR), δ "}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T41","span":{"begin":98,"end":100},"obj":"Chemical"},{"id":"T42","span":{"begin":596,"end":603},"obj":"Chemical"},{"id":"T43","span":{"begin":629,"end":637},"obj":"Chemical"},{"id":"T45","span":{"begin":754,"end":762},"obj":"Chemical"}],"attributes":[{"id":"A41","pred":"chebi_id","subj":"T41","obj":"http://purl.obolibrary.org/obo/CHEBI_30145"},{"id":"A42","pred":"chebi_id","subj":"T42","obj":"http://purl.obolibrary.org/obo/CHEBI_33252"},{"id":"A43","pred":"chebi_id","subj":"T43","obj":"http://purl.obolibrary.org/obo/CHEBI_17303"},{"id":"A44","pred":"chebi_id","subj":"T43","obj":"http://purl.obolibrary.org/obo/CHEBI_58097"},{"id":"A45","pred":"chebi_id","subj":"T45","obj":"http://purl.obolibrary.org/obo/CHEBI_17303"},{"id":"A46","pred":"chebi_id","subj":"T45","obj":"http://purl.obolibrary.org/obo/CHEBI_58097"}],"text":"on at the same sites (Upadhyay et al. 2010; Bora et al. 2012; Qiu et al. 2013; Alaee et al. 2014; Li et al. 2016; Shrot et al. 2017). Although a few studies have started to examine opiate-HIV interactions in white matter (see below), we predict that the interactive effects on myelin dysregulation will significantly worsen CNS outcomes.\nPreclinical studies indicate opioid-induced neuroimmune signaling alter the saliency of opioid reward and physical dependence (Narita et al. 2006; Hutchinson et al. 2008, 2009). Direct injections of astrocyte-conditioned medium containing cytokines into the nucleus accumbens (NAc) increase morphine conditioned place preference (Narita et al. 2006). Drugs reported to selectively attenuate glial inflammation block morphine conditioned place preference and attenuate symptoms of opioid withdrawal (Narita et al. 2006; Hutchinson et al. 2009; Liu et al. 2010). μ (MOR), δ "}

{"project":"LitCovid-PubTator","denotations":[{"id":"161","span":{"begin":188,"end":191},"obj":"Species"},{"id":"175","span":{"begin":902,"end":905},"obj":"Gene"},{"id":"182","span":{"begin":629,"end":637},"obj":"Chemical"},{"id":"183","span":{"begin":754,"end":762},"obj":"Chemical"},{"id":"185","span":{"begin":729,"end":753},"obj":"Disease"}],"attributes":[{"id":"A161","pred":"tao:has_database_id","subj":"161","obj":"Tax:12721"},{"id":"A175","pred":"tao:has_database_id","subj":"175","obj":"Gene:4988"},{"id":"A182","pred":"tao:has_database_id","subj":"182","obj":"MESH:D009020"},{"id":"A183","pred":"tao:has_database_id","subj":"183","obj":"MESH:D009020"},{"id":"A185","pred":"tao:has_database_id","subj":"185","obj":"MESH:D007249"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"on at the same sites (Upadhyay et al. 2010; Bora et al. 2012; Qiu et al. 2013; Alaee et al. 2014; Li et al. 2016; Shrot et al. 2017). Although a few studies have started to examine opiate-HIV interactions in white matter (see below), we predict that the interactive effects on myelin dysregulation will significantly worsen CNS outcomes.\nPreclinical studies indicate opioid-induced neuroimmune signaling alter the saliency of opioid reward and physical dependence (Narita et al. 2006; Hutchinson et al. 2008, 2009). Direct injections of astrocyte-conditioned medium containing cytokines into the nucleus accumbens (NAc) increase morphine conditioned place preference (Narita et al. 2006). Drugs reported to selectively attenuate glial inflammation block morphine conditioned place preference and attenuate symptoms of opioid withdrawal (Narita et al. 2006; Hutchinson et al. 2009; Liu et al. 2010). μ (MOR), δ "}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T25593","span":{"begin":394,"end":403},"obj":"http://purl.obolibrary.org/obo/GO_0023052"},{"id":"T77592","span":{"begin":638,"end":666},"obj":"http://purl.obolibrary.org/obo/GO_1990708"},{"id":"T42576","span":{"begin":735,"end":747},"obj":"http://purl.obolibrary.org/obo/GO_0006954"},{"id":"T73341","span":{"begin":763,"end":791},"obj":"http://purl.obolibrary.org/obo/GO_1990708"}],"text":"on at the same sites (Upadhyay et al. 2010; Bora et al. 2012; Qiu et al. 2013; Alaee et al. 2014; Li et al. 2016; Shrot et al. 2017). Although a few studies have started to examine opiate-HIV interactions in white matter (see below), we predict that the interactive effects on myelin dysregulation will significantly worsen CNS outcomes.\nPreclinical studies indicate opioid-induced neuroimmune signaling alter the saliency of opioid reward and physical dependence (Narita et al. 2006; Hutchinson et al. 2008, 2009). Direct injections of astrocyte-conditioned medium containing cytokines into the nucleus accumbens (NAc) increase morphine conditioned place preference (Narita et al. 2006). Drugs reported to selectively attenuate glial inflammation block morphine conditioned place preference and attenuate symptoms of opioid withdrawal (Narita et al. 2006; Hutchinson et al. 2009; Liu et al. 2010). μ (MOR), δ "}

{"project":"LitCovid-sentences","denotations":[{"id":"T99","span":{"begin":38,"end":55},"obj":"Sentence"},{"id":"T100","span":{"begin":56,"end":72},"obj":"Sentence"},{"id":"T101","span":{"begin":73,"end":91},"obj":"Sentence"},{"id":"T102","span":{"begin":92,"end":107},"obj":"Sentence"},{"id":"T103","span":{"begin":108,"end":126},"obj":"Sentence"},{"id":"T104","span":{"begin":127,"end":133},"obj":"Sentence"},{"id":"T105","span":{"begin":134,"end":337},"obj":"Sentence"},{"id":"T106","span":{"begin":338,"end":478},"obj":"Sentence"},{"id":"T107","span":{"begin":479,"end":502},"obj":"Sentence"},{"id":"T108","span":{"begin":503,"end":515},"obj":"Sentence"},{"id":"T109","span":{"begin":516,"end":681},"obj":"Sentence"},{"id":"T110","span":{"begin":682,"end":688},"obj":"Sentence"},{"id":"T111","span":{"begin":689,"end":850},"obj":"Sentence"},{"id":"T112","span":{"begin":851,"end":874},"obj":"Sentence"},{"id":"T113","span":{"begin":875,"end":891},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"on at the same sites (Upadhyay et al. 2010; Bora et al. 2012; Qiu et al. 2013; Alaee et al. 2014; Li et al. 2016; Shrot et al. 2017). Although a few studies have started to examine opiate-HIV interactions in white matter (see below), we predict that the interactive effects on myelin dysregulation will significantly worsen CNS outcomes.\nPreclinical studies indicate opioid-induced neuroimmune signaling alter the saliency of opioid reward and physical dependence (Narita et al. 2006; Hutchinson et al. 2008, 2009). Direct injections of astrocyte-conditioned medium containing cytokines into the nucleus accumbens (NAc) increase morphine conditioned place preference (Narita et al. 2006). Drugs reported to selectively attenuate glial inflammation block morphine conditioned place preference and attenuate symptoms of opioid withdrawal (Narita et al. 2006; Hutchinson et al. 2009; Liu et al. 2010). μ (MOR), δ "}

{"project":"2_test","denotations":[{"id":"32876803-20558415-62957879","span":{"begin":38,"end":42},"obj":"20558415"},{"id":"32876803-21070508-62957880","span":{"begin":56,"end":60},"obj":"21070508"},{"id":"32876803-23650554-62957881","span":{"begin":73,"end":77},"obj":"23650554"},{"id":"32876803-25035700-62957882","span":{"begin":92,"end":96},"obj":"25035700"},{"id":"32876803-26794650-62957883","span":{"begin":108,"end":112},"obj":"26794650"},{"id":"32876803-28424016-62957884","span":{"begin":127,"end":131},"obj":"28424016"},{"id":"32876803-16407899-62957885","span":{"begin":479,"end":483},"obj":"16407899"},{"id":"32876803-18706994-62957886","span":{"begin":503,"end":507},"obj":"18706994"},{"id":"32876803-18938237-62957887","span":{"begin":509,"end":513},"obj":"18938237"},{"id":"32876803-16407899-62957888","span":{"begin":682,"end":686},"obj":"16407899"},{"id":"32876803-16407899-62957889","span":{"begin":851,"end":855},"obj":"16407899"},{"id":"32876803-18938237-62957890","span":{"begin":875,"end":879},"obj":"18938237"},{"id":"32876803-20519536-62957891","span":{"begin":892,"end":896},"obj":"20519536"}],"text":"on at the same sites (Upadhyay et al. 2010; Bora et al. 2012; Qiu et al. 2013; Alaee et al. 2014; Li et al. 2016; Shrot et al. 2017). Although a few studies have started to examine opiate-HIV interactions in white matter (see below), we predict that the interactive effects on myelin dysregulation will significantly worsen CNS outcomes.\nPreclinical studies indicate opioid-induced neuroimmune signaling alter the saliency of opioid reward and physical dependence (Narita et al. 2006; Hutchinson et al. 2008, 2009). Direct injections of astrocyte-conditioned medium containing cytokines into the nucleus accumbens (NAc) increase morphine conditioned place preference (Narita et al. 2006). Drugs reported to selectively attenuate glial inflammation block morphine conditioned place preference and attenuate symptoms of opioid withdrawal (Narita et al. 2006; Hutchinson et al. 2009; Liu et al. 2010). μ (MOR), δ "}