PMC:7463108 / 96122-96886 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T904","span":{"begin":15,"end":18},"obj":"Body_part"},{"id":"T905","span":{"begin":107,"end":110},"obj":"Body_part"},{"id":"T906","span":{"begin":221,"end":225},"obj":"Body_part"},{"id":"T907","span":{"begin":267,"end":278},"obj":"Body_part"},{"id":"T908","span":{"begin":283,"end":291},"obj":"Body_part"},{"id":"T909","span":{"begin":376,"end":384},"obj":"Body_part"},{"id":"T910","span":{"begin":394,"end":398},"obj":"Body_part"},{"id":"T911","span":{"begin":413,"end":424},"obj":"Body_part"},{"id":"T912","span":{"begin":509,"end":512},"obj":"Body_part"},{"id":"T913","span":{"begin":624,"end":629},"obj":"Body_part"},{"id":"T914","span":{"begin":635,"end":639},"obj":"Body_part"},{"id":"T915","span":{"begin":682,"end":685},"obj":"Body_part"},{"id":"T916","span":{"begin":745,"end":749},"obj":"Body_part"}],"attributes":[{"id":"A904","pred":"fma_id","subj":"T904","obj":"http://purl.org/sig/ont/fma/fma278683"},{"id":"A905","pred":"fma_id","subj":"T905","obj":"http://purl.org/sig/ont/fma/fma55675"},{"id":"A906","pred":"fma_id","subj":"T906","obj":"http://purl.org/sig/ont/fma/fma67122"},{"id":"A907","pred":"fma_id","subj":"T907","obj":"http://purl.org/sig/ont/fma/fma275020"},{"id":"A908","pred":"fma_id","subj":"T908","obj":"http://purl.org/sig/ont/fma/fma77618"},{"id":"A909","pred":"fma_id","subj":"T909","obj":"http://purl.org/sig/ont/fma/fma77618"},{"id":"A910","pred":"fma_id","subj":"T910","obj":"http://purl.org/sig/ont/fma/fma67122"},{"id":"A911","pred":"fma_id","subj":"T911","obj":"http://purl.org/sig/ont/fma/fma275020"},{"id":"A912","pred":"fma_id","subj":"T912","obj":"http://purl.org/sig/ont/fma/fma278683"},{"id":"A913","pred":"fma_id","subj":"T913","obj":"http://purl.org/sig/ont/fma/fma50801"},{"id":"A914","pred":"fma_id","subj":"T914","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A915","pred":"fma_id","subj":"T915","obj":"http://purl.org/sig/ont/fma/fma278683"},{"id":"A916","pred":"fma_id","subj":"T916","obj":"http://purl.org/sig/ont/fma/fma9712"}],"text":"The effects of HIV Tat on expression levels of opioid peptide and receptor levels depend on the individual CNS region involved as well as levels of tat transgene expression (Fitting et al. 2010b). For example, while PDYN mRNA levels were significantly reduced in the hippocampus and striatum of Tat-expressing mice, POMC was only significantly reduced by Tat induction in the striatum and PENK mRNA levels in the hippocampus were affected by chronic (but not acute) Tat exposure (Fitting et al. 2010b). Thus, HIV may alter the endogenous opioid system by modifying the expression of opioid peptides and their receptors in a brain- and cell-type specific manner. The consequences of HIV-1-dependent alterations in the endogenous opioid system to HAND are uncertain."}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T174","span":{"begin":107,"end":110},"obj":"Body_part"},{"id":"T175","span":{"begin":283,"end":291},"obj":"Body_part"},{"id":"T176","span":{"begin":376,"end":384},"obj":"Body_part"},{"id":"T177","span":{"begin":624,"end":629},"obj":"Body_part"}],"attributes":[{"id":"A174","pred":"uberon_id","subj":"T174","obj":"http://purl.obolibrary.org/obo/UBERON_0001017"},{"id":"A175","pred":"uberon_id","subj":"T175","obj":"http://purl.obolibrary.org/obo/UBERON_0002435"},{"id":"A176","pred":"uberon_id","subj":"T176","obj":"http://purl.obolibrary.org/obo/UBERON_0002435"},{"id":"A177","pred":"uberon_id","subj":"T177","obj":"http://purl.obolibrary.org/obo/UBERON_0000955"}],"text":"The effects of HIV Tat on expression levels of opioid peptide and receptor levels depend on the individual CNS region involved as well as levels of tat transgene expression (Fitting et al. 2010b). For example, while PDYN mRNA levels were significantly reduced in the hippocampus and striatum of Tat-expressing mice, POMC was only significantly reduced by Tat induction in the striatum and PENK mRNA levels in the hippocampus were affected by chronic (but not acute) Tat exposure (Fitting et al. 2010b). Thus, HIV may alter the endogenous opioid system by modifying the expression of opioid peptides and their receptors in a brain- and cell-type specific manner. The consequences of HIV-1-dependent alterations in the endogenous opioid system to HAND are uncertain."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T963","span":{"begin":54,"end":61},"obj":"http://purl.obolibrary.org/obo/PR_000018263"},{"id":"T964","span":{"begin":107,"end":110},"obj":"http://www.ebi.ac.uk/efo/EFO_0000302"},{"id":"T965","span":{"begin":107,"end":110},"obj":"http://www.ebi.ac.uk/efo/EFO_0000908"},{"id":"T966","span":{"begin":107,"end":110},"obj":"http://purl.obolibrary.org/obo/UBERON_0001017"},{"id":"T967","span":{"begin":590,"end":598},"obj":"http://purl.obolibrary.org/obo/PR_000018263"},{"id":"T968","span":{"begin":622,"end":623},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T969","span":{"begin":624,"end":629},"obj":"http://purl.obolibrary.org/obo/UBERON_0000955"},{"id":"T970","span":{"begin":624,"end":629},"obj":"http://www.ebi.ac.uk/efo/EFO_0000302"},{"id":"T971","span":{"begin":635,"end":644},"obj":"http://purl.obolibrary.org/obo/CL_0000000"}],"text":"The effects of HIV Tat on expression levels of opioid peptide and receptor levels depend on the individual CNS region involved as well as levels of tat transgene expression (Fitting et al. 2010b). For example, while PDYN mRNA levels were significantly reduced in the hippocampus and striatum of Tat-expressing mice, POMC was only significantly reduced by Tat induction in the striatum and PENK mRNA levels in the hippocampus were affected by chronic (but not acute) Tat exposure (Fitting et al. 2010b). Thus, HIV may alter the endogenous opioid system by modifying the expression of opioid peptides and their receptors in a brain- and cell-type specific manner. The consequences of HIV-1-dependent alterations in the endogenous opioid system to HAND are uncertain."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T84666","span":{"begin":54,"end":61},"obj":"Chemical"},{"id":"T81260","span":{"begin":590,"end":598},"obj":"Chemical"}],"attributes":[{"id":"A89237","pred":"chebi_id","subj":"T84666","obj":"http://purl.obolibrary.org/obo/CHEBI_16670"},{"id":"A46923","pred":"chebi_id","subj":"T81260","obj":"http://purl.obolibrary.org/obo/CHEBI_16670"}],"text":"The effects of HIV Tat on expression levels of opioid peptide and receptor levels depend on the individual CNS region involved as well as levels of tat transgene expression (Fitting et al. 2010b). For example, while PDYN mRNA levels were significantly reduced in the hippocampus and striatum of Tat-expressing mice, POMC was only significantly reduced by Tat induction in the striatum and PENK mRNA levels in the hippocampus were affected by chronic (but not acute) Tat exposure (Fitting et al. 2010b). Thus, HIV may alter the endogenous opioid system by modifying the expression of opioid peptides and their receptors in a brain- and cell-type specific manner. The consequences of HIV-1-dependent alterations in the endogenous opioid system to HAND are uncertain."}

{"project":"LitCovid-PubTator","denotations":[{"id":"3372","span":{"begin":216,"end":220},"obj":"Gene"},{"id":"3373","span":{"begin":295,"end":298},"obj":"Gene"},{"id":"3374","span":{"begin":316,"end":320},"obj":"Gene"},{"id":"3375","span":{"begin":355,"end":358},"obj":"Gene"},{"id":"3376","span":{"begin":389,"end":393},"obj":"Gene"},{"id":"3377","span":{"begin":466,"end":469},"obj":"Gene"},{"id":"3378","span":{"begin":148,"end":151},"obj":"Gene"},{"id":"3379","span":{"begin":19,"end":22},"obj":"Gene"},{"id":"3380","span":{"begin":310,"end":314},"obj":"Species"},{"id":"3381","span":{"begin":682,"end":687},"obj":"Species"},{"id":"3382","span":{"begin":15,"end":18},"obj":"Species"},{"id":"3383","span":{"begin":509,"end":512},"obj":"Species"}],"attributes":[{"id":"A3372","pred":"tao:has_database_id","subj":"3372","obj":"Gene:18610"},{"id":"A3373","pred":"tao:has_database_id","subj":"3373","obj":"Gene:234724"},{"id":"A3374","pred":"tao:has_database_id","subj":"3374","obj":"Gene:18976"},{"id":"A3375","pred":"tao:has_database_id","subj":"3375","obj":"Gene:234724"},{"id":"A3376","pred":"tao:has_database_id","subj":"3376","obj":"Gene:18619"},{"id":"A3377","pred":"tao:has_database_id","subj":"3377","obj":"Gene:234724"},{"id":"A3378","pred":"tao:has_database_id","subj":"3378","obj":"Gene:6898"},{"id":"A3379","pred":"tao:has_database_id","subj":"3379","obj":"Gene:6898"},{"id":"A3380","pred":"tao:has_database_id","subj":"3380","obj":"Tax:10090"},{"id":"A3381","pred":"tao:has_database_id","subj":"3381","obj":"Tax:11676"},{"id":"A3382","pred":"tao:has_database_id","subj":"3382","obj":"Tax:12721"},{"id":"A3383","pred":"tao:has_database_id","subj":"3383","obj":"Tax:12721"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"The effects of HIV Tat on expression levels of opioid peptide and receptor levels depend on the individual CNS region involved as well as levels of tat transgene expression (Fitting et al. 2010b). For example, while PDYN mRNA levels were significantly reduced in the hippocampus and striatum of Tat-expressing mice, POMC was only significantly reduced by Tat induction in the striatum and PENK mRNA levels in the hippocampus were affected by chronic (but not acute) Tat exposure (Fitting et al. 2010b). Thus, HIV may alter the endogenous opioid system by modifying the expression of opioid peptides and their receptors in a brain- and cell-type specific manner. The consequences of HIV-1-dependent alterations in the endogenous opioid system to HAND are uncertain."}

{"project":"LitCovid-sentences","denotations":[{"id":"T1228","span":{"begin":0,"end":188},"obj":"Sentence"},{"id":"T1229","span":{"begin":189,"end":196},"obj":"Sentence"},{"id":"T1230","span":{"begin":197,"end":494},"obj":"Sentence"},{"id":"T1231","span":{"begin":495,"end":502},"obj":"Sentence"},{"id":"T1232","span":{"begin":503,"end":661},"obj":"Sentence"},{"id":"T1233","span":{"begin":662,"end":764},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"The effects of HIV Tat on expression levels of opioid peptide and receptor levels depend on the individual CNS region involved as well as levels of tat transgene expression (Fitting et al. 2010b). For example, while PDYN mRNA levels were significantly reduced in the hippocampus and striatum of Tat-expressing mice, POMC was only significantly reduced by Tat induction in the striatum and PENK mRNA levels in the hippocampus were affected by chronic (but not acute) Tat exposure (Fitting et al. 2010b). Thus, HIV may alter the endogenous opioid system by modifying the expression of opioid peptides and their receptors in a brain- and cell-type specific manner. The consequences of HIV-1-dependent alterations in the endogenous opioid system to HAND are uncertain."}