PMC:7463108 / 91701-92004 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T870","span":{"begin":86,"end":89},"obj":"Body_part"}],"attributes":[{"id":"A870","pred":"fma_id","subj":"T870","obj":"http://purl.org/sig/ont/fma/fma278683"}],"text":"Overall, the results in c-h suggest (1) an important role for glial CCR5 in mediating HIV-1 and opiate neurotoxic interactions, (2) that CCR5 deficiency influences signaling through MOR, and (3) that CCR5 (and perhaps MOR) act via a BDNF intermediary to promote or obstruct neuronal survival (Kim et al."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T925","span":{"begin":164,"end":173},"obj":"http://purl.obolibrary.org/obo/SO_0000418"},{"id":"T926","span":{"begin":231,"end":232},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"text":"Overall, the results in c-h suggest (1) an important role for glial CCR5 in mediating HIV-1 and opiate neurotoxic interactions, (2) that CCR5 deficiency influences signaling through MOR, and (3) that CCR5 (and perhaps MOR) act via a BDNF intermediary to promote or obstruct neuronal survival (Kim et al."}

{"project":"LitCovid-PubTator","denotations":[{"id":"3154","span":{"begin":68,"end":72},"obj":"Gene"},{"id":"3155","span":{"begin":182,"end":185},"obj":"Gene"},{"id":"3156","span":{"begin":200,"end":204},"obj":"Gene"},{"id":"3157","span":{"begin":218,"end":221},"obj":"Gene"},{"id":"3158","span":{"begin":233,"end":237},"obj":"Gene"},{"id":"3168","span":{"begin":86,"end":91},"obj":"Species"},{"id":"3200","span":{"begin":96,"end":113},"obj":"Disease"},{"id":"3201","span":{"begin":137,"end":152},"obj":"Disease"}],"attributes":[{"id":"A3154","pred":"tao:has_database_id","subj":"3154","obj":"Gene:1234"},{"id":"A3155","pred":"tao:has_database_id","subj":"3155","obj":"Gene:4988"},{"id":"A3156","pred":"tao:has_database_id","subj":"3156","obj":"Gene:1234"},{"id":"A3157","pred":"tao:has_database_id","subj":"3157","obj":"Gene:4988"},{"id":"A3158","pred":"tao:has_database_id","subj":"3158","obj":"Gene:627"},{"id":"A3168","pred":"tao:has_database_id","subj":"3168","obj":"Tax:11676"},{"id":"A3200","pred":"tao:has_database_id","subj":"3200","obj":"MESH:D020258"},{"id":"A3201","pred":"tao:has_database_id","subj":"3201","obj":"MESH:D007153"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Overall, the results in c-h suggest (1) an important role for glial CCR5 in mediating HIV-1 and opiate neurotoxic interactions, (2) that CCR5 deficiency influences signaling through MOR, and (3) that CCR5 (and perhaps MOR) act via a BDNF intermediary to promote or obstruct neuronal survival (Kim et al."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T175","span":{"begin":164,"end":173},"obj":"http://purl.obolibrary.org/obo/GO_0023052"},{"id":"T176","span":{"begin":274,"end":291},"obj":"http://purl.obolibrary.org/obo/GO_0043524"}],"text":"Overall, the results in c-h suggest (1) an important role for glial CCR5 in mediating HIV-1 and opiate neurotoxic interactions, (2) that CCR5 deficiency influences signaling through MOR, and (3) that CCR5 (and perhaps MOR) act via a BDNF intermediary to promote or obstruct neuronal survival (Kim et al."}

{"project":"LitCovid-sentences","denotations":[{"id":"T1185","span":{"begin":0,"end":303},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Overall, the results in c-h suggest (1) an important role for glial CCR5 in mediating HIV-1 and opiate neurotoxic interactions, (2) that CCR5 deficiency influences signaling through MOR, and (3) that CCR5 (and perhaps MOR) act via a BDNF intermediary to promote or obstruct neuronal survival (Kim et al."}