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PMC:7463108 / 87586-92237 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T843 30-38 Body_part denotes tyrosine http://purl.org/sig/ont/fma/fma82768
T844 157-161 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T845 277-280 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T846 290-294 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T847 369-380 Body_part denotes lymphocytes http://purl.org/sig/ont/fma/fma62863
T848 441-444 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T849 703-708 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T850 826-833 Body_part denotes neurons http://purl.org/sig/ont/fma/fma54527
T851 917-920 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T852 998-1005 Body_part denotes neurons http://purl.org/sig/ont/fma/fma54527
T853 1030-1061 Body_part denotes glial fibrillary acidic protein http://purl.org/sig/ont/fma/fma63860
T854 1063-1067 Body_part denotes GFAP http://purl.org/sig/ont/fma/fma67326|http://purl.org/sig/ont/fma/fma63860
T856 1092-1102 Body_part denotes astrocytes http://purl.org/sig/ont/fma/fma54537
T857 1258-1262 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T858 1300-1303 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T859 1377-1381 Body_part denotes glia http://purl.org/sig/ont/fma/fma54541
T860 1416-1420 Body_part denotes glia http://purl.org/sig/ont/fma/fma54541
T861 1746-1750 Body_part denotes glia http://purl.org/sig/ont/fma/fma54541
T862 1765-1772 Body_part denotes neurons http://purl.org/sig/ont/fma/fma54527
T863 2426-2430 Body_part denotes glia http://purl.org/sig/ont/fma/fma54541
T864 2514-2518 Body_part denotes glia http://purl.org/sig/ont/fma/fma54541
T865 2691-2700 Body_part denotes microglia http://purl.org/sig/ont/fma/fma68923
T866 2766-2770 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T867 2878-2882 Body_part denotes glia http://purl.org/sig/ont/fma/fma54541
T868 3066-3070 Body_part denotes glia http://purl.org/sig/ont/fma/fma54541
T869 3201-3205 Body_part denotes glia http://purl.org/sig/ont/fma/fma54541
T870 4201-4204 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T170 1274-1279 Body_part denotes scale http://purl.obolibrary.org/obo/UBERON_0002542

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T907 20-29 http://purl.obolibrary.org/obo/CLO_0001658 denotes activates
T908 55-56 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T909 148-161 http://purl.obolibrary.org/obo/CLO_0001658 denotes activate cell
T910 290-294 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T911 634-638 http://purl.obolibrary.org/obo/CLO_0001185 denotes 2018
T912 703-708 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T913 770-771 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T914 1014-1015 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T915 1092-1102 http://purl.obolibrary.org/obo/CL_0000127 denotes astrocytes
T916 1157-1158 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T917 1170-1171 http://purl.obolibrary.org/obo/CLO_0001021 denotes b
T918 1258-1262 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T919 1294-1295 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T920 1296-1297 http://purl.obolibrary.org/obo/CLO_0001021 denotes b
T921 1546-1550 http://purl.obolibrary.org/obo/CLO_0001545 denotes a 72
T922 2263-2267 http://purl.obolibrary.org/obo/CLO_0001185 denotes 2018
T923 2691-2700 http://purl.obolibrary.org/obo/CL_0000129 denotes microglia
T924 2766-2770 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T925 4279-4288 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T926 4346-4347 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T927 4419-4423 http://purl.obolibrary.org/obo/CLO_0001185 denotes 2018
T928 4427-4428 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T929 4429-4430 http://purl.obolibrary.org/obo/CLO_0001021 denotes b
T930 4547-4551 http://purl.obolibrary.org/obo/CLO_0001185 denotes 2018

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T37512 30-38 Chemical denotes tyrosine http://purl.obolibrary.org/obo/CHEBI_18186
T67699 309-317 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T334 599-607 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T85477 730-738 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T68690 931-939 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T74954 1054-1061 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T30670 1314-1322 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T20723 1502-1510 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T15211 1624-1632 Chemical denotes naloxone http://purl.obolibrary.org/obo/CHEBI_7459
T22372 1650-1658 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T96389 1900-1908 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T350 1952-1960 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T37556 2080-2088 Chemical denotes naloxone http://purl.obolibrary.org/obo/CHEBI_7459
T353 2172-2180 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T17637 2396-2398 Chemical denotes Co http://purl.obolibrary.org/obo/CHEBI_27638
T37828 2902-2910 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T7043 3141-3149 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T89089 3365-3373 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T362 3634-3642 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T6684 3750-3758 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T61446 3896-3904 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T49943 4006-4014 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T370 4638-4640 Chemical denotes CC http://purl.obolibrary.org/obo/CHEBI_28940

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
3108 890-894 Gene denotes CCR5 Gene:1234
3109 899-903 Gene denotes BDNF Gene:627
3110 1030-1061 Gene denotes glial fibrillary acidic protein Gene:2670
3111 1063-1067 Gene denotes GFAP Gene:2670
3112 1132-1149 Gene denotes μ-opioid receptor Gene:4988
3113 1151-1154 Gene denotes MOR Gene:4988
3114 1164-1168 Gene denotes CCR5 Gene:1234
3115 1306-1309 Gene denotes Tat Gene:6898
3116 1356-1360 Gene denotes CCR5 Gene:1234
3117 1421-1424 Gene denotes MSN Gene:4478
3118 1438-1441 Gene denotes Tat Gene:6898
3119 1520-1523 Gene denotes Tat Gene:6898
3120 1600-1603 Gene denotes Tat Gene:6898
3121 1786-1789 Gene denotes Tat Gene:6898
3122 2014-2017 Gene denotes Tat Gene:6898
3123 2197-2200 Gene denotes MOR Gene:4988
3124 2453-2457 Gene denotes CCR5 Gene:1234
3125 2488-2492 Gene denotes CCR5 Gene:1234
3126 2524-2528 Gene denotes CCR5 Gene:1234
3127 2578-2582 Gene denotes BDNF Gene:627
3128 2598-2602 Gene denotes BDNF Gene:627
3129 2651-2655 Gene denotes BDNF Gene:627
3130 2702-2707 Gene denotes mBDNF Gene:12064
3131 2778-2783 Gene denotes mBDNF Gene:12064
3132 2792-2796 Gene denotes BDNF Gene:627
3133 2896-2899 Gene denotes Tat Gene:6898
3134 2943-2947 Gene denotes BDNF Gene:627
3135 2952-2957 Gene denotes mBDNF Gene:12064
3136 2988-2992 Gene denotes BDNF Gene:627
3137 2993-2998 Gene denotes mBDNF Gene:12064
3138 3056-3060 Gene denotes CCR5 Gene:1234
3139 3178-3182 Gene denotes BDNF Gene:627
3140 3275-3279 Gene denotes BDNF Gene:627
3141 3280-3285 Gene denotes mBDNF Gene:12064
3142 3406-3410 Gene denotes BDNF Gene:627
3143 3411-3416 Gene denotes mBDNF Gene:12064
3144 3558-3562 Gene denotes CCR5 Gene:1234
3145 3584-3589 Gene denotes mBDNF Gene:12064
3146 3626-3629 Gene denotes Tat Gene:6898
3147 3681-3684 Gene denotes MSN Gene:4478
3148 3725-3728 Gene denotes Tat Gene:6898
3149 3800-3803 Gene denotes Tat Gene:6898
3150 3842-3845 Gene denotes Tat Gene:6898
3151 3937-3942 Gene denotes mBDNF Gene:12064
3152 3998-4001 Gene denotes Tat Gene:6898
3153 4097-4100 Gene denotes Tat Gene:6898
3154 4183-4187 Gene denotes CCR5 Gene:1234
3155 4297-4300 Gene denotes MOR Gene:4988
3156 4315-4319 Gene denotes CCR5 Gene:1234
3157 4333-4336 Gene denotes MOR Gene:4988
3158 4348-4352 Gene denotes BDNF Gene:627
3159 3715-3720 Gene denotes mBDNF Gene:12064
3160 2615-2620 Gene denotes mBDNF Gene:12064
3161 2029-2032 Gene denotes MSN Gene:4478
3162 3742-3745 Gene denotes Tat Gene:6898
3163 3357-3360 Gene denotes Tat Gene:6898
3164 2104-2107 Gene denotes Tat Gene:6898
3165 923-926 Gene denotes Tat Gene:6898
3166 917-922 Species denotes HIV-1 Tax:11676
3167 1300-1305 Species denotes HIV-1 Tax:11676
3168 4201-4206 Species denotes HIV-1 Tax:11676
3169 931-939 Chemical denotes morphine MESH:D009020
3170 1314-1322 Chemical denotes morphine MESH:D009020
3171 1502-1510 Chemical denotes morphine MESH:D009020
3172 1624-1632 Chemical denotes naloxone MESH:D009270
3173 1638-1646 Chemical denotes Naloxone MESH:D009270
3174 1650-1658 Chemical denotes morphine MESH:D009020
3175 1900-1908 Chemical denotes morphine MESH:D009020
3176 1952-1960 Chemical denotes morphine MESH:D009020
3177 2080-2088 Chemical denotes naloxone MESH:D009270
3178 2172-2180 Chemical denotes morphine MESH:D009020
3179 2902-2910 Chemical denotes morphine MESH:D009020
3180 3141-3149 Chemical denotes morphine MESH:D009020
3181 3365-3373 Chemical denotes morphine MESH:D009020
3182 3634-3642 Chemical denotes morphine MESH:D009020
3183 3750-3758 Chemical denotes morphine MESH:D009020
3184 3896-3904 Chemical denotes morphine MESH:D009020
3185 4006-4014 Chemical denotes morphine MESH:D009020
3186 960-972 Disease denotes cytotoxicity MESH:D064420
3187 1445-1455 Disease denotes neurotoxic MESH:D020258
3188 1532-1540 Disease denotes toxicity MESH:D064420
3189 1733-1750 Disease denotes CCR5-deficit glia MESH:D009461
3190 1872-1880 Disease denotes toxicity MESH:D064420
3191 2108-2116 Disease denotes toxicity MESH:D064420
3192 2274-2284 Disease denotes neurotoxic MESH:D020258
3193 2302-2321 Disease denotes CCR5-deficient MSNs MESH:D007153
3194 2771-2776 Disease denotes death MESH:D003643
3195 2857-2882 Disease denotes CCR5-deficient mixed glia MESH:D060085
3196 3186-3205 Disease denotes CCR5-deficient glia MESH:D007153
3197 3468-3483 Disease denotes CCR5 deficiency MESH:D007153
3198 3814-3824 Disease denotes neurotoxic MESH:D020258
3199 4015-4023 Disease denotes toxicity MESH:D064420
3200 4211-4228 Disease denotes opiate neurotoxic MESH:D020258
3201 4252-4267 Disease denotes CCR5 deficiency MESH:D007153
3223 7-11 Gene denotes BDNF Gene:627
3224 13-18 Gene denotes mBDNF Gene:12064
3225 58-62 Gene denotes TrkB Gene:4915
3226 111-115 Gene denotes BDNF Gene:627
3227 121-125 Gene denotes BDNF Gene:627
3228 133-139 Gene denotes p75NTR Gene:4804
3229 254-258 Gene denotes BDNF Gene:627
3230 350-354 Gene denotes BDNF Gene:627
3231 447-452 Gene denotes gp120 Gene:3700
3232 488-493 Gene denotes mBDNF Gene:12064
3233 548-552 Gene denotes CCR5 Gene:1234
3234 593-596 Gene denotes Tat Gene:6898
3235 722-725 Gene denotes Tat Gene:6898
3236 793-798 Gene denotes mBDNF Gene:12064
3237 841-845 Gene denotes CCR5 Gene:1234
3238 483-487 Gene denotes BDNF Gene:627
3239 441-446 Species denotes HIV-1 Tax:11676
3240 730-738 Chemical denotes morphine MESH:D009020
3241 162-167 Disease denotes death MESH:D003643
3242 277-289 Disease denotes HIV-infected MESH:D015658
3243 650-665 Disease denotes CCR5-deficiency MESH:D007153

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T171 157-167 http://purl.obolibrary.org/obo/GO_0008219 denotes cell death
T172 1690-1707 http://purl.obolibrary.org/obo/GO_0043524 denotes neuronal survival
T173 2755-2776 http://purl.obolibrary.org/obo/GO_0012501 denotes programmed cell death
T174 2766-2776 http://purl.obolibrary.org/obo/GO_0008219 denotes cell death
T175 4279-4288 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T176 4389-4406 http://purl.obolibrary.org/obo/GO_0043524 denotes neuronal survival

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T1158 0-177 Sentence denotes Mature BDNF (mBDNF) activates tyrosine receptor kinase B (TrkB) and is neuroprotective, while the precursor to BDNF, pro-BDNF, binds p75NTR and can activate cell death pathways.
T1159 178-334 Sentence denotes Based on findings of significant, reversible reductions in glially produced BDNF after exposure to HIV-infected cell supernatant ± morphine (Masvekar et al.
T1160 335-407 Sentence denotes 2014), altered BDNF processing in lymphocytes from PWH (Avdoshina et al.
T1161 408-467 Sentence denotes 2011), and following exposure to HIV-1 gp120 (Bachis et al.
T1162 468-633 Sentence denotes 2012), the pro-BDNF:mBDNF ratio was analyzed in supernatants from wild-type vs. CCR5-null striatal glial cultures exposed to Tat ± morphine for 6 or 24 h (Kim et al.
T1163 634-649 Sentence denotes 2018) (Fig. 6).
T1164 650-874 Sentence denotes CCR5-deficiency reduced this ratio by over 2-fold in cells treated with Tat and morphine after 6 h (Fig. 6), indicating a relative increase in mBDNF that may partially protect neurons in the CCR5-deficient glial environment.
T1165 875-1013 Sentence denotes Fig. 6 Role of CCR5 and BDNF in mediating HIV-1 Tat and morphine-induced interactive cytotoxicity in striatal medium spiny neurons (MSNs).
T1166 1014-1299 Sentence denotes A proportion of glial fibrillary acidic protein (GFAP)-immunolabeled striatal astrocytes display punctate patterns of μ-opioid receptor (MOR) (a) and CCR5 (b) (43.8 ± 2.4%) immunofluorescence—with some faint immunoreactivity extending into the cell processes; scale bars = 10 μm (a-b).
T1167 1300-1388 Sentence denotes HIV-1 Tat and morphine are no longer toxic to MSNs when CCR5 is deleted from glia (c-f).
T1168 1389-1637 Sentence denotes In C57BL/J wild-type mixed glia-MSN co-cultures, Tat is neurotoxic (*p = 0.001 vs. controls), and co-exposure to morphine enhanced Tat-induced toxicity over a 72-h period (**p < 0.001 vs. controls, p < 0.05 vs. Tat) and antagonized by naloxone (c).
T1169 1638-1712 Sentence denotes Naloxone or morphine by themselves had no effect on neuronal survival (c).
T1170 1713-1937 Sentence denotes In co-cultures with CCR5-deficit glia and wild-type neurons, exposure to Tat by itself is significantly toxic (*p < 0.001 vs. controls); however, the enhanced toxicity seen with combined morphine exposure was eliminated (d).
T1171 1938-2060 Sentence denotes Unexpectedly, morphine co-treatment entirely abolished the toxic effects of Tat, restoring MSN survival to control levels.
T1172 2061-2262 Sentence denotes Pre-treatment with naloxone re-established Tat toxicity, suggesting that the paradoxical protective effects of morphine are mediated by MOR (or perhaps another opioid receptor type) (d) (see Kim et al.
T1173 2263-2269 Sentence denotes 2018).
T1174 2270-2395 Sentence denotes The neurotoxic patterns seen in CCR5-deficient MSNs and wild-type glial co-cultures are similar to wild-type co-cultures (e).
T1175 2396-2523 Sentence denotes Co-cultures in which MSNs and glia are both deficient in CCR5 are similar to those in which CCR5 is only deficient in glia (f).
T1176 2524-2650 Sentence denotes CCR5 deletion alters the expression and processing of BDNF precursor (pro-BDNF) to mature (mBDNF) by mixed-glial cultures (g).
T1177 2651-2965 Sentence denotes BDNF is expressed by both astroglia and microglia; mBDNF is neuroprotective, while pro-BDNF can promote programmed cell death. mBDNF and pro-BDNF levels were analyzed in conditioned media from wild-type or CCR5-deficient mixed glia treated with Tat ± morphine after 6 h or 24 h to assess pro-BDNF and mBDNF levels.
T1178 2966-3131 Sentence denotes The proportion of pro-BDNF/mBDNF levels was significantly higher in wild-type compared to CCR5-null glia at 24 h (lower row; g), suggesting reduced neuronal support.
T1179 3132-3334 Sentence denotes Although morphine significantly decreased pro-BDNF in CCR5-deficient glia at both 6 h and 24 h compared to control levels (not shown), the pro-BDNF/mBDNF ratios were unaltered (upper and lower rows; g).
T1180 3335-3573 Sentence denotes By contrast, combined Tat and morphine significantly decreased the pro-BDNF/mBDNF ratio at 6 h, suggesting transient protection with CCR5 deficiency that was not fully sustained at 24 h (p = 0.17) (*p < 0.05, wild-type vs. CCR5-null) (g).
T1181 3574-3657 Sentence denotes Exogenous mBDNF is neuroprotective against combined Tat and morphine treatment (h).
T1182 3658-3799 Sentence denotes Wild-type, mixed glial-MSN co-cultures were treated with mBDNF and Tat, or combined Tat and morphine (represented by dotted survival curves).
T1183 3800-3920 Sentence denotes Tat alone was neurotoxic (*p < 0.05), and Tat was significantly worsened by co-exposing MSNs to morphine (**p < 0.0001).
T1184 3921-4114 Sentence denotes The addition of mBDNF (50 ng/ml; 72 h) fully protected MSNs against combined Tat and morphine toxicity, but only tended to protect (albeit not significantly) MSNs treated with Tat alone (#)(h).
T1185 4115-4418 Sentence denotes Overall, the results in c-h suggest (1) an important role for glial CCR5 in mediating HIV-1 and opiate neurotoxic interactions, (2) that CCR5 deficiency influences signaling through MOR, and (3) that CCR5 (and perhaps MOR) act via a BDNF intermediary to promote or obstruct neuronal survival (Kim et al.
T1186 4419-4651 Sentence denotes 2018). (a-b) Modified and reprinted with permission from Podhaizer et al. (2012). (c-h) Modified and reprinted from Kim et al. (2018), which is an open access article distributed under the terms of the Creative Commons CC BY license

2_test

Id Subject Object Predicate Lexical cue
32876803-24949623-62958291 335-339 24949623 denotes 2014
32876803-21422985-62958292 408-412 21422985 denotes 2011
32876803-22787033-62958293 468-472 22787033 denotes 2012
32876803-22101471-62958294 4494-4498 22101471 denotes 2012