> top > docs > PMC:7463108 > spans > 84821-86608 > annotations

PMC:7463108 / 84821-86608 JSONTXT

Annnotations TAB JSON ListView MergeView

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T818 27-30 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T819 50-54 Body_part denotes glia http://purl.org/sig/ont/fma/fma54541
T820 114-118 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T821 288-295 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T822 324-331 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T823 625-628 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T824 645-655 Body_part denotes astrocytes http://purl.org/sig/ont/fma/fma54537
T825 664-673 Body_part denotes microglia http://purl.org/sig/ont/fma/fma68923
T826 868-878 Body_part denotes astrocytes http://purl.org/sig/ont/fma/fma54537
T827 883-892 Body_part denotes microglia http://purl.org/sig/ont/fma/fma68923
T828 993-996 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T829 1006-1016 Body_part denotes astrocytes http://purl.org/sig/ont/fma/fma54537
T830 1102-1105 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T831 1121-1130 Body_part denotes microglia http://purl.org/sig/ont/fma/fma68923
T832 1276-1285 Body_part denotes microglia http://purl.org/sig/ont/fma/fma68923
T833 1291-1294 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T834 1474-1479 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T835 1498-1501 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T188 631-640 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T189 1436-1445 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T190 1495-1497 Disease denotes R5 http://purl.obolibrary.org/obo/MONDO_0016654
T191 1519-1521 Disease denotes R5 http://purl.obolibrary.org/obo/MONDO_0016654
T192 1552-1554 Disease denotes R5 http://purl.obolibrary.org/obo/MONDO_0016654
T193 1588-1590 Disease denotes R5 http://purl.obolibrary.org/obo/MONDO_0016654
T194 1616-1618 Disease denotes R5 http://purl.obolibrary.org/obo/MONDO_0016654

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T876 44-49 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T877 72-73 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T878 114-118 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T879 172-173 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T880 191-192 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T881 223-224 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T882 225-233 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T883 398-399 http://purl.obolibrary.org/obo/CLO_0001021 denotes b
T884 529-530 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T885 645-655 http://purl.obolibrary.org/obo/CL_0000127 denotes astrocytes
T886 664-673 http://purl.obolibrary.org/obo/CL_0000129 denotes microglia
T887 696-697 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T888 765-773 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T889 868-878 http://purl.obolibrary.org/obo/CL_0000127 denotes astrocytes
T890 883-892 http://purl.obolibrary.org/obo/CL_0000129 denotes microglia
T891 1006-1016 http://purl.obolibrary.org/obo/CL_0000127 denotes astrocytes
T892 1121-1130 http://purl.obolibrary.org/obo/CL_0000129 denotes microglia
T893 1276-1285 http://purl.obolibrary.org/obo/CL_0000129 denotes microglia
T894 1426-1428 http://purl.obolibrary.org/obo/CLO_0050510 denotes 18
T895 1474-1479 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T896 1645-1646 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T897 1647-1648 http://purl.obolibrary.org/obo/CLO_0001021 denotes b

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T5718 58-67 Chemical denotes maraviroc http://purl.obolibrary.org/obo/CHEBI_63608
T295 92-102 Chemical denotes antagonist http://purl.obolibrary.org/obo/CHEBI_48706
T15052 161-169 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T60468 288-295 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T47897 324-331 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T43994 368-374 Chemical denotes ligand http://purl.obolibrary.org/obo/CHEBI_52214
T54004 442-450 Chemical denotes triazole http://purl.obolibrary.org/obo/CHEBI_38597
T59698 474-480 Chemical denotes ligand http://purl.obolibrary.org/obo/CHEBI_52214
T303 540-545 Chemical denotes probe http://purl.obolibrary.org/obo/CHEBI_50406
T2279 819-828 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T26201 898-906 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T43395 952-961 Chemical denotes maraviroc http://purl.obolibrary.org/obo/CHEBI_63608
T30455 1033-1041 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T96445 1079-1089 Chemical denotes antagonist http://purl.obolibrary.org/obo/CHEBI_48706
T81282 1150-1158 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T78388 1302-1310 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T13049 1524-1532 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T3701 1557-1566 Chemical denotes maraviroc http://purl.obolibrary.org/obo/CHEBI_63608
T318 1568-1571 Chemical denotes MVC http://purl.obolibrary.org/obo/CHEBI_63608
T15381 1597-1600 Chemical denotes MVC http://purl.obolibrary.org/obo/CHEBI_63608
T24754 1625-1628 Chemical denotes MVC http://purl.obolibrary.org/obo/CHEBI_63608
T5763 1631-1641 Chemical denotes naltrexone http://purl.obolibrary.org/obo/CHEBI_7465

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
2881 83-87 Gene denotes CCR5 Gene:1234
2882 88-91 Gene denotes MOR Gene:4988
2883 193-196 Gene denotes MOR Gene:4988
2884 197-201 Gene denotes CCR5 Gene:1234
2885 307-310 Gene denotes MOR Gene:4988
2886 343-347 Gene denotes CCR5 Gene:1234
2887 575-578 Gene denotes MOR Gene:4988
2888 583-587 Gene denotes CCR5 Gene:1234
2889 735-738 Gene denotes Tat Gene:6898
2890 1235-1238 Gene denotes MOR Gene:4988
2891 1243-1247 Gene denotes CCR5 Gene:1234
2892 1769-1773 Gene denotes Hage Gene:55510
2893 1328-1332 Gene denotes Hage Gene:55510
2894 27-32 Species denotes HIV-1 Tax:11676
2895 44-49 Species denotes human Tax:9606
2896 1498-1503 Species denotes HIV-1 Tax:11676
2897 993-996 Species denotes HIV Tax:12721
2898 1102-1105 Species denotes HIV Tax:12721
2899 1291-1294 Species denotes HIV Tax:12721
2900 161-169 Chemical denotes morphine MESH:D009020
2901 442-450 Chemical denotes triazole MESH:D014230
2902 898-906 Chemical denotes morphine MESH:D009020
2903 952-961 Chemical denotes maraviroc MESH:D000077592
2904 1033-1041 Chemical denotes morphine MESH:D009020
2905 1150-1158 Chemical denotes morphine MESH:D009020
2906 1302-1310 Chemical denotes morphine MESH:D009020
2907 1524-1532 Chemical denotes morphine MESH:D009020
2908 1631-1641 Chemical denotes naltrexone MESH:D009271
2909 625-640 Disease denotes HIV-1 infection MESH:D015658
2910 1436-1445 Disease denotes infection MESH:D007239
2911 1465-1473 Disease denotes infected MESH:D007239

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T169 1221-1231 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T1140 278-613 Sentence denotes The green protein represents MOR and the blue protein represents CCR5, while the bivalent ligand is colored in yellow. (b) Different binding pocket (green) for the triazole moiety of the bivalent ligand yellow) at 0 ns and 6.0 ns. (c) Construction of a chemical probe that interacts with both the MOR and CCR5 receptors simultaneously.
T1141 614-787 Sentence denotes To monitor HIV-1 infection (d) astrocytes and (e) microglia were transfected with a pBlue3′LTR-luc reporter sensitive to Tat expression and luciferase activity was measured.
T1142 788-929 Sentence denotes Data indicate that maraviroc’s antiviral effects are completely negated in both astrocytes and microglia when morphine is present (red bars).
T1143 930-1052 Sentence denotes Interestingly, unlike maraviroc, the bivalent compound blocked HIV entry in astrocytes irrespective of morphine treatment.
T1144 1053-1170 Sentence denotes By contrast, the bivalent antagonist exacerbated HIV infectivity in microglia in the presence of morphine (red bars).
T1145 1171-1339 Sentence denotes The findings reveal fundamental differences in co-regulation of MOR and CCR5 expression in astroglia and microglia upon HIV and/or morphine exposure (see El-Hage et al.
T1146 1340-1346 Sentence denotes 2013).
T1147 1347-1787 Sentence denotes Values are luminescence intensity ± SEM from 3 to 5 independent experiments at 18 h post-infection (*p < 0.005 vs. un-infected cells; $p < 0.05 vs. R5 HIV-1; #p < 0.05 vs. R5 + morphine (M); ¶p < 0.05 vs. R5 + maraviroc (MVC); §p < 0.05 vs. R5 + M + MVC; ¥p < 0.05 vs. R5 + M + MVC + naltrexone). (a–b) Modified and reprinted with permission from Arnatt et al. (2016). (c–e) Modified and reprinted with permission from El-Hage et al. (2013)

2_test

Id Subject Object Predicate Lexical cue
32876803-27720326-62958290 1709-1713 27720326 denotes 2016