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PMC:7463108 / 77998-79627 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T751 0-4 Body_part denotes Gene http://purl.org/sig/ont/fma/fma74402
T752 89-114 Body_part denotes neurotransmitter receptor http://purl.org/sig/ont/fma/fma67184
T753 149-152 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T754 187-191 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T755 505-508 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T756 509-518 Body_part denotes chemokine http://purl.org/sig/ont/fma/fma241981
T757 638-641 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T758 712-715 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T759 795-799 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T760 865-868 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T761 936-939 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T762 1042-1045 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T763 1117-1121 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T764 1405-1413 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T765 1475-1480 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T766 1623-1626 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T182 1320-1335 Disease denotes drug dependence http://purl.obolibrary.org/obo/MONDO_0005303

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T813 0-4 http://purl.obolibrary.org/obo/OGG_0000000002 denotes Gene
T814 115-124 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes are
T815 182-185 http://purl.obolibrary.org/obo/PR_000001004 denotes CD4
T816 187-191 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T817 531-540 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T818 795-799 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T819 919-920 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T820 958-960 http://purl.obolibrary.org/obo/CLO_0050510 denotes 18
T821 1117-1121 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T822 1475-1480 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T823 1572-1577 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T52018 84-88 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T10090 89-105 Chemical denotes neurotransmitter http://purl.obolibrary.org/obo/CHEBI_25512
T81858 1163-1167 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T16078 1320-1324 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T80871 1438-1440 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T262 1564-1571 Chemical denotes ligands http://purl.obolibrary.org/obo/CHEBI_52214

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id tao:has_standard_notation
2669 30-35 Gene denotes OPRM1 Gene:4988
2670 40-45 Gene denotes OPRK1 Gene:4986
2671 69-73 Gene denotes DRD1 Gene:1812
2672 78-82 Gene denotes DRD2 Gene:1813
2673 182-185 Gene denotes CD4 Gene:920
2674 489-492 Gene denotes MOR Gene:4988
2675 620-623 Gene denotes MOR Gene:4988
2676 696-699 Gene denotes MOR Gene:4988
2677 789-794 Gene denotes OPRM1 Gene:4988
2678 961-966 Gene denotes OPRM1 Gene:4988
2679 1358-1363 Gene denotes OPRM1 Gene:4988
2680 1431-1436 Gene denotes TNF-α Gene:7124
2681 1438-1443 Gene denotes IL-10 Gene:3586
2682 1445-1450 Gene denotes IFN-γ Gene:3458
2683 1560-1563 Gene denotes MOR Gene:4988
2684 1579-1584 Gene denotes OPRM1 Gene:4988
2685 951-956 Species denotes women Tax:9606
2686 1623-1628 Species denotes HIV-1 Tax:11676
2687 149-152 Species denotes HIV Tax:12721
2688 505-508 Species denotes HIV Tax:12721
2689 638-641 Species denotes HIV Tax:12721
2690 712-715 Species denotes HIV Tax:12721
2691 865-868 Species denotes HIV Tax:12721
2692 1042-1045 Species denotes HIV Tax:12721
2693 363-375 Disease denotes opiate abuse MESH:D009293
2694 936-950 Disease denotes HIV-1-infected MESH:D015658
2695 1163-1178 Disease denotes drug metabolism MESH:D065606
2696 1320-1335 Disease denotes drug dependence MESH:D019966
2697 1341-1346 Mutation denotes A118G rs1799971

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T150 531-540 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T151 818-826 http://purl.obolibrary.org/obo/GO_0045292 denotes splicing
T152 905-914 http://purl.obolibrary.org/obo/GO_0007610 denotes behaviors
T153 1163-1178 http://purl.obolibrary.org/obo/GO_0017144 denotes drug metabolism
T154 1168-1178 http://purl.obolibrary.org/obo/GO_0008152 denotes metabolism
T155 1375-1385 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T156 1405-1423 http://purl.obolibrary.org/obo/GO_0001816 denotes cytokine secretion
T157 1414-1423 http://purl.obolibrary.org/obo/GO_0046903 denotes secretion

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T1063 0-217 Sentence denotes Gene polymorphisms of opioid (OPRM1 and OPRK1) and non-opioid (e.g., DRD1 and DRD2) drug/neurotransmitter receptor genes are associated with altered HIV infectivity, viral loads and CD4+ cell counts (Proudnikov et al.
T1064 218-236 Sentence denotes 2012; Regan et al.
T1065 237-256 Sentence denotes 2012; Jacobs et al.
T1066 257-280 Sentence denotes 2013; Proudnikov et al.
T1067 281-299 Sentence denotes 2013; Dever et al.
T1068 300-306 Sentence denotes 2014).
T1069 307-388 Sentence denotes Not only do MORs mediate the behavioral consequences of opiate abuse (Bond et al.
T1070 389-407 Sentence denotes 1998; Szeto et al.
T1071 408-426 Sentence denotes 2001; Ikeda et al.
T1072 427-445 Sentence denotes 2005; Kreek et al.
T1073 446-461 Sentence denotes 2005; Xu et al.
T1074 462-673 Sentence denotes 2014b), but the ability of MOR to modulate HIV chemokine co-receptor signaling through cross desensitization or through direct molecular interactions suggest MOR may influence HIV infectivity at multiple levels.
T1075 674-915 Sentence denotes The unique ability of MOR to modulate HIV co-receptor function, prompted inquiry regarding whether variants of the OPRM1 gene (polymorphisms or splicing variants) might differentially effect HIV infectivity and/or opiate addictive behaviors.
T1076 916-1103 Sentence denotes In a sample of 1031 HIV-1-infected women, 18 OPRM1 polymorphisms were significantly associated with decreases or increases in HIV infectivity and responsiveness to cART (Proudnikov et al.
T1077 1104-1110 Sentence denotes 2012).
T1078 1111-1218 Sentence denotes Other gene polymorphisms, such as enzymes affecting drug metabolism (Meyer and Zanger 1997; Benowitz et al.
T1079 1219-1336 Sentence denotes 2006) and other neurochemical systems (Herman and Balogh 2012; Koob and Volkow 2016) can also affect drug dependence.
T1080 1337-1498 Sentence denotes The A118G variant of OPRM1 alters the regulation of proinflammatory cytokine secretion (i.e., TNF-α, IL-10, IFN-γ) from peripheral immune cells (Matsunaga et al.
T1081 1499-1505 Sentence denotes 2009).
T1082 1506-1629 Sentence denotes Overall, these findings suggest that polymorphisms in MOR ligands/genes (OPRM1) can influence the pathophysiology of HIV-1.

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T59 895-914 Phenotype denotes addictive behaviors http://purl.obolibrary.org/obo/HP_0030858

2_test

Id Subject Object Predicate Lexical cue
32876803-22457278-62958258 218-222 22457278 denotes 2012
32876803-22034138-62958259 237-241 22034138 denotes 2012
32876803-23392455-62958260 281-285 23392455 denotes 2013
32876803-11338173-62958261 408-412 11338173 denotes 2001
32876803-15925706-62958262 427-431 15925706 denotes 2005
32876803-15734726-62958263 446-450 15734726 denotes 2005
32876803-22457278-62958265 1104-1108 22457278 denotes 2012
32876803-9131254-62958266 1197-1201 9131254 denotes 1997
32876803-17112802-62958267 1219-1223 17112802 denotes 2006
32876803-27475769-62958268 1298-1302 27475769 denotes 2016