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PMC:7463108 / 76-1928 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T36418 161-164 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T60544 185-207 Body_part denotes central nervous system http://purl.org/sig/ont/fma/fma55675
T59550 209-212 Body_part denotes CNS http://purl.org/sig/ont/fma/fma55675
T34528 362-365 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T34449 539-542 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T43923 580-584 Body_part denotes HAND http://purl.org/sig/ont/fma/fma9712
T63421 728-731 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T26171 761-764 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T51689 777-781 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T88958 973-976 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T13436 1163-1166 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T69159 1234-1237 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T39171 1238-1247 Body_part denotes chemokine http://purl.org/sig/ont/fma/fma241981
T64264 1473-1478 Body_part denotes Blood http://purl.org/sig/ont/fma/fma9670
T26336 1479-1484 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T43402 1526-1529 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T14505 1612-1626 Body_part denotes tight junction http://purl.org/sig/ont/fma/fma67397
T96043 1627-1635 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T51030 1693-1698 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T69233 1816-1821 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 185-207 Body_part denotes central nervous system http://purl.obolibrary.org/obo/UBERON_0001017
T2 193-207 Body_part denotes nervous system http://purl.obolibrary.org/obo/UBERON_0001016
T3 209-212 Body_part denotes CNS http://purl.obolibrary.org/obo/UBERON_0001017
T4 1473-1492 Body_part denotes Blood-brain barrier http://purl.obolibrary.org/obo/UBERON_0000120
T5 1479-1484 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T6 1693-1698 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T7 1816-1821 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 137-153 Disease denotes immunodeficiency http://purl.obolibrary.org/obo/MONDO_0021094

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T9974 131-136 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T45969 154-159 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T24986 185-207 http://purl.obolibrary.org/obo/UBERON_0001017 denotes central nervous system
T38936 185-207 http://www.ebi.ac.uk/efo/EFO_0000302 denotes central nervous system
T51456 185-207 http://www.ebi.ac.uk/efo/EFO_0000908 denotes central nervous system
T39921 209-212 http://www.ebi.ac.uk/efo/EFO_0000302 denotes CNS
T78273 209-212 http://www.ebi.ac.uk/efo/EFO_0000908 denotes CNS
T61752 209-212 http://purl.obolibrary.org/obo/UBERON_0001017 denotes CNS
T57883 777-781 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T35359 899-900 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T81874 901-906 http://purl.obolibrary.org/obo/CLO_0009985 denotes focus
T47640 1473-1478 http://purl.obolibrary.org/obo/UBERON_0000178 denotes Blood
T18975 1473-1478 http://www.ebi.ac.uk/efo/EFO_0000296 denotes Blood
T73965 1479-1484 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T21933 1479-1484 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T54654 1618-1626 http://purl.obolibrary.org/obo/UBERON_0007651 denotes junction
T9825 1693-1698 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T35601 1693-1698 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T50159 1816-1821 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T45065 1816-1821 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T1 1627-1635 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T2 1846-1851 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
11 1206-1223 Gene denotes μ-opioid receptor Gene:4988
12 1225-1228 Gene denotes MOR Gene:4988
13 131-159 Species denotes human immunodeficiency virus Tax:12721
14 761-766 Species denotes HIV-1 Tax:11676
15 1163-1168 Species denotes HIV-1 Tax:11676
16 161-164 Species denotes HIV Tax:12721
17 362-365 Species denotes HIV Tax:12721
18 728-731 Species denotes HIV Tax:12721
19 973-976 Species denotes HIV Tax:12721
20 1234-1237 Species denotes HIV Tax:12721
21 526-578 Disease denotes neuroHIV and HIV-associated neurocognitive disorders MESH:D020943
24 1770-1794 Gene denotes some efflux transporters
25 1526-1529 Species denotes HIV Tax:12721

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T96803 989-1001 http://purl.obolibrary.org/obo/GO_0009405 denotes pathogenesis
T85650 1599-1608 http://purl.obolibrary.org/obo/GO_0009056 denotes breakdown
T12576 1775-1781 http://purl.obolibrary.org/obo/GO_0140352 denotes efflux
T35890 1775-1781 http://purl.obolibrary.org/obo/GO_0140115 denotes efflux

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T3 0-214 Sentence denotes With the current national opioid crisis, it is critical to examine the mechanisms underlying pathophysiologic interactions between human immunodeficiency virus (HIV) and opioids in the central nervous system (CNS).
T4 215-403 Sentence denotes Recent advances in experimental models, methodology, and our understanding of disease processes at the molecular and cellular levels reveal opioid-HIV interactions with increasing clarity.
T5 404-611 Sentence denotes However, despite the substantial new insight, the unique impact of opioids on the severity, progression, and prognosis of neuroHIV and HIV-associated neurocognitive disorders (HAND) are not fully understood.
T6 612-837 Sentence denotes In this review, we explore, in detail, what is currently known about mechanisms underlying opioid interactions with HIV, with emphasis on individual HIV-1-expressed gene products at the molecular, cellular and systems levels.
T7 838-1089 Sentence denotes Furthermore, we review preclinical and clinical studies with a focus on key considerations when addressing questions of whether opioid-HIV interactive pathogenesis results in unique structural or functional deficits not seen with either disease alone.
T8 1090-1292 Sentence denotes These considerations include, understanding the combined consequences of HIV-1 genetic variants, host variants, and μ-opioid receptor (MOR) and HIV chemokine co-receptor interactions on the comorbidity.
T9 1293-1452 Sentence denotes Lastly, we present topics that need to be considered in the future to better understand the unique contributions of opioids to the pathophysiology of neuroHIV.
T10 1453-1520 Sentence denotes Graphical Abstract Blood-brain barrier and the neurovascular unit.
T11 1521-1699 Sentence denotes With HIV and opiate co-exposure (represented below the dotted line), there is breakdown of tight junction proteins and increased leakage of paracellular compounds into the brain.
T12 1700-1852 Sentence denotes Despite this, opiate exposure selectively increases the expression of some efflux transporters, thereby restricting brain penetration of specific drugs.

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T1 137-153 Phenotype denotes immunodeficiency http://purl.obolibrary.org/obo/HP_0002721