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PMC:7463108 / 68676-70486 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T665 36-39 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T666 89-106 Body_part denotes neural stem cells http://purl.org/sig/ont/fma/fma86684
T667 101-106 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T668 113-116 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T669 404-407 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T670 500-510 Body_part denotes stem cells http://purl.org/sig/ont/fma/fma63368
T671 505-510 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T672 535-542 Body_part denotes neurons http://purl.org/sig/ont/fma/fma54527
T673 580-593 Body_part denotes dentate gyrus http://purl.org/sig/ont/fma/fma61922
T674 608-611 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T675 647-656 Body_part denotes chemokine http://purl.org/sig/ont/fma/fma241981
T676 768-773 Body_part denotes Notch http://purl.org/sig/ont/fma/fma75036
T677 810-814 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T678 866-873 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T679 943-951 Body_part denotes platelet http://purl.org/sig/ont/fma/fma62851
T680 1039-1042 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T681 1136-1139 Body_part denotes CNS http://purl.org/sig/ont/fma/fma55675
T682 1194-1207 Body_part denotes dentate gyrus http://purl.org/sig/ont/fma/fma61922
T683 1233-1236 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T684 1264-1271 Body_part denotes neurons http://purl.org/sig/ont/fma/fma54527
T685 1276-1280 Body_part denotes glia http://purl.org/sig/ont/fma/fma54541
T686 1448-1452 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T687 1560-1567 Body_part denotes neurons http://purl.org/sig/ont/fma/fma54527
T688 1572-1576 Body_part denotes glia http://purl.org/sig/ont/fma/fma54541
T689 1730-1733 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T690 1793-1800 Body_part denotes neurons http://purl.org/sig/ont/fma/fma54527
T691 1805-1809 Body_part denotes glia http://purl.org/sig/ont/fma/fma54541

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T162 588-593 Body_part denotes gyrus http://purl.obolibrary.org/obo/UBERON_0000200
T163 1136-1139 Body_part denotes CNS http://purl.obolibrary.org/obo/UBERON_0001017
T164 1202-1207 Body_part denotes gyrus http://purl.obolibrary.org/obo/UBERON_0000200

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T745 89-106 http://purl.obolibrary.org/obo/CL_0000047 denotes neural stem cells
T746 213-217 http://purl.obolibrary.org/obo/CLO_0001185 denotes 2018
T747 219-222 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T748 500-510 http://purl.obolibrary.org/obo/CL_0000034 denotes stem cells
T749 692-694 http://purl.obolibrary.org/obo/CLO_0001022 denotes Li
T750 692-694 http://purl.obolibrary.org/obo/CLO_0007314 denotes Li
T751 808-814 http://purl.obolibrary.org/obo/CLO_0001020 denotes a cell
T752 840-850 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T753 856-865 http://purl.obolibrary.org/obo/CLO_0001658 denotes activated
T754 930-939 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T755 974-976 http://purl.obolibrary.org/obo/CLO_0001869 denotes BB
T756 1136-1139 http://www.ebi.ac.uk/efo/EFO_0000302 denotes CNS
T757 1136-1139 http://www.ebi.ac.uk/efo/EFO_0000908 denotes CNS
T758 1136-1139 http://purl.obolibrary.org/obo/UBERON_0001017 denotes CNS
T759 1448-1452 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T760 1662-1666 http://purl.obolibrary.org/obo/CLO_0001185 denotes 2018
T761 1682-1686 http://purl.obolibrary.org/obo/CLO_0001185 denotes 2018

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T66011 692-694 Chemical denotes Li http://purl.obolibrary.org/obo/CHEBI_30145
T86050 866-873 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T13220 974-976 Chemical denotes BB http://purl.obolibrary.org/obo/CHEBI_53109

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
2414 120-125 Gene denotes gp120 Gene:3700
2415 616-621 Gene denotes gp120 Gene:3700
2416 851-882 Gene denotes MAPK-activated protein kinase 2 Gene:9261
2417 887-893 Gene denotes Cdc25B Gene:994
2418 999-1003 Gene denotes BDNF Gene:627
2419 1331-1337 Gene denotes ERK1/2 Gene:5595
2420 1347-1350 Gene denotes p53 Gene:7157
2421 1356-1359 Gene denotes p21 Gene:644914
2422 1388-1397 Gene denotes cyclin D1 Gene:595
2423 670-674 Gene denotes Tran Gene:7154
2424 36-39 Species denotes HIV Tax:12721
2425 113-116 Species denotes HIV Tax:12721
2426 404-407 Species denotes HIV Tax:12721
2427 608-611 Species denotes HIV Tax:12721
2428 1039-1042 Species denotes HIV Tax:12721
2429 1233-1236 Species denotes HIV Tax:12721
2430 1730-1733 Species denotes HIV Tax:12721
2431 647-665 Gene denotes chemokine receptor Gene:7852

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T130 144-156 http://purl.obolibrary.org/obo/GO_0022008 denotes neurogenesis
T131 751-763 http://purl.obolibrary.org/obo/GO_0022008 denotes neurogenesis
T132 810-831 http://purl.obolibrary.org/obo/GO_0000075 denotes cell cycle checkpoint
T133 810-820 http://purl.obolibrary.org/obo/GO_0007049 denotes cell cycle
T134 851-855 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T135 930-939 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T136 960-966 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T137 1250-1271 http://purl.obolibrary.org/obo/GO_0048699 denotes generation of neurons
T138 1326-1330 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T139 1331-1335 http://purl.obolibrary.org/obo/GO_0004707 denotes ERK1
T140 1388-1394 http://purl.obolibrary.org/obo/GO_0016538 denotes cyclin
T141 1432-1440 http://purl.obolibrary.org/obo/GO_0051318 denotes G1 phase
T142 1448-1458 http://purl.obolibrary.org/obo/GO_0007049 denotes cell cycle

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T950 0-107 Sentence denotes Besides being able to infect hNPCs, HIV may also affect their maturation and the fate of neural stem cells.
T951 108-172 Sentence denotes That HIV or gp120 can inhibit adult neurogenesis (Okamoto et al.
T952 173-189 Sentence denotes 2007; Lee et al.
T953 190-212 Sentence denotes 2013; Putatunda et al.
T954 213-297 Sentence denotes 2018) has been the topic of past reviews (Schwartz and Major 2006; Venkatesan et al.
T955 298-315 Sentence denotes 2007; Peng et al.
T956 316-392 Sentence denotes 2008, 2011; Ferrell and Giunta 2014; Hauser and Knapp 2014; Putatunda et al.
T957 393-399 Sentence denotes 2019).
T958 400-607 Sentence denotes How HIV inhibits the self-renewal, tripotential differentiation, and survival of neural progenitors/stem cells or the genesis of adult neurons in the subgranular zone (SGZ) of the dentate gyrus is uncertain.
T959 608-785 Sentence denotes HIV and gp120 [via actions at the same chemokine receptor(s) (Tran and Miller 2005; Li and Ransohoff 2008)] are proposed to modulate the adult neurogenesis via Notch (Fan et al.
T960 786-911 Sentence denotes 2016), by obstructing a cell cycle checkpoint via the activation MAPK-activated protein kinase 2 and Cdc25B/C (Okamoto et al.
T961 912-989 Sentence denotes 2007), or through signaling by platelet-derived growth factor BB (Chao et al.
T962 990-1015 Sentence denotes 2014) or BDNF (Lee et al.
T963 1016-1022 Sentence denotes 2013).
T964 1023-1312 Sentence denotes The extent that HIV regulates the genesis of neural progenitors within the subventricular zone of the developing CNS through similar mechanisms as in the adult SGZ of the dentate gyrus is uncertain—even though HIV disrupts the generation of neurons and glia during maturation or in adults.
T965 1313-1482 Sentence denotes For example, MAPK/ERK1/2 enhances p53- and p21-dependent downregulation of cyclin D1 hindering progression through the G1 phase of the cell cycle in hNPCs (Mishra et al.
T966 1483-1501 Sentence denotes 2010; Malik et al.
T967 1502-1508 Sentence denotes 2014).
T968 1509-1681 Sentence denotes Importantly, opioids too can affect the genesis of neurons and glia during maturation or in the adult directly via convergent pathways (Hauser and Knapp 2018; Kibaly et al.
T969 1682-1810 Sentence denotes 2018) suggesting yet another site of opioid and HIV interactions in dysregulating the creation and fate of new neurons and glia.

2_test

Id Subject Object Predicate Lexical cue
32876803-18371353-62958201 173-177 18371353 denotes 2007
32876803-30314515-62958202 213-217 30314515 denotes 2018
32876803-16842084-62958203 274-278 16842084 denotes 2006
32876803-21637744-62958204 322-326 21637744 denotes 2011
32876803-25134912-62958205 347-351 25134912 denotes 2014
32876803-25175867-62958206 370-374 25175867 denotes 2014
32876803-30899112-62958207 393-397 30899112 denotes 2019
32876803-18177992-62958208 709-713 18177992 denotes 2008
32876803-27807176-62958209 786-790 27807176 denotes 2016
32876803-18371353-62958210 912-916 18371353 denotes 2007
32876803-24469921-62958211 1502-1506 24469921 denotes 2014
32876803-29410949-62958212 1662-1666 29410949 denotes 2018