PMC:7463108 / 5756-6983 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T50043","span":{"begin":35,"end":57},"obj":"Body_part"},{"id":"T17352","span":{"begin":59,"end":62},"obj":"Body_part"},{"id":"T59163","span":{"begin":992,"end":995},"obj":"Body_part"},{"id":"T77573","span":{"begin":1058,"end":1063},"obj":"Body_part"}],"attributes":[{"id":"A60406","pred":"fma_id","subj":"T50043","obj":"http://purl.org/sig/ont/fma/fma55675"},{"id":"A91650","pred":"fma_id","subj":"T17352","obj":"http://purl.org/sig/ont/fma/fma55675"},{"id":"A13008","pred":"fma_id","subj":"T59163","obj":"http://purl.org/sig/ont/fma/fma74412"},{"id":"A79604","pred":"fma_id","subj":"T77573","obj":"http://purl.org/sig/ont/fma/fma50801"}],"text":"The effects of opioid abuse on the central nervous system (CNS) have been extensively examined. Immediate effects of opioids result in decreased levels of consciousness, sedation (Collett 1998; Thompson 2000; Indelicato and Portenoy 2002), drowsiness, and sleep disturbances (Moore and Dimsdale 2002; Bourne and Mills 2004; Qureshi and Lee-Chiong 2004). While acute opioid exposure can impair cognition in healthy subjects (Lawlor 2002; Ersek et al. 2004), enduring cognitive and psychomotor deficits occur with chronic opioid use (Sjogren et al. 2000; Dublin et al. 2015; Roberts et al. 2018; Wollman et al. 2019; Serafini et al. 2020), including altered pain perception (opioid-induced hyperalgesia), dysregulated reward/saliency processing, hyperkatifeia, and epigenetic changes, which can persist years following abstinence (Ersche et al. 2006; Browne et al. 2020). The behavioral changes seen with long-term opioid use are accompanied by lasting structural and epigenetic (e.g., altered DNA methylation and expression of non-coding RNAs) alterations in brain regions implicated in mood, reward, and motivation (Upadhyay et al. 2010; Dublin et al. 2015; Volkow and Morales 2015; Koob and Volkow 2016; Serafini et al. 2020)."}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T8","span":{"begin":35,"end":57},"obj":"Body_part"},{"id":"T9","span":{"begin":43,"end":57},"obj":"Body_part"},{"id":"T10","span":{"begin":59,"end":62},"obj":"Body_part"},{"id":"T11","span":{"begin":1058,"end":1063},"obj":"Body_part"}],"attributes":[{"id":"A8","pred":"uberon_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/UBERON_0001017"},{"id":"A9","pred":"uberon_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/UBERON_0001016"},{"id":"A10","pred":"uberon_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/UBERON_0001017"},{"id":"A11","pred":"uberon_id","subj":"T11","obj":"http://purl.obolibrary.org/obo/UBERON_0000955"}],"text":"The effects of opioid abuse on the central nervous system (CNS) have been extensively examined. Immediate effects of opioids result in decreased levels of consciousness, sedation (Collett 1998; Thompson 2000; Indelicato and Portenoy 2002), drowsiness, and sleep disturbances (Moore and Dimsdale 2002; Bourne and Mills 2004; Qureshi and Lee-Chiong 2004). While acute opioid exposure can impair cognition in healthy subjects (Lawlor 2002; Ersek et al. 2004), enduring cognitive and psychomotor deficits occur with chronic opioid use (Sjogren et al. 2000; Dublin et al. 2015; Roberts et al. 2018; Wollman et al. 2019; Serafini et al. 2020), including altered pain perception (opioid-induced hyperalgesia), dysregulated reward/saliency processing, hyperkatifeia, and epigenetic changes, which can persist years following abstinence (Ersche et al. 2006; Browne et al. 2020). The behavioral changes seen with long-term opioid use are accompanied by lasting structural and epigenetic (e.g., altered DNA methylation and expression of non-coding RNAs) alterations in brain regions implicated in mood, reward, and motivation (Upadhyay et al. 2010; Dublin et al. 2015; Volkow and Morales 2015; Koob and Volkow 2016; Serafini et al. 2020)."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T11","span":{"begin":15,"end":27},"obj":"Disease"},{"id":"T12","span":{"begin":256,"end":274},"obj":"Disease"}],"attributes":[{"id":"A11","pred":"mondo_id","subj":"T11","obj":"http://purl.obolibrary.org/obo/MONDO_0001225"},{"id":"A12","pred":"mondo_id","subj":"T12","obj":"http://purl.obolibrary.org/obo/MONDO_0003406"}],"text":"The effects of opioid abuse on the central nervous system (CNS) have been extensively examined. Immediate effects of opioids result in decreased levels of consciousness, sedation (Collett 1998; Thompson 2000; Indelicato and Portenoy 2002), drowsiness, and sleep disturbances (Moore and Dimsdale 2002; Bourne and Mills 2004; Qureshi and Lee-Chiong 2004). While acute opioid exposure can impair cognition in healthy subjects (Lawlor 2002; Ersek et al. 2004), enduring cognitive and psychomotor deficits occur with chronic opioid use (Sjogren et al. 2000; Dublin et al. 2015; Roberts et al. 2018; Wollman et al. 2019; Serafini et al. 2020), including altered pain perception (opioid-induced hyperalgesia), dysregulated reward/saliency processing, hyperkatifeia, and epigenetic changes, which can persist years following abstinence (Ersche et al. 2006; Browne et al. 2020). The behavioral changes seen with long-term opioid use are accompanied by lasting structural and epigenetic (e.g., altered DNA methylation and expression of non-coding RNAs) alterations in brain regions implicated in mood, reward, and motivation (Upadhyay et al. 2010; Dublin et al. 2015; Volkow and Morales 2015; Koob and Volkow 2016; Serafini et al. 2020)."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T46447","span":{"begin":35,"end":57},"obj":"http://purl.obolibrary.org/obo/UBERON_0001017"},{"id":"T4426","span":{"begin":35,"end":57},"obj":"http://www.ebi.ac.uk/efo/EFO_0000302"},{"id":"T16238","span":{"begin":35,"end":57},"obj":"http://www.ebi.ac.uk/efo/EFO_0000908"},{"id":"T71114","span":{"begin":59,"end":62},"obj":"http://www.ebi.ac.uk/efo/EFO_0000302"},{"id":"T75797","span":{"begin":59,"end":62},"obj":"http://www.ebi.ac.uk/efo/EFO_0000908"},{"id":"T24892","span":{"begin":59,"end":62},"obj":"http://purl.obolibrary.org/obo/UBERON_0001017"},{"id":"T31624","span":{"begin":588,"end":592},"obj":"http://purl.obolibrary.org/obo/CLO_0001185"},{"id":"T67954","span":{"begin":1058,"end":1063},"obj":"http://purl.obolibrary.org/obo/UBERON_0000955"},{"id":"T23415","span":{"begin":1058,"end":1063},"obj":"http://www.ebi.ac.uk/efo/EFO_0000302"}],"text":"The effects of opioid abuse on the central nervous system (CNS) have been extensively examined. Immediate effects of opioids result in decreased levels of consciousness, sedation (Collett 1998; Thompson 2000; Indelicato and Portenoy 2002), drowsiness, and sleep disturbances (Moore and Dimsdale 2002; Bourne and Mills 2004; Qureshi and Lee-Chiong 2004). While acute opioid exposure can impair cognition in healthy subjects (Lawlor 2002; Ersek et al. 2004), enduring cognitive and psychomotor deficits occur with chronic opioid use (Sjogren et al. 2000; Dublin et al. 2015; Roberts et al. 2018; Wollman et al. 2019; Serafini et al. 2020), including altered pain perception (opioid-induced hyperalgesia), dysregulated reward/saliency processing, hyperkatifeia, and epigenetic changes, which can persist years following abstinence (Ersche et al. 2006; Browne et al. 2020). The behavioral changes seen with long-term opioid use are accompanied by lasting structural and epigenetic (e.g., altered DNA methylation and expression of non-coding RNAs) alterations in brain regions implicated in mood, reward, and motivation (Upadhyay et al. 2010; Dublin et al. 2015; Volkow and Morales 2015; Koob and Volkow 2016; Serafini et al. 2020)."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T17","span":{"begin":992,"end":995},"obj":"Chemical"}],"attributes":[{"id":"A17","pred":"chebi_id","subj":"T17","obj":"http://purl.obolibrary.org/obo/CHEBI_16991"}],"text":"The effects of opioid abuse on the central nervous system (CNS) have been extensively examined. Immediate effects of opioids result in decreased levels of consciousness, sedation (Collett 1998; Thompson 2000; Indelicato and Portenoy 2002), drowsiness, and sleep disturbances (Moore and Dimsdale 2002; Bourne and Mills 2004; Qureshi and Lee-Chiong 2004). While acute opioid exposure can impair cognition in healthy subjects (Lawlor 2002; Ersek et al. 2004), enduring cognitive and psychomotor deficits occur with chronic opioid use (Sjogren et al. 2000; Dublin et al. 2015; Roberts et al. 2018; Wollman et al. 2019; Serafini et al. 2020), including altered pain perception (opioid-induced hyperalgesia), dysregulated reward/saliency processing, hyperkatifeia, and epigenetic changes, which can persist years following abstinence (Ersche et al. 2006; Browne et al. 2020). The behavioral changes seen with long-term opioid use are accompanied by lasting structural and epigenetic (e.g., altered DNA methylation and expression of non-coding RNAs) alterations in brain regions implicated in mood, reward, and motivation (Upadhyay et al. 2010; Dublin et al. 2015; Volkow and Morales 2015; Koob and Volkow 2016; Serafini et al. 2020)."}

{"project":"LitCovid-PubTator","denotations":[{"id":"103","span":{"begin":15,"end":27},"obj":"Disease"},{"id":"104","span":{"begin":240,"end":250},"obj":"Disease"},{"id":"105","span":{"begin":256,"end":274},"obj":"Disease"},{"id":"106","span":{"begin":466,"end":500},"obj":"Disease"},{"id":"107","span":{"begin":656,"end":660},"obj":"Disease"},{"id":"108","span":{"begin":688,"end":700},"obj":"Disease"},{"id":"109","span":{"begin":744,"end":757},"obj":"Disease"}],"attributes":[{"id":"A103","pred":"tao:has_database_id","subj":"103","obj":"MESH:D009293"},{"id":"A104","pred":"tao:has_database_id","subj":"104","obj":"MESH:D006970"},{"id":"A105","pred":"tao:has_database_id","subj":"105","obj":"MESH:D012893"},{"id":"A106","pred":"tao:has_database_id","subj":"106","obj":"MESH:D003072"},{"id":"A107","pred":"tao:has_database_id","subj":"107","obj":"MESH:D010146"},{"id":"A108","pred":"tao:has_database_id","subj":"108","obj":"MESH:D006930"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"The effects of opioid abuse on the central nervous system (CNS) have been extensively examined. Immediate effects of opioids result in decreased levels of consciousness, sedation (Collett 1998; Thompson 2000; Indelicato and Portenoy 2002), drowsiness, and sleep disturbances (Moore and Dimsdale 2002; Bourne and Mills 2004; Qureshi and Lee-Chiong 2004). While acute opioid exposure can impair cognition in healthy subjects (Lawlor 2002; Ersek et al. 2004), enduring cognitive and psychomotor deficits occur with chronic opioid use (Sjogren et al. 2000; Dublin et al. 2015; Roberts et al. 2018; Wollman et al. 2019; Serafini et al. 2020), including altered pain perception (opioid-induced hyperalgesia), dysregulated reward/saliency processing, hyperkatifeia, and epigenetic changes, which can persist years following abstinence (Ersche et al. 2006; Browne et al. 2020). The behavioral changes seen with long-term opioid use are accompanied by lasting structural and epigenetic (e.g., altered DNA methylation and expression of non-coding RNAs) alterations in brain regions implicated in mood, reward, and motivation (Upadhyay et al. 2010; Dublin et al. 2015; Volkow and Morales 2015; Koob and Volkow 2016; Serafini et al. 2020)."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T14073","span":{"begin":256,"end":261},"obj":"http://purl.obolibrary.org/obo/GO_0030431"},{"id":"T32162","span":{"begin":393,"end":402},"obj":"http://purl.obolibrary.org/obo/GO_0050890"},{"id":"T91677","span":{"begin":992,"end":1007},"obj":"http://purl.obolibrary.org/obo/GO_0006306"},{"id":"T65053","span":{"begin":996,"end":1007},"obj":"http://purl.obolibrary.org/obo/GO_0032259"}],"text":"The effects of opioid abuse on the central nervous system (CNS) have been extensively examined. Immediate effects of opioids result in decreased levels of consciousness, sedation (Collett 1998; Thompson 2000; Indelicato and Portenoy 2002), drowsiness, and sleep disturbances (Moore and Dimsdale 2002; Bourne and Mills 2004; Qureshi and Lee-Chiong 2004). While acute opioid exposure can impair cognition in healthy subjects (Lawlor 2002; Ersek et al. 2004), enduring cognitive and psychomotor deficits occur with chronic opioid use (Sjogren et al. 2000; Dublin et al. 2015; Roberts et al. 2018; Wollman et al. 2019; Serafini et al. 2020), including altered pain perception (opioid-induced hyperalgesia), dysregulated reward/saliency processing, hyperkatifeia, and epigenetic changes, which can persist years following abstinence (Ersche et al. 2006; Browne et al. 2020). The behavioral changes seen with long-term opioid use are accompanied by lasting structural and epigenetic (e.g., altered DNA methylation and expression of non-coding RNAs) alterations in brain regions implicated in mood, reward, and motivation (Upadhyay et al. 2010; Dublin et al. 2015; Volkow and Morales 2015; Koob and Volkow 2016; Serafini et al. 2020)."}

{"project":"LitCovid-sentences","denotations":[{"id":"T50","span":{"begin":0,"end":95},"obj":"Sentence"},{"id":"T51","span":{"begin":96,"end":353},"obj":"Sentence"},{"id":"T52","span":{"begin":354,"end":449},"obj":"Sentence"},{"id":"T53","span":{"begin":450,"end":546},"obj":"Sentence"},{"id":"T54","span":{"begin":547,"end":566},"obj":"Sentence"},{"id":"T55","span":{"begin":567,"end":587},"obj":"Sentence"},{"id":"T56","span":{"begin":588,"end":608},"obj":"Sentence"},{"id":"T57","span":{"begin":609,"end":630},"obj":"Sentence"},{"id":"T58","span":{"begin":631,"end":842},"obj":"Sentence"},{"id":"T59","span":{"begin":843,"end":862},"obj":"Sentence"},{"id":"T60","span":{"begin":863,"end":869},"obj":"Sentence"},{"id":"T61","span":{"begin":870,"end":1131},"obj":"Sentence"},{"id":"T62","span":{"begin":1132,"end":1151},"obj":"Sentence"},{"id":"T63","span":{"begin":1152,"end":1220},"obj":"Sentence"},{"id":"T64","span":{"begin":1221,"end":1227},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"The effects of opioid abuse on the central nervous system (CNS) have been extensively examined. Immediate effects of opioids result in decreased levels of consciousness, sedation (Collett 1998; Thompson 2000; Indelicato and Portenoy 2002), drowsiness, and sleep disturbances (Moore and Dimsdale 2002; Bourne and Mills 2004; Qureshi and Lee-Chiong 2004). While acute opioid exposure can impair cognition in healthy subjects (Lawlor 2002; Ersek et al. 2004), enduring cognitive and psychomotor deficits occur with chronic opioid use (Sjogren et al. 2000; Dublin et al. 2015; Roberts et al. 2018; Wollman et al. 2019; Serafini et al. 2020), including altered pain perception (opioid-induced hyperalgesia), dysregulated reward/saliency processing, hyperkatifeia, and epigenetic changes, which can persist years following abstinence (Ersche et al. 2006; Browne et al. 2020). The behavioral changes seen with long-term opioid use are accompanied by lasting structural and epigenetic (e.g., altered DNA methylation and expression of non-coding RNAs) alterations in brain regions implicated in mood, reward, and motivation (Upadhyay et al. 2010; Dublin et al. 2015; Volkow and Morales 2015; Koob and Volkow 2016; Serafini et al. 2020)."}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T4","span":{"begin":240,"end":250},"obj":"Phenotype"},{"id":"T5","span":{"begin":256,"end":274},"obj":"Phenotype"},{"id":"T6","span":{"begin":656,"end":660},"obj":"Phenotype"},{"id":"T7","span":{"begin":688,"end":700},"obj":"Phenotype"},{"id":"T8","span":{"begin":874,"end":892},"obj":"Phenotype"}],"attributes":[{"id":"A4","pred":"hp_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/HP_0002329"},{"id":"A5","pred":"hp_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/HP_0002360"},{"id":"A6","pred":"hp_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/HP_0012531"},{"id":"A7","pred":"hp_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/HP_0031005"},{"id":"A8","pred":"hp_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/HP_0000708"}],"text":"The effects of opioid abuse on the central nervous system (CNS) have been extensively examined. Immediate effects of opioids result in decreased levels of consciousness, sedation (Collett 1998; Thompson 2000; Indelicato and Portenoy 2002), drowsiness, and sleep disturbances (Moore and Dimsdale 2002; Bourne and Mills 2004; Qureshi and Lee-Chiong 2004). While acute opioid exposure can impair cognition in healthy subjects (Lawlor 2002; Ersek et al. 2004), enduring cognitive and psychomotor deficits occur with chronic opioid use (Sjogren et al. 2000; Dublin et al. 2015; Roberts et al. 2018; Wollman et al. 2019; Serafini et al. 2020), including altered pain perception (opioid-induced hyperalgesia), dysregulated reward/saliency processing, hyperkatifeia, and epigenetic changes, which can persist years following abstinence (Ersche et al. 2006; Browne et al. 2020). The behavioral changes seen with long-term opioid use are accompanied by lasting structural and epigenetic (e.g., altered DNA methylation and expression of non-coding RNAs) alterations in brain regions implicated in mood, reward, and motivation (Upadhyay et al. 2010; Dublin et al. 2015; Volkow and Morales 2015; Koob and Volkow 2016; Serafini et al. 2020)."}

{"project":"2_test","denotations":[{"id":"32876803-9771273-62957828","span":{"begin":188,"end":192},"obj":"9771273"},{"id":"32876803-10937910-62957829","span":{"begin":203,"end":207},"obj":"10937910"},{"id":"32876803-11773191-62957830","span":{"begin":233,"end":237},"obj":"11773191"},{"id":"32876803-11863402-62957831","span":{"begin":295,"end":299},"obj":"11863402"},{"id":"32876803-15023109-62957832","span":{"begin":318,"end":322},"obj":"15023109"},{"id":"32876803-11920548-62957833","span":{"begin":431,"end":435},"obj":"11920548"},{"id":"32876803-15297954-62957834","span":{"begin":450,"end":454},"obj":"15297954"},{"id":"32876803-26289681-62957835","span":{"begin":567,"end":571},"obj":"26289681"},{"id":"32876803-30314567-62957836","span":{"begin":588,"end":592},"obj":"30314567"},{"id":"32876803-30359116-62957837","span":{"begin":609,"end":613},"obj":"30359116"},{"id":"32876803-31806085-62957838","span":{"begin":631,"end":635},"obj":"31806085"},{"id":"32876803-16160707-62957839","span":{"begin":843,"end":847},"obj":"16160707"},{"id":"32876803-31477236-62957840","span":{"begin":863,"end":867},"obj":"31477236"},{"id":"32876803-20558415-62957841","span":{"begin":1132,"end":1136},"obj":"20558415"},{"id":"32876803-26289681-62957842","span":{"begin":1152,"end":1156},"obj":"26289681"},{"id":"32876803-26276628-62957843","span":{"begin":1177,"end":1181},"obj":"26276628"},{"id":"32876803-27475769-62957844","span":{"begin":1199,"end":1203},"obj":"27475769"},{"id":"32876803-31806085-62957845","span":{"begin":1221,"end":1225},"obj":"31806085"}],"text":"The effects of opioid abuse on the central nervous system (CNS) have been extensively examined. Immediate effects of opioids result in decreased levels of consciousness, sedation (Collett 1998; Thompson 2000; Indelicato and Portenoy 2002), drowsiness, and sleep disturbances (Moore and Dimsdale 2002; Bourne and Mills 2004; Qureshi and Lee-Chiong 2004). While acute opioid exposure can impair cognition in healthy subjects (Lawlor 2002; Ersek et al. 2004), enduring cognitive and psychomotor deficits occur with chronic opioid use (Sjogren et al. 2000; Dublin et al. 2015; Roberts et al. 2018; Wollman et al. 2019; Serafini et al. 2020), including altered pain perception (opioid-induced hyperalgesia), dysregulated reward/saliency processing, hyperkatifeia, and epigenetic changes, which can persist years following abstinence (Ersche et al. 2006; Browne et al. 2020). The behavioral changes seen with long-term opioid use are accompanied by lasting structural and epigenetic (e.g., altered DNA methylation and expression of non-coding RNAs) alterations in brain regions implicated in mood, reward, and motivation (Upadhyay et al. 2010; Dublin et al. 2015; Volkow and Morales 2015; Koob and Volkow 2016; Serafini et al. 2020)."}