PMC:7463108 / 5756-6983
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T50043 | 35-57 | Body_part | denotes | central nervous system | http://purl.org/sig/ont/fma/fma55675 |
| T17352 | 59-62 | Body_part | denotes | CNS | http://purl.org/sig/ont/fma/fma55675 |
| T59163 | 992-995 | Body_part | denotes | DNA | http://purl.org/sig/ont/fma/fma74412 |
| T77573 | 1058-1063 | Body_part | denotes | brain | http://purl.org/sig/ont/fma/fma50801 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T8 | 35-57 | Body_part | denotes | central nervous system | http://purl.obolibrary.org/obo/UBERON_0001017 |
| T9 | 43-57 | Body_part | denotes | nervous system | http://purl.obolibrary.org/obo/UBERON_0001016 |
| T10 | 59-62 | Body_part | denotes | CNS | http://purl.obolibrary.org/obo/UBERON_0001017 |
| T11 | 1058-1063 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/UBERON_0000955 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T11 | 15-27 | Disease | denotes | opioid abuse | http://purl.obolibrary.org/obo/MONDO_0001225 |
| T12 | 256-274 | Disease | denotes | sleep disturbances | http://purl.obolibrary.org/obo/MONDO_0003406 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T46447 | 35-57 | http://purl.obolibrary.org/obo/UBERON_0001017 | denotes | central nervous system |
| T4426 | 35-57 | http://www.ebi.ac.uk/efo/EFO_0000302 | denotes | central nervous system |
| T16238 | 35-57 | http://www.ebi.ac.uk/efo/EFO_0000908 | denotes | central nervous system |
| T71114 | 59-62 | http://www.ebi.ac.uk/efo/EFO_0000302 | denotes | CNS |
| T75797 | 59-62 | http://www.ebi.ac.uk/efo/EFO_0000908 | denotes | CNS |
| T24892 | 59-62 | http://purl.obolibrary.org/obo/UBERON_0001017 | denotes | CNS |
| T31624 | 588-592 | http://purl.obolibrary.org/obo/CLO_0001185 | denotes | 2018 |
| T67954 | 1058-1063 | http://purl.obolibrary.org/obo/UBERON_0000955 | denotes | brain |
| T23415 | 1058-1063 | http://www.ebi.ac.uk/efo/EFO_0000302 | denotes | brain |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T17 | 992-995 | Chemical | denotes | DNA | http://purl.obolibrary.org/obo/CHEBI_16991 |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 103 | 15-27 | Disease | denotes | opioid abuse | MESH:D009293 |
| 104 | 240-250 | Disease | denotes | drowsiness | MESH:D006970 |
| 105 | 256-274 | Disease | denotes | sleep disturbances | MESH:D012893 |
| 106 | 466-500 | Disease | denotes | cognitive and psychomotor deficits | MESH:D003072 |
| 107 | 656-660 | Disease | denotes | pain | MESH:D010146 |
| 108 | 688-700 | Disease | denotes | hyperalgesia | MESH:D006930 |
| 109 | 744-757 | Disease | denotes | hyperkatifeia |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T14073 | 256-261 | http://purl.obolibrary.org/obo/GO_0030431 | denotes | sleep |
| T32162 | 393-402 | http://purl.obolibrary.org/obo/GO_0050890 | denotes | cognition |
| T91677 | 992-1007 | http://purl.obolibrary.org/obo/GO_0006306 | denotes | DNA methylation |
| T65053 | 996-1007 | http://purl.obolibrary.org/obo/GO_0032259 | denotes | methylation |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T50 | 0-95 | Sentence | denotes | The effects of opioid abuse on the central nervous system (CNS) have been extensively examined. |
| T51 | 96-353 | Sentence | denotes | Immediate effects of opioids result in decreased levels of consciousness, sedation (Collett 1998; Thompson 2000; Indelicato and Portenoy 2002), drowsiness, and sleep disturbances (Moore and Dimsdale 2002; Bourne and Mills 2004; Qureshi and Lee-Chiong 2004). |
| T52 | 354-449 | Sentence | denotes | While acute opioid exposure can impair cognition in healthy subjects (Lawlor 2002; Ersek et al. |
| T53 | 450-546 | Sentence | denotes | 2004), enduring cognitive and psychomotor deficits occur with chronic opioid use (Sjogren et al. |
| T54 | 547-566 | Sentence | denotes | 2000; Dublin et al. |
| T55 | 567-587 | Sentence | denotes | 2015; Roberts et al. |
| T56 | 588-608 | Sentence | denotes | 2018; Wollman et al. |
| T57 | 609-630 | Sentence | denotes | 2019; Serafini et al. |
| T58 | 631-842 | Sentence | denotes | 2020), including altered pain perception (opioid-induced hyperalgesia), dysregulated reward/saliency processing, hyperkatifeia, and epigenetic changes, which can persist years following abstinence (Ersche et al. |
| T59 | 843-862 | Sentence | denotes | 2006; Browne et al. |
| T60 | 863-869 | Sentence | denotes | 2020). |
| T61 | 870-1131 | Sentence | denotes | The behavioral changes seen with long-term opioid use are accompanied by lasting structural and epigenetic (e.g., altered DNA methylation and expression of non-coding RNAs) alterations in brain regions implicated in mood, reward, and motivation (Upadhyay et al. |
| T62 | 1132-1151 | Sentence | denotes | 2010; Dublin et al. |
| T63 | 1152-1220 | Sentence | denotes | 2015; Volkow and Morales 2015; Koob and Volkow 2016; Serafini et al. |
| T64 | 1221-1227 | Sentence | denotes | 2020). |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T4 | 240-250 | Phenotype | denotes | drowsiness | http://purl.obolibrary.org/obo/HP_0002329 |
| T5 | 256-274 | Phenotype | denotes | sleep disturbances | http://purl.obolibrary.org/obo/HP_0002360 |
| T6 | 656-660 | Phenotype | denotes | pain | http://purl.obolibrary.org/obo/HP_0012531 |
| T7 | 688-700 | Phenotype | denotes | hyperalgesia | http://purl.obolibrary.org/obo/HP_0031005 |
| T8 | 874-892 | Phenotype | denotes | behavioral changes | http://purl.obolibrary.org/obo/HP_0000708 |
2_test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 32876803-9771273-62957828 | 188-192 | 9771273 | denotes | 1998 |
| 32876803-10937910-62957829 | 203-207 | 10937910 | denotes | 2000 |
| 32876803-11773191-62957830 | 233-237 | 11773191 | denotes | 2002 |
| 32876803-11863402-62957831 | 295-299 | 11863402 | denotes | 2002 |
| 32876803-15023109-62957832 | 318-322 | 15023109 | denotes | 2004 |
| 32876803-11920548-62957833 | 431-435 | 11920548 | denotes | 2002 |
| 32876803-15297954-62957834 | 450-454 | 15297954 | denotes | 2004 |
| 32876803-26289681-62957835 | 567-571 | 26289681 | denotes | 2015 |
| 32876803-30314567-62957836 | 588-592 | 30314567 | denotes | 2018 |
| 32876803-30359116-62957837 | 609-613 | 30359116 | denotes | 2019 |
| 32876803-31806085-62957838 | 631-635 | 31806085 | denotes | 2020 |
| 32876803-16160707-62957839 | 843-847 | 16160707 | denotes | 2006 |
| 32876803-31477236-62957840 | 863-867 | 31477236 | denotes | 2020 |
| 32876803-20558415-62957841 | 1132-1136 | 20558415 | denotes | 2010 |
| 32876803-26289681-62957842 | 1152-1156 | 26289681 | denotes | 2015 |
| 32876803-26276628-62957843 | 1177-1181 | 26276628 | denotes | 2015 |
| 32876803-27475769-62957844 | 1199-1203 | 27475769 | denotes | 2016 |
| 32876803-31806085-62957845 | 1221-1225 | 31806085 | denotes | 2020 |