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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T555 18-21 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T556 80-85 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T557 221-226 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T558 996-1007 Body_part denotes vasculature http://purl.org/sig/ont/fma/fma69050
T559 1017-1035 Body_part denotes perivascular space http://purl.org/sig/ont/fma/fma323243|http://purl.org/sig/ont/fma/fma323272
T561 1043-1053 Body_part denotes parenchyma http://purl.org/sig/ont/fma/fma45732
T562 1061-1069 Body_part denotes striatum http://purl.org/sig/ont/fma/fma77618
T563 1148-1154 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T564 1215-1219 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T565 1352-1370 Body_part denotes perivascular space http://purl.org/sig/ont/fma/fma323243|http://purl.org/sig/ont/fma/fma323272
T567 1371-1381 Body_part denotes parenchyma http://purl.org/sig/ont/fma/fma45732
T568 1445-1454 Body_part denotes left-hand http://purl.org/sig/ont/fma/fma9714
T569 1547-1558 Body_part denotes capillaries http://purl.org/sig/ont/fma/fma63194
T570 1559-1581 Body_part denotes post-capillary venules http://purl.org/sig/ont/fma/fma63191
T571 1564-1573 Body_part denotes capillary http://purl.org/sig/ont/fma/fma63194
T572 1683-1695 Body_part denotes blood vessel http://purl.org/sig/ont/fma/fma63183
T573 1776-1788 Body_part denotes white matter http://purl.org/sig/ont/fma/fma83929
T574 1807-1815 Body_part denotes striatum http://purl.org/sig/ont/fma/fma77618
T575 1942-1948 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T576 1952-1958 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T577 1969-1977 Body_part denotes striatum http://purl.org/sig/ont/fma/fma77618
T578 2130-2138 Body_part denotes striatum http://purl.org/sig/ont/fma/fma77618
T579 2223-2229 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T580 2233-2239 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T110 80-85 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T111 221-226 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T112 996-1007 Body_part denotes vasculature http://purl.obolibrary.org/obo/UBERON_0002049
T113 1017-1035 Body_part denotes perivascular space http://purl.obolibrary.org/obo/UBERON_0014930
T114 1043-1053 Body_part denotes parenchyma http://purl.obolibrary.org/obo/UBERON_0000353
T115 1061-1069 Body_part denotes striatum http://purl.obolibrary.org/obo/UBERON_0002435
T116 1148-1154 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T117 1352-1370 Body_part denotes perivascular space http://purl.obolibrary.org/obo/UBERON_0014930
T118 1371-1381 Body_part denotes parenchyma http://purl.obolibrary.org/obo/UBERON_0000353
T119 1450-1454 Body_part denotes hand http://purl.obolibrary.org/obo/UBERON_0002398
T120 1559-1581 Body_part denotes post-capillary venules http://purl.obolibrary.org/obo/UBERON_0035428
T121 1564-1573 Body_part denotes capillary http://purl.obolibrary.org/obo/UBERON_0001982
T122 1683-1695 Body_part denotes blood vessel http://purl.obolibrary.org/obo/UBERON_0001981
T123 1683-1688 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T124 1689-1695 Body_part denotes vessel http://purl.obolibrary.org/obo/UBERON_0000055
T125 1776-1788 Body_part denotes white matter http://purl.obolibrary.org/obo/UBERON_0002316
T126 1807-1815 Body_part denotes striatum http://purl.obolibrary.org/obo/UBERON_0002435
T127 1908-1913 Body_part denotes Scale http://purl.obolibrary.org/obo/UBERON_0002542
T128 1942-1948 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T129 1969-1977 Body_part denotes striatum http://purl.obolibrary.org/obo/UBERON_0002435
T130 2130-2138 Body_part denotes striatum http://purl.obolibrary.org/obo/UBERON_0002435
T131 2223-2229 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T646 80-85 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T647 80-85 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T648 144-145 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T649 221-226 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T650 221-226 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brain
T651 303-308 http://purl.obolibrary.org/obo/CLO_0007836 denotes mouse
T652 309-315 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brains
T653 309-315 http://www.ebi.ac.uk/efo/EFO_0000302 denotes brains
T654 389-390 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T655 403-404 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T656 735-736 http://purl.obolibrary.org/obo/CLO_0001021 denotes b
T657 1215-1219 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T658 1664-1665 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T659 1683-1695 http://purl.obolibrary.org/obo/UBERON_0001981 denotes blood vessel
T660 1683-1695 http://www.ebi.ac.uk/efo/EFO_0000817 denotes blood vessel
T661 1952-1958 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T662 2233-2239 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T663 2358-2359 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T125 32-40 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T127 197-203 Chemical denotes tracer http://purl.obolibrary.org/obo/CHEBI_35204
T88715 333-341 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T13546 432-440 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T66413 568-576 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T134 666-674 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T136 724-732 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T138 862-870 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T81225 887-895 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T142 916-924 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T37279 1184-1197 Chemical denotes Hoechst 33342 http://purl.obolibrary.org/obo/CHEBI_51232
T79767 1220-1226 Chemical denotes nuclei http://purl.obolibrary.org/obo/CHEBI_33252
T42686 1281-1284 Chemical denotes DIC http://purl.obolibrary.org/obo/CHEBI_4305|http://purl.obolibrary.org/obo/CHEBI_53092
T5674 1410-1418 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T61069 1862-1867 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T21571 2015-2023 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T2284 2060-2072 Chemical denotes dolutegravir http://purl.obolibrary.org/obo/CHEBI_76010
T19714 2081-2089 Chemical denotes abacavir http://purl.obolibrary.org/obo/CHEBI_421707
T29469 2103-2113 Chemical denotes lamivudine http://purl.obolibrary.org/obo/CHEBI_63577
T20462 2193-2201 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T49655 2317-2325 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T84615 2342-2350 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
2041 119-122 Gene denotes Tat Gene:234724
2042 230-233 Gene denotes Tat Gene:234724
2043 259-262 Gene denotes Tat Gene:234724
2044 357-360 Gene denotes Tat Gene:234724
2045 625-628 Gene denotes Tat Gene:234724
2046 635-638 Gene denotes Tat Gene:234724
2047 817-820 Gene denotes Tat Gene:234724
2048 837-840 Gene denotes Tat Gene:234724
2049 857-860 Gene denotes Tat Gene:234724
2050 882-885 Gene denotes Tat Gene:234724
2051 2001-2004 Gene denotes Tat Gene:234724
2052 2272-2275 Gene denotes Tat Gene:234724
2053 2292-2295 Gene denotes Tat Gene:234724
2054 2312-2315 Gene denotes Tat Gene:234724
2055 2337-2340 Gene denotes Tat Gene:234724
2056 24-27 Gene denotes Tat Gene:6898
2057 297-300 Gene denotes Tat Gene:234724
2058 18-23 Species denotes HIV-1 Tax:11676
2059 273-277 Species denotes mice Tax:10090
2060 303-308 Species denotes mouse Tax:10090
2061 371-375 Species denotes mice Tax:10090
2062 896-900 Species denotes mice Tax:10090
2063 944-955 Species denotes horseradish Tax:3704
2064 1427-1431 Species denotes mice Tax:10090
2065 1853-1857 Species denotes mice Tax:10090
2066 2351-2355 Species denotes mice Tax:10090
2067 32-40 Chemical denotes morphine MESH:D009020
2068 333-341 Chemical denotes morphine MESH:D009020
2069 432-440 Chemical denotes morphine MESH:D009020
2070 568-576 Chemical denotes morphine MESH:D009020
2071 666-674 Chemical denotes morphine MESH:D009020
2072 724-732 Chemical denotes morphine MESH:D009020
2073 862-870 Chemical denotes morphine MESH:D009020
2074 887-895 Chemical denotes morphine MESH:D009020
2075 916-924 Chemical denotes morphine MESH:D009020
2076 1184-1197 Chemical denotes Hoechst 33342 MESH:C017807
2077 1410-1418 Chemical denotes morphine MESH:D009020
2078 2015-2023 Chemical denotes morphine MESH:D009020
2079 2060-2072 Chemical denotes dolutegravir MESH:C562325
2080 2081-2089 Chemical denotes abacavir MESH:C106538
2081 2103-2113 Chemical denotes lamivudine MESH:D019259
2082 2193-2201 Chemical denotes morphine MESH:D009020
2083 2317-2325 Chemical denotes morphine MESH:D009020
2084 2342-2350 Chemical denotes morphine MESH:D009020
2085 48-57 Disease denotes leakiness MESH:C535298

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T106 944-972 http://purl.obolibrary.org/obo/GO_0004601 denotes horseradish peroxidase (HRP)

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T791 0-101 Sentence denotes Fig. 3 Effects of HIV-1 Tat and morphine on BBB leakiness and on antiretroviral brain concentrations.
T792 102-392 Sentence denotes After 14 days of Tat induction, there was a significant increase in the 10 kDa (Cascade Blue®) tracer leakage into the brain in Tat + placebo as compared to Tat − placebo mice (*p < 0.05) and in Tat − mouse brains upon exposure to morphine as compared to Tat − placebo mice (*p < 0.05) (a).
T793 393-741 Sentence denotes There was a significant main effect of morphine, resulting in reduced integrity of the BBB and increased leakage of the higher molecular weight (40 kDa and 70 kDa) tracers in morphine-exposed groups as compared to the those groups (Tat + and Tat − together) not exposed to morphine (placebo) (#p < 0.05; significant main effect of morphine) (b, c).
T794 742-901 Sentence denotes Data represent the fold change in mean fluorescence intensity ± SEM; n = 8 Tat−/placebo, n = 6 Tat+/placebo, n = 9 Tat−/morphine, and n = 7 Tat+/morphine mice.
T795 902-1077 Sentence denotes Additionally, morphine exposure increased horseradish peroxidase (HRP) extravasation from the vasculature into the perivascular space and/or parenchyma in the striatum (d, e).
T796 1078-1315 Sentence denotes HRP antigenicity was detected by indirect immunofluorescence (red) in tissue sections counterstained with Hoechst 33342 (blue) to reveal cell nuclei and visualized by differential interference contrast (DIC)-enhanced confocal microscopy.
T797 1316-1477 Sentence denotes HRP extravasation into the striatal perivascular space/parenchyma was especially prevalent in morphine-exposed mice (arrowheads; left-hand panels in e versus d).
T798 1478-1748 Sentence denotes The dotted lines (············) indicate the approximate edge of the capillaries/post-capillary venules; while intermittent dotted lines (· · · · · · ·) indicate the approximate edge of a partly sectioned blood vessel that appears partially outside the plane of section.
T799 1749-1816 Sentence denotes The asterisks (*) indicate white matter tracts within the striatum.
T800 1817-1868 Sentence denotes Representative samples from ≥ n = 4 mice per group.
T801 1869-1907 Sentence denotes All images are the same magnification.
T802 1908-1926 Sentence denotes Scale bar = 10 μm.
T803 1927-1984 Sentence denotes Antiretroviral tissue-to-plasma ratios in striatum (f–g).
T804 1985-2203 Sentence denotes Irrespective of Tat exposure, morphine significantly reduced the levels of dolutegravir (f) and abacavir (g), but not lamivudine (h), within the striatum, as compared to placebo. (* p < 0.05; main effect for morphine).
T805 2204-2429 Sentence denotes Data represent the tissue-to-plasma ratios ± SEM sampled from n = 9 Tat−/placebo, n = 9 Tat+/placebo, n = 6 Tat−/morphine, and n = 8 Tat+/morphine mice. (a–h) Modified and reprinted with permission from Leibrand et al. (2019)

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T46 1017-1035 Phenotype denotes perivascular space http://purl.obolibrary.org/obo/HP_0012520
T47 1352-1370 Phenotype denotes perivascular space http://purl.obolibrary.org/obo/HP_0012520