PMC:7463108 / 52860-53318
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7463108","sourcedb":"PMC","sourceid":"7463108","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7463108","text":"While the events underlying the disruption of neuronal-microglial activation that trigger the emergence of latent HIV are unclear, the induction of HIV expression appears to involve the production of DAMPs by injured neurons and can be turned “on”, e.g., by methamphetamine-induced sigma-1 (σ1) receptor activation, TNF-α and IL-1β, and TLR3 activation can be turned “off” by CX3CL1/fractalkine or glucocorticoid receptor activation (Alvarez-Carbonell et al.","tracks":[{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T516","span":{"begin":114,"end":117},"obj":"Body_part"},{"id":"T517","span":{"begin":148,"end":151},"obj":"Body_part"},{"id":"T518","span":{"begin":217,"end":224},"obj":"Body_part"},{"id":"T519","span":{"begin":326,"end":330},"obj":"Body_part"}],"attributes":[{"id":"A516","pred":"fma_id","subj":"T516","obj":"http://purl.org/sig/ont/fma/fma278683"},{"id":"A517","pred":"fma_id","subj":"T517","obj":"http://purl.org/sig/ont/fma/fma278683"},{"id":"A518","pred":"fma_id","subj":"T518","obj":"http://purl.org/sig/ont/fma/fma54527"},{"id":"A519","pred":"fma_id","subj":"T519","obj":"http://purl.org/sig/ont/fma/fma86583"},{"subj":"T516","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T517","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T518","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T519","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T603","span":{"begin":66,"end":76},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T604","span":{"begin":304,"end":314},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T605","span":{"begin":342,"end":352},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T606","span":{"begin":422,"end":432},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"}],"attributes":[{"subj":"T603","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T604","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T605","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T606","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T3867","span":{"begin":258,"end":273},"obj":"Chemical"},{"id":"T74","span":{"begin":326,"end":328},"obj":"Chemical"},{"id":"T37470","span":{"begin":398,"end":412},"obj":"Chemical"}],"attributes":[{"id":"A40751","pred":"chebi_id","subj":"T3867","obj":"http://purl.obolibrary.org/obo/CHEBI_6809"},{"id":"A77495","pred":"chebi_id","subj":"T74","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A54785","pred":"chebi_id","subj":"T74","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A5169","pred":"chebi_id","subj":"T37470","obj":"http://purl.obolibrary.org/obo/CHEBI_24261"},{"subj":"T3867","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T74","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T37470","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"1953","span":{"begin":316,"end":321},"obj":"Gene"},{"id":"1954","span":{"begin":326,"end":331},"obj":"Gene"},{"id":"1955","span":{"begin":337,"end":341},"obj":"Gene"},{"id":"1956","span":{"begin":376,"end":382},"obj":"Gene"},{"id":"1957","span":{"begin":383,"end":394},"obj":"Gene"},{"id":"1958","span":{"begin":398,"end":421},"obj":"Gene"},{"id":"1960","span":{"begin":114,"end":117},"obj":"Species"},{"id":"1961","span":{"begin":148,"end":151},"obj":"Species"},{"id":"1962","span":{"begin":258,"end":273},"obj":"Chemical"}],"attributes":[{"id":"A1953","pred":"tao:has_database_id","subj":"1953","obj":"Gene:7124"},{"id":"A1954","pred":"tao:has_database_id","subj":"1954","obj":"Gene:3552"},{"id":"A1955","pred":"tao:has_database_id","subj":"1955","obj":"Gene:7098"},{"id":"A1956","pred":"tao:has_database_id","subj":"1956","obj":"Gene:6376"},{"id":"A1957","pred":"tao:has_database_id","subj":"1957","obj":"Gene:6376"},{"id":"A1958","pred":"tao:has_database_id","subj":"1958","obj":"Gene:2908"},{"id":"A1960","pred":"tao:has_database_id","subj":"1960","obj":"Tax:12721"},{"id":"A1961","pred":"tao:has_database_id","subj":"1961","obj":"Tax:12721"},{"id":"A1962","pred":"tao:has_database_id","subj":"1962","obj":"MESH:D008694"},{"subj":"1953","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1954","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1955","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1956","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1957","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1958","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1960","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1961","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1962","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T92","span":{"begin":398,"end":432},"obj":"http://purl.obolibrary.org/obo/GO_0004883"},{"id":"T93","span":{"begin":398,"end":432},"obj":"http://purl.obolibrary.org/obo/GO_0004879"}],"attributes":[{"subj":"T92","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T93","pred":"source","obj":"LitCovid-PD-GO-BP"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T740","span":{"begin":0,"end":458},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T740","pred":"source","obj":"LitCovid-sentences"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PD-FMA-UBERON","color":"#93d4ec","default":true},{"id":"LitCovid-PD-CLO","color":"#ecea93"},{"id":"LitCovid-PD-CHEBI","color":"#d093ec"},{"id":"LitCovid-PubTator","color":"#93ecb6"},{"id":"LitCovid-PD-GO-BP","color":"#ec9c93"},{"id":"LitCovid-sentences","color":"#93a4ec"}]}]}}