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PMC:7463108 / 50851-52508 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T505 55-58 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T506 695-698 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T507 771-778 Body_part denotes neurons http://purl.org/sig/ont/fma/fma54527
T508 852-861 Body_part denotes dendrites http://purl.org/sig/ont/fma/fma67314
T509 949-962 Body_part denotes aspartic acid http://purl.org/sig/ont/fma/fma82760
T510 1568-1575 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T136 739-745 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T596 131-132 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T597 381-382 http://purl.obolibrary.org/obo/CLO_0001021 denotes b
T598 1078-1086 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T599 1092-1093 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T600 1586-1587 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T601 1588-1589 http://purl.obolibrary.org/obo/CLO_0001021 denotes b

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T56524 7-15 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T22 87-96 Chemical denotes ryanodine http://purl.obolibrary.org/obo/CHEBI_8925
T54050 98-101 Chemical denotes RyR http://purl.obolibrary.org/obo/CHEBI_8925
T24 190-199 Chemical denotes ryanodine http://purl.obolibrary.org/obo/CHEBI_8925
T4899 209-218 Chemical denotes ryanodine http://purl.obolibrary.org/obo/CHEBI_8925
T26 223-231 Chemical denotes pyruvate http://purl.obolibrary.org/obo/CHEBI_15361
T553 259-267 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T61869 298-308 Chemical denotes Nimodipine http://purl.obolibrary.org/obo/CHEBI_7575
T41653 343-353 Chemical denotes dantrolene http://purl.obolibrary.org/obo/CHEBI_4317
T31 422-431 Chemical denotes ryanodine http://purl.obolibrary.org/obo/CHEBI_8925
T4654 471-479 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T47424 544-554 Chemical denotes nimodipine http://purl.obolibrary.org/obo/CHEBI_7575
T96207 556-566 Chemical denotes dantrolene http://purl.obolibrary.org/obo/CHEBI_4317
T9447 571-579 Chemical denotes pyruvate http://purl.obolibrary.org/obo/CHEBI_15361
T14570 643-645 Chemical denotes TM http://purl.obolibrary.org/obo/CHEBI_55460|http://purl.obolibrary.org/obo/CHEBI_74861
T32988 647-649 Chemical denotes TM http://purl.obolibrary.org/obo/CHEBI_55460|http://purl.obolibrary.org/obo/CHEBI_74861
T39702 663-671 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T69404 709-717 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T44 797-805 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T46 868-873 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T68016 876-883 Chemical denotes hydroxy http://purl.obolibrary.org/obo/CHEBI_43176
T48 886-892 Chemical denotes methyl http://purl.obolibrary.org/obo/CHEBI_32875|http://purl.obolibrary.org/obo/CHEBI_29309
T50651 914-918 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T52793 938-962 Chemical denotes N-methyl-D-aspartic acid http://purl.obolibrary.org/obo/CHEBI_31882
T29928 940-946 Chemical denotes methyl http://purl.obolibrary.org/obo/CHEBI_32875|http://purl.obolibrary.org/obo/CHEBI_29309
T65599 947-962 Chemical denotes D-aspartic acid http://purl.obolibrary.org/obo/CHEBI_17364
T6522 949-962 Chemical denotes aspartic acid http://purl.obolibrary.org/obo/CHEBI_22660
T67050 958-962 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T85819 1011-1013 Chemical denotes Na http://purl.obolibrary.org/obo/CHEBI_26708
T58 1054-1056 Chemical denotes Na http://purl.obolibrary.org/obo/CHEBI_26708
T79856 1108-1111 Chemical denotes ATP http://purl.obolibrary.org/obo/CHEBI_15422|http://purl.obolibrary.org/obo/CHEBI_30616
T12888 1161-1163 Chemical denotes Na http://purl.obolibrary.org/obo/CHEBI_26708
T38030 1169-1171 Chemical denotes Na http://purl.obolibrary.org/obo/CHEBI_26708
T87801 1283-1291 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T3614 1330-1332 Chemical denotes Na http://purl.obolibrary.org/obo/CHEBI_26708
T82906 1352-1359 Chemical denotes calcium http://purl.obolibrary.org/obo/CHEBI_22984|http://purl.obolibrary.org/obo/CHEBI_29320
T40213 1416-1425 Chemical denotes ryanodine http://purl.obolibrary.org/obo/CHEBI_8925
T28773 1427-1430 Chemical denotes RyR http://purl.obolibrary.org/obo/CHEBI_8925
T21964 1465-1473 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T33921 1568-1575 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
1839 98-101 Gene denotes RyR Gene:6262
1840 134-137 Gene denotes Tat Gene:6898
1841 701-704 Gene denotes Tat Gene:6898
1842 986-989 Gene denotes MOR Gene:4988
1843 1427-1430 Gene denotes RyR Gene:6262
1844 1494-1497 Gene denotes MOR Gene:4988
1845 1275-1278 Gene denotes Tat Gene:6898
1846 789-792 Gene denotes Tat Gene:6898
1847 651-654 Gene denotes Tat Gene:6898
1848 618-621 Gene denotes Tat Gene:6898
1849 463-466 Gene denotes Tat Gene:6898
1850 251-254 Gene denotes Tat Gene:6898
1851 59-62 Gene denotes Tat Gene:6898
1852 695-700 Species denotes HIV-1 Tax:11676
1853 55-58 Species denotes HIV Tax:12721
1854 7-15 Chemical denotes Morphine MESH:D009020
1855 77-81 Chemical denotes Ca2+ MESH:D000069285
1856 87-96 Chemical denotes ryanodine MESH:D012433
1857 160-164 Chemical denotes Ca2+ MESH:D000069285
1858 190-199 Chemical denotes ryanodine MESH:D012433
1859 209-218 Chemical denotes ryanodine MESH:D012433
1860 223-231 Chemical denotes pyruvate MESH:D019289
1861 259-267 Chemical denotes morphine MESH:D009020
1862 290-294 Chemical denotes Ca2+ MESH:D000069285
1863 298-308 Chemical denotes Nimodipine MESH:D009553
1864 317-321 Chemical denotes Ca2+ MESH:D000069285
1865 343-353 Chemical denotes dantrolene MESH:D003620
1866 393-397 Chemical denotes Ca2+ MESH:D000069285
1867 422-431 Chemical denotes ryanodine MESH:D012433
1868 471-479 Chemical denotes morphine MESH:D009020
1869 502-506 Chemical denotes Ca2+ MESH:D000069285
1870 544-554 Chemical denotes nimodipine MESH:D009553
1871 556-566 Chemical denotes dantrolene MESH:D003620
1872 571-579 Chemical denotes pyruvate MESH:D019289
1873 663-671 Chemical denotes Morphine MESH:D009020
1874 709-717 Chemical denotes morphine MESH:D009020
1875 1244-1248 Chemical denotes Ca2+ MESH:D000069285
1876 1283-1291 Chemical denotes morphine MESH:D009020
1877 1352-1359 Chemical denotes calcium MESH:D002118
1878 1416-1425 Chemical denotes ryanodine MESH:D012433
1879 1465-1473 Chemical denotes morphine MESH:D009020
1880 1538-1542 Chemical denotes Ca2+ MESH:D000069285
1881 730-745 Disease denotes neuronal injury MESH:D009410

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T90 1251-1262 http://purl.obolibrary.org/obo/GO_0042592 denotes homeostasis
T91 1352-1372 http://purl.obolibrary.org/obo/GO_0051209 denotes calcium mobilization

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T731 0-297 Sentence denotes Fig. 2 Morphine exacerbates the excitotoxic effects of HIV Tat by mobilizing Ca2+ from ryanodine (RyR)-sensitive internal stores. (a) Tat-induced increases in [Ca2+]i were not attenuated by ryanodine, whereas ryanodine and pyruvate attenuate combined Tat and morphine-induced increases in [Ca2+]i.
T732 298-650 Sentence denotes Nimodipine (L-type Ca2+ channel blocker) and dantrolene did not show any effects. (b) Average [Ca2+]i over 10 min indicated ryanodine significantly blocked combined Tat and morphine-induced increases in [Ca2+]i, whereas no effects were noted for nimodipine, dantrolene, or pyruvate. *p < 0.05 vs. control, #p < 0.05 vs. Tat 50 nM, §p < 0.05 vs. TM, TM:
T733 651-779 Sentence denotes Tat 50 nM + Morphine 500 nM. (c) Summary of HIV-1 Tat and morphine interactive neuronal injury in striatal medium spiny neurons.
T734 780-1225 Sentence denotes Combined Tat and morphine promotes structural and functional defects in dendrites via α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPAR), N-methyl-D-aspartic acid receptors (NMDAR), and MOR, causing influxes of Na+ and/or Ca2+, compensatory increases in Na+/K+-dependent ATPase activity, and a rapid loss in ATP mobilization with an inability to extrude excess Na+ via Na+/K+-ATPase caused by mitochondrial hyperpolarization.
T735 1226-1657 Sentence denotes Dysregulation of [Ca2+]i homeostasis by combined Tat and morphine appears to be mediated downstream of [Na+]i at the level of calcium mobilization, which in turn appears to be regulated via ryanodine (RyR)-sensitive sites, and enhanced by morphine exposure likely via MOR-dependent stimulation of PI3-kinase and Ca2+ mobilization via the Gβγ protein subunit. (a-b) Modified and reprinted with permission from Fitting et al. (2014a)